Clinical Significance and Pathogenic Mechanisms of Long Non-Coding RNA TRPM2-AS in Cancers by Shichen Huang MS, Bowen Li MS, Huanyu Chen MD, Cheng Rong, Zheng Yang MD, Xianqin Zhang PhD

“…Moreover, TRPM2-AS is involved in regulating the cell proliferation, migration, invasion, apoptosis, drug or radio resistance by serving as a competing endogenous RNA, directly bounding to proteins and regulating multiple signaling pathways. …”
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Cancer treatment comes to age: from one-size-fits-all to next-generation sequencing (NGS) technologies by Sepideh Parvizpour, Hanieh Beyrampour-Basmenj, Jafar Razmara, Farhad Farhadi, Mohd Shahir Shamsir

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Porphyria Cutanea Tarda in a Patient with End-Stage Renal Disease: A Case of Successful Treatment with Deferoxamine and Ferric Carboxymaltose by Natacha Rodrigues, Fernando Caeiro, Alice Santana, Teresa Mendes, Leonor Lopes

“…Every time oxide iron was started, the patient developed clinical features of the disease, resolving after the suspension of the drug. A decision was made to start the patient on ferric carboxymaltose, which was well tolerated without disease symptoms and need of further blood transfusions. …”
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The Use of 99mTc-Methoxy-isobutyl-isonitrile (sestaMIBI) Uptake on Scintigraphy (99m-STS) in Amiodarone-Induced Thyrotoxicosis: Case Series and Review of the Literature by Ghada Elshimy, Mahmoud Alsayed, Jerome Targovnik, Gamal Sidarous, Kresimira M. Milas

“…Amiodarone is a class III antiarrhythmic drug, used by cardiologists to treat arrhythmia including atrial fibrillation (A fib) and ventricular fibrillation. …”
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Validity of patient-derived xenograft mouse models for lung cancer based on exome sequencing data by Jaewon Kim, Hwanseok Rhee, Jhingook Kim, Sanghyuk Lee

“…Patient-derived xenograft (PDX) mouse models are frequently used to test the drug efficacy in diverse types of cancer. They are known to recapitulate the patient characteristics faithfully, but a systematic survey with a large number of cases is yet missing in lung cancer. …”
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Potential Nephroprotective Effect of Kaempferol: Biosynthesis, Mechanisms of Action, and Clinical Prospects by Maulana Yusuf Alkandahri, Asman Sadino, Barolym Tri Pamungkas, Zulpakor Oktoba, Maya Arfania, Nia Yuniarsih, Eko Sri Wahyuningsih, Yuliani Dewi, Sri Ayu Winarti, Sri Tantia Dinita

“…Despite significant advancements in modern treatment, there is no fully effective drug for repairing its function, providing complete protection, and assisting in cell regeneration. …”
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Epidemiological and Genome-Wide Association Study of Gastritis or Gastric Ulcer in Korean Populations by Sumin Oh, Sejong Oh

“…As a result of the logistic regression, a relation with hyperlipidemia, coronary artery disease, myocardial infarction, hyperlipidemia therapy, hypotensive or antihypotensive drug, diastolic blood pressure, and gastritis was seen in males; the results of this study suggest that vascular disease has a potential association with gastritis in males.…”
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Predicting the structure and stability of oxide nanoscrolls from dichalcogenide precursors by Adway Gupta, Arunima K. Singh

“…Low-dimensional nanostructures such as nanotubes, nanoscrolls, and nanofilms have found applications in a wide variety of fields such as photocatalysis, sensing, and drug delivery. Recently, it was demonstrated that nanoscrolls of Mo and W transition metal oxides, which do not exhibit van der Waals (vdW) layering in their bulk counterparts, can be successfully synthesized using plasma processing of corresponding layered transition metal dichalcogenides. …”
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Biological Effects of Culture Substrates on Human Pluripotent Stem Cells by Yohei Hayashi, Miho Kusuda Furue

“…Understanding the role of culture substrates in hPSC self-renewal and differentiation enables us to control hPSC behavior precisely and to establish scalable or microfabricated culture technologies for regenerative medicine and drug development.…”
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Chronic abdominal pain and persistent disorder of nutritional status by V. T. Ivashkin, Ye. A. Poluyektova

“…According to the results of investigation in the patient with tesselated personality disorder somatoform disorder was diagnosed (generalized somatoform pain). Treatment included drug therapy along with repeated conversations with the patient, that resulted in relative stabilization of her state.Conclusion. …”
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Modern features of the cryptocurrency use for terrorist financing, money laundering and other unlawful activities: prospective countermeasures by D. S. Melnyk

“…The modern methods (mechanisms) of using cryptocurrencies as a means of payment in the drug trade, for legalisation of proceeds of crime, financing of terrorist, intelligence and subversive, separatist and other illegal activities in Ukraine, including under martial law, are highlighted. …”
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Cell fusion as a driver of metastasis: re-evaluating an old hypothesis in the age of cancer heterogeneity by Eduardo López-Collazo, Eduardo López-Collazo, Eduardo López-Collazo, Eduardo López-Collazo, Laura Hurtado-Navarro, Laura Hurtado-Navarro

“…This process has been shown to potentially drive tumour progression, drug resistance, and cancer recurrence. In this review, we explore the potential mechanisms that govern cancer cell fusion, the molecular mediators involved, the metastatic characteristics acquired by fusion-derived hybrids, and their clinical significance in human cancer. …”
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Deciphering Oxidative Stress in Cardiovascular Disease Progression: A Blueprint for Mechanistic Understanding and Therapeutic Innovation by Zhaoshan Zhang, Jiawei Guo

“…Second, it summarizes the cardiovascular protective effects, mechanisms of action, and animal models of various antioxidants, offering insights into future drug development. Third, it discusses the applications, advantages, limitations, and potential molecular targets of gene therapy in CVDs, providing a foundation for novel therapeutic strategies. …”
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Phosphodiesterase 4 inhibition as a novel treatment for stroke by Jiahong Zhong, Xihui Yu, Zhuomiao Lin

“…The use of thrombolytic drugs is most common in the treatment of stroke; however, its efficacy is limited due to its time-sensitive nature and propensity for increased bleeding. …”
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Nucleoside analogues in treatment of liver cirrhosis as an outcome of chronic hepatitis B by I. G. Bakulin

“…Its antiviral effect limited basically by development of drug resistance of a virus as a result of mutant strains development. …”
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Real-world pharmacovigilance of ofatumumab in multiple sclerosis: a comprehensive FAERS data analysis by Hui Chen

“…Comprehensive real-world safety data are crucial for informing clinical practice.MethodsThe FDA Adverse Event Reporting System database was utilized to perform a disproportionality analysis, covering reports from Q3 2020 to Q2 2024, in which ofatumumab was identified as the primary suspected drug. Statistical approaches used included the Reporting Odds Ratio, Proportional Reporting Ratio, Bayesian Confidence Propagation Neural Network, and Multi-item Gamma Poisson Shrinker. …”
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Prospects of MMX Mesalazine in Routine Outpatient Treatment of Ulcerative Colitis by Yu. P. Uspenskiy, S. V. Ivanov, Yu. A. Fominykh

“…A general review of treatment approaches to ulcerative colitis (UC) and the importance of oral 5-aminosalicylic acid (5-ASA) for its routine outpatient management.Key points. The choice of drug therapy for UC remission induction and maintenance is linked to the intestinal lesion extent and disease attack severity. …”
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Establishing endotoxin limits to enhance the reliability of in vitro immunogenicity risk assessments by Yun Hee Jeong, Gillian Lennon, Geertruida Veldman, Daniel M. Serna, Alexander Ibrahimov

“…Immunogenic responses to biotherapeutics often lead to termination of their development because the resulting anti-drug-antibodies (ADA) can negatively impact pharmacology, safety, and efficacy. …”
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Promising inhibitors against main protease of SARS CoV-2 from medicinal plants: In silico identification by EBENEZER OLUWAKEMI, SHAPI MICHAEL

“…The docked complex analysis shows that the ligands selectively bind with the target residues and binding affinity of amentoflavone (–10.1 kcal mol–1), isotheaflavin-3’-gallate (–9.8 kcal mol–1), tomentin A and D (–8.0 and –8.8 kcal mol–1), theaflavin-3,3’-digallate (–8.6 kcal mol–1), papyriflavonol A (–8.4 kcal mol–1), iguesterin (–8.0 kcal mol–1) and savinin (–8.3 kcal mol–1) were ranked above the binding affinity of the reference, co-crystal ligand, ML188, a furan-2-carboxamide-based compound. To pinpoint the drug-like compound among the top-ranked compounds, the Lipinski’s rule of five and pharmacokinetic properties of all the selected compounds were evaluated. …”
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Use of Adjuvant Sorafenib in Liver Transplant Recipients with High-Risk Hepatocellular Carcinoma by Kirti Shetty, Chiranjeev Dash, Jacqueline Laurin

“…Dose reduction improved tolerance of drug. The overall rate of HCC recurrence was decreased in the adjuvant therapy group compared to historical controls (29% versus 75%, P=0.07). …”
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