Measuring Measuring iron concentration in the blood samples of some autistic children from Baghdad City by Ezzuldin sulaiman, Hind Suhail Abdulhay

“… Autism spectrum disorder (ASD) research delved into the correlation between genetic susceptibility and various environmental factors, including diet, drug exposure, and environmental toxicants such as exposure to heavy metals. …”
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Simultaneous Determination of Nine Neonicotinoid Insecticides and Five Metabolites in Meat by QuEChERS Coupled with Ultra-high Performance Liquid Chromatography-Tandem Mass Spectro... by LIN Binbin, YANG Zhijin, HUANG Xuliang, LIN Xiaolian

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Features of restoring the mental health of law enforcement officers who participated in the operation of the United Forces by O. S. Kolesnichenko

“…Experience shows that if servicemen do nothing during this period, this will greatly contribute to the development of negative individual and group experiences and conditions, the occurrence of misconduct, drunkenness, drug addiction, etc. This program contains a set of group and individual work methods, namely: debriefing, aimed at switching the minds of employees (combatants) from the zone of extreme conditions to the usual life, receiving relief, reducing the feeling of uniqueness and abnormality of own reactions, reducing internal tension, reducing the severity of psychological consequences after experienced stress; sessions of psycho-emotional self-regulation; treatment measures; individual psychological counseling. …”
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Epithelial to Mesenchymal Transition Relevant Subtypes with Distinct Prognosis and Responses to Chemo- or Immunotherapies in Osteosarcoma by Yang Zhou, Gai Li, Hu Li, Fuchong Lai, Pingguo Duan, Ming Cheng

“…Immunological features were evaluated through immune cell infiltration, immune checkpoint expression, and activity of cancer immunity cycle. Drug sensitivity was estimated with the GDSC database. …”
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Tabaquismo by Alfredo Darío Espinosa Brito, Alfredo Espinosa Roca

“…Negative consequences for the health of individuals are described as well as deleterious social and economic impacts associated to this habit. A drug therapy is also provided as another possible individual strategy to quit smoking.…”
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New Insights in Genetic Cholestasis: From Molecular Mechanisms to Clinical Implications by Eva Sticova, Milan Jirsa, Joanna Pawłowska

“…In addition to familial intrahepatic cholestasis, partial defects in ATP8B1, ABCB11, and ABCB4 predispose patients to drug-induced cholestasis and intrahepatic cholestasis in pregnancy. …”
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Optimized Synthesis of Magnesium Oxide Nanoparticles as Bactericidal Agents by Mohammad Moslem Imani, Mohsen Safaei

“…According to the results, magnesium oxide nanoparticles can significantly reduce the number of Gram-positive and Gram-negative bacteria and can be used as an appropriate alternative to commonly used antibacterial compounds in order to tackle drug resistance among pathogens.…”
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A Review on Expression, Pathological Roles, and Inhibition of TMPRSS2, the Serine Protease Responsible for SARS-CoV-2 Spike Protein Activation by Jyotirmoy Sarker, Pritha Das, Sabarni Sarker, Apurba Kumar Roy, A. Z. M. Ruhul Momen

“…These findings provide valid reasons for the assumption that inhibiting TMPRSS2 can have a beneficial effect in reducing the cellular entry of the virus, ultimately affecting the infection rate and case severity. Several drug development studies are going on to develop potential inhibitors of the protease, using both conventional and computational approaches. …”
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Major Histocompatibility Class II Pathway Is Not Required for the Development of Nonalcoholic Fatty Liver Disease in Mice by Gilles Willemin, Catherine Roger, Armelle Bauduret, Kaori Minehira

“…Single-nucleotide polymorphisms within major histocompatibility class II (MHC II) genes have been associated with an increased risk of drug-induced liver injury. However, it has never been addressed whether the MHC II pathway plays an important role in the development of nonalcoholic fatty liver disease, the most common form of liver disease. …”
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MultiChem: predicting chemical properties using multi-view graph attention network by Heesang Moon, Mina Rho

“…Abstract Background Understanding the molecular properties of chemical compounds is essential for identifying potential candidates or ensuring safety in drug discovery. However, exploring the vast chemical space is time-consuming and costly, necessitating the development of time-efficient and cost-effective computational methods. …”
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Tramadol Induced Adrenal Insufficiency: Histological, Immunohistochemical, Ultrastructural, and Biochemical Genetic Experimental Study by Shereen Abdelhakim Abdelaleem, Osama A. Hassan, Rasha F. Ahmed, Nagwa M. Zenhom, Rehab A. Rifaai, Nashwa F. El-Tahawy

“…It is the most consumed narcotic drug that is prescribed in the world. Tramadol abuse has dramatically increased in Egypt. …”
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Susceptibility Profiles of Mycobacterium ulcerans Isolates to Streptomycin and Rifampicin in Two Districts of the Eastern Region of Ghana by Enid Owusu, Mercy Jemima Newman, Nana Konama Kotey, Amos Akumwena, Elizabeth Bannerman

“…Background. Drug resistance is a major challenge in antibiotic chemotherapy. …”
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The tetracycline resistome is shaped by selection for specific resistance mechanisms by each antibiotic generation by Kevin S. Blake, Yao-Peng Xue, Vincent J. Gillespie, Skye R. S. Fishbein, Niraj H. Tolia, Timothy A. Wencewicz, Gautam Dantas

“…Abstract The history of clinical resistance to tetracycline antibiotics is characterized by cycles whereby the deployment of a new generation of drug molecules is quickly followed by the discovery of a new mechanism of resistance. …”
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Management of Hypertension in Intrapericardial Paraganglioma by Nicola Rotolo, Andrea Imperatori, Alessandro Bacuzzi, Valentina Conti, Massimo Castiglioni, Lorenzo Dominioni

“…We review here the current modalities of perioperative fluid and hypotensive drug administration in the setting of surgery for functioning intrapericardial paraganglioma and discuss the recently proposed paradigm shift that omits preoperative preparation.…”
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Biomolecules of the Horseshoe Crab’s Hemolymph: Components of an Ancient Defensive Mechanism and Its Impact on the Pharmaceutical and Biomedical Industry by Md. Ashrafuzzaman, Mamudul Hasan Razu, Nazmir-Nur Showva, Tohmina Afroze Bondhon, Md. Moniruzzaman, Sad Al Rezwan Rahman, Md. Raisul Islam Rabby, Fatema Akter, Mala Khan

“…These biomolecules are antimicrobial and antibacterial, enabling them to be drug resistant. This review is aimed at explaining the biomolecules identified in the horseshoe crab’s hemolymph and their application scopes in the pharmaceutical and biotechnology sectors.…”
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Intensive pharmacovigilance of Heberprot-P® in patients with diabetic foot ulcer by Annavely González Ocaña, Ana María Ramos Cedeño, Yeny Dueñas Pérez, Francisco Carlos Valladares Más, Yahima Arrechea Betancourt

“…<p><strong>Foundation</strong>: Intensive pharmacovigilance is an effective tool to detect adverse reactions in relatively new drugs that have sanitary registration by a regulatory agency.…”
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Invasive Pneumococcal Disease: Still Lots to Learn and a Need for Standardized Data Collection Instruments by T. J. Marrie, G. J. Tyrrell, Sumit R. Majumdar, Dean T. Eurich

“…High rates of smoking, excessive alcohol use, and illicit drug use were seen. Almost all (87%) had a major comorbidity and 15% had functional limitations prior to admission. …”
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Development of an ANN optimized mucoadhesive buccal tablet containing flurbiprofen and lidocaine for dental pain by Hussain Amjad, Syed Muhammad Ali, Abbas Nasir, Hanif Sana, Arshad Muhammad Sohail, Bukhari Nadeem Irfan, Hussain Khalid, Akhlaq Muhammad, Ahmad Zeeshan

“…The formulations were evaluated for their physicochemical properties, mucoadhesive strength and mucoadhesion time, swellability index and in vitro release of active agents. Release of both drugs depended on the relative ratio of HPMC:SA. …”
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Clinical Presentations and Characteristics of NSAIDs Hypersensitivity in a Tertiary Care Hospital in Indonesia: A Case Series by Nurmesa A, Zakiyah N, Insani WN

“…However, they have also been identified as the second most common cause of drug-induced hypersensitivity reactions, after beta-lactam antibiotics. …”
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The Role of Aggregates of Therapeutic Protein Products in Immunogenicity: An Evaluation by Mathematical Modeling by Liusong Yin, Xiaoying Chen, Abhinav Tiwari, Paolo Vicini, Timothy P. Hickling

“…However, TPP can induce unwanted immune responses that can impact both drug efficacy and patient safety. The presence of aggregates is of particular concern as they have been implicated in inducing both T cell-independent and T cell-dependent immune responses. …”
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