The Association of the Phylogenetic Typing of the Klebsiella pneumoniae Isolates with Antibiotic Resistance by Shabnam Baghbanijavid, Hossein Samadi Kafil, Safar Farajniya, Seyed Reza Moaddab, Hasan Hosainzadegan, Fatemeh Yeganeh Sefidan, Mojtaba Varshouchi, Hamed Ebrahimzadeh Leylabadlo, Reza Ghotaslou

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Diabetic Macular Edema Pathophysiology: Vasogenic versus Inflammatory by Pedro Romero-Aroca, Marc Baget-Bernaldiz, Alicia Pareja-Rios, Maribel Lopez-Galvez, Raul Navarro-Gil, Raquel Verges

“…In the future, diagnosing the physiopathology of each patient with DME will help us to select the most effective drug.…”
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Management of a Female Patient with Irritable Bowel Syndrome and Somatoform Disorder by E. A. Trush, E. A. Poluektova, A. G. Beniashvili, O. S. Shifrin

“…For patients whose complaints meet the diagnostic criteria for IBS, a two-stage differential diagnosis may be justified: at the first stage, differentiation of IBS and organic diseases of the gastrointestinal tract is carried out; at the second stage - IBS and somatization disorder. Kolofort can be the drug of choice both in patients with IBS and the pharmacological part of therapy in patients with somatization disorder.…”
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A New Combination Formula for Treatment of Fungal Keratitis: An Experimental Study by Hala Mohamed El-Mofty, Mohamad Amr Salah Eddin Abdelhakim, Mohamed Farid El-Miligi, Mohamed A. El-Nabarawi, Islam Ahmed Hamed Khalil

“…Gels containing high polymer concentration showed both high viscosity and mucoadhesion properties with slower drug release. The infected eyes treated with slow release formula containing both drugs showed better curing of the cornea and pathologically less inflammation than eyes treated with fast release formula. …”
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The role of reaction temperature in synthesizing clove-derived copper oxide nanoparticles for brain cancer treatment by Mehrnoosh Fakhredin, Fatemeh Shariatmadar Tehrani, Maryam Aliannezhadi

“…The CuO NPs displayed remarkable anti-cancer activity against the C6 cell line, with increased drug concentrations in the wells resulting in high cytotoxicity. …”
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Patient Characteristics Associated with HCV Treatment Adherence, Treatment Completion, and Sustained Virologic Response in HIV Coinfected Patients by Glenn Wagner, Karen Chan Osilla, Jeffrey Garnett, Bonnie Ghosh-Dastidar, Laveeza Bhatti, Matthew Bidwell Goetz, Mallory Witt

“…Nearly half (46%) the sample had active psychiatric problems and 13% had illicit drug use at treatment onset; 28% reported <100% treatment adherence, 38% did not complete treatment (mostly due to virologic nonresponse), and intent to treat SVR rate was 49%. …”
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Musculoskeletal Corticosteroid Injection during COVID-19 Pandemic in Sabah: Is It Safe? by Mohamad Azwan Aziz, Redzal Abu Hanifah, Azmi Mohamed Mohd Nahar

“…In this current COVID-19 pandemic, many clinicians would differ from this treatment as steroid is considered an immunosuppressive drug and could risk the patient of developing severe adverse effects if contracting COVID-19. …”
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Neuroprotection as a Therapeutic Target for Diabetic Retinopathy by Cristina Hernández, Massimo Dal Monte, Rafael Simó, Giovanni Casini

“…However, clinical trials to determine not only the effectiveness and safety but also the compliance of a noninvasive route of drug administration are needed.…”
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Small Molecules Greatly Improve Conversion of Human-Induced Pluripotent Stem Cells to the Neuronal Lineage by Sally K. Mak, Y. Anne Huang, Shifteh Iranmanesh, Malini Vangipuram, Ramya Sundararajan, Loan Nguyen, J. William Langston, Birgitt Schüle

“…Efficient in vitro differentiation into specific cell types is more important than ever after the breakthrough in nuclear reprogramming of somatic cells and its potential for disease modeling and drug screening. Key success factors for neuronal differentiation are the yield of desired neuronal marker expression, reproducibility, length, and cost. …”
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Characterization of older adults' sexual life in a health area by Juan Miguel Benítez García, Julio César Camero Machín, Jesús Cuello Ávila, Juan Carlos Curbelo Fajardo

“…The following variables were analyzed: sex, marital status, education, sexual life, preferred sexual techniques, sexual functioning, causes that prevent the performance of the sexual act, associated diseases and drug use.<br /><strong>Results:</strong> there was a predominance of primary school level, marital status without partners, female sex and sexual inactivity; vaginal intercourse predominated as the most frequent way of manifesting sexual activity. …”
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Therapeutic Response of Alopecia Areata-Associated Nail Changes to Baricitinib by Ashley Wittmer, Katherine De Jong, Lauren Bolish, Lindsey Finklea

“…Baricitinib is an immunomodulatory drug that acts as a selective and reversible inhibitor of JAK proteins and is indicated for adult patients with moderate to severe rheumatoid arthritis who have not responded to other disease-modifying antirheumatic drugs. …”
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Spectroscopic, DFT, anti-bacterial, and in-silico investigations of novel semicarbazone and thiosemicarbazone synthesised from asymmetrical chalcones by Nikita Sharma, Har Lal Singh

“…Antimicrobial drugs that target human pathogenic bacteria and fungi include derivatives of thiosemicarbazone and semicarbazone. …”
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Narrowing the gap between machine learning scoring functions and free energy perturbation using augmented data by Ísak Valsson, Matthew T. Warren, Charlotte M. Deane, Aniket Magarkar, Garrett M. Morris, Philip C. Biggin

“…However, current models lack robust evaluation and fail on tasks encountered in (hit-to-) lead optimisation, such as ranking the binding affinity of a congeneric series of ligands, thereby limiting their application in drug discovery. Here, we address these issues by first introducing a novel attention-based graph neural network model called AEV-PLIG (atomic environment vector–protein ligand interaction graph). …”
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Prevalence and factors associated with multidrug resistant Escherichia coli carriage on chicken farms in west Nile region in Uganda: A cross-sectional survey. by Ceaser Adibaku Nyolimati, Jonathan Mayito, Emmanuel Obuya, Atim Stella Acaye, Emmanuel Isingoma, Daniel Kibombo, D M Byonanebye, Richard Walwema, David Musoke, Christopher Garimoi Orach, Francis Kakooza

“…Infections with multi-drug-resistant (MDR) pathogens in food-animals threaten public health and food security. …”
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Regenerative Medicine for Neurological Disorders by Dong-Hyuk Park, David J. Eve, Yong-Gu Chung, Paul R. Sanberg

“…A number of studies focused on novel methods for drug monitoring or graft tracking, and combination therapy with stem cells and medicine, such as cytokines or trophic factors. …”
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SEEG-Based Bilateral Seizure Network Analysis for Neurostimulation Treatment by Genchang Peng, Mehrdad Nourani, Jay Harvey

“…Epilepsy patients with drug-resistant seizures emanating from two or more distinct regions of left and right hemispheres are the primary candidates for neurostimulation treatment. …”
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Genetic advancements in breast cancer treatment: a review by Marzieh Shokoohi, Sadaf Sedaghatshoar, Homaira Arian, Milad Mokarami, Fatemeh Habibi, Fatemeh Bamarinejad

“…Traditional treatments, including surgery, chemotherapy, and radiation, face limitations such as drug resistance, metastasis, and severe side effects. …”
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Establishing core data elements for colorectal cancer and mapping to FHIR resources: Towards interoperable Iranian health information systems by Raoof Nopour, Somayeh Nasiri, Maryam Ahmadi, Mohammad Shirkhoda

“…Results: Ten CRC data categories of classes were obtained from the literature review and Delphi, including administrative, diagnosis, therapeutic procedure, follow-up, patient referral, vital status, drug, clinical assessment, signs and symptoms, and history of conditions. …”
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The protective effect and crucial biological pathways analysis of Trametes lactinea mycelium polysaccharides on acute alcoholic liver injury in mice based on transcriptomics and me... by Jinbin Hao, Liyun Ye, Guoliang Meng, Yanjiao Song, Junsheng Fu, Xiaoping Wu

“…The transcriptome data revealed the involvement of many differentially expressed genes in chemical carcinogenesis, drug metabolism, and metabolism of xenobiotics by cytochrome P450. …”
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Development and Validation of a Liquid Chromatography-Mass Spectrometry Assay for Determination of Cromolyn Sodium in Skin Permeation Studies by Miranda Kay Holman, Stacy D Brown, Dorcas Frempong, Ashana Puri, Steven Dinh

“…Overall, the simplified, validated method showed sensitivity in detecting CS in skin without interference and was applied to demonstrate quantification of drug in skin following 4% cromolyn sodium gel exposure.…”
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