The Effects of Baclofen for the Treatment of Gastroesophageal Reflux Disease: A Meta-Analysis of Randomized Controlled Trials by Shujie Li, Shengying Shi, Feng Chen, Jingming Lin

“…All reported side effects of baclofen were of mild-to-moderate intensity, and the drug was well tolerated. Conclusion. Abundant evidence suggests that baclofen may be a useful approach for the treatment of GERD patients; however, a larger well-designed research study would further confirm this recommendation.…”
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A Joint Technology Combining the Advantages of Capillary Microsampling with Mass Spectrometry Applied to the Trans-Resveratrol Pharmacokinetic Study in Mice by Ying Xu, Song-xia Zhang, Jing Guo, Li-jie Chen, Yu-ligh Liou, Tai Rao, Jing-bo Peng, Ying Guo, Wei-hua Huang, Zhi-rong Tan, Dong-sheng Ou-yang, Hong-hao Zhou, Wei Zhang, Yao Chen

“…Thus, present work aims to find an effective strategy for overcoming these challenges using trans-resveratrol as a tool drug. Based on the idea of a joint technology, the capillary microsampling (CMS) was chosen for blood sample collection from mice after delivery of trans-resveratrol (150 mg/kg) by gavage, and a high-performance liquid chromatography-tandem mass spectrometry (HPLC-MS/MS) method was developed for the determination of trans-resveratrol and its main metabolites. …”
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A Phage‐Based Approach to Identify Antivirulence Inhibitors of Bacterial Type IV Pili by Tori M. Shimozono, Nancy J. Vogelaar, Megan T. O'Hara, Zhaomin Yang

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Design of a polarization independent terahertz metamaterial absorber for biomedical sensing applications by Tasnim Mahfuz, Arif Hossan, Naymur Rahman

“…The biomedical applications include non-invasive detection of subtle changes within tissues, monitoring drug delivery processes or even early-stage disease diagnosis.…”
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Assessing environmental and human health risks of pharmaceutical contamination in surface water by Ioana-Antonia Cimpean, Florentina Laura Chiriac, Diana Constantinescu-Groposila, Victor Constantin Cojocaru, Vasile Ion Iancu

“…According to the literature, they are classified into several therapeutic classes, the ones of interest for this paper being non-steroidal anti-inflammatory drugs; antidiabetic drugs, and antacid drugs. The mentioned drugs have raised concerns due to their presence in the environment and the potential health risks they pose. …”
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Light-induced rearrangement from macrocyclic to bicyclic lactam: A case study of N-chlorinated laurolactam by Zubčić Gabrijel, Pavić Kristina, You Jiangyang, Vrček Valerije, Portada Tomislav, Bešić Erim, Šakić Davor

“…Converting macrocycle lactams into bicyclic lactams is proposed as an additional way to further increase the metabolic stability of peptide-based drugs. Unfortunately, the synthesis of bicyclic lactams has to start almost from scratch. …”
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Human microbiome, applied to clinical practice by V. T. Ivashkin, K. V. Ivashkin

“…There is a need to study of possible effects of altered microbiome on drug interactions and the immune status. The model of bacterial involvement in colorectal cancer progression is under study. …”
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Improved production strain maintenance technique for Burkholderia mallei 5584 (Master seed) used for glander diagnostic agent production by E. A. Artemeva, L. A. Melnikova, L. I. Zaynullin, N. K. Bukova

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Targeting Fibrosis: From Molecular Mechanisms to Advanced Therapies by Xingpeng Di, Ya Li, Jingwen Wei, Tianyue Li, Banghua Liao

“…The major etiology of fibrosis is an injury caused by genetic heterogeneity, trauma, virus infection, alcohol, mechanical stimuli, and drug. Persistent abnormal activation of “quiescent” fibroblasts that interact with or do not interact with the immune system via complicated signaling cascades, in which parenchymal cells are also triggered, is identified as the main mechanism involved in the initiation and progression of fibrosis. …”
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High-throughput method characterizes hundreds of previously unknown antibiotic resistance mutations by Matthew J. Jago, Jake K. Soley, Stepan Denisov, Calum J. Walsh, Danna R. Gifford, Benjamin P. Howden, Mato Lagator

“…We compare four E. coli strains exposed to ciprofloxacin, cycloserine, or nitrofurantoin and identify 812 resistance mutations, many in genes and regulatory regions not previously associated with resistance. We find that multi-drug and antibiotic-specific resistance are acquired through categorically different types of mutations, and that minor genotypic differences significantly influence evolutionary routes to resistance. …”
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TRIM25: A Global Player of Cell Death Pathways and Promising Target of Tumor-Sensitizing Therapies by Wolfgang Eberhardt, Usman Nasrullah, Josef Pfeilschifter

“…A growing body of evidence has highlighted the multifaceted role of tripartite motif 25 (TRIM25) in controlling different aspects of tumorigenesis, including chemotherapeutic drug resistance. Accordingly, overexpression of TRIM25 is observed in many tumors and frequently correlates with a poor patient survival. …”
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DICER1: The Argonaute Endonuclease Family Member and Its Role in Pediatric and Youth Pathology by Consolato M. Sergi, Fabrizio Minervini

“…The ubiquity of this enzyme in the human body makes it an exquisite target for nanotechnology-supported therapies and repurposing drug approaches.…”
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Prevention of respiratory syncytial virus infection in children. Recommendations of the Polish Society of Paediatrics and the National Paediatric Consultant by Teresa Jackowska, August Wrotek, Iwona Beń-Skowronek, Łukasz Dembiński, Tomasz Jarmoliński, Artur Mazur, Anna Medyńska, Katarzyna Plata-Nazar, Jan Styczyński, Tomasz Szczepański, Ewa Toporowska-Kowalska, Piotr Hartmann, Hanna Czajka, Jarosław Peregud-Pogorzelski

“…In Poland, the monoclonal antibody palivizumab (Synagis) is currently available to protect infants against RSV as part of a drug programme. It is provided exclusively for premature infants and children at risk and should be administered monthly during the RSV season. …”
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The Relationship between Statin and Risk of Age-Related Macular Degeneration: A Systematic Review and Meta-Analysis by Ezatollah Memarzadeh, Saeid Heidari-Soureshjani

“…According to the results of this study, taking statins does not increase or decrease the risk of AMD development. Therefore, this drug group cannot be considered a protective or risk factor for the occurrence of AMD.…”
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Advanced spectrophotometric chemometric methods for resolving the binary mixture of doxylamine succinate and pyridoxine hydrochloride by Katsarov Plamen, Gergov Georgi, Alin Aylin, Pilicheva Bissera, Al-Degs Yahya, Simeonov Vasil, Kassarova Margarita

“…The prediction power of partial least squares (PLS) and multivariate curve resolution-alternating least squares (MCR-ALS) methods have been studied for simultaneous quantitative analysis of the binary drug combination - doxylamine succinate and pyridoxine hydrochloride. …”
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Ultrasonographic measurement of the peroneal and tibial nerves in patients with rheumatoid arthritis with symptoms or signs of polyneuropathy: A cross-sectional study by Serdar Kaymaz, Hakan Alkan, Uǧur Karasu, Veli Çobankara

“…Background: Drug toxicity, vasculitis, entrapment neuropathy, and amyloidosis are among the various different reasons of peripheral neuropathy in rheumatoid arthritis (RA). …”
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A refined, minimally invasive, reproducible ovine ischaemia–reperfusion–infarction model using implantable defibrillators: Methodology and validation by Charlene Pius, Barbara Niort, Emma J. Radcliffe, Andrew W. Trafford

“…The novelty and refinement in the procedure stems from utilization of implantable cardiac defibrillators prior to coronary engagement, balloon angioplasty to induce infarction, and intra‐operative anti‐arrhythmic drug protocols to reduce adverse arrhythmic events. …”
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A New Kinetic Spectrophotometric Method for the Quantitation of Amorolfine by César Soto, Cristian Poza, David Contreras, Jorge Yáñez, Fallon Nacaratte, M. Inés Toral

“…The proposed method was successfully validated for the application of the determination of the drug in the spiked tap water samples and the percentage recoveries were 94.0–105.0%. …”
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Evaluation of Extended Interval Dosing Aminoglycosides in the Morbidly Obese Population by Ashley L. Ross, Jennifer L. Tharp, Gerald R. Hobbs, Richard McKnight, Aaron Cumpston

“…Twenty-two of the 31 patients (71%) achieved an appropriate serum drug concentration. Four patients (13%) were found to be supratherapeutic and 5 patients (16%) subtherapeutic. …”
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Association of Leukocytosis with Amphetamine and Cocaine Use by John R. Richards, Valeria F. Farias, Chris S. Clingan

“…With a total of 1,206 patients, 877 (72.7%) amphetamines/cocaine-negative drug screen controls had mean WBC 8.4±2.6×103/µL. …”
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