Legionnaires' Disease with Facial Nerve Palsy by Shailesh R. Basani, Salwa Mohamed Ahmed, Eyassu Habte-Gabr

“…He denied smoking, alcohol or illicit drug use. Chest X-ray showed bilateral lower lobe infiltrates. …”
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Ezetimibe: An Unusual Suspect in Angioedema by Tiffany Lu, Tarundeep Grewal

“…We describe a case of new onset angioedema likely due to Ezetimibe therapy in an elderly patient with a prior history of drug-induced bradykinin reactions who had been on the medication for multiple years. …”
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Double preloaded internal up-and-over technique for total transfemoral four vessel thoracoabdominal multibranch endoprosthesis with temporary aortic balloon occlusion for ruptured... by Sukgu M. Han, MD, MS, Imani McElroy, MD, Gustavo S. Oderich, MD

“…The thoracoabdominal multibranch endoprosthesis (TAMBE) is the first off-the-shelf, four-vessel branched endograft to obtain US Food and Drug Administration commercial approval for the treatment of complex abdominal and thoracoabdominal aortic aneurysms. …”
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Application of HPLC with ELSD Detection for the Assessment of Azelaic Acid Impurities in Liposomal Formulation by Stanislaw Han, Katarzyna Karlowicz-Bodalska, Dorota Szura, Lukasz Ozimek, Witold Musial

“…The method enables separation of azelaic acid from the identified and unidentified impurities and from the excipients used in the drug form.…”
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Sarcopenia and Age-Related Endocrine Function by Kunihiro Sakuma, Akihiko Yamaguchi

“…Since sarcopenia is largely attributed to various molecular mediators affecting fiber size, mitochondrial homeostasis, and apoptosis, numerous targets exist for drug discovery. In this paper, we summarize the current understanding of the endocrine contribution to sarcopenia and provide an update on hormonal intervention to try to improve endocrine defects. …”
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Biomarkers as Key Contributors in Treating Malignant Melanoma Metastases by Camila Ferreira de Souza, Alice Santana Morais, Miriam Galvonas Jasiulionis

“…This is justified because of a subpopulation of cells presenting a remarkable molecular heterogeneity, which is able to explain the drug resistance and the growing mortality rates worldwide. …”
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Immunomodulatory effects of inosine pranobex on cytokine production by human lymphocytes by Lasek Witold, Janyst Michał, Wolny Rafał, Zapała Łukasz, Bocian Katarzyna, Drela Nadzieja

“…Inosine pranobex (inosine dimepranol acedoben, isoprinosine) (Inos) is an immunomodulatory and antiviral drug used in some viral infections, especially in patients with weakened immunity. …”
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Therapeutic Approaches for Peripheral and Central Neuropathic Pain by Délia Szok, János Tajti, Aliz Nyári, László Vécsei

“…In trigeminal neuralgia, carbamazepine and oxcarbazepine are the first-choice drugs. In drug-refractory cases, interventional, physical, and psychological therapies are available. …”
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Advanced Alveolar Soft Part Sarcoma Treated with Pazopanib over Three Years by Yoji Shido, Yukihiro Matsuyama

“…This case suggests that pazopanib may be useful as a first-line drug against unresectable ASPS and that longitudinal assessment of brain metastasis should be performed in similar cases.…”
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Autoimmune hepatitis: new in diagnostics, a pathogenesis and treatment by Ye. N. Shirokova, K. V. Ivashkin, V. T. Ivashkin

“…Improvement of corticosteroid treatment allows to determine candidates for alternative treatment. Budesonide is a drug of choice for the patients who were not receiving treatment before. …”
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Temperature-Responsive Gelation of Type I Collagen Solutions Involving Fibril Formation and Genipin Crosslinking as a Potential Injectable Hydrogel by Shunji Yunoki, Yoshimi Ohyabu, Hirosuke Hatayama

“…The elastic modulus of the 0.5% PSC/genipin gel system could be adjusted in a range of 2.5 to 50 kPa by the PSC and genipin concentrations, suggesting that a PSC/genipin solution is a potential injectable gel system for drug and cell carriers, with mechanical properties matching those of living tissues.…”
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Design, synthesis and molecular docking of novel triazole derivatives as potential CoV helicase inhibitors by Zaher Nashwa Hafez, Mostafa Mohammed Ismail, Altaher Abdullah Yousef

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The Hematopoietic Niche in Myeloproliferative Neoplasms by Annette H. Schmitt-Graeff, Roland Nitschke, Robert Zeiser

“…Nonneoplastic MSCs in turn can promote aggressiveness and drug resistance of malignant cells. In the future, strategies to counteract the pathological interaction between the niche and neoplastic HSCs may offer additional treatment strategies for MPN patients.…”
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Into the clinic: Talimogene laherparepvec (T-VEC), a first-in-class intratumoral oncolytic viral therapy by Ann W. Silk, Howard L. Kaufman, Hasan Rehman, Michael P. Kane

“…Herein, we review the development of T-VEC, and suggest how it fits into the in the current clinical treatment paradigm, and provide pearls for drug preparation, administration, and monitoring of response to therapy.…”
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Overlapping Clinical Manifestations of Multisystem Inflammatory Syndrome in Children with Other Endemic Diseases of Pakistan: A Case Report by Anam Zafar, Sughra Wahid, Asad Ullah, Hassan Mumtaz

“…The authors present the case of an 8-year-old who presented with non-specific febrile illness which was managed as extensively drug-resistant typhoid with meropenem. The patient developed abdominal pain and hypotension during the hospital stay. …”
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Modelling Peroxisomal Disorders in Zebrafish by Chenxing S. Jiang, Michael Schrader

“…Advantages for the investigation of peroxisomes during development and approaches to the application of zebrafish models for drug screening are discussed.…”
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An Insight into Potential Pharmacotherapeutic Agents for Painful Diabetic Neuropathy by Zunaira Qureshi, Murtaza Najabat Ali, Minahil Khalid

“…These drugs are only partially effective and have adverse effects associated with their use. …”
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Health information-seeking on Reddit, by people who use opioids by Margaret Sullivan, Jonah Hancock, George Shaw, Chaoqun Ni

“…In the most recent year that data is available, 101,035 people died from drug overdoses in the United States. For people who use drugs, obtaining treatment remains a significant barrier due to issues of fear, stigmatisation, and illegality. …”
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From detection to elimination: iron-based nanomaterials driving tumor imaging and advanced therapies by Dong Xie, Linglin Sun, Manxiang Wu, Qiang Li

“…Regarding treatment, INMs play a key role in advanced strategies such as immunotherapy, magnetic hyperthermia, and synergistic combination therapy, which effectively overcome tumor-induced drug resistance and reduce systemic toxicity. The integration of INMs with artificial intelligence (AI) and radiomics further expands its capabilities for precise tumor identification, and treatment optimization, and amplifies treatment monitoring. …”
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Management of Residual Neuromuscular Blockade Recovery: Age-Old Problem with a New Solution by Michael S. Green, Archana Gundigi Venkatesh, Ranjani Venkataramani

“…Sugammadex is a novel drug that selectively binds to aminosteroid nondepolarizing muscle relaxants and reverses even a deep level of NMB. …”
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