Synthesis and crystal structure of (S,E)-4-hydroxy-3-(2-((4aR,6aS,7R,10aS,10bR)-3,3,6a,10b-tetramethyl-8-methylenedecahydro-1H-naphtho[2,1-d][1,3]dioxin-7-yl)ethylidene)dihydrofura... by Li Shi-Qing, Zhou Jian, Dong Zhang-Chao, Pan Bo Wen, Shi Yang, Zhou Ying

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An Update on Anti-Helicobacter Pylori Treatment in Children by Renuka Khurana, Lori Fischbach, Naoki Chiba, Sander Veldhuyzen van Zanten

“…The objective of the present review was to summarize data from pediatric studies that have examined treatment efficacy, safety, drug resistance and reinfection rates related to anti-H pylori therapies. …”
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Detection of Garlic Powder Adulteration Using FTIR Spectroscopy and Chemometrics: A Case Study in an Indonesia Marketplace by Avika Rizky Elvira, Anggita Rosiana Putri, Luthfi Ahmad Muchlashi

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Community Development in the Rural Areas through Traditional Indigenous Knowledge by Godfrey, Barigye, Siraje, Kaaya

“…Also, the rural area is seen as the place where the elderly, disabled, victims of war, unemployed, drug addicts and those with poor political governance reside. …”
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Virtual reality-based cognitive–behavioural therapy for the treatment of anxiety in patients with acute myocardial infarction: a randomised clinical trial by Jiajun Weng, Junbo Ge, Jiajia Liu, Juying Qian, Xiao Huang, Yuanyuan Li, Juan Peng, Yan'e Lu, Dong Huang, Pingyuan Yang, Shikun Xu, Lihua Guan, Qibing Wang, Zexin Zhao, Yabin Wei

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Spondilitis Tuberkulosa Cervical by Roni Eka Saputra, Irsal Munandar

“…Treatment consists of antituberculosis drug with or without surgical<br />intervention. …”
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Carriage of Extended-Spectrum-β-Lactamase- and AmpC-β-Lactamase-Producing Enterobacteriaceae (ESBL-PE) in Healthy Community and Outpatient Department (OPD) Patients in Nepal by Dipendra Kumar Mandal, Shiv Kumar Sah, Shyam Kumar Mishra, Sangita Sharma, Hari Prasad Kattel, Sanjeet Pandit, Pranav Kumar Yadav, Ujjwal Laghu, Rajani Lama, Niranjan Prasad Sah, Jeevan Bahadur Sherchand, Keshav Parajuli, Anup Bastola, Sher Bahadur Pun, Basista Prasad Rijal, Bharat Mani Pokharel

“…We, therefore, aim to determine the prevalence of ESBL and AmpC-β-lactamase-producing Enterobacteriaceae and also to determine their drug resistance pattern. Methods. During a 6-month period (November 2014–April 2015), a total of 190 stool specimens from 190 participants were obtained from different population. …”
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Local and distant response to intratumoral immunotherapy assessed by immunoPET in mice by Aurélien Marabelle, Louis Meyblum, Lambros Tselikas, Thierry de Baere, Sandrine Susini, Fréderic Deschamps, Baptiste Bonnet, Céline Chevaleyre, Benoit Jego, Dimitri Kereselidze, Vincent Lebon, Charles Truillet

“…This immunoPET approach is applicable for clinical practice to support evidence-based drug development.…”
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Low-dose trimethoprim-sulfamethoxazole for the treatment of Pneumocystis jirovecii pneumonia (LOW-TMP): protocol for a phase III randomised, placebo-controlled, dose-comparison tri... by Andrea Benedetti, Cecilia T Costiniuk, Kosar Khwaja, Andrew Johnson, Barret Rush, Darrell Tan, Ranjani Somayaji, Salman Qureshi, Michaeline McGuinty, Nicole Ezer, Sara Belga, Emily G. McDonald, Zahra N. Sohani, Guillaume Butler-Laporte, Andrew Aw, Alex Carignan, Matthew P. Cheng, Bryan Coburn, Dan Gregson, Alexander Lawandi, Victor Leung, Sylvain Lother, Derek MacFadden, Leighanne Parkes, Valerie Roy, Ilan Schwartz, Miranda So, Emilie Trinh, Todd C. Lee

“…The current standard of care, trimethoprim-sulfamethoxazole (TMP-SMX) at a dose of 15–20 mg/kg/day, is associated with serious adverse drug events (ADE) in 20%–60% of patients. ADEs include hypersensitivity reactions, drug-induced liver injury, cytopenias and renal failure, all of which can be treatment limiting. …”
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PDL1 inhibitors may be associated with a lower risk of allograft rejection than PD1 and CTLA4 inhibitors: analysis of the WHO pharmacovigilance database by Alexandre O. Gérard, Alexandre O. Gérard, Alexandre O. Gérard, Diane Merino, Diane Merino, Jonathan Benzaquen, Alexandre Destere, Delphine Borchiellini, Clément Gosset, Clément Gosset, Fanny Rocher, Marine Andreani, Charles-Hugo Marquette, Henri Montaudié, Henri Montaudié, Milou-Daniel Drici, Antoine Sicard, Antoine Sicard

“…Disproportionality analysis compares the proportion of reports with a specific adverse drug reaction (ADR) and a given drug to the proportion of reports with the same ADR and other drugs. …”
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Preparation of Multicore Millimeter-Sized Spherical Alginate Capsules to Specifically and Sustainedly Release Fish Oil by Lina Tao, Panpan Wang, Ting Zhang, Mengzhen Ding, Lijie Liu, Ningping Tao, Xichang Wang, Jian Zhong

“…Specific and sustained release of nutrients from capsules to the gastrointestinal tract has attracted many attentions in the field of food and drug delivery. In this work, we reported a monoaxial dispersion electrospraying-ionotropic gelation technique to prepare multicore millimeter-sized spherical capsules for specific and sustained release of fish oil. …”
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An anoikis-related signature predicts prognosis and immunotherapy response in gastrointestinal cancers by Ruyi Liu, Ruyi Liu, Ruyi Liu, Ruyi Liu, Ruyi Liu, Yuchen Liu, Yuchen Liu, Yuchen Liu, Yuchen Liu, Yuchen Liu, Weicheng Huang, Weicheng Huang, Weicheng Huang, Weicheng Huang, Weicheng Huang, Pengxiang Chen, Pengxiang Chen, Pengxiang Chen, Pengxiang Chen, Pengxiang Chen, Yufeng Cheng, Yufeng Cheng, Yufeng Cheng, Yufeng Cheng, Yufeng Cheng

“…Moreover, patients with high Anoscores had higher levels of immune cell infiltration and higher immune checkpoint expression. The drug sensitivity analysis revealed that patients with high or low Anoscores were sensitive to different chemotherapies and targeted drugs. …”
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Differentiating Between Perfluorohexyloctane Ophthalmic Solution and Water-Free Cyclosporine Ophthalmic Solution 0.1% for Dry Eye Disease: A Review of Preclinical and Clinical Char... by Laura M. Periman, Darrell E. White, Douglas Katsev

“…The shorter chain length of PFBP enables it to better solubilize cyclosporine and improve drug delivery to ocular tissues. Although both of these ophthalmic drops utilize SFAs, their differences—in physicochemical properties and the mechanisms by which they are understood to intervene in the DED cycle—are important considerations in treatment selection for patients with DED.…”
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Artemisia dracunculus essential oil: phytochemical study, pre-treatment and co-treatment effects on morphine withdrawal syndrome by Zahra Lorigooini, Fatemeh Heibati, Seyyed Matin Ahmadi, Sareh Mohammadi, Mahmoud Rafieian-Kopaei

“…Abstract Drug addiction is one of the most important global problems. …”
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Function, Structure, and Transport Aspects of ZIP and ZnT Zinc Transporters in Immune Cells by Bum-Ho Bin, Juyeon Seo, Sung Tae Kim

“…A precise, comprehensive understanding of the structures and transport mechanisms of ZIP and ZnT in combination with mice experiments would provide promising drug targets as well as a basis for identifying other transporters with therapeutic potential.…”
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A Case of Sevoflurane Use during Pregnancy in the Management of Persistent Status Asthmaticus by Jessica Parrott, Mitch Tener, Katie Dennis, Matthew Sharpe, Cecily Clark-Ganheart

“…Histologic features suggested drug induced hepatic injury. Liver function subsequently normalized. …”
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Laparoscopic Surgery for Recurrent Crohn's Disease by Antonino Spinelli, Matteo Sacchi, Piero Bazzi, Nicoletta Leone, Silvio Danese, Marco Montorsi

“…In spite of the recent improvements in drug therapy, surgery still represents the most frequent treatment for Crohn's disease (CD) complications. …”
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Exploration on the Interaction Ability of Antitumor Compound Bis-[2,6-difluoro-N-(hydroxyl-<κ>O)benzamidato-<κ>O]dibutylitin(IV) with Human Peroxisome Proliferator-Activated Recept... by Jiaqi Mai, Yunlan Li, Xiaozhi Qiao, Xiaoqing Ji, Qingshan Li

“…In this study, several methods were used to study the interaction between DBDF2,6T and hPPARγ protein, including fluorescence quenching, three-dimensional (3D) fluorescence, drug affinity responsive target stability (DARTS), ultrafiltration-LC, and molecular docking. …”
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Imaging in connective tissue disease-associated interstitial lung disease by Praveen P G. Rao, Kushal Joshi, Sidath Liyanage, Daniel Dalili, Gouri Koduri

“…Other less common but well-recognized patterns are organizing pneumonia, lymphocytic interstitial pneumonitis, diffuse alveolar damage, and disease-modifying antirheumatic drug-related pneumonitis. A systematic approach with a focus on the dominant pattern, zonal distribution, and additional specific features such as necrobiotic nodules (rheumatoid arthritis) and dilated esophagus (systemic sclerosis) should, in a majority of the cases, lead to the right diagnosis. …”
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Anticancer Role of PPARγ Agonists in Hematological Malignancies Found in the Vasculature, Marrow, and Eyes by P. J. Simpson-Haidaris, S. J. Pollock, S. Ramon, N. Guo, C. F. Woeller, S. E. Feldon, R. P. Phipps

“…However, longer survival is accompanied by increased incidence of comorbidities due, in part, to drug side effects and toxicities. It is well accepted that inflammation and tumorigenesis are linked. …”
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