The Change in HbA1c Associated with Initial Adherence and Subsequent Change in Adherence among Diabetes Patients Newly Initiating Metformin Therapy by Gregory A. Nichols, A. Gabriela Rosales, Teresa M. Kimes, Kaan Tunceli, Karen Kurtyka, Panagiotis Mavros

“…We conducted a observational study of 2,844 type 2 diabetes patients who initiated metformin as their first antihyperglycemic drug. Using HbA1c measures before, 6–12 months after, and up to 3 years after metformin initiation, we analyzed HbA1c change as a function of initial adherence and change in adherence. …”
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Patient and caregiver perspectives of select non-communicable diseases in India: A scoping review. by Sindhu Nila, Eliza Dutta, S S Prakash, Sophy Korula, Anu Mary Oommen

“…Repeated visits to crowded centres, drug refill issues, unavailability of specific services in government facilities, and expensive private care characterised diabetes care, while cancer care involved delayed diagnosis and treatment, communication, and pain management issues.…”
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Lemon-derived nanoparticle-functionalized hydrogels regulate macrophage reprogramming to promote diabetic wound healing by Enyou Jin, Yusheng Yang, Shengjie Cong, Dengke Chen, Ruixiong Chen, Jun Zhang, Yanjun Hu, Weini Chen

“…To solve the problems of continuous drug delivery and penetration depth, Lemon Exosomes were loaded into a hydrogel constructed of Gelatin Methacryloyl (GelMA) and Dialdehyde Starch (DAS) that closely fits to the skin, absorbs water, swells, and is moist and breathable, effectively promoting the sustained and slow release of exosomes and resulting in excellent performance for diabetic wound healing. …”
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Molecular Characterization of Methicillin Resistant and Extended Spectrum ?-Lactamase Staphylococcus aureus Isolated from Burn Patients by Shawnm Ahmed Aziz

“…Vancomycin, a glycopeptide antibiotic remains a drug of choice for treatment of severe Methicillin Resistance S. aureus infections. …”
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The cholesterol metabolite 25-hydroxycholesterol suppresses porcine deltacoronavirus via lipophagy inhibition and mTORC1 modulation by Jia-lu Zhang, Xue-fei Wang, Jia-lin Li, Cong Duan, Jiu-feng Wang

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Vascular Reactivity Concerning Orthosiphon stamineus Benth-Mediated Antihypertensive in Aortic Rings of Spontaneously Hypertensive Rats by Nurul Maizan Manshor, Aidiahmad Dewa, Mohd Zaini Asmawi, Zhari Ismail, Nadiah Razali, Zurina Hassan

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Exploring Advances in Natural Plant Molecules for Allergic Rhinitis Immunomodulation in Vivo and in Vitro by Li B, Dong B, Xie L, Li Y

“…However, with the growing awareness of AR and rising expectations for improvements in quality of life, these treatments have become associated with a higher incidence of side effects and an elevated risk of drug resistance. Furthermore, the development of AR is intricately associated with dysregulation of the immune system, yet the underlying pathogenetic mechanisms remain incompletely understood. …”
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Corpus callosotomy for treatment of pediatric epilepsy: two clinical cases and a literature review by R. Matonytė, S. Ročka, J. Grikinienė

“…However, even if the disease is diagnosed early and appropriate antiepileptic drug therapy is prescribed, epileptic seizures persist in 20-40% of patients. …”
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Chronic hepatitis C course at elderly and therapeutic approach by M. V. Mayevskaya, M. A. Morozova

“…This complication requires careful monitoring of hemoglobin and hematocrit level during the whole period of treatment and, if necessary, decline of drug doses according to established algorithms.Conclusion. …”
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Fluoroquinolone-specific resistance trajectories in E. coli and their dependence on the SOS-response by Lisa Teichmann, Sam Luitwieler, Johan Bengtsson-Palme, Benno ter Kuile

“…However, resistance to these drugs presents a growing challenge. The SOS response, a DNA repair pathway activated by DNA damage, is known to influence resistance development, yet its role in fluoroquinolone resistance is not fully understood. …”
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Criminological analysis of criminal radicalism state among convicts in penal institutions by P. Yu. Danylchenko

“…Taking into account the latent part of crime in penitentiary institutions, especially drug-related crimes, violent sex crimes, criminal offenses against health and property, the real share of criminal radicalism among prisoners is about 10 %. …”
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Pregnancy in an Asymptomatic Woman with Porencephalic and Arachnoid Cysts by Franco Pepe, Gianmarco Marchese, Gabriele Giuseppe Pepe, Elisabetta Zambrotta, Giulio Insalaco, Claudia Garraffo, Valeria La Rosa

“…EEG did not show any epileptiform or seizure-like activity. No antiepileptic drug was prescribed due to the absence of symptoms since many years. …”
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Research progress on the antiviral immune regulation of ubiquitin ligase F-box family by MENG Xiangbo, LI Tianqi, ZHANG Tong

“…Although several FBP-targeting inhibitors have been developed, there are limited reports on the application of FBPs in antiviral drug research. Given the large number of FBP family members, further research is required on the functions and mechanisms of FBPs in virus-host interactions, to provide novel directions for the development of antiviral drugs.…”
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Methicillin-Resistant Staphylococcus aureus: Docking-Based Virtual Screening and Molecular Dynamics Simulations to Identify Potential Penicillin-Binding Protein 2a Inhibitors from... by Motahareh Masumi, Fatemeh Noormohammadi, Fatemeh Kianisaba, Fatemeh Nouri, Mohammad Taheri, Amir Taherkhani

“…This study suggests that kaempferol 3-rutinoside-7-sophoroside and rutin may be considered as drug candidates for therapeutic aims in several human infections associated with MRSA. …”
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Characterisation of the Aerodynamic Aerosol Classifier Transfer Function for Particle Sizes up to 5 Micrometres by Simon D. Payne, Tyler J. Johnson, Jonathan P. R. Symonds

“…This upper size range is significantly higher than that offered by other common aerosol classifiers, such as the approximate 1 µm upper limit typical of the Differential Mobility Analyser (DMA), and it is well suited to many applications, including OPC calibration, bio-aerosols, drug delivery and inhalation studies, and atmospheric dust analysis. …”
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Hypolipidemic Effect of Chloroform Extract of Lagenaria siceraria: Potential Inhibitory Activity of Phytochemicals Targeting the HMG-CoA Reductase Revealed by Molecular Docking and... by Qudsia Kanwal, Mahmood Ahmed, Atiq Ur-Rehman, Aneela Anwar, Samiah Shahid, Atif Shahzad, Attaullah Shah Bukhari, Muhammad Ahmad, Numan Yousaf, Muhammad Muddassar

“…Atorvastatin (10 mg/kg bw) was used as a standard drug. Administration of Lagenaria siceraria extract lowers the total cholesterol (TC), triglyceride (TG), and low-density lipoproteins-cholesterol (LDL-C) levels whereas elevating the high-density lipoproteins-cholesterol (HDL-C) level. …”
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The role of natural products targeting macrophage polarization in sepsis-induced lung injury by Yake Li, Sinan Ai, Yuan Li, Wangyu Ye, Rui Li, Xiaolong Xu, Qingquan Liu

“…Despite significant advances in SALI research, effective drug therapies are still lacking. Therefore, the development of new treatments for SALI is urgently needed. …”
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Amphiphiles Self-Assembly: Basic Concepts and Future Perspectives of Supramolecular Approaches by Domenico Lombardo, Mikhail A. Kiselev, Salvatore Magazù, Pietro Calandra

“…While amphiphiles self-assembly has attracted considerable attention for decades due to their extensive applications in material science, drug and gene delivery, recent developments in nanoscience stimulated the combination of the simple approaches of amphiphile assembly with the advanced concept of supramolecular self-assembly for the development of more complex, hierarchical nanostructures. …”
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Advances in lysosomal escape mechanisms for gynecological cancer nano-therapeutics by Heng Wei, Yingying Hao, Jin Zhang, Yue Qi, Chong Feng, Chen Zhang

“…Gynecological cancers present significant treatment challenges due to drug resistance and adverse side effects. This review explores advancements in lysosomal escape mechanisms, essential for enhancing nano-therapeutic efficacy. …”
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The Effect of SP/NK1R on the Expression and Activity of Catalase and Superoxide Dismutase in Glioblastoma Cancer Cells by Faranak Korfi, Hossein Javid, Reza Assaran Darban, Seyed Isaac Hashemy

“…The present study showed that aprepitant inhibited SP’s oxidizing effects via inducing the antioxidant effects of catalase and SOD in the U87 cell line. Therefore, this drug might be introduced as a potential candidate for controlling glioblastoma cancer in animal models and clinical trials.…”
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