Preclinical research models for endometrial cancer: development and selection of animal models by Yang Xue, Wei Shi, Bing Lun, Meilin Kan, Mengling Jia, Yuelin Wu, Li Yang, Li Yang

“…These models better simulate tumor molecular mechanisms and treatments, with the organoid-based patient-derived xenograft model (O-PDX) showing great promise in drug screening and personalized therapy. The application of humanized models remains limited due to technical challenges and high costs. …”
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Therapeutic Study of Thermosensitive Hydrogel Loaded with Super-Activated Platelet Lysate Combined with Core Decompression Technology for the Treatment of Femoral Head Necrosis by Zhipeng Huang, Zhe Zhao, Jun Lang, Wantao Wang, Yinsheng Fu, Wenbo Wang

“…The hydrogel showed satisfactory encapsulation efficiency and release of the growth factors in a sustained manner, indicating its suitability as a drug carrier. The sPL-loaded hydrogel was inserted into the necrotic femoral head of a rat model and core decompression was applied and resulted in significantly accelerated bone repair and regeneration. …”
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Generation of a human induced pluripotent stem cell (iPSC) line ERPLi004-A from an Alpha-1 antitrypsin deficiency (AATD) patient with SERPINA1 mutation by Harshini Surendran, Rajani Battu, Renjitha Gopurappilly, Chethala N. Vishnuprasad, Rajarshi Pal

“…The iPSC line expresses pluripotency markers, generates three germ layers in vitro and retains a normal karyotype (P20) and can provide an ideal tool for disease modelling, drug screening, and personalized medicine.…”
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A Western Case of Intravascular Large B-Cell Lymphoma as Unusual Cause of Persistent Fever by Pier Paolo Piccaluga, Stefania Paolini, Cristina Campidelli, Nicola Vianelli, Luigi Bolondi

“…Fever of unknown origin (FUO) is a common and challenging clinical condition that can be referred, among others, to infections, drug’s effects, various inflammatory disorders, and cancers. …”
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Study on the Dynamic Biological Characteristics of Sca-1+ Hematopoietic Stem and Progenitor Cell Senescence by Shan Geng, Xin-Yi Mu, Xiong-Bin Chen, Ji-Ying Hou, Dao-Yong Jia, Chun-Yan Xu, Ya-Ping Wang

“…And the dynamic biological characteristics of HSPCs senescence may also contribute to the clinical optimal time for antiaging drug intervention.…”
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Incorporation of Amphipathic Diblock Copolymer in Lipid Bilayer for Improving pH Responsiveness by Tian Xia, Weiju Hao, Yazhuo Shang, Shouhong Xu, Honglai Liu

“…These results revealed that the synthesized copolymers increased the difference in DOX cumulative release between pH 7.4 and 6.0, that is, improved the pH-controllability of the drug release from hybrid liposomes.…”
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Use of sacubitril/valsartan in non‐compaction cardiomyopathy: a case report by Marcely Gimenes Bonatto, Rodrigo Albanez, Vera Maria Cury Salemi, Lídia Zytynski Moura

“…There is no study evaluating this drug effects in non‐compaction cardiomyopathy (NCCM) individuals. …”
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Amazonia in Brazilian military thought: Army and Navy conceptual frameworks and strategic actions in the 90s by Dilceu Roberto Pivatto Junior, Raul Cavedon Nunes

“…The end of the Cold War and the rise of new issues in the regional security agenda such as drug trafficking and the environment, led the Brazilian military to rethink its defense strategy, developing new hypotheses of regional conflict which included the potential participation of extra-continental powers.…”
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Early growth response 1 transcription factor and its context-dependent functions in glioblastoma by Saleh Rasras, Esma’il Akade, Seyed Ehsan Mohammadianinejad, Maedeh Barahman, Mohammad Bahadoram

“…Despite its oncogenic functions, EGR1 can also suppress tumours by upregulating non-steroidal anti-inflammatory drug-activated gene 1 and phosphatase and tensin homolog deleted on chromosome ten, and inhibiting invasion and metastasis. …”
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Validation of Simultaneous Quantitative Method of HIV Protease Inhibitors Atazanavir, Darunavir and Ritonavir in Human Plasma by UPLC-MS/MS by Tulsidas Mishra, Pranav S. Shrivastav

“…The validated method can be useful in determining plasma concentration of these protease inhibitors for therapeutic drug monitoring and in high throughput clinical studies.…”
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Characterization of the Active Ingredient and Prediction of the Potential Mechanism of Dahuoluo Pill via Mass Spectrometry with the Network Pharmacology Method by Haoran Xu, Yuelin Bi, Xin Feng, Jiaqi Wang, Gengyuan Yu, Tonghua Zhang, Tianyi Li, Xuhua Gao, Runhua Liu, Yu Sun, Hao Wu, Linlin Fang, Chenning Zhang, Yikun Sun

“…This study preliminarily reveals the potential mechanisms by which DHLP ameliorates rheumatoid arthritis and provides a basis for further evaluation of the drug’s efficacy.…”
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Severe Case of Plasmodium falciparum Malaria in a Pregnant Woman from Nigeria by Kruti Yagnik, Bilal Farooqi, Molly W. Mandernach, Anthony P. Cannella, Gautam Kalyatanda

“…A review on the treatment of severe malaria in all trimesters of pregnancy supports the WHO recommendation for intravenous artesunate as the drug of choice. This case illustrates the importance of recognizing malaria in pregnant women from endemic countries and shows that artesunate compounds can be used safely in pregnancy, particularly with high parasitemia.…”
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Uptake of Single-Walled Carbon Nanotubes Conjugated with DNA by Microvascular Endothelial Cells by Joseph Harvey, Lifeng Dong, Kyoungtae Kim, Jacob Hayden, Jianjie Wang

“…SWCNTs conjugated with drugs or genes travel in the systemic circulation to reach target cells or tissues following extravasation from microvessels although the interaction between SWCNT conjugates and the microvascular endothelial cells (ECs) remains unknown. …”
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A disproportionality analysis of FDA adverse event reporting system events for misoprostol by Li Yang, Wenting Xu

“…Although most AEs complied with the drug instruction, new AEs signals such as congenital aqueductal stenosis and congenital brain damage were also identified. …”
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Recurrent Catatonia due to Episodic Obsessive-Compulsive Disorder by Soumitra Das, Sakshi Prasad, Palak Atul Fichadia, Abhigan Babu Shrestha, Ozge C. Amuk Williams, Anil Bachu

“…Gauging the severity of her symptoms and poor drug compliance, the patient was opted for and successfully treated with ECT. …”
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Heart rhythm disorders and features of their management at COVID-19 pandemic by Yu.M. Mostovoy, T.D. Danilevych

“…In addition, there are controversial questions about the features of their management, drug interactions, routing and prognosis of the patients. …”
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Lipid Membrane Self-Assembly and Synthesis in the Lab by Rapid, Low-Cost Microfluidics Approaches by Kathleen Hardwick, Shane O'Reilly

“…The main uses for liposomes are in drug delivery systems and as animal cell models. …”
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Cognitive Behavioral Therapy of a Generalized Anxiety Disorder Case Comorbid with Health Anxiety by Nalan Kara

“…Paroxetine 20 mg/day prescribed and besides drug treatment CBT was started. CBT process begun with evaluation and case formulation, the aims of therapy were established and psycoeducation for CBT and anxiety was given. …”
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Comparison of the Effects of Intrathecal Fentanyl and Intrathecal Morphine on Pain in Elective Total Knee Replacement Surgery by Refika Kılıçkaya, Yavuz Orak, Mehtap Arda Balcı, Fatih Balcı, İlker Ünal

“…After obtaining the approval of the Erciyes University Medical Faculty Clinical Drug Trials Ethics Committee, as well as the verbal and written consent of the patients, we included 50 patients in our prospective, randomized study. …”
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Valbenazine for the Treatment of Adults with Tardive Dyskinesia by Harshit Gupta, Alycee R. Moity, Allison Jumonville, Sarah Kaufman, Amber N. Edinoff, Alan D. Kaye

“…However, further research, including additional direct comparison studies, should be conducted to fully evaluate this drug’s usefulness.…”
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