Nelfinavir Impairs Glycosylation of Herpes Simplex Virus 1 Envelope Proteins and Blocks Virus Maturation by Soren Gantt, Eliora Gachelet, Jacquelyn Carlsson, Serge Barcy, Corey Casper, Michael Lagunoff

“…Selection of HSV-1 resistance to NFV was not achieved despite multiple passages under drug pressure. NFV did not significantly affect the level of expression of late HSV-1 gene products. …”
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Development of a Controlled Release of Salicylic Acid Loaded Stearic Acid-Oleic Acid Nanoparticles in Cream for Topical Delivery by J. O. Woo, M. Misran, P. F. Lee, L. P. Tan

“…Lipid nanoparticles are colloidal carrier systems that have extensively been investigated for controlled drug delivery, cosmetic and pharmaceutical applications. …”
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Antibiotic Resistance of Salmonella enterica Serovar Typhi in Kolkata, India, and In Vitro Experiments on Effect of Combined Chemotherapy by Shyamapada Mandal, Manisha DebMandal, Nishith Kumar Pal

“…Keeping in mind the anticipation of development of resistance to Ct/Cf, we prepared the treatment regimen for MDR enteric fever, based on the double-drug synergy tests in vitro; Cp-gentamycin (FICI 0.121–0.216) and Cp-trimethoprim (FICI 0.14–0.483) combinations were found effective against S. …”
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Oxidative stress-driven enhanced iron production and scavenging through Ferroportin reorientation worsens anemia in antimony-resistant Leishmania donovani infection. by Souradeepa Ghosh, Krishna Vamshi Chigicherla, Shirin Dasgupta, Yasuyuki Goto, Budhaditya Mukherjee

“…Understanding these mechanisms is crucial for managing LD-R-infections and their associated complications like severe anemia, and may also provide valuable mechanistic insights into understanding drug unresponsiveness developed in other intracellular pathogens that rely on host iron.…”
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The Association of COPD Exacerbations with New Onset Type 2 Diabetes among Medicare Patients by Joseph S. Marino, Cynthiya Ruban, Christopher M. Blanchette

“…Exacerbations of COPD are commonly treated with corticosteroids, a class of drug known to cause insulin resistance. The objective of this study was to assess the rate of exacerbations requiring emergency room visits, hospitalizations or any medical encounter (a combination of emergency room and hospitalizations) between COPD patients who did and did not develop type 2 diabetes. …”
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Enhanced Isolation of Streptomyces from Different Soil Habitats in Calamba City, Laguna, Philippines using a Modified Integrated Approach by Jhon Wilson A. Antido, Fresthel Monica M. Climacosa

“…These Streptomyces isolates can be valuable for future drug discovery and development research.…”
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Health Literacy Status and Understanding of the Prescription Instructions in Diabetic Patients by Shivangini Singh, Sahana Devadasa Acharya, Ashwin Kamath, Sheetal D. Ullal, Rathnakar P. Urval

“…A cross-sectional survey was conducted in 263 adult diabetic patients who were assessed for their understanding of route of intake of the prescribed medication(s), frequency of intake, number of medication(s) to be consumed each time, indication for the medication(s), and the relation of drug intake with food. The HL of the patients was assessed by using Rapid Estimate of Adult Literacy in Medicine, a screening test comprising of 66 health-related words. …”
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Nanoparticle Therapy Is a Promising Approach in the Management and Prevention of Many Diseases: Does It Help in Curing Alzheimer Disease? by Lamyaa M. Kassem, Nada A. Ibrahim, S. Ayesha Farhana

“…Nanomedical application provides a promising drug delivery revolution for the treatment of neurodegenerative diseases (NDDs). …”
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Stellettin B Isolated from Stelletta Sp. Reduces Migration and Invasion of Hepatocellular Carcinoma Cells through Reducing Activation of the MAPKs and FAK/PI3K/AKT/mTOR Signaling P... by Tsung-Chang Tsai, Wen-Tung Wu, Jen-Jie Lin, Jui-Hsin Su, Yu-Jen Wu

“…In this study, we used Stellettin B, an active compound isolated from Stelletta sponges, as the experimental drug and evaluated its inhibition effects on cell migration and invasion in human hepatoma cells (HA22T and HepG2). …”
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Fractionation and evaluation of proteins in roots of Echinacea purpurea (L.) Moench by Balciunaite Gabriele, Juodsnukyte Jovita, Savickas Arunas, Ragazinskiene Ona, Siatkute Luka, Zvirblyte Gitana, Mistiniene Edita, Savickiene Nijole

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Comparative Pharmacokinetics of Levofloxacin in Healthy and Renal Damaged Muscovy Ducks following Intravenous and Oral Administration by Mohamed Aboubakr, Ahmed Soliman

“…Following PO administration, the peak serum concentration (Cmax) was higher in renal damaged than in healthy ducks and was achieved at maximum time (tmax) of 2.47 and 2.05 h, respectively. The drug was eliminated (t1/2(el)) at a significant slower rate (3.94 h) in renal damaged than in healthy ducks (2.89 h). …”
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Molecular Insights in the Anticancer Activity of Natural Tocotrienols: Targeting Mitochondrial Metabolism and Cellular Redox Homeostasis by Raffaella Chiaramonte, Giulia Sauro, Domenica Giannandrea, Patrizia Limonta, Lavinia Casati

“…Cancer cells maintain moderate levels of ROS to promote tumorigenesis, metastasis, and drug resistance; indeed, once the cytotoxicity threshold is exceeded, ROS trigger oxidative damage, ultimately leading to cell death. …”
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Myalgia and Hematuria in Association with Clonidine and Arginine Administration for Growth Hormone Stimulation Tests by Meghan Glibbery, Adam Fleming, Rahul Chanchlani, Olufemi Abiodun Ajani, Norma Marchetti, Alexa Marr, M. Constantine Samaan

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Modern Conflicts Features in Latin America. The Role of the OAS in the Settlement of the Falklands Conflict by Y. I. Strashko

“…The former persist in protection of freedoms and the Western way of life against global threats such as international terrorism (especially after 9/11), drug trafficking, gunrunning, money laundering and others crimes (especially those involving violence). …”
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Diffuse Alveolar Hemorrhage Associated with Edoxaban Therapy by Kenichi Nitta, Hiroshi Imamura, Akihiro Yashio, Satoko Kashima, Katsunori Mochizuki

“…On day 38, she developed fungemia, which was treated with an antifungal drug. On day 43, she presented with dyspnea. Chest computed tomography scan showed bilateral diffuse ground-glass opacities in the whole lung fields. …”
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Titrimetric and Spectrophotometric Determination of Metaprolol tartrate in Pharmaceuticals Using N-Bromosuccinimide by K. Basavaiah, B. C. Somashekar

“…One titrimetric and two spectrophotometric methods are presented for the assay of metaprolol tartrate (MPT) in bulk drug and in tablets. The methods employ N-bromosuccinimide (NBS) as the oxidimetric reagent and two dyes, methyl orange and indigo carmine as spectrophotometric reagents. …”
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Synthesis, Characterization, Molecular Docking, and In Silico ADME Study for Some New Different Derivatives for Succiniohydrazide by Asmaa A. Maryoosh, Oday H. R. Al-Jeilawi

“…Among all synthesis compounds, compound 2b has excellent results compared with colchicine and can be considered a good anti-bacterial against Escherichia coli and an anti-breast cancer drug. …”
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Fully automated in vivo screening system for multi-organ imaging and pharmaceutical evaluation by Junhan Duan, Guanming Lin, Kangjian Jiao, Xiaohui Hong, Xudong Lin

“…Using this platform, we examine the cardiac sensitivity of an antipsychotic drug with multiple concentration gradients, and reveal dramatic diversity and complexity in the accurate chemical regulation of cardiac functions in vivo. …”
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Efficacy and Tolerability of the Association of Sibutramine and Orlistat for Six Months in Overweight and Obese Patients by Alfredo Halpern, Renata B. Pepe, Ana Paola Monegaglia, Mônica Beyruti, Maria Edna de Melo, Marcio C. Mancini

“…The association of orlistat and sibutramine is quite efficient and it seems to promote a higher rate of weight loss than that reported in clinical studies performed with each drug separately.…”
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Amarogentin suppresses cell proliferation and EMT process through inducing ferroptosis in colorectal cancer by Chao Wang, Zihao You, Guoqing Zhou, Juanjuan Dong, Sihao Tong, Guoping Sun

“…This discovery suggested that AG may be one effective drug for ameliorating CRC progression.…”
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