Novel 4-aminoquinazoline derivatives as new leads for anticancer drug discovery by Ghorab Mostafa M., Alsaid Mansour S.

“…Seven of the novel compounds exhibited higher activity than the reference drug doxorubicin. The corresponding compounds 3, 4, 5, 8, 10, 11 and 12 exhibited higher activity with IC50 values from 22.75 to 43.44 μmol L−1, compared to the reference drug doxorubicin with IC50 value of 47.90 μmol L−1. …”
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Identification of Levothyroxine Antichagasic Activity through Computer-Aided Drug Repurposing by Carolina L. Bellera, Darío E. Balcazar, Lucas Alberca, Carlos A. Labriola, Alan Talevi, Carolina Carrillo

“…A conformation-independent classifier capable of identifying Cz inhibitors was derived from a 163-compound dataset and later applied in a virtual screening campaign on the DrugBank database, which compiles FDA-approved and investigational drugs. 54 approved drugs were selected as candidates, 3 of which were acquired and tested on Cz and T. cruzi epimastigotes proliferation. …”
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Effect of folpet on hypoglycaemia, intestinal microbiota, and drug resistance genes in mice by Tingting Cao, Yajie Guo, Liangqiang Lin, Dan Wang, Zhiyang Liu, Xuan Zou, Yuebin Ke, Ziquan Lv

“…Metagenomic sequencing and drug resistance gene analyses were performed to explore changes in the abundance of gut microbiota members and drug resistance genes in mice after folpet administration. …”
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A reaction-diffusion system modeling the spread of resistance to an antimalarial drug by Nicolas Bacaër, Cheikh Sokhna

“…A mathematical model representing the diffusion of resistance toan antimalarial drug is developed. Resistance can spread only whenthe basic reproduction number of the resistant parasites is biggerthan the basic reproduction number of the sensitive parasites(which depends on the fraction of infected people treated with theantimalarial drug). …”
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Antondine Injection-Associated Fixed Drug Eruption: A Case Report by Yan Yang, Peng-Fei Li, Qiang Ma, Xiao-Na Wang, Qing Chen, Ling-Yun Ma, Hao Tang, Zhen Wang

“…Background: Fixed drug eruption (FDE) is a drug hypersensitivity reaction caused by antibiotics and non-steroidal anti-inflammatory drugs primarily. …”
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DOMINANT FACTORS CAUSES OF DRUG ABUSE IN ADOLESCENTS AT THE LAMONGAN DISTRICT PENITENTIARY by Khotibul Umam, Agung Prasetyo

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Stability Indicating HPLC Determination of Risperidone in Bulk Drug and Pharmaceutical Formulations by Zarna R. Dedania, Ronak R. Dedania, Navin R. Sheth, Jigar B. Patel, Bhavna Patel

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Drug Testing for Newborn Exposure to Illicit Substances in Pregnancy: Pitfalls and Pearls by Karen J. Farst, Jimmie L. Valentine, R. Whit Hall

“…Estimates of the prevalence of drug usage during pregnancy vary by region and survey tool used. …”
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Research in compulsory drug detention centres in China: Characteristics and ethical considerations by Yazid Barhoush, Joseph J. Amon

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Skin Testing to Identify Safe Drugs for Patients with Rocuronium-Induced Anaphylaxis by Manzo Suzuki, Hajime Kawase, Azusa Ogita, Hiroyasu Bito

“…Skin tests including the SPT followed by the IDT revealed rocuronium as the drug that caused anaphylaxis and vecuronium as a safe drug to use for the subsequent general anesthesia. …”
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Improving drug–target affinity prediction by adaptive self-supervised learning by Qing Ye, Yaxin Sun

Subjects: “…Drug-target affinity…”
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Repurposing the Antidiabetic Drugs Glyburide, Gliquidone, and Glipizide in Combination with Benznidazole for <i>Trypanosoma cruzi</i> Infection by Citlali Vázquez, Rusely Encalada, Isabel Jiménez-Galicia, Rogelio Gómez-Escobedo, Gildardo Rivera, Benjamín Nogueda-Torres, Emma Saavedra

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Ezetimibe Anticancer Activity via the p53/Mdm2 Pathway by Charmy Twala, Sibusiso Malindisa, Chamone Munnik, Selisha Sooklal, Monde Ntwasa

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Feasibility and acceptability of multiple methods of recording injecting drug use episode data among people who inject drugs in Melbourne, Australia: a pilot evaluation study protocol by Alexis Roth, Peter Higgs, Paul Dietze, Nick Scott, Daniel O’Keefe, Filip Djordjevic, Ashleigh Cara Stewart, Dylan Vella-Horne, Zoe Gleeson, Damian Pavlyshyn, Matthew Gill, Rebekka Petrovic, Ben Cocchiaro

“…Introduction Opioid overdose and blood-borne virus transmission are key health risks for people who inject drugs. Existing study methods that record data on injecting drug risks mostly rely on retrospective self-reporting that, while valid, are limited to being broad and subject to recall bias. …”
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From the Criminalization of Substances to the “War on Drugs” Policy: A Century of Prohibitionism in Brazil by José Guilherme Magalhães e Silva, Luís Felipe Zilli, Letícia Godinho de Souza

Subjects: “…Drugs…”
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Assessment of potential drug-drug interactions in hospitalized patients with infectious diseases: an experience from a secondary care hospital [version 4; peer review: 2 approved, 2 not approved] by Padma G.M. Rao, Rashid Ain Ur, Sathvik Belagodu Sridhar, Abu Nawa Ahmad Ismail, Javedh Shareef

Subjects: “…Drug interactions…”
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The Emergence of Extensively Drug-Resistant Tuberculosis (TB): TB/HIV Coinfection, Multidrug-Resistant TB and the Resulting Public Health Threat from Extensively Drug-Resistant TB, Globally and in Canada by Paul E Alexander, Prithwish De

“…Resistance to anti-tuberculosis (TB) drugs continues to present a major challenge to global public health. …”
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Inappropriate medication prescribing, polypharmacy, potential drug-drug interactions and medication regimen complexity in older adults attending three referral hospitals in Asmara, Eritrea: a cross-sectional study by Nuru Abdu, Saleh Idrisnur, Hanae Said, Lude Kifle, Natnael Habte, Semira Ghirmai, Tomas Tewelde, Senai Mihreteab Siele, Eyasu H. Tesfamariam

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Santé et biens communs : un regard de juriste. by Isabelle Moine-Dupuis

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Identification of Mutations that Encode Drug Resistance in the Polymerase Gene of the Human Immunodeficiency Virus by Zhengxian Gu, Hengsheng Fang, Horacio Salomon, Qing Gao, Mark A Wainberg

“…When the 65 and 184 mutations were combined into HXB2-D, the resultant construct did not possess higher levels of resistance lo any of these drugs than observed with the site 65 or 184 mutation alone. …”
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