Remdesivir-induced severe hypoglycemia in an elderly man without diabetes: a case report by Yasunori Nagano, Hisae Aoki, Juri David, Naoko Iwahashi Kondo, Makimi Aizawa, Toshiyuki Sumita, Yuki Hamada, Yuki Yamamoto, Kaoru Yamada

“…The Naranjo algorithm, a tool for evaluating the causality of adverse drug reactions, classified the event as “Probable” (6 points). …”
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Marked Direct Hyperbilirubinemia due to Ceftriaxone in an Adult with Sickle Cell Disease by Daniyeh Khurram, Leonid Shamban, Robert Kornas, Maryann Paul

“…Drugs are a significant cause of liver injury. Drug-induced liver injury (DILI) can cause acute hepatitis, cholestasis, or a mixed pattern. …”
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Exploring the Mechanisms of Zhenbao Pills in the Treatment of Stroke through Network Pharmacology Combined with Mendelian Randomization by Yanhong Liu, Yunqi Hua, Xiaoe Jia

“…Methods: This research accessed databases to pinpoint the core components and identify the targets of ZBP and stroke. “Drug–component–target” networks were established, followed by enrichment analysis of identified targets. …”
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Cognitive behvioral psychotherapy of a severe anorexia nervosa case by Selcuk ASLAN, Mahmut GURBUZ, Simge VURAL

“…In the course of disorder, patients hold irrational fears of becoming overweight and are committed to lose weight with/without engaging bulimic behaviors. The effectiveness of drug treatment and psychotherapy is scant. Therefore, in this paper, treatment process of a 28 y.o patient with anorexia nervosa whom hospitalized to inpatient unit with 33kg is presented to discuss the effectiveness CBT treatment. …”
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Acute Liver Failure among Patients on Efavirenz-Based Antiretroviral Therapy by Innocent Lule Segamwenge, Miriam Kaunanele Bernard

“…During a 6-month period, four patients without other known risk factors for acute hepatitis presented with symptomatic drug-induced liver injury with varying symptoms and outcomes. …”
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Purpose, subject matter and objectives of forensic medicine by O. S. Moiseyenko

“…It has been stated that the main tasks of forensic medicine as a branch of science are: study of human physiology and pathology, as well as the relationship of these processes with the knowledge of the cause of death and other traumatic injuries; development and improvement of methods for detection and assessment of traumatic injuries and their consequences, as well as establishment of the relationship between trauma and health consequences; detection of the impact of physical and chemical factors on human health, as well as establishment of the causes and consequences of the impact of these factors; determining the state of human health in the context of criminal investigation, including assessment of the state of alcohol or drug intoxication and its impact on human behaviour and actions; studying the relationship between the state of health and the crime committed, as well as establishing the facts of the presence and nature of injuries of victims.…”
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Downregulation of LncRNA SNHG7 Sensitizes Colorectal Cancer Cells to Resist Anlotinib by Regulating miR-181a-5p/GATA6 by Deng Pan, Kehe Chen, Ping Chen, Yu Liu, Yingying Wu, Jingning Huang

“…Given its important regulatory role in cancer biology, we wondered whether SNHG7 is involved in drug resistance to anlotinib (ATB) in CRC. To answer this, we quantified the expression of SNHG7 by quantitative real-time PCR. …”
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Plasma Gelsolin Levels Decrease in Diabetic State and Increase upon Treatment with F-Actin Depolymerizing Versions of Gelsolin by Neeraj Khatri, Amin Sagar, Nagesh Peddada, Vikas Choudhary, Bhupinder Singh Chopra, Veena Garg, Renu Garg, Ashish

“…Oral glucose tolerance test in mice models showed that subcutaneous administration of recombinant pGSN and its F-actin depolymerizing competent versions brought down blood sugar levels comparable to Sitagliptin, a drug used to manage hyperglycemic condition. Further, daily dose of pGSN or its truncated versions to diabetic mice for a week kept sugar levels close to normal values. …”
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Phylogeny, Phytomedicines, Phytochemistry, Pharmacological Properties, and Toxicity of Croton gratissimus Burch (Euphorbiaceae) by Kirkland Dingili Magwilu, Joseph Mwanzia Nguta, Isaac Mapenay, Dorine Matara

“…This would give a great indication of discovering new novelties that can give a breakthrough in drug discovery.…”
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Targeting BCMA in multiple myeloma: designs, challenges, and future directions by Yi Hu, Yuetao Xie, Xiaodong Wang, Lufeng Yang, He Geng, Zugang Yi, Yao Zhang, Lin Ma, Fang Chen

“…Various CAR designs, utilizing different BCMA recognition domains, have yielded promising clinical results, leading to the approval of two BCMA-targeting CAR T cell therapies by the US Food and Drug Administration (FDA) for the treatment of MM. …”
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Sources of Dietary Fiber and the Association of Fiber Intake with Childhood Obesity Risk (in 2–18 Year Olds) and Diabetes Risk of Adolescents 12–18 Year Olds: NHANES 2003–2006... by Mary Brauchla, WenYen Juan, Jon Story, Sibylle Kranz

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Miglustat Reverts the Impairment of Synaptic Plasticity in a Mouse Model of NPC Disease by G. D’Arcangelo, D. Grossi, M. Racaniello, A. Cardinale, A. Zaratti, S. Rufini, A. Cutarelli, V. Tancredi, D. Merlo, C. Frank

“…We then investigated the effects of Miglustat, a recent approved drug for the treatment of NPCD. We found that in vivo Miglustat administration in NPC1−/− mice was able to rescue synaptic plasticity deficits, to restore ERKs activation and to counteract hyperexcitability. …”
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Failure of Miltefosine Treatment in Two Dogs with Natural Leishmania infantum Infection by Daniela Proverbio, Eva Spada, Giada Bagnagatti De Giorgi, Roberta Perego

“…In view of the low number of antileishmanial drugs available and the fact that some of these are used in human as well as veterinary medicine, it is of paramount importance that drug resistance is monitored and documented.…”
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Swirling Flow and Wall Shear: Evaluating the BioMimics 3D Helical Centerline Stent for the Femoropopliteal Segment by Timothy M. Sullivan, Thomas Zeller, Masato Nakamura, Colin G. Caro, Michael Lichtenberg

“…The BioMimics 3D self-expanding nitinol stent represents a strategy for femoropopliteal intervention that is alternative or complementary to deployment of drug-coated stents or balloons. Whereas conventional straight stents reduce arterial curvature and disturb blood flow, creating areas of low wall shear, where neointimal hyperplasia predominantly develops, the helical centerline geometry of the BioMimics 3D maintains or imparts arterial curvature, promotes laminar swirling blood flow, and elevates wall shear to protect against atherosclerosis and restenosis. …”
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Comprehensive Analysis of Gene Signatures of m6ARNA Methylation Regulators in Lung Adenocarcinoma and Development of a Risk Scoring System by Chundi Gao, Huayao Li, Wenzhe Ma, Qiming Zhang, Cun Liu, Lijuan Liu, Jing Zhuang, Changgang Sun

“…The recent application of targeted immunotherapy has greatly improved the clinical outcomes of patients with lung adenocarcinoma (LUAD), but drug resistance continues to emerge, and to evaluate and to improve patient prognosis are arduous. …”
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Laser-Based Propagation of Human iPS and ES Cells Generates Reproducible Cultures with Enhanced Differentiation Potential by Kristi A. Hohenstein Elliott, Cory Peterson, Anuradha Soundararajan, Natalia Kan, Brandon Nelson, Sean Spiering, Mark Mercola, Gary R. Bright

“…Proper maintenance of stem cells is essential for successful utilization of ESCs/iPSCs as tools in developmental and drug discovery studies and in regenerative medicine. …”
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The role of non-alcoholic fatty liver disease in the formation of atherosclerotic vascular lesions in patients with abdominal obesity by N. L. Denisov, V. B. Grinevich, Ye. V. Chernetsova, Yu. A. Kravchuk, K. V. Ivashkin

“…Patients’ symptoms, past history, were evaluated to exclude alcoholic or drug-induced liver disease, anthropometric parameters were studied. …”
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The Difference a Year Can Make: How Antibiotic Resistance Mechanisms in <i>Pseudomonas aeruginosa</i> Have Changed in Northwestern Transylvania by Matei-Ștefan Dobrescu, Dan-Alexandru Țoc, Adrian-Gabriel Pană, Carmen Costache, Anca Butiuc-Keul

“…The results reveal a concerning increase in multidrug-resistant (MDR) and extensively drug-resistant (XDR) isolates over the two-year period. …”
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Anti-Inflammatory Prostanoids: Focus on the Interactions between Electrophile Signaling and Resolution of Inflammation by Beatriz Díez-Dacal, Dolores Pérez-Sala

“…However, their complex structure results in an inter- and intramolecular selectivity of the residues being modified, thus opening the way for structure-activity and drug discovery studies. Detailed characterization of cyPG interactions with cellular proteins will help us to understand their mechanism of action fully and establish their therapeutic potential in inflammation.…”
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Microbial Load and Antibiotic Resistance of Escherichia coli and Staphylococcus aureus Isolated from Ready-to-Eat (RTE) Khebab Sold on a University Campus and Its Environs in Ghana by Azumah Ayamah, Augustina Angelina Sylverken, Linda Aurelia Ofori

“…Also, the S. aureus and E. coli isolated were multiresistant to the antibiotics tested and could be a medium for the transmission of antibiotic-resistant bacteria and therefore expose consumers to a high risk of contracting foodborne infections with drug-resistant strains.…”
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