Chitosan Hydrogels for Chondroitin Sulphate Controlled Release: An Analytical Characterization by Annalisa Bianchera, Enrico Salomi, Matteo Pezzanera, Elisabeth Ruwet, Ruggero Bettini, Lisa Elviri

“…Scanning electron microscopy (SEM), attenuated total reflectance-Fourier transform infrared spectroscopy (ATR-FTIR), and liquid chromatography-UV spectrophotometry (LC-UV) techniques were exploited to obtain qualitative and quantitative descriptions of polymer and drug behaviour in the biomaterial. As for morphology, SEM analysis allowed the evaluation of scaffold porosity in terms of pore size and distribution both at the surface (Feret diameter 58±19 μm) and on the cross section (Feret diameter 106±51 μm). …”
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Deciphering the Role of Adrenergic Receptors in Alzheimer’s Disease: Paving the Way for Innovative Therapies by Androulla N. Miliotou, Andria Kotsoni, Lefteris C. Zacharia

“…Neurodegenerative diseases are currently among the most devastating diseases with no effective disease-modifying drugs in the market, with Alzheimer’s disease (AD) being the most prevalent. …”
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NEDD4 family E3 ligases in osteoporosis: mechanisms and emerging potential therapeutic targets by Heng Wu, Junhui Zuo, Yu Dai, Hairui Li, Song Wang

“…This review delineates the role of NEDD4 family in osteoporosis and identifies potential drug targets within these pathways, offering insights into novel therapeutic approaches for osteoporosis through targeted intervention.…”
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The real-world safety of Ofatumumab: a pharmacovigilance analysis based on the FDA adverse event reporting system by Yue Zhou, Yutong Wu, Xiao Zhao, Lingxu Xu, Mingguang Sun, Zhaoyou Meng

“…Additionally, we identified potential AEs not specified on the drug label, such as Asthenia, Hypoesthesia, Dizziness, Malaise, Injection site pain, Paresthesia, and Diarrhea.ConclusionsThis investigation has identified several AEs associated with Ofatumumab and revealed previously unacknowledged potential adverse reaction signals. …”
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Ginkgolide B Blocks Vascular Remodeling after Vascular Injury via Regulating Tgfβ1/Smad Signaling Pathway by Quan Wang, Shuai Ni, Li Ling, Siqi Wang, Hanbin Xie, Zhanhong Ren

“…Moreover, the beneficial effect of GB is abolished after incubated with pirfenidone (PFD, a drug for idiopathic pulmonary fibrosis, IPF), which can inhibit Tgfβ1. …”
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MORF: Multi-view oblique random forest for hepatotoxicity prediction by Binsheng Sui, Qingzhuo He, Bowei Yan, Kunhong Liu, Yong Xu, Song He, Xiaochen Bo

“…Summary: Hepatotoxicity prediction is significant in drug development, so the experts expect to get effective and reliable references. …”
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Treatment of Severe Hypertriglyceridemia with Continuous Insulin Infusion by Yesica Rodríguez Santana, Andrea Nimo Román, Iker García Sáez, José Manuel López Alvarez, Eduardo Consuegra Llapur, Rafael González Jorge

“…Most patients with SH suffer primary or genetic abnormality in lipid metabolism in combination with a precipitating factor such as uncontrolled diabetes mellitus, alcoholism, and drug intake. The standard treatment of hypertriglyceridemia (HTG) with omega 3 fatty acids and fibrates, along with dietary changes, has no effect on an emergency situation. …”
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Abuse potential of fentanyl and fentanyl analogues by Anusha Thumma, Kwadwo Mfoafo, Niloofar Babanejad, Alborz Omidian, Yadollah Omidi, Hamid Omidian

“…Results: The gold standard for treating both acute and chronic pain is fentanyl, but abuse of the drug has exploded globally since the late 2000s. …”
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WGCNA and integrative network analysis identify CHRNA5 and CTLA4 as potential therapeutic targets against angiosarcoma by Trishla Bhatnagar, Madiha Haider, Mohd Yasir Khan, Mohammad Zahid Ashraf

“…The intersection of true hub genes from MCC analysis of WGCNA modules and high-degree nodes from an unclustered network revealed eight consistently overexpressed genes in all angiosarcoma samples.Among the eight enriched genes, CHRNA5 and CTLA4, are exclusively overexpressed in angiosarcoma and not in other cancers of the same tissue origin, with significant drug-protein interactions suggesting their potential as therapeutic targets.…”
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Treatment of Functional Dyspepsia in Outpatients after COVID-19 Infection by M. S. Turchina, Yu. M. Morozov, T. I. Obolenskaya

“…All patients were divided in 2 groups by randomization: Group 1 received omeprazole at a dose of 80 mg/day, Group 2 received a combination of omeprazole and Kolofort® (a combined action drug product containing technologically processed antibodies to S100, TNF-alpha, and histamine) at a dose of 80 mg/day. …”
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A Descriptive Study on Common Causes, Treatment and Outcome of Neck Injuries by Hamna Abdu Nazir, Wilson Desai, Reshma Chavan, Sarvesh Azgaonkar

“…Resolving societal issues like poverty and drug addiction, implementing government enforcement measures, and improving communication systems can reduce complications and death rates. …”
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Co(II) Complex of Mefloquine Hydrochloride: Synthesis, Antimicrobial Potential, Antimalaria and Toxicological Activities by Adediji J. Femi, Obaleye J. Ayoola

“…Transition metal complex of Co(II) with Mefloquine hydrochloride (antimalaria drug) was synthesized using template method. Chemical analysis including conductivity measurements and spectroscopic studies were used to propose the geometry and mode of binding of the ligand to metal ion. …”
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Grewia tenax-Mediated Silver Nanoparticles as Efficient Antibacterial and Antifungal Agents by Priyanka Yadav, Monisha Singhal, Sreemoyee Chatterjee, Surendra Nimesh, Nidhi Gupta

“…Nanoparticles have gained immense interest as probable drug molecules against microbial infections. Metal nanoparticles synthesized via exploring the reduction potential and capping activity of plants were found to have remarkable antimicrobial activity. …”
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All-Trans Retinoic Acid-Induced Pseudotumor Cerebri during Induction Therapy for Acute Promyelocytic Leukemia: A Case Report and Literature Review by Dylan Holmes, Prakash Vishnu, Russell K. Dorer, David M. Aboulafia

“…Though considered to be a relatively safe drug, use of ATRA can lead to several side effects such as retinoic acid syndrome and pseudotumor cerebri (PC). …”
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Anti-Inflammatory Properties of Dendrimers per se by Myriam Hayder, Séverine Fruchon, Jean-Jacques Fournié, Mary Poupot, Rémy Poupot

“…Thereof, dendrimers emerge as promising, although heretical, drug candidates for the treatment of still-uncured chronic inflammatory disorders. …”
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Development and Validation of a Precise Method for Determination of Benzalkonium Chloride (BKC) Preservative, in Pharmaceutical Formulation of Latanoprost Eye Drops by J. Mehta, K. Patidar, N. Vyas

“…The method was successfully applied for the determination of BKC in a pharmaceutical formulation of latanoprost ophthalmic solution without any interference from common excipients and drug substance. All the validation parameters were within the acceptance range, concordant to ICH guidelines.…”
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Pediatric Traumatic Brain Injury and Autism: Elucidating Shared Mechanisms by Rahul Singh, Ryan C. Turner, Linda Nguyen, Kartik Motwani, Michelle Swatek, Brandon P. Lucke-Wold

“…We discuss potential therapeutic and pharmacologic options as well as potential novel drug targets. Furthermore, we highlight advances in understanding of brain circuitry that is being propelled by improved imaging modalities. …”
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Effect of Subantimicrobial Dose Doxycycline Treatment on Gingival Crevicular Fluid Levels of MMP-9 and MMP-13 in Periodontitis Stage 2, Grade B in Subjects with Type 2 Diabetes Mel... by Mai S. Attia, Jazia A. Alblowi

“…A total of thirty patients were divided into the following two groups with reference to periodontitis, type 2 diabetes mellitus, and administration of the doxycycline drug: Group I: patients with periodontitis stage 2, grade B and type 2 diabetes mellitus who received SRP only. …”
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A Qualitative Study of Nursing Students’ Experiences in Fall Prevention for Older Home Care Clients by Riitta Turjamaa, Marja Äijö, Tarja Tervo-Heikkinen, Marja Silén-Lipponen

“…However, evaluation of nutrition and adverse drug effects seemed to be ignored. In addition, fall prevention during home visits included concrete fall prevention in authentic client situations, confidential relationships with older clients, and evidence-based knowledge. …”
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Medication adherence and non-adherence in arterial hypertension: a narrative review by Claudio Tomasino, Marco Tomasino

“…Adherence is influenced by various factors including drug regimen complexity, patient education, and socioeconomic status. …”
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