Physicochemical Characterisation of Polysaccharides from the Seeds and Leaves of Miracle Fruit (Synsepalum dulcificum) and Their Antioxidant and α-Glucosidase Inhibitory Activities... by Huajun Jian, Fang Qiao, Jie Chen, Nongyue He

“…The α-glucosidase inhibition of MFP-L was remarkably better than the positive control, acarbose (an antidiabetes drug). More specifically, the 50% inhibitory concentration (IC50) values of α-glucosidase activities for MFP-S, MFP-L, and acarbose were 33, 0.01, and 1 mg mL−1, separately. …”
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Case Report: Cognitive Behavioral Therapy Of A Patient With Pathological Gambling by S. Olga Guriz, Aslı Ekinci, M. Hakan Türkçapar

“…In this report, the effectiveness of Rational Emotive Behavior Therapy that accompanied a drug therapy is discussed in a case of a pathological gambling with comorbid depression.…”
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Participation of the SCO in Peacekeeping Activities, Prevention and Settlement of Conflicts by K. M. Barskiy

“…One of the main priorities in the activities of the SCO is a cooperation in providing regional security and stability in the areas of counteraction against terrorism, separatism, extremism, drug tarfficking, other types of trans-border organized crime and against use of information-communication technologies in destructive purposes. …”
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Involvement of Coenzyme Q10 in Various Neurodegenerative and Psychiatric Diseases by Alireza Ebrahimi, Amirhossein Kamyab, Sahar Hosseini, Sedigheh Ebrahimi, Soheil Ashkani-Esfahani

“…Since then, several investigations have indicated that the drug may benefit patients with cardiovascular, neuromuscular, and neurodegenerative illnesses. …”
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Genome Sequencing of Hericium coralloides by a Combination of PacBio RS II and Next-Generation Sequencing Platforms by Caixia Zhang, Lijun Xu, Jian Li, Jiansong Chen, Manjun Yang

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Modelling Laser Milling of Microcavities for the Manufacturing of DES with Ensembles by Pedro Santos, Daniel Teixidor, Jesus Maudes, Joaquim Ciurana

“…A set of designed experiments, involving the use of a pulsed Nd:YAG laser system milling 316L Stainless Steel, serve to study the laser-milling process of microcavities in the manufacture of drug-eluting stents (DES). Diameter, depth, and volume error are considered to be optimized as functions of the process parameters, which include laser intensity, pulse frequency, and scanning speed. …”
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In silico evaluation, characterization, and in vitro anticancer activity of curcumin–nimbin loaded nanoformulation in HCT-116 cell lines by Arumugam Madeswaran, Selvam Tamilazhagan, Sellappan Mohan

“…Chemotherapy medications are often limited in use due to issues like drug resistance, P-glycoprotein efflux, and relapse of chemotherapy. …”
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Combination of ERG9 Repression and Enzyme Fusion Technology for Improved Production of Amorphadiene in Saccharomyces cerevisiae by Rama Raju Baadhe, Naveen Kumar Mekala, Sreenivasa Rao Parcha, Yalavarthy Prameela Devi

“…Our main objective was to overproduce amorpha 4-11-diene, which is a key precursor molecule of artemisinin (antimalarial drug) produced naturally in plant Artemisia annua through mevalonate pathway. …”
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Identification of Potential Selective PAK4 Inhibitors Through Shape and Protein Conformation Ensemble Screening and Electrostatic-Surface-Matching Optimization by Xiaoxuan Zhang, Meile Zhang, Yihao Li, Ping Deng

“…Our findings provide a novel approach for developing selective PAK4 inhibitors and lay the theoretical foundation for future anticancer drug design.…”
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Growth and metabolic activities of cowpea seedlings exposed to artificial pond wastewaterâtreated soil by F. I. Achuba, M. N. Oshiokpu

“…Conclusion The major effects of APWW on plants were stimulation of growth parameters, increase in concentration of macromolecules as well as increase in activities of starch-metabolizing enzymes, and peroxidase activity with no adverse effect on antioxidant, respiratory and drug-metabolizing enzymes, thus, suggesting that artificial pond wastewater has positive effect on cowpea seedlings and can act as organic fertilizer for cowpea cultivation.…”
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Absence of the Genetic Marker IS6110 from a Strain of Mycobacterium tuberculosis Isolated in Ontario by Susan T Howard, Matthew T Oughton, Albert Haddad, Wendy M Johnson

“…A culture grown from a bronchoalveolar lavage specimen was identified as Mycobacterium tuberculosis by standard biochemical methods. Drug-susceptibility testing indicated the strain was resistant to pyrazinamide (PZA), and a mutation was detected within pncA, a gene associated with PZA resistance. …”
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Biosensitivity and Theoretical Electronic Structure Investigations on 3-(2-Hydroxyphenyl)-2-iminothiazolidin-4-one and Its Zn2+ and Cd2+ Metal Complexes by Zewdu Bezu Gemechu, Boobalan Maria Susai, Abi M. Taddesse, Endale Teju Bedada, R. Ramamoorthy

“…The result evidenced better bioactive performance of the metal complex (though lower than the standard drug) than the free ligand against Escherichia coli, Staphylococcus aureus, and Salmonella typhi bacteria, as well as Fusarium oxysporum and Aspergillus niger fungal strains. …”
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Intratumoral microbiota, fatty acid metabolism, and tumor microenvironment constitute an unresolved trinity in colon adenocarcinoma by Guangyi Liu, Kun Liu, Lei Ji, Yang Li

“…More importantly, the crosstalk between the three can have a significant impact on prognosis, response to immunotherapy, and drug sensitivity of patients. Pathological image profiling showed that changes in the TME originating from intratumoral microbiota disturbance could be reflected in pathological image features. …”
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Effectiveness of Sofpironium Bromide in Patients with Primary Axillary Hyperhidrosis Who Experienced Residual or Recurrence of Axillary Odor after Surgery for Axillary Osmidrosis by Masanobu Sakisaka, Akihiko Takushima

“…Objectives: Sofpironium bromide is the first topical anticholinergic drug approved in Japan for the treatment of primary axillary hyperhidrosis. …”
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ACE Inhibitor-Induced Angioedema of the Intestine: Case Report, Incidence, Pathophysiology, Diagnosis and Management by Gavin Oudit, Nigel Girgrah, Johane Allard

“…AIAI is diagnosed based on the temporal relationship between the symptomatic presentation and drug use, absence of alternative diagnoses including other causes of angioedema, and the prompt resolution of symptoms upon discontinuation of the ACE inhibitor. …”
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Convalescent plasma therapy in severe coronavirus disease-2019: A narrative review by Rasmi Ranjan Sahoo, Kasturi Hazarika, Prashant Bafna, Manesh Manoj, Anupam Wakhlu

“…Passive immunotherapy using whole blood or plasma from recovered patients is a potential therapeutic strategy for infections with no known drug therapy or prophylactic vaccines. Much before, the concept of transfusing neutralizing antibodies through convalescent blood or plasma was established; this modality demonstrated its effectiveness in containing the havoc caused by diphtheria and tetanus during the early 20th century. …”
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Neuromuscular Monitoring, Muscle Relaxant Use, and Reversal at a Tertiary Teaching Hospital 2.5 Years after Introduction of Sugammadex: Changes in Opinions and Clinical Practice by Thomas Ledowski, Jing Shen Ong, Tom Flett

“…Since the introduction of Sugammadex, 69% (n=20) of respondents felt it provided “faster turnover,” less postoperative residual neuromuscular blockade (n=23; 79%), and higher anesthetist satisfaction (n=17; 59%). 45% (n=13) of colleagues reported that they would feel professionally impaired without the unrestricted availability of Sugammadex, and 1 colleague would refuse to work in a hospital without this drug being freely available. In clinical practice Sugammadex was frequently (57%) mildly overdosed, with 200 mg being the most commonly administered dose.…”
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Nanocomposite of electrochemically reduced graphene oxide and gold nanourchins for electrochemical DNA detection by Mostafa Azimzadeh, Zahra Aghili, Behrooz Jannat, Saeid Jafari, Saeed Rafizadeh Tafti, Navid Nasirizadeh

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Family Harmony and Da'wah: Preventing Juvenile Delinquency Through Da'wah Program by the Paccinongan Youth Harmony Association by Ibnu Azka, Nurul Ramadhani, Fathur Baldan Haramain

“…The research results show that adolescent problems cover various aspects, such as mental disorders, family conflicts, negative relationships, drug use, and the inability to manage emotions. Factors contributing to these problems include the social environment, individual factors, and media influence. …”
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Is a Consensus Case Definition for Viral Associated Lower Respiratory Tract Disease (LRTD) in Clinical Trials Possible? by S. Elizabeth Williams, Bradford Gessner, Elizabeth Begier, Negar Aliabadi, Kumar Ilangovan, Luis Jodar, Cassandra Hall-Murray, Giovanni Checcucci Lisi, Edward Walsh

“…Here we review the key differences in criteria for case definitions, highlight strategies to best approximate compatibility between definitions, and review vaccine efficacy results among currently US Food and Drug Administration (FDA)-approved vaccines using these strategies. …”
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