Release of siRNA from Liposomes Induced by Curcumin by Kazuyo Fujita, Yoshie Hiramatsu, Hideki Minematsu, Masaharu Somiya, Shun’ichi Kuroda, Masaharu Seno, Shuji Hinuma

“…Liposomes are a potential carrier of small interfering RNA (siRNA) for drug delivery systems (DDS). In this study, we searched for a molecule capable of controlling the release of siRNA from a certain type of liposomes and found that curcumin could induce the release of siRNA from the liposomes encapsulating siRNA within 30 min. …”
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Biofilm Formation and blaOXA Genes Detection Among Acinetobacter baumannii from Clinical Isolates in a Tertiary Care Kirtipur Hospital, Nepal by Upasana Ghimire, Rupesh Kandel, Mary Neupane, Sanjit Shrestha, Sudeep K C, Santosh Khanal, Dev Raj Joshi

“…This study was carried to associate the biofilm formation with the drug resistance pattern of A. baumannii and to detect blaOXA-23, blaOXA-24, and blaOXA-51 from carbapenem resistance isolates. (2) Methods: Among different clinical samples, a total of 19 Acinetobacter spp. were identified with conventional microbiological procedures. …”
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Elucidating Molecular Interactions of Natural Inhibitors with HPV-16 E6 Oncoprotein through Docking Analysis by Satish Kumar, Lingaraja Jena, Sneha Galande, Sangeeta Daf, Kanchan Mohod, Ashok K. Varma

“…The life-threatening infection caused by HPV demands the need for designing anticancerous drugs. In the recent years, different compounds from natural origins, such as carrageenan, curcumin, epigallocatechin gallate, indole-3-carbinol, jaceosidin, and withaferin, have been used as a hopeful source of anticancer therapy. …”
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Prevalence and Antibiotic Resistance Patterns of Ocular Bacterial Strains Isolated from Pediatric Patients in University Hospital of Campania “Luigi Vanvitelli,” Naples, Italy by Francesco Petrillo, Veronica Folliero, Biagio Santella, Gianluigi Franci, Francesco Foglia, Maria C. Trotta, Maria T. Della Rocca, Teresio Avitabile, Caterina Gagliano, Marilena Galdiero

“…Therefore, the identification of the causal bacteria and antimicrobial sensitivity tests are mandatory to select the effective drug for the treatment of eye infections and prevent the development of antibiotic-resistant bacteria.…”
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Unleashing the potential of extracellular vesicles for ulcerative colitis and Crohn's disease therapy by George Chigozie Njoku, Cathal Patrick Forkan, Fumie Mitani Soltysik, Peter Lindberg Nejsum, Flemming Pociot, Reza Yarani

“…EVs are nano-sized vesicles that are non-replicating and carry bioactive molecules that modulate immune responses, promote tissue repair, can facilitate drug delivery and, therefore, hold great therapeutic promise. …”
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Spectral Investigation and In Vitro Antibacterial Evaluation of NiII and CuII Complexes of Schiff Base Derived from Amoxicillin and α-Formylthiophene (αft) by Narendra Kumar Chaudhary, Parashuram Mishra

“…The antibacterial sensitivity study suggests promising activities of Haαft (Ligand) and M(Haαft)2 complexes against four clinical pathogenic bacteria, namely, E. coli, P. vulgaris, P. aeruginosa, and S. aureus, though being less active than the standard drug amikacin.…”
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The tyrosine kinase inhibitor lenvatinib is oxidized by rat cytochromes P450 and affects their expression in rat liver by Indra Radek, Jelínková Sandra, Kollárová Katarína, Zahumenská Petra, Dvořák Josef, Dušková Šárka, Dračínská Helena

“…Lenvatinib is an orally effective tyrosine kinase inhibitor used to treat several types of tumors, including progressive, radioiodine-refractory differentiated thyroid cancer and advanced renal cell carcinoma. Although this drug is increasingly used in therapy, its metabolism and effects on the organism are still not described in detail. …”
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Effect of Gelatin/Xanthan Gum Ratios on Jackfruit Leaf Extract Nanoemulsion Gel Stability and Properties by Haswani Maisarah Mustafa, Nor Amaiza Mohd. Amin, Rabitah Zakaria, Mohd. Shamsul Anuar, Azhari Samsu Baharuddin

“…Furthermore, all stable nanoemulsion gels demonstrated shear thinning behavior, and the highest amount of XAN ratio blends at 2.0% (MA) enhanced the viscosity of the nanoemulsion by fine tuning the rheological characteristics of the targeted gelled nanoemulsion suitable for future topical drug delivery application.…”
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Identification and characterization of a novel tetrapeptide from enzymatic hydrolysates of Baijiu byproduct by Qiang Wu, Changqing Zhong, Guirong Zeng, Xu Zhang, Liping Xiang, Chang Wan, Yougui Yu

“…The peptide QGVP hydrolyzed from distilled spent grain proteins of Chinese strong-flavor Baijiu was expected to be used as a food ingredient to prevent or co-treat hypertension with other chemical drugs.…”
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Infertility and risk of ovarian cancer: A systematic review and meta analysis by Indra Sambasivam, H. Gladius Jennifer, Saravanan Chinnaiyan

“…The current meta-analysis showed that women who used infertility drugs had a higher risk of developing OC than those having a history of infertility.…”
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Frequency and types of antibiotic usage in a referral neonatal intensive care unit, based on the world health organization classification (AwaRe) by Farzaneh Hematian, Seyyed Mohammad Hassan Aletayeb, Masoud Dehdashtian, Mohammad Reza Aramesh, Arash Malakian, Mahboobeh Sadat Aletayeb

“…Results Out of 502 examined patient files, antibiotics were prescribed for 483 neonates. The most common drug combinations were ampicillin and amikacin. The mean number and duration of antibiotic administration were 2.14 drugs and 7.78 days, respectively. 84.3% of infants received antibiotics for ten days or less. …”
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In silico data mining of large-scale databases for the virtual screening of human interleukin-2 inhibitors by Halim Sobia Ahsan, Zaheer-Ul-Haq, Khan Ajmal, Al-Rawahi Ahmed, Al-Harrasi Ahmed

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Comparison of United States and Canadian Glaucoma Medication Costs and Price Change from 2006 to 2013 by Matthew B. Schlenker, Graham E. Trope, Yvonne M. Buys

“…We also calculated real wholesale price changes from 2006 to 2013 based on the Average Wholesale Price (USA) and the Ontario Drug Benefit Price (Canada). Results. US brand name medication costs were on average 4x more than Canadian medication costs (range: 1.9x–6.9x), averaging a cost difference of $859 annually. …”
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7-Chloroquinolin-4-yl Arylhydrazone Derivatives: Synthesis and Antifungal Activity by Auri R. Duval, Pedro H. Carvalho, Maieli C. Soares, Daniela P. Gouvêa, Geonir M. Siqueira, Rafael G. Lund, Wilson Cunico

“…Several compounds exhibited minimum inhibitory concentration (MIC) and minimum fungicidal concentration (MFC) activities comparable with the first-line drug fluconazole. These results could be considered as an important starting point for the rational design of new antifungal agents.…”
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Engagement and Preparedness of Urban Accredited Social Health Activists (U-ASHAs) for Delivery of Tuberculosis (TB) Care: Findings From two Cities in Maharashtra, India by Vidula S. Purohit, Shilpa Santosh Karvande, Daksha Y. Shah, Omprakash B. Vallepawar, Omprakash J. Yadav, Nerges F. Mistry

“…Just half-day training for TB as part of 8-day general induction training, brief updates before ACFs, and the absence of an on-the-job supervisory structure resulted in TB knowledge gaps particularly for the latest diagnostic tests, adverse drug reactions, government schemes for TB patients, and contact tracing. …”
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Risk Assessment of BRONJ in Oncologic Patients Treated with Bisphosphonates: Follow-Up to 18 Months by Scilla Sparabombe, Lucia Vitali, Alessandra Nori, Ricarda Sara Berlin, Marta Mazur, Giovanna Orsini, Angelo Putignano

“…Bisphosphonates related osteonecrosis of the jaw (BRONJ) is a pathological condition characterized by bone exposure or latent infection in patients treated with the drug. The aim of the study is to monitor the BRONJ level of risk health in patients with cancer, according to a preventive clinical protocol, which is firstly aimed at reducing risk factors such as the periodontal infections. …”
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The Haematological Effects of Oleanolic Acid in Streptozotocin-Induced Diabetic Rats: Effects on Selected Markers by Charity M. Baloyi, A. Khathi, Ntethelelo H. Sibiya, Phikelelani S. Ngubane

“…Insulin is the mainstay drug in type 1 diabetes mellitus (T1D); however, the use of insulin is associated with haematological alterations that could further worsen cardiovascular complications. …”
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Antifungal Susceptibility and Biofilm Production of Candida spp. Isolated from Clinical Samples by Munmun B. Marak, Biranthabail Dhanashree

“…Voriconazole was the next effective drug with 81.11% susceptibility. 24.44% of strains were resistant to fluconazole. …”
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Genomic characterization of antimicrobial-resistance and virulence factors in Salmonella isolates obtained from pig farms in Antioquia, Colombia. by María Isabel García-Álvarez, Juana L Vidal, Pilar Donado-Godoy, Jared Smith, Nikki Shariat, María Fernanda Valencia, Luis M Gómez-Osorio, Sara López-Osorio, Jenny J Chaparro-Gutiérrez

“…<h4>Conclusion</h4>The presence of multi-drug resistant Salmonella strains in pigs destined for human consumption in Antioquia, Colombia was determined. …”
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Acute Necrotizing Pancreatitis following Long-Term Antipsychotic Use by David T. Liebers, Adaora Ofomata, Ryan Badolato, Emily Mills, Pantea Farahmand

“…This case highlights that although exceedingly rare, prescribers should be aware of the risk for drug-induced pancreatitis in patients stable on antipsychotic medications.…”
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