Using Protein Painting Mass Spectrometry to Define Ligand Receptor Interaction Sites for Acetylcholine Binding Protein by Alexandru Graur, Natalie Erickson, Nadine Kabbani

“…This strategy can be used with computational structural modeling to identify binding regions involved in drug targeting at the nAChR.…”
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Kidney Stone Disease: An Update on Current Concepts by Tilahun Alelign, Beyene Petros

“…Currently, there is no satisfactory drug to cure and/or prevent kidney stone recurrences. …”
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Severe Case of Chronic Pelvic Pain Syndrome: Recovery after Injection of Procaine into the Vesicoprostatic Plexus—Case Report and Discussion of Pathophysiology and Mechanisms of Ac... by R. M. Kronenberg, S. M. Ludin, L. Fischer

“…We describe a patient with a 35-year history of a severe chronic pelvic pain syndrome (CPPS) that failed to adequately respond to various drug therapies and other treatments by different specialists. …”
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Familial Exudative Vitreoretinopathy-Related Disease-Causing Genes and Norrin/β-Catenin Signal Pathway: Structure, Function, and Mutation Spectrums by Hongtao Xiao, Yuna Tong, Yuxuan Zhu, Min Peng

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The Role of SGLT2 Inhibitor on the Treatment of Diabetic Retinopathy by Wenjun Sha, Song Wen, Lin Chen, Bilin Xu, Tao Lei, Ligang Zhou

“…Sodium-dependent glucose transporter 2 inhibitor (SGLT2i) is a new antidiabetic drug which is mainly used in clinical practice to control blood glucose of patients with type 2 diabetes prone to develop chronic heart failure. …”
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Photoredox/Cr-catalyzed enantioselective radical-polar crossover transformation via C-H functionalization by Si-Yuan Tang, Zhan-Jie Wang, Yu Ao, Ning Wang, Huan-Ming Huang

“…The asymmetric radical-polar crossover transformation could build two chiral centers simultaneously and demonstrates broad substrate tolerance, accommodating various drug-derived aldehydes, (hetero)aromatics, and 1,3-diene derivatives. …”
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Successfully Climbing the “STAIRs”: Surmounting Failed Translation of Experimental Ischemic Stroke Treatments by Michael P. Kahle, Gregory J. Bix

“…Therefore, this paper will focus on considerations for several key aspects of preclinical stroke studies including the selection and execution of the animal stroke model, drug/experimental treatment administration, and outcome measures to improve experimental validity and translation potential. …”
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Diffuse Alveolar Hemorrhage due to Acute Mitral Valve Regurgitation by Creticus P. Marak, Parijat S. Joy, Pragya Gupta, Yana Bukovskaya, Achuta K. Guddati

“…Diffuse alveolar hemorrhage (DAH) can be caused by several etiologies including vasculitis, drug exposure, anticoagulants, infections, mitral valve stenosis, and regurgitation. …”
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CHEMOTYPE VERBOCCIDENTAFURAN IN Baccharis punctulata (Asteraceae): FURANIC SESQUITERPENES CORRELATION AND MOLECULAR DOCKING INTO THE BENZODIAZEPINE RECEPTOR by Jociani Ascari, Murilo S. de Oliveira, André L. Rüdiger, Elaine Elisabetsky, Domingos S. Nunes, Jorge Iulek, Dilamara R. Scharf, Gustavo Heiden

“…The results suggest that both compounds 1 and 2 must have affinity for the cavity at a1-y2 interface and support the development of pharmacological research on the compound verboccidentafuran 1 as a drug candidate for modulating the GABA/benzodiazepine complex in the central nervous system.…”
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The Effect Of 0.01% Atropine On Myopia Progression by Amber Khalid

“…Patients were followed for three years, with two years dedicated to observing treatment responses and a one-year washout period for the drug. A comparison of baseline and 24-month means revealed an increase in myopia of 0.84 in the interventional group and 1.55 in the control group. …”
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Determination of Benzalkonium Chloride in Nasal Drops by High-Performance Liquid Chromatography by Danijela A. Kostić, Snezana S. Mitić, Danijela Č. Nasković, Aleksandra R. Zarubica, Milan N. Mitic

“…The method was successfully applied for the determination of BKC in a pharmaceutical formulation of nasal drop solution without any interference from common excipients and drug substance. All the validation parameters were within the acceptance range, concordant to ICH guidelines.…”
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Hyperthermic Intraperitoneal Chemotherapy with Melphalan: A Summary of Clinical and Pharmacological Data in 34 Patients by Lana Bijelic, Paul H. Sugarbaker, O. Anthony Stuart

“…The optimal agents for HIPEC have not been established. Melphalan is a drug with broad activity and a favorable profile for intraperitoneal application. …”
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Mutanome Engineered RNA Immunotherapy: Towards Patient-Centered Tumor Vaccination by Mathias Vormehr, Barbara Schrörs, Sebastian Boegel, Martin Löwer, Özlem Türeci, Ugur Sahin

“…Preclinical and early clinical data suggest that synthetic mRNA can serve as potent drug format allowing the cost efficient production of highly efficient vaccines in a timely manner. …”
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GSK-3𝜷: A Bifunctional Role in Cell Death Pathways by Keith M. Jacobs, Sandeep R. Bhave, Daniel J. Ferraro, Jerry J. Jaboin, Dennis E. Hallahan, Dinesh Thotala

“…GSK-3β has emerged as an important molecular target for drug development.…”
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Potential Role of the Inflammasome-Derived Inflammatory Cytokines in Pulmonary Fibrosis by Rupa Biswas, Melisa Bunderson-Schelvan, Andrij Holian

“…Recent evidence suggesting that the fibrotic process can be reversed via blockade of pathways associated with inflammasome activity may provide hope for future drug strategies. In this paper we will give an introduction to pulmonary fibrosis and its known causes. …”
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Severe Hypertriglyceridemia Induced Pancreatitis in Pregnancy by Natasha Gupta, Seema Ahmed, Lemuel Shaffer, Paula Cavens, Josef Blankstein

“…Acute pancreatitis has been well associated with gallstone disease, alcoholism, or drug abuse but rarely seen in association with severe hypertriglyceridemia. …”
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South African strides towards attaining green analytical methods and a green environment for environmental analysis of pharmaceuticals by Lawrence Mzukisi Madikizela, Vusumzi Emmanuel Pakade

“…In recent years, multi-residue drug analysis has been a focal point rather than a single pharmaceutical analysis. …”
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Aortic Valve Papillary Fibroelastoma Associated with Acute Cerebral Infarction: A Case Report by Nobuhiro Takeuchi, Masanori Takada, Koichi Fujita, Yoshiharu Nishibori, Takao Maruyama, Kazuyoshi Naba

“…An 80-year-old woman with a history of congestive heart failure, atrial fibrillation, and hypertension was transferred to our institution with hematemesis. Her drug regimen included 2 mg warfarin potassium/day to prevent thromboembolic events. …”
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Is Oral Omega-3 Effective in Reducing Mucocutaneous Side Effects of Isotretinoin in Patients with Acne Vulgaris? by Mina Mirnezami, Hoda Rahimi

“…Isotretinoin is recommended in the treatment of recalcitrant or severe acne, but it is associated with common adverse effects that frequently result in patients incompliance and discontinuation of the drug. The present study was designed to assess the efficacy of oral omega-3 in decreasing the adverse effects of isotretinoin. …”
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The Role of Vitamin D in the Management of Chronic Pain in Fibromyalgia: A Narrative Review by Hannah W. Haddad, Allison C. Jumonville, Katarina J. Stark, Shavonne N. Temple, Chukwudum C. Dike, Elyse M. Cornett, Alan D. Kaye

“…Currently, the Food and Drug Administration (FDA) has approved the use of three medications to treat FM: pregabalin, duloxetine, and milnacipran. …”
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