Necrotizing Fasciitis in Paroxysmal Nocturnal Hemoglobinuria by Pusem Patir, Yakup Isik, Yigit Turk, Mehmet Can Ugur, Cengiz Ceylan, Gulnur Gorgun, Nihal Mete Gokmen, Guray Saydam, Fahri Sahin

“…He was subsequently started on eculizumab therapy, with starting and maintenance doses set as per drug labelling. Progression of the patient’s leg ulcers during follow-up, with fulminant tissue destruction, purulent discharge, and necrotic patches, led to a later diagnosis of necrotizing fasciitis due to Pseudomonas aeruginosa and Klebsiella pneumonia infection. …”
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A Reliable Method for Identification of Antibiotics by Terahertz Spectroscopy and SVM by Jin Guo, Hu Deng, Quancheng Liu, Linyu Chen, Zhonggang Xiong, Liping Shang

“…Thus, our study does not only confirm that the t-SNE-PSO-SVM model proves to be a reliable method for antibiotics identification, but also confirms that the combination of THz-TDS and chemometric pattern recognition has great potential for drug detection.…”
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Biphasic Equilibrium Dialysis of Poly(N-Isopropyl Acrylamide) Nanogels Synthesized at Decreased Temperatures for Targeted Delivery of Thermosensitive Bioactives by Witold Musial, Jiri Michálek, Janusz Pluta, Anna Jaromin, Magdalena Pietka-Ottlik, Martin Pradny

“…Due to small size in the range below the diameter of the capillaries, they are proposed as drug delivery carriers. The aim of the study was to estimate the influence of composition and reaction conditions during synthesis of poly-N-isopropyl acrylamide cross-linked by polyethylene glycol diacrylate on the purification rates of the polymer. …”
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SARS-CoV-2-induced cytokine storm drives prolonged testicular injury and functional impairment in mice that are mitigated by dexamethasone. by Stefanos Giannakopoulos, Jin Pak, Jackson Bakse, Monika A Ward, Vivek R Nerurkar, Michelle D Tallquist, Saguna Verma

“…The efficacy of inflammation-suppressing drug in preventing testicular injury was also evaluated. …”
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OIE and FAO join forces to counter ASF by N. V. Lebedev, A. S. Igolkin, K. N. Gruzdev

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A Systematic Review of the Causes and Management of Ischaemic Stroke Caused by Nontissue Emboli by Ciaran Judge, Sarah Mello, David Bradley, Joseph Harbison

“…We categorized the pathology of the emboli into the following groups: air embolism (141 reports), other arterial gas embolisms (49 reports), missiles and foreign bodies (16 reports), and others, including drug embolism, cotton wool, and vascular sclerosant agents. …”
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PPARα Is Required for PPARδ Action in Regulation of Body Weight and Hepatic Steatosis in Mice by Wojciech G. Garbacz, Jeffrey T. J. Huang, Larry G. Higgins, Walter Wahli, Colin N. A. Palmer

“…PPARα is a target of well established lipid-lowering drugs. PPARδ (also known as PPARβ/δ) has been investigated as a promising antidiabetic drug target; however, the evidence in the literature on PPARδ effect on hepatic lipid metabolism is inconsistent. …”
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Immunotherapy and Antivascular Targeted Therapy in Patients’ Treatment with Concurrent Malignant Tumors after Organ Transplantation: Opportunity or Challenge by Bairu Shen, Zi Guo, Peng Huang, Minghua Tan, Xiaoshen Zhang, Siyao Lin, Changshan Song, Jiaqing Wang, Minqian Huang

“…Antivascular targeted therapy is one of the options worth considering; the risk of side effects of drug therapy is something that needs to be closely monitored when combined with immunotherapy.…”
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Prolonged Toxic Encephalopathy following Accidental 4-Aminopyridine Overdose by Maria Ballesta Méndez, Vincent van Pesch, Arnaud Capron, Philippe Hantson

“…Background. 4-Aminopyridine (4-AP) is a drug that is used to improve motor fatigue in patients suffering from multiple sclerosis (MS). …”
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Impacto ambiental de la ivermectina eliminada por bovinos tratados en otoño, sobre la coprofauna y la degradación de la materia fecal en pasturas (tandil, argentina) by L. E. Iglesias, C. A. Saumell, L. A. Fusé, A. L. Lifschitz, E. M. Rodriguez, P. E. Steffan, C. A. Fiel

“…All the fecal samples of the treated calves presented drug, being samples on 1 and 3 dpt samples those with the higher concentration and higher organic matter content (p<0.05) for the whole experimental period too. …”
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Toxic Epidermal Necrolysis (TEN)/Stevens-Johnson Syndrome (SJS) Epidemiology and Mortality Rate at King Fahad Specialist Hospital (KFSH) in Qassim Region of Saudi Arabia: A Retrosp... by Abdullah Alajaji, Jagannath Chandra Shekaran, Omar Mohammed Aldhabbah, Hajar Abdullah Alhindi, Nouf Salem Almazyad, Ziyad Abdulrahman Aljutayli, Saleh Abaalkhail, Saleh Alfouzan

“…Toxic epidermal necrolysis (TEN) and Stevens-Johnson syndrome (SJS) are life-threatening conditions caused by drug reactions. There are multiple causative drugs and different risk factors associated with SJS/TEN. …”
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Faster onset of action with topical levocabastine than with oral cetirizine by Michel A. Drouin, William H. Yang, Frederick Horak

“…Within 15 min of study drug administration, 36% of levocabastine-treated patients reported relief from nasal symptoms and 32% relief from ocular symptoms compared with 10% and 17% of patients on cetirizine, respectively. …”
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Comparison of postoperative analgesia by preemptive use of intravenous paracetamol and intravenous ketorolac in patients undergoing elective laparoscopic surgeries by Syed Najeebullah Khadri, R Shankar Anand, K Soundarya Priyadharsini, T. Krishna Prasad

“…Results: The mean time to the first rescue drug among the paracetamol group was lower and statistically significant (P < 0.05) compared to the ketorolac group. …”
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Molecular Basis of GABA Hypofunction in Adolescent Schizophrenia-Like Animals by Xiaodan Wang, Ying Hu, Wenxin Liu, Yuanyuan Ma, Xi Chen, Ting Xue, Donghong Cui

“…Our findings on molecular basis of GABA deficits could provide potential drug targets of GABAergic rescue for early prevention and intervention.…”
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Shigellosis Caused by CTX-M Type ESBL Producing Shigella flexneri in Two Siblings of Rural Nepal: First Case Report from the Country by Narayan Prasad Parajuli, Govardhan Joshi, Bashu Dev Pardhe, Jyotsna Shakya, Anjeela Bhetwal, Shreena Shakya, Roshan Pandit, Sumesh Shreekhanda Shrestha, Puspa Raj Khanal

“…In MDR strains, the third-generation cephalosporins have been used for the treatment, but, unfortunately, emerging reports of enzyme mediated β-lactam resistance among Shigella isolates from various parts of the world have greatly compromised the therapy of pediatric dysentery. In Nepal, drug resistant strains of Shigella spp. have been reported, but MDR and extended spectrum β-lactamase (ESBL) producing strains were previously unknown. …”
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Virtual screening and molecular docking of Indonesian phytoconstituents as potential inhibitors of peroxisome proliferator-activated receptor gamma in polycystic ovary syndrome by Tunjungseto Arif, Iffatunnisa Fakhriyah, Pratiwi Intan Winta, Alif Azzam Muhyiddin Afrizal, Ahsan Fadhil, Santoso Budi

“…Quercitol also met the Lipinski criteria, showing favourable bioavailability as a drug candidate. Hence, these findings will provide a theoretical basis for further studies as regards drugs targeting PPARG in PCOS.…”
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High Level Aminoglycoside Resistance and Distribution of Aminoglycoside Resistant Genes among Clinical Isolates of Enterococcus Species in Chennai, India by Elango Padmasini, R. Padmaraj, S. Srivani Ramesh

“…Enterococci are nosocomial pathogen with multiple-drug resistance by intrinsic and extrinsic mechanisms. …”
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Knowledge, Attitude, and Practice of Community towards an Onchocerciasis Elimination Program from South West Ethiopia by Haile Worku, Misganaw Mola, Bizuwork Derebew Alemu, Sebwedin Surur Jemal, Aklilu Ayiza, Samuel Getachew, Nitin Mahendra Chauhan, Sunil Tulshiram Hajare, Suresh Chandra Singh, Mohammed Kuddus, Vijay J. Upadhye

“…According to 56% of the community, offering incentives for community drug distributors (CDD) has the potential to make the elimination campaign more successful. …”
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Screening of multi deep learning-based de novo molecular generation models and their application for specific target molecular generation by Yishu Wang, Mengyao Guo, Xiaomin Chen, Dongmei Ai

“…Moreover, we evaluated the performance of these NLP-based generation models and another new model architecture based on a selective state space and selected the best approach jointing a transfer learning strategy for de novo drug discovery to target L858R/T790M/C797S-mutant EGFR in non-small cell lung cancer.…”
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Benefits of the use of porcine skin for the management of toxic epidermal necrolysis injuries: Review of the literature by Juan Ludeña, Diana Rojas, Pedro Ciudad, Walter Navarro, Rafael Rossi, Annelisse Travi

“…Toxic epidermal necrolysis (TEN) is a rare immune-mediated adverse skin reaction; secondary in most cases to the administration of a drug. Due to its high mortality, immediate diagnosis and management in an intensive care unit is essential. …”
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