Human Cardiac Fibroblast Number and Activation State Modulate Electromechanical Function of hiPSC-Cardiomyocytes in Engineered Myocardium by Cassady E. Rupert, Tae Yun Kim, Bum-Rak Choi, Kareen L. K. Coulombe

“…Cardiac tissue engineering using hiPSC-derived cardiomyocytes is a promising avenue for cardiovascular regeneration, pharmaceutical drug development, cardiotoxicity evaluation, and disease modeling. …”
Get full text

Antimalarial, Antioxidant, and Toxicological Evaluation of Extracts of Celtis africana, Grosseria vignei, Physalis micrantha, and Stachytarpheta angustifolia by Michael Konney Laryea, Lawrence Sheringham Borquaye

“…The activities of these plants obtained in this study partly give credence to their folkloric use in herbal medicines and suggest that they could provide promising lead compounds for malaria drug discovery programs.…”
Get full text

Antibacterial Activities and In Vitro Anti-Inflammatory (Membrane Stability) Properties of Methanolic Extracts of Gardenia coronaria Leaves by Amin Chowdhury, Shofiul Azam, Mohammed Abdullah Jainul, Kazi Omar Faruq, Atiqul Islam

“…The lower concentrations of Methanolic leaf extract of Gardenia coronaria gave good antimicrobial and anti-inflammatory activity, but higher concentrations gave relatively more projecting antibacterial activity in vitro as compared with Kanamycin. The crude drug’s anti-inflammatory effects were compared with those of Aspirin as positive control. …”
Get full text

A Case of De Novo Antiglomerular Basement Membrane Disease Presenting during Pregnancy by F. A. K. Lodhi, T. Akcan, J. N. Mojarrab, S. Sajjad, R. Blonsky

“…A 23-year-old woman approximately 15 weeks pregnant experienced weakness, nausea, vomiting, and anorexia for one week and anuria for 48 hours. No known drug allergies and no significant social or family history for kidney or genitourinary disease were reported. …”
Get full text

Changes in Lysine Methylation Contribute to the Cytotoxicity of Curcumin in Colon Cancer Cells by Roberta Santarelli, Paola Currà, Michele Di Crosta, Roberta Gonnella, Maria Saveria Gilardini Montani, Mara Cirone

“…Interestingly, curcumin also reduced mutp53 expression, suggesting that it could enhance the efficacy of other therapies, particularly in overcoming drug resistance mechanisms associated with mutp53. …”
Get full text

Etanercept Attenuates Traumatic Brain Injury in Rats by Reducing Brain TNF-α Contents and by Stimulating Newly Formed Neurogenesis by Chong-Un Cheong, Ching-Ping Chang, Chien-Ming Chao, Bor-Chih Cheng, Chung-Zhing Yang, Chung-Ching Chio

Get full text

ACTH4 -10, Substance P, and Dizolcipine (Mk-801) Accelerate Functional Recovery After Hemilabyrinthectomy in Goldfish by R. Mattioli, J. P. Huston, R. E. Spieler

“…In this study, we evaluated the goldfish model of hemilabyrinthectomy for investigating potential recovery-promoting drugs. In this lesion model, the unilateral removal of the labyrinth induces a postural imbalance in response to light (Dorsal Light Reflex), from which the animals can recover over time. …”
Get full text

Impact of Methamphetamine Abuse: A Rare Case of Rapid Cerebral Aneurysm Growth with Review of Literature by James Fowler, Brian Fiani, Syed A. Quadri, Vladimir Cortez, Mudassir Frooqui, Atif Zafar, Fahad Shabbir Ahmed, Asad Ikram, Anirudh Ramachandran, Javed Siddiqi

“…In light of vascular pathologies the possibility of drug-induced pseudoaneurysm should also be considered in young patients with history of meth abuse.…”
Get full text

Budget Impact Analysis of Treatment Flow Optimization in Epilepsy Patients: Estimating Potential Impacts with Increased Referral Rate to Specialized Care by Masaki Iwasaki, Takashi Saito, Akiko Tsubota, Tatsunori Murata, Yuta Fukuoka, Kazutaka Jin

“…The costs for the four-drug therapy by non-specialized care were eliminated. …”
Get full text

Investigation of biometabolites and novel antimicrobial peptides derived from promising source Cordyceps militaris and effect of non-small cell lung cancer genes computationally. by Muhammad Afzal, Mai Abdel Haleem A Abusalah, Neelum Shehzadi, Muhammad Absar, Naveed Ahmed, Sarmir Khan, Yalnaz Naseem, Noshaba Mehmood, Kirnpal Kaur Banga Singh

“…Computational analysis on non-small cell lung cancer genes (NSCLC) was performed on quantified compounds to interpret the biometabolites from C. militaris that could be potential drug candidate molecules with high specificity and potency. …”
Get full text

Green packaging system based on hybrid zein/inulin nanofibers activated with copper oxide nanoparticles and Foeniculum vulgare essential oil for preservation of fresh beef by Sara Gholizadeh, Ali Ehsani, Sajed Amjadi, Hossein Ahangari, Vahid Panahiazar

Get full text

Problems of the activity of canine units of the National Police in the conditions of war by V. S. Seliukov

“…In addition, the facts of illegal drug trafficking in the places of hostilities, cases of the involvement of service dogs of the National Police in anti-mine activities and the search for corpses and places of mass burials have become increasingly widespread. …”
Get full text

Antibacterial Efficacy and Healing Potential of Honey from Different Zones in Nigeria on Diabetic-Induced Wound Infection in Wistar Rats by Obakpororo Ejiro Agbagwa, Chimezie Ekeke, Precious Chidinma Israel

“…There is an increase in drug-resistant strains causing infection, thus making available therapeutics less effective. …”
Get full text

Diffusion Smart-seq3 of breast cancer spheroids to explore spatial tumor biology and test evolutionary principles of tumor heterogeneity by Antony Cougnoux, Loay Mahmoud, Per A. Johnsson, Alper Eroglu, Louise Gsell, Jakob Rosenbauer, Rickard Sandberg, Jean Hausser

“…Smart-seq3D can offer a cost-efficient approach to explore how cells adapt their transcriptome to different micro-environments, reveal spatial determinants of drug resistance and could serve to characterize spatial interactions between cancer and stromal/immune cells in 3D co-cultures.…”
Get full text

The Comparison of Clinical Epidemiology of Hospitalized Patients with COVID-19 during the Third and Fourth Waves of the Pandemic in Gorgan by Samira Eshghinia, Rahmat Allah Sharifi Far, Naghimeh Hajimoradloo, Ali Sinesepehr, Ahmad Sohrsbi, Mousa Imeri, Amir Reza Khodanazar Kalti, Erfan Rezaie Shirazi, Roghieh Golsha

“…The mean duration of hospitalization was longer in the third wave than in the fourth wave (P = 0.001). The drugs administered most in these two waves were remdesivir, dexamethasone, and heparin, and the patients who received these drugs were compared in the third and fourth waves (P = 0.001). …”
Get full text

Proton magnetic resonance spectroscopy-based evaluation of metabolic abnormalities in the right dorsolateral prefrontal cortex and caudate nucleus in treatment-naïve patients with... by Gagan Hans, Uma Sharma, Novy Gupte, Ragul Ganesh, Vaibhav Patil, Pratap Sharan

“…Methods: The present study investigated the metabolic profile of two brain regions, namely right DLPFC and CN, by using single voxel in-vivo proton magnetic resonance spectroscopy (1H MRS) in drug-naive patients with OCD (n = 17, mean age = 30.71 ± 10.104 years) and compared it with healthy controls (n = 13, mean age = 30.77 ± 5.449 years). …”
Get full text

Acute Pericarditis Occurring Three Days after Intravesical Instillation of Mitomycin C after Transurethral Bladder Tumor Resection in a 64-Year-Old Woman by Vineet Meghrajani, Arsalan Hashmi, Shuo Cheng Lin, Zvi Plawes, Shelly Brejt

“…During her angiogram, it was found that she had multiple stenotic coronary artery lesions, with no acute total coronary occlusions, and percutaneous coronary intervention (PCI) was done with placement of a single drug-eluting stent for a 95% stenotic lesion in the left anterior descending artery. …”
Get full text

Associations between Attention-Deficit Hyperactivity Disorder (ADHD) Treatment and Patient Nutritional Status and Height by Mariana F. Granato, Alexandre A. Ferraro, Denise M. Lellis, Erasmo B. Casella

“…The aim of this study was to compare the nutritional profile of a Brazilian cohort of ADHD patients with that of the general population and to analyze the association between ADHD drug treatment (with methylphenidate), nutritional status, and height of these individuals. …”
Get full text

Immunogenicity of RSV F DNA Vaccine in BALB/c Mice by Erdal Eroglu, Ankur Singh, Swapnil Bawage, Pooja M. Tiwari, Komal Vig, Shreekumar R. Pillai, Vida A. Dennis, Shree R. Singh

“…There is no vaccine or a less effective drug available against RSV infections. Natural RSV infection stimulates the Th1 immune response and activates the production of neutralizing antibodies, while earlier vaccine trials that used UV-inactivated RSV exacerbated the disease due to the activation of the allergic Th2 response. …”
Get full text

The Pathogenesis of Necroptosis-Dependent Signaling Pathway in Cerebral Ischemic Disease by Yang Xu, Ji Zhang, Lingsong Ma, Shoucai Zhao, Shizun Li, Tingting Huang, Zhaohu Chu

“…Multiple inhibitors of RIPK1 and MLKL have been developed to block the cascade of signal pathways for procedural necrosis and represent potential leads for drug development. In this review, we highlight recent progress in the study of roles for necroptosis in cerebral ischemic disease and discuss how these modifications delicately control necroptosis.…”
Get full text