Exploring ethical considerations in medical research: Harnessing pre-generated transformers for AI-powered ethics discussions. by Takuya Mori, Takuya Watanabe, Shinji Kosugi

“…It also raised points about potential side effects of off-label drug use. However, it could not offer specific measures for psychological considerations or broader ethical issues, providing limited ethical insights. …”
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Bioactivity-guided isolation and molecular modeling of the anti-inflammatory constituents from the leaves of Duranta erecta Linn. by Marina Sobhy, Farid N. Kirollos, Sameh F. AbouZid, Nasser S. M. Ismail, Riham A. El-Shiekh, Essam Abdel-Sattar

“…Overall, the data reported in this study add to our understanding of the pharmacological properties of the examined plant and Duranterectoside A (1) and pave the way for future research and investigation in inflammation and drug discovery.…”
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Inhibition of TNF-α and JNK Signaling Pathway Can Reduce Paclitaxel-Induced Apoptosis of Mouse Cardiomyocytes by Shuang Ren, Tianwen Huang, Danyan Ou, Luhuai Feng, Sisi Huang, Chaonan Zhou, Lianying Ge

“…Paclitaxel (PTX) is a widely used chemotherapeutic drug for treating tumors. However, studies have shown that it can cause cardiac problems such as arrhythmia, myocarditis, chronic cardiomyopathy, and heart failure. …”
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Beyond immortality: Epstein–Barr virus and the intricate dance of programmed cell death in cancer development by Arezoo Esmaeili, Prankur Awasthi, Samira Tabaee

“…A deeper understanding of the molecular underpinnings of EBV's influence on cell death not only enriches the field of viral oncology but also pinpoints targets for drug development. Furthermore, the insights gleaned from this review could catalyze the design of vaccines aimed at preventing EBV infection or curtailing its oncogenic impact. …”
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Microneedle-Based Approaches for Skin Disease Treatment by Yanhua Han, Xiaoyu Qin, Weisen Lin, Chen Wang, Xuanying Yin, Jiaxin Wu, Yang Chen, Xiaojia Chen, Tongkai Chen

“…Highlights Microneedles (MNs) are used extensively for treating skin diseases due to their capability to provide less-invasive targeted drug delivery. Intelligent MNs can be fabricated from biocompatible materials with specialized properties, thereby providing improved treatment efficacy. …”
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The Effect of Gram Negative Bacteria on Semen Parameters of a Sample of Infertile Men and Antibiotic Susceptibility Tests by Huda Mohammed Jawed, Mohammed Shamkhi Jabur

“…Record of Gram negative bacilli was sensitive to Vancomycin, Rifampicin, and Trimmethoprim/sulfamethoxazole combination drug while Fusidicacid was resistant from most Gram negative bacilli. …”
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Connecting electronic health records to a biomedical knowledge graph to link clinical phenotypes and molecular endotypes in atopic dermatitis by Francesca Frau, Paul Loustalot, Margaux Törnqvist, Nina Temam, Jean Cupe, Martin Montmerle, Franck Augé

“…Abstract Precision medicine is defined by the U.S. Food & Drug Administration as “an innovative approach to tailoring disease prevention and treatment that considers differences in people’s genes, environments, and lifestyles”. …”
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he Shanghai Cooperation Organization and its role in the contemporary system of international relations (On the 20th anniversary of the SCO) by D. V. Malyshev

“…The latter particularly imply an increasing threat of terrorism, extremism, and drug traffi  cking from Afghanistan to neighboring countries in Central Asia. …”
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Effects of Acyclovir and IVIG on Behavioral Outcomes after HSV1 CNS Infection by Chandran Ramakrishna, Mari S. Golub, Abby Chiang, Teresa Hong, Markus Kalkum, Edouard M. Cantin

“…We hypothesized that CNS inflammation is casually involved in behavioral abnormalities after HSE and that treatment with ACV and pooled human immunoglobulin (IVIG), an immunomodulatory drug, would improve outcomes compared to mice treated with phosphate buffered saline (PBS) or ACV alone. …”
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Investigation of Pharmacokinetic Parameters of Trelagliptin in Egyptian Volunteers Using Sensitive LC-MS/MS: A Comparative Study with a Japanese Population by Shereen Mowaka, Nermeen Ashoush, Mariam M. Tadros, Bassam M. Ayoub

“…Trelagliptin (TLN) is a novel once-weekly antidiabetic drug that enhanced the patient compliance in type 2 diabetes. …”
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Targeting HIF-1α to Prevent Renal Ischemia-Reperfusion Injury: Does It Work? by Kapil Sethi, Kenny Rao, Damien Bolton, Oneel Patel, Joseph Ischia

“…The aim of this review is to highlight the techniques and drugs that target HIF-1α and ameliorate IRI associated with renal ischemia. …”
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Anti-Onchocercal Properties of Extracts of Scoparia dulcis and Cylicodiscus gabunensis by Tiku Edward Tiku, Moses Samje, Napoleon Mfonku, Fidelis Cho-Ngwa

“…The elimination of onchocerciasis is hampered by the absence of suitable drugs that are effective against adult filariae. …”
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Exploration of Nitrate Reductase Metabolic Pathway in Corynebacterium pseudotuberculosis by Sintia Almeida, Cassiana Sousa, Vinícius Abreu, Carlos Diniz, Elaine M. S. Dorneles, Andrey P. Lage, Debmalya Barh, Vasco Azevedo

“…Findings about pathogen metabolism can contribute to the identification of relationship between nitrate reductase and the C. pseudotuberculosis pathogenicity, virulence factors, and discovery of drug targets.…”
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The role of Box A of HMGB1 in producing γH2AX associated DNA breaks in lung cancer by Sirapat Settayanon, Pithi Chanvorachote, Apiwat Mutirangura

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The Psychological Impact of Divorce on Children in Manado City, North Sulawesi by Ardianto Ardianto, Edi Gunawan, Nasruddin Yusuf, Munir Tubagus

“…These psychological impacts are then reflected in various aspects of the child's life, including a decline in academic performance, lack of motivation to study, and deviant behaviors such as drug use or engaging in promiscuous activities. In facing these challenges, it is crucial for children to receive adequate social and psychological support. …”
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Exploring TNFR1: from discovery to targeted therapy development by Yingying Li, Ruiwei Ye, Haorui Dai, Jiayi Lin, Yue Cheng, Yonghong Zhou, Yiming Lu

“…This review emphasizes the emerging field of targeted therapies aimed at selectively modulating TNFR1 activity, identifying promising therapeutic strategies that exploit TNFR1 as a drug target through an evaluation of current clinical trials and preclinical studies. …”
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Design, Synthesis, enzyme inhibitory activity and molecular docking studies of new 1,2,3-triazole linked nucleobases by Aditya Aggarwal, Chanchal Vashisth, Komal Bharti, Neera Raghav, Surender Kumar

“…Compound 5h exhibited the highest enzyme inhibitory activity (trypsin, % inhibition = 81.55) at 10−7 M concentration in comparison to the reference drug orlistat.…”
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Development of a Predictive Model of Tuberculosis Transmission among Household Contacts by Saibin Wang

“…Ten variables (gender, age, TB history, diabetes, HIV, index patient’s drug resistance, socioeconomic status, spoligotypes, and the index-contact share sleeping room status) filtered through the LASSO regression technique were finally included in the predictive model. …”
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Assessing traditional Chinese medicine from a molecular perspective by Minhui Su, Wenxi Wang, Xudong Sun, Lihong Li, Weihong Tan

“…Nucleic acids, a class of star functional molecules, are notable for their versatile applications in molecular diagnostics, gene therapy, and drug development. Therefore, in this study, we review the extensive use of nucleic acid aptamers in medicinal practice. …”
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Early and Ultraearly Administration of Tranexamic Acid in Traumatic Brain Injury: Our 8-Year-Long Clinical Experience by Nurdan Acar, Mustafa Emin Canakci, Ugur Bilge

“…TXA appears to be a safe drug with few side effects in the short term in head injuries. …”
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