Switching Stable Kidney Transplant Recipients to a Generic Tacrolimus Is Feasible and Safe, but It Must Be Monitored by Fernando González, René López, Elizabeth Arriagada, René Carrasco, Natalia Gallardo, Eduardo Lorca

“…Tacrolimus is the primary immunosuppressive drug used in kidney transplant patients. Replacing brand name products with generics is a controversial issue that we studied after a Chilean Ministry of Health mandate to implement such a switch. …”
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Differentially Expressed Genes Study Shown Potential for BCG Stimulation in Reducing the Severity of COVID-19 by Irandi Putra Pratomo, Aryo Tedjo, Dimas R Noor, Wisnu Ananta Kusuma

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Computational Study of Trisindoline 5 Against Overexpressed EGFR Protein on Breast Cancer Stem Cell by Nurhayati A.P.D., Fatoni M., Santoso M., Wati F.A.

“…The existing inhibitory drugs used to treat the EGFR that act as the master regulator of the signaling network still have a limited response in breast cancer. …”
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Quantitative Analysis of Six Phenolic Acids in Artemisia capillaris (Yinchen) by HPLC-DAD and Their Transformation Pathways in Decoction Preparation Process by Fang Tian, Qun-Jia Ruan, Ying Zhang, Hui Cao, Zhi-Guo Ma, Gai-Lian Zhou, Meng-Hua Wu

“…In conclusion, this study provides a chemical basis for quality control of Yinchen decoction, and the changes of selected markers in decoction could give us some novel perspectives to study the relationship between substances and drug efficacy.…”
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Curcumin mimics of potential chemoprevention with NQO1 induction properties by Dalia R. Aboshouk, Ahmed R. Hamed, Siva S. Panda, Mohamed S. Bekheit, M. Adel Youssef, Adel S. Girgis

“…LPS-induced iNOS production in RAW264.7 macrophages of the most promising agents discovered (5ab and 5ac) displayed concentration-dependent with comparable activities to the reference anti-inflammatory drug indomethacin. Molecular modeling studies (including QSAR, molecular docking and molecular dynamics) were accessed supporting the observed biological profiles.…”
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Complex Laparoscopic Myomectomy with Severe Adhesions Performed with Proper Preventive Measures and Power Morcellation Provides a Safe Choice in Certain Infertility Cases by Jaime Alfaro-Alfaro, María de los Ángeles Flores-Manzur, Roberto Nevarez-Bernal, Rodrigo Ayala-Yáñez

“…Two years ago, the Food and Drug Administration in the United States of America (FDA) issued the alert on power morcellation for uterine leiomyomas, addressing the risk of malignant cell spreading within the abdominal cavity (actual risk assessment from 1 in 360 to 1 in 7400 cases). …”
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VDAC1: A Key Player in the Mitochondrial Landscape of Neurodegeneration by Shirel Argueti-Ostrovsky, Shir Barel, Joy Kahn, Adrian Israelson

“…By unraveling the complex involvement of VDAC1 in neurodegenerative processes, this review highlights potential avenues for future research and drug development aimed at alleviating mitochondrial-related neurodegeneration.…”
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NIGERIA'S FOREIGN POLICY AND TRANSBORDER CRIME: AN OVERIEW by OWUDA RASHIDA LAMIDI

“…West African nation Nigeria faces drug, human, gun, and cybercrime. These criminal operations threaten the nation's security, diplomatic relations, and global reputation. …”
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Determination of the management of a patient with stable ischemic heart disease according to the data of fractional flow reserve study by M.V. Stan, A.V. Khokhlov, О.J. Zharinov, O.V. Zelenchuk, B.M. Todurov

“…The combination of functional class II angina with unclear result of a stress test, as well as the lack of optimal drug therapy at the time of examination led to the decision to assess physiological significance of all existing stenoses by determining the FFR. …”
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The Implications of Liver Biopsy Results in Patients with Myeloproliferative Neoplasms Being Treated with Ruxolitinib by Douglas Tremblay, Juan Putra, Alexander Vogel, Adam Winters, Ronald Hoffman, Thomas D. Schiano, Maria Isabel Fiel, John O. Mascarenhas

“…A variety of liver pathology was observed including extramedullary hematopoiesis, obliterative portal venopathy, and drug-induced liver injury. In all cases reviewed, the liver biopsy had significant treatment implications. …”
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Targeting T-Cell Activation for Malaria Immunotherapy: Scoping Review by Balsa Nobility Gustifante, Shafia Khairani, Nisa Fauziah, Silvita Fitri Riswari, Afiat Berbudi

“…Malaria remains a critical global health issue due to high mortality rates, drug resistance, and low treatment efficacy. The genetic variability of <i>Plasmodium</i> proteins complicates the development of long-lasting immunity, as it impedes the human immune system’s ability to sustain effective responses. …”
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State of the Art, Unresolved Issues, and Future Research Directions in the Fight against Hepatitis C Virus: Perspectives for Screening, Diagnostics of Resistances, and Immunization by Cecilia Trucchi, Andrea Orsi, Cristiano Alicino, Laura Sticchi, Giancarlo Icardi, Filippo Ansaldi

“…However, the emergence of drug resistance and the suboptimal activity of DAAs therapies against diverse HCV genotypes have been observed, determining treatment failure and hampering an effective control of HCV spread worldwide. …”
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Characterization and antibacterial activity of biogenic iron nanoparticles using Proteus mirabilis by Mais Emad Ahmed, Huda Mohammed Hasan, Anfal Jabbar Kttafah

“…Results: The results found that at 128 μg/mL minimum inhibitory concentration, we have demonstrated the potent antibacterial properties of FeONPs produced through biological procedures against Gram-positive and Gram-negative bacteria that are resistant to many drugs. These NPs, including their antimicrobial qualities, how they work, how they affect drug-resistant microbes, the risks involved with using them, the unique qualities of NPs, their mode of action as antibacterial properties, and the elements that influence how well they function in a therapeutic setting all are thoroughly investigated. …”
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Untypical Amlodipine-Induced Gingival Hyperplasia by Verica Pavlic, Nina Zubovic, Sanja Ilic, Tijana Adamovic

“…At one-month follow-up, drug replacement and SRP resulted in some reduction of the inflammation and significant reduction of symptoms. …”
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Effectiveness and Safety of Botulinum Toxin Type A in Children with Musculoskeletal Conditions: What Is the Current State of Evidence? by Noémi Dahan-Oliel, Bahar Kasaai, Kathleen Montpetit, Reggie Hamdy

“…Future studies including larger samples, longer follow-up periods and a comparison group are required to provide evidence on the effectiveness and safety of this drug in children with musculoskeletal conditions.…”
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Evaluation of Wound-Healing Activity of Hydrogel Extract of Sansevieria trifasciata Leaves (Asparagaceae) by Nia Yuniarsih, Himyatul Hidayah, Neni Sri Gunarti, Anggun Hari Kusumawati, Farhamzah Farhamzah, Asman Sadino, Maulana Yusuf Alkandahri

“…Therefore, S. trifasciata leaves extract has the potential to be developed as a wound-healing drug derived from herbal plants formulated into hydrogel preparations.…”
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Unlocking biological complexity: the role of machine learning in integrative multi-omics by Ravindra Kumar, Rajrani Ruhel, Andre J. van Wijnen

“…By integrating machine learning in multi-omics, we can enhance our understanding of drug discovery, disease, pathway, and network analysis. …”
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Antibacterial and quorum sensing regulatory activities of some traditional Eastern-European medicinal plants by Tolmacheva Anna A., Rogozhin Eugene A., Deryabin Dmitry G.

“…These data confirm that multicomponent anti-infectious mechanisms are used by plants, which may be useful for drug development…”
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Experiences of nurses and patients with the implementation of the CCMDD programme by Ragosebo P. Sekopa, Robert T. Netangaheni

“…Results: Positive experiences included overcrowding and workload reduction, saving of time and money for transport, improves medication adherence, reduction in incidents of file loss, reduction in patient waiting times, preservation of clinic drug supplies and easy and convenience. However, negative experiences such as shortage of staff, the lack of communication and information on the CCMDD programme hindered the effectiveness of the CCMDD programme. …”
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Exploring comorbidity and pharmacological treatment patterns in psoriasis - a retrospective population-based cross-sectional study by Nelly Hamgård, Albert Duvetorp, Anna Hägg, Sandra Jerkovic Gulin, Oliver Seifert

“…Data on comorbidity and dispensation of prescribed drugs against these comorbid conditions were analyzed. …”
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