Sustained release biodegradable solid lipid microparticles: Formulation, evaluation and statistical optimization by response surface methodology by Hanif Muhammad, Khan Hafeez Ullah, Afzal Samina, Mahmood Asif, Maheen Safirah, Afzal Khurram, Iqbal Nabila, Andleeb Mehwish, Abbas Nazar

“…For preparing nebivolol loaded solid lipid microparticles (SLMs) by the solvent evaporation microencapsulation process from carnauba wax and glyceryl monostearate, central composite design was used to study the impact of independent variables on yield (Y1), entrapment efficiency (Y2) and drug release (Y3). SLMs having a 10-40 μm size range, with good rheological behavior and spherical smooth surfaces, were produced. …”
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Elevated Serum IL-17 Expression at Cessation Associated with Graves’ Disease Relapse by Jianhui Li, Xiaohua Sun, Danzhen Yao, Jinying Xia

“…Background. Antithyroid drug (ATD) treatment occupies the cornerstone therapeutic modality of Graves’ disease (GD) with a high relapse rate after discontinuation. …”
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Diverse Molecular Genotypes of Mycobacterium tuberculosis Complex Isolates Circulating in the Free State, South Africa by Anneke Van der Spoel van Dijk, Pakiso M. Makhoahle, Leen Rigouts, Kamaldeen Baba

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Identification of potent TMPRSS4 inhibitors through structural modeling and molecular dynamics simulations by Ismail Hdoufane, Mehdi Oubahmane, Youssef Habibi, Christelle Delaite, Mohammed M. Alanazi, Driss Cherqaoui

“…FDA-approved, clinical/preclinical drugs and natural products were docked to the pocket of TMPRSS4. …”
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Involuntary intoxication caused by vaping the synthetic cannabinoid ADB-BUTINACA: A case report by Elise M.A. Slob, Maryam Lyousoufi, Sharif Pasha, Erik B. Wilms

“…When clinical presentation and/or initial recreational drugs testing results are inconclusive, additional testing with LC-QTOF-MS can be valuable.…”
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Effect of cyclosporin A on inflammatory cytokine production by U937 monocyte-like cells by Juan E. Losa Garcia, María Rosa Martín de Cabo, Fernando Mateos Rodríguez, Jesús Pérez Losada, Antonio Jiménez López, José Luis Pérez Arellano

“…Cyclosporin A (CsA) is an immunosuppresor drug that has been used in the treatment of several types of inflammatory diseases. …”
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Prevention of Foodborne Listeriosis by JM Farber, J Harwig, A Carter

“…Diagnosis of listeriosis usually requires isolation of the organism from sterile sites such as blood, cerebrospinal fluid, placenta and meconium and gastric aspirates from neonates. The recommended drug of choice is high dose intravenous ampicillin. …”
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Recent Advances in Three-Dimensional Stem Cell Culture Systems and Applications by Xiaowen Wu, Junxiang Su, Jizhen Wei, Nan Jiang, Xuejun Ge

“…Then the application of three-dimensional cell culture system is further explored, such as in the fields of drug screening, organoids and assembloids. Finally, the directions for future research of three-dimensional cell culture are stated briefly.…”
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Could the Inflation Reduction Act Maximum Fair Price Hurt Patients? by Anne M. Sydor, Esteban Rivera, Robert Popovian

“…**Background:** The Inflation Reduction Act’s Medicare Drug Price Negotiation Program allows the federal government to negotiate caps for select medications. …”
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Oxytocin attenuates demand for cocaine in female rats by Amy S. Kohtz, Hannah Davies, Belle Lin, Gary Aston-Jones

“…There are substantial sex differences in substance use disorders (SUDs), and a key feature of SUD is pathologically high economic demand for drug. The hypothalamic neuropeptide oxytocin (OXT) is heavily implicated in the modern treatment of SUDs. …”
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Clinical Use of Dostarlimab in Advanced Stage and Recurrent Endometrial Cancer: Patient Selection and Perspectives by Bujnak AC, File B, Tewari KS

“…On August 1st, 2024, the United States Food and Drug Administration expanded the indication of the immunologic anti-PD-1 checkpoint inhibitor, dostarlimab, and chemotherapy in endometrial cancer. …”
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Efficacy and tolerance of second-generation antipsychotics in anorexia nervosa: A systematic scoping review. by Solène Thorey, Corinne Blanchet, Sélim Benjamin Guessoum, Marie Rose Moro, Maude Ludot, Emilie Carretier

“…However, few clinical trials have been conducted so far and no pharmacological treatment has yet been approved by the Food and Drug Administration. The aim of this paper is to conduct a systematic scoping review exploring the effectiveness and safety of atypical antipsychotics in anorexia nervosa (AN).…”
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Development of a novel, high-throughput imaged capillary isoelectric focusing-Western method to characterize charge heterogeneity of monoclonal antibody heavy and light chains by Gangadhar Dhulipala, Alanna Broszeit, Kun Lu, Nisha Palackal, Erica Pyles

“…Further, the developed method can be applied in different aspects of drug development, such as comparability, release or stability testing given its ability to provide identity, as well as qualitative and quantitative comparative analysis.…”
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The first clinical experience of Marshall’s vein alcohol ablation in complex treatment of persistent atrial fibrillation by V.V. Boiko, S.V. Rybchynskyi, D.O. Lopin, A.S. Vnukova, D.Ye. Volkov

“…Current scientific data suggest that when drug therapy is ineffective, ablation of AF substrate is a most important stage in the treatment of arrhythmia, as well as optimal method of control and prevention of further cardiovascular events. …”
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The Protective Effect of Lidocaine on Septic Rats via the Inhibition of High Mobility Group Box 1 Expression and NF-κB Activation by Huan-Liang Wang, Yan-Qiu Xing, Ying-Xue Xu, Fei Rong, Wei-Fu Lei, Wen-Hua Zhang

“…Lidocaine, a common local anesthetic drug, has anti-inflammatory effects. It has demonstrated a protective effect in mice from septic peritonitis. …”
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The Effect of Rebamipide on Ocular Surface Disorders Induced by Latanoprost and Timolol in Glaucoma Patients by Naoto Tokuda, Yasushi Kitaoka, Akiko Matsuzawa, Junsuke Miyamoto, Shinsuke Sakae, Yasunari Munemasa, Hitoshi Takagi

“…Our data suggests that rebamipide treatment may reduce the occurrence of drug-induced ocular surface disorder.…”
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A Prospective Open-Label Multicentre Trial on the Use of 1 G, Once Daily Ceftriaxone in Lower Respiratory Tract Infections by Donald E Low, Lionel A Mandell

“…Three adverse event (hives, diarrhea and phlebitis at the injection site) were possibly related to the study drug. A cross-Canada in vitro susceptibility surveillance study of bacterial pathogens. frequently the cause of pneumonia. found ceftriaxone to have minimal inhibitory concentrations in 90% of isolates that would support such a dosing regimen. with the exception of Enterobacter species. …”
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Dutasteride nanoemulsion preparation to inhibit 5‐alpha‐hair follicle reductase enzymes in the hair follicle; an ex vivo study by Mehri Memar Bashi Aval, Elham Hoveizi, Reza Mombeiny, Mostafa Kazemi, Saeedeh Saeedi, Shima Tavakol

“…The Present dutasteride nanocarrier would promise a prolonged and sustained‐release drug delivery system for Alopecia therapy.…”
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Alternative treatment methods for bovine mastitis: prospects and limitations (review) by V. D. Zubareva, O. V. Sokolova, M. V. Bytov, A. S. Krivonogova, S. V. Volskaya

“…Mastitis remains the most common problem of dairy industry despite the preventive measures and treatment schemes being developed. Antibacterial drugs remain first line agents for therapy of the mammary gland inflammatory diseases in animals. …”
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Exploring Strategies to Prevent and Treat Ovarian Cancer in Terms of Oxidative Stress and Antioxidants by Yanru Long, Houhui Shi, Jiatian Ye, Xiaorong Qi

“…Oxidative stress can cause oxidative damage, promote the development of ovarian cancer, and even result in drug resistance. Therefore, studying oxidative stress in ovarian cancer is important for the prevention and treatment of ovarian cancer. …”
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