Physiology-informed regularisation enables training of universal differential equation systems for biological applications. by Max de Rooij, Balázs Erdős, Natal A W van Riel, Shauna D O'Donovan

“…These models can aid in the discovery of disease mechanisms and potential drug targets. However, on one hand the development and validation of knowledge-based mechanistic models is time-consuming and does not scale well with increasing features in medical data. …”
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Coronary Artery and Peripheral Vascular Disease in a Patient with Poorly Differentiated Thyroid Cancer Treated with the Tyrosine Kinase Inhibitor Lenvatinib by Vineeth Sukrithan, Lisa Kim, Jennifer A. Sipos, Ashima Goyal, Ye Zhou, Daniel Addison, Manisha Shah, Bhavana Konda, Ajay Vallakati

“…However, in the phase III SELECT trial of the drug in thyroid cancer, 5.4% of patients on lenvatinib experienced arterial thromboembolic events, with 2.7% experiencing severe grade ≥3 toxicities associated with arterial vascular events. …”
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Spatially controlled multicellular differentiation of stem cells using triple factor-releasing metal–organic framework-coated nanoline arrays by Yeon-Woo Cho, Min-Ji Kang, Joon-Ha Park, Yun-Sik Eom, Tae-Hyung Kim

“…Abstract Improved in vitro models are needed for regenerative therapy and drug screening. Here, we report on functionally aligned nanoparticle-trapped nanopattern arrays for spatially controlled, precise mesenchymal stem cell differentiation on a single substrate. …”
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Secretomes from Mesenchymal Stem Cells against Acute Kidney Injury: Possible Heterogeneity by Kenji Tsuji, Shinji Kitamura, Jun Wada

“…Over the past few decades, many studies identified trophic factors from MSCs, which attenuate renal injury in a variety of animal acute kidney injury models, including renal ischemia-reperfusion injury and drug-induced renal injury, using microarray and proteomic analysis. …”
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Baricitinib for the Management of SARS-CoV-2-Infected Patients: A Systematic Review and Meta-Analysis of Randomised Controlled Trials by Sivananthan Manoharan, Lee Ying Ying

“…Therefore, it needs to be explored to further understand the clinical benefits of this drug in the management of COVID-19 patients. Does baricitinib statistically significantly reduce mortality and disease progression in COVID-19 patients? …”
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Administrative Criminal Reform in Providing Accountability for Skincare Actors Who Have Not Registered with BPOM by Aulia Putri, Ifahda Pratama Hapsari

“…The study aimed to analyze which problem from skincare products none approval from Indonesian Food and Drug Administration  (BPOM) This is serious problem the affects public health and damages consumer trust. …”
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Vibrio parahaemolyticus: Exploring its Incidence in Malaysia and the Potential of Streptomyces sp. as an Anti-Vibrio Agent by Ke-Yan Loo, Loh Teng-Hern Tan, Jodi Woan-Fei Law, Priyia Pusparajah, Sunny Hei Wong, Kok-Gan Chan, Learn-Han Lee, Vengadesh Letchumanan

“…., a class of filamentous, Gram-positive bacteria that produce a variety of bioactive compounds during their life cycle, which can be useful in drug discovery. The bioactive compounds produced by Streptomyces sp. have been proven to have microbiota-modulating and stimulatory effects on the host, enhancing immunity and providing protective effects against V. parahaemolyticus infections. …”
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Use of Artemisinin- Combination Therapies in Port Harcourt by OA Shorinwa, OO Ebong

“…The respondents that took artemisinin based combination drugs were 230 (32.1%), those that took artesunate only were 174 (24.3%), those that took chloroquine were 101 (14.1%) while those that took sulphadoxine/pyrimethamine were 140 (19.5%) while 72 (10%) took other antimalarial drugs. …”
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A Pharmacotherapy and ECT resistant OCD patient’s Cognitive Behavioral Therapy by Tacettin KURU, M. Hakan TÜRKÇAPAR

“…Results: Cognitive Behavioral Therapy is an effective treatment for treatment-resistant patients with drug and ECT. [JCBPR 2013; 2(3.000): 173-181]…”
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Physalin B Suppresses Inflammatory Response to Lipopolysaccharide in RAW264.7 Cells by Inhibiting NF-κB Signaling by Yanjun Yang, Lang Yi, Qing Wang, Bingbing Xie, Congwei Sha, Yan Dong

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Risky behaviours and injuries amongst Catalan children with ADHD: does pharmacological treatment improve outcomes? by Toni Mora, Rowena Jacobs, Jordi Cid, David Roche

“…We test whether medication use for ADHD decreases the likelihood of risky behaviour (sexual behaviour, alcohol, tobacco, and drug consumption) and injuries amongst children aged 6–18. …”
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In-Silico Evaluation of Binding Interaction and ADME Properties of Novel Pyrazoline and Pyrimidine Derivatives Targeting Cyclooxygenase-2 Enzyme by Sarmad Abbas Fadhil, Karima Fadhil Ali, Wesen Adel Mehde

“…Through in-silico methods, the binding affinity of these derivatives to the COX-2 receptor was predicted using computer simulations and compared with the reference drug, meloxicam. Docking studies employing gold software facilitated the visualization of ligand-protein interactions, utilizing the crystal structure of the COX-2 protein (PDB ID: 4m11). …”
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Complete Whole-Genome Sequence of Streptomyces sp. MUM 178J, a Potential Anti-Vibrio Agent by Ke-Yan Loo, Loh Teng-Hern Tan, Kah-Ooi Chua, Priyia Pusparajah, Kok-Gan Chan, Learn-Han Lee, Jodi Woan-Fei Law, Vengadesh Letchumanan

“… Streptomyces sp. is a group of filamentous, Gram-positive bacteria notoriously known for their capabilities in producing bioactive compounds that have been used as novel drugs and lead in drug development. The Streptomyces sp. …”
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Gambaran Tingkat Kepatuhan Pengobatan Pasien TB Paru by Endang Martini, Rika Sarfika, Siti Yuliharni

“… Adherence to tuberculosis (TB) treatment is crucial for achieving cure and preventing drug resistance. Low adherence can lead to treatment failure and increase the risk of infection transmission. …”
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From Lab to Clinic: Effect of Academia–Industry Collaboration Characteristics on Oncology Phase 1 Trial Entry by Wonseok Yang, Sang‐Won Lee

“…This study sheds light on how the characteristics of partnerships influence the success rates of early‐phase research, providing valuable insights for future strategic planning in oncology drug development.…”
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Inflammation, impaired motor function and visceral hypersensitivity: the main mechanisms of functional disorders of the gastrointestinal tract (materials of the Expert Council and... by V. T. Ivashkin, I. V. Maev, A. S. Trukhmanov, A. A. Sheptulin, T. L. Lapina, V. I. Simanenkov, K. A. Sokolov

“…This often leads to the prescription of a complex of various medications to such patients, which increases the risk of undesirable drug interactions and side effects. Multitargeted therapy involves the use of drugs that simultaneously affect different pathogenetic links. …”
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The effect of chloramhenicol on production of laying hens and determination of chloramphenicol residues in eggs by Ahmet ACET, Şakir D. TUNCER, Behiç COŞKUN, Ömer DEMET, Bünyamin TRAŞ, Erol BAYTOK

“…Then the levels of residues decreased and were not detected on the day 30 after withdrawal of the drug.…”
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Efficacy of Nivolumab in a Patient with Metastatic Renal Cell Carcinoma and End-Stage Renal Disease on Dialysis: Case Report and Literature Review by Jawaher Ansari, Muhammad Ali, Ashraf Farrag, Arwa M. Ali, Abdulaziz Alhamad

“…In addition, there is uncertainty regarding drug dosing/pharmacokinetics, lack of safety and efficacy data, and potential for increased toxicity when using targeted therapy or immunotherapy for the management of patients with mRCC on dialysis. …”
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Application of Synthetic Polymeric Scaffolds in Breast Cancer 3D Tissue Cultures and Animal Tumor Models by Girdhari Rijal, Chandra Bathula, Weimin Li

“…The scaffolding technology has appealing potentials to be applied in anticancer drug screening for a better control of the progression of human cancers.…”
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New Insights into Aspirin’s Anticancer Activity: The Predominant Role of Its Iron-Chelating Antioxidant Metabolites by George J. Kontoghiorghes

“…The mode of action of aspirin as a chelating antioxidant pro-drug of the ACMs, with continuous presence in LTLDA users, increases the prospect for prophylaxis in cancer and other diseases. …”
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