Reprogramming the tumor immune microenvironment using engineered dual-drug loaded Salmonella by Dinh-Huy Nguyen, Sung-Hwan You, Hien Thi-Thu Ngo, Khuynh Van Nguyen, Khang Vuong Tran, Tan-Huy Chu, So-young Kim, Sang-Jun Ha, Yeongjin Hong, Jung-Joon Min

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In Situ Gelling Dexamethasone Oromucosal Formulation: Physical Characteristics Influencing Drug Delivery by Daniel Krchňák, Ľudmila Balážová, Michal Hanko, Dominika Žigrayová, Miroslava Špaglová

“…The influence of mint EO and DEX solubilization on the physical properties (pH measurements, rheological analysis, swelling ability, and texture analysis) and in vitro drug release was studied. Key findings revealed that HPMC-based formulation containing mint EO and PG exhibited best swelling properties (700 ± 46% after 5 h), adequate adhesiveness and in vitro drug release (34.7 ± 5.9%). …”
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A new score for predicting intracranial hemorrhage in patients using anticoagulant drugs by Fuxin Ma, Zhiwei Zeng, Jiana Chen, Chengfu Guan, Wenlin Xu, Chunhua Wang, Jinhua Zhang

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Sulforaphane in alternative cancer chemotherapy: From carcinogenesis suppression to drug resistance reversal by Seyed Mohammad Doodmani, Payman Rahimzadeh, Najma Farahani, Seyedalireza Mirilavasani, Mina Alimohammadi, Noushin Nabavi, Elmira Alaei, Afshin Taheriazam, Maryam Abedi, Nadia Shafiee, Salman Daneshi, Mehrdad Hashemi

“…When combined with chemotherapy drugs, SFN enhances tumor suppression and mitigates drug resistance in human cancers. …”
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Recent advances in iontophoresis-assisted microneedle devices for transdermal biosensing and drug delivery by Gaobo Wang, Natsuho Moriyama, Soichiro Tottori, Matsuhiko Nishizawa

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Drug-Induced Hypersensitivity Syndrome: A Clinical, Radiologic, and Histologic Mimic of Lymphoma by Faaria Gowani, Bradley Gehrs, Teresa Scordino

“…Drug-induced hypersensitivity syndrome (DIHS; also known as drug reaction with eosinophilia and systemic symptoms, or DRESS) is a rare, potentially life-threatening condition that typically presents 2–8 weeks after drug exposure with fever, rash, organ dysfunction, and lymphadenopathy. …”
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Deep-insights: Nanoengineered gel-based localized drug delivery for arthritis management by Anitha Sriram, Harshada Ithape, Pankaj Kumar Singh

“…Additionally, conventional intra-articular drug delivery also leads to rapid clearance of drugs from the synovial joint tissue. …”
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A Mathematical Model for the Dynamics of Onchocerciasis With Vector Control and Mass Drug Administration by Martin Karuhanga, Victor Yiga

“…Numerical simulations indicate that administering highly effective drugs to infected individuals significantly reduces the number of cases. …”
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Hydrocortisone for Preventing Adverse Drug Reactions to Snake Antivenom: A Meta-Analysis by Jihua Feng, Zimeng Wu, Qiao Yu, Hongyuan Li, Pan Ji, Yanli Yang, Xiaoliang Zeng, Xiaowen Zheng, Chunling Zhao, Jianfeng Zhang

“…Pretreatment with hydrocortisone (prehydrocortisone) has been used to protect against adverse drug reactions (ADRs) following antivenom administration after snakebite. …”
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Ketamine-Induced Cystitis: A Comprehensive Review of the Urologic Effects of This Psychoactive Drug by Danyon J. Anderson, Jessica Zhou, David Cao, Matthew McDonald, Maya Guenther, Jamal Hasoon, Omar Viswanath, Alan D. Kaye, Ivan Urits

“…Ketamine is a common medical anesthetic and analgesic but is becoming more widely used as a recreational drug. Significant side effects on the urinary tract are associated with frequent recreational ketamine use most notably ketamine-induced cystitis (KIC). …”
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Significance of non-steroidal anti-inflammatory drugs in the prevention and treatment of cervical cancer by Xun Kan, Zhenhuan Zhou, Lianlian Liu, Reziwanguli Aiskikaer, Yinggang Zou

“…Nonsteroidal anti-inflammatory drugs (NSAIDs) have demonstrated the capability to significantly inhibit COX activity, playing a crucial preventive and therapeutic role in various tumors. …”
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Bacterial Spinal Epidural and Psoas Abscess in Pregnancy Associated with Intravenous Drug Use by Tirtza N. Spiegel Strauss, Sarah L. Pachtman, Burton Rochelson

“…We report a case of a 25-year-old G3 P0020 at 36 weeks of gestational age with history of intravenous drug abuse presenting with acute-onset and severe back pain. …”
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From Blood to Therapy: The Revolutionary Application of Platelets in Cancer-Targeted Drug Delivery by Lijuan Xie, Fengxu Gan, Yun Hu, Yibin Zheng, Junshan Lan, Yuting Liu, Xiaofang Zhou, Jianyu Zheng, Xing Zhou, Jie Lou

“…These systems utilize nanoparticles shielded and directed by platelet membrane coatings for efficient drug delivery. This review highlights the role of platelets in cancer therapy, summarizes the advancements in platelet-based drug delivery systems, and discusses their integration with other cancer treatments. …”
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Drug Target Identification and Prioritization for Treatment of Ovine Foot Rot: An In Silico Approach by Abhishek Acharya, Lalit C. Garg

“…These proteins may be considered as potential vaccine candidates or drug targets for designing antibiotics against the bacterium. …”
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Extreme Environment Streptomyces: Potential Sources for New Antibacterial and Anticancer Drug Leads? by Periyasamy Sivalingam, Kui Hong, John Pote, Kandasamy Prabakar

“…Consequently, the increased morbidity and mortality, which are associated with multidrug resistance bacteria, urgently require the discovery of novel and more efficient drugs. Conversely, cancer is a growing complex human disease that demands new drugs with no or fewer side effects. …”
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Mexiletine and False Positive Urine Drug Screen for Amphetamine: A Case Review by Sumit Sohal, Mina Sous, Gauri Pethe, Shanmugha V. Padmanabhan, Rajesh Akbari, Shahriar Dadkhah

“…Advanced heart failure patients commonly suffer from ventricular arrhythmias which can be managed by antiarrhythmic drugs like mexiletine. These ventricular arrhythmias can be complicated by illicit drug use which alter outcomes and can potentially impact the patient-physician relationship through countertransference. …”
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Azithromycin-Induced Thrombocytopenia: A Rare Etiology of Drug-Induced Immune Thrombocytopenia by Muhammad Umer Butt, Ahmad Jabri, Samy Claude Elayi

“…Drug-induced thrombocytopenia requires a high suspicion for diagnosis and a broad investigation to exclude other etiologies of low platelets. …”
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Fluorescence Lifetime Imaging for Quantification of Targeted Drug Delivery in Varying Tumor Microenvironments by Amit Verma, Vikas Pandey, Catherine Sherry, Taylor Humphrey, Christopher James, Kailie Matteson, Jason T. Smith, Alena Rudkouskaya, Xavier Intes, Margarida Barroso

“…Especially, MFLI FRET is a unique imaging modality that can directly quantify target engagement with the potential to elucidate the role of the TME in drug delivery efficacy in intact live tumor xenografts.…”
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Me’phaa, Women, Resistance and Sense of Place in the Displacements of Exactivism and Drug Trafficking by Erika Sebastián Aguilar

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Key oncogenes and candidate drugs for hepatitis-B-driven hepatocellular carcinoma progression by Liqin Ruan, Ningbo Fang, Xinhua Zhao, Weili Chen, Zhaoping Wu, Xiaoyong Wu

“…Among 8 genes, MKI67, EZH2, and CDCA5 were hub ones. Finally, 7 drugs target at least three HB-LC genes and can be used as novel drugs. …”
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