A combination of topical and systemic administration of brimonidine is neuroprotective in the murine optic nerve crush model. by Ruta Maciulaitiene, Giedrius Kalesnykas, Dainius Haroldas Pauza, Ingrida Januleviciene

“…Brimonidine is an intraocular pressure-lowering drug with reported neuroprotective properties. This study aimed to compare the neuroprotective effects of topical and intraperitoneal (IP) brimonidine on RGCs from different retinal segments in a murine optic nerve crush (ONC) model.…”
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Tackling Extended Hospital Stays in Patients with Acute Bacterial Skin and Skin Structure Infections by Gavin Barlow, Michael Wilke, Guillaume Béraud

“…However, such patients require monitoring for drug adherence to oral regimens or complications associated with daily intravenous administration, such as injection site reactions and infection. …”
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Spontaneous Apoptosis, Oxidative Status and Immunophenotype Markers in Blood Lymphocytes of AIDS Patients by Gabriele A. Losa, Riccardo Graber

“…Peripheral blood mononuclear cells (PBMC) from 251 HIV‐positive drug abusers of known clinical stage and from 40 healthy donors were tested for conventional immunologic markers (CD3, CD4, CD8, CD19, CD14, CD16/CD56, CD45 and HLA‐DR). …”
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Animal Models of Diabetes-Associated Renal Injury by Zahra Samadi Noshahr, Hossein Salmani, Abolfazl Khajavi Rad, Amirhossein Sahebkar

“…These models are developed by chemical, surgical, genetic, drug, and diet/nutrition interventions or combination of two or more methods. …”
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Biomarker-Based Targeting of the Androgen-Androgen Receptor Axis in Advanced Prostate Cancer by Manish Kohli, Rui Qin, Rafael Jimenez, Scott M. Dehm

“…Recent therapeutic advances for managing advanced prostate cancer include the successful targeting of the androgen-AR axis with several new drugs in castrate resistant prostate cancer including abiraterone acetate and enzalutamide (MDV3100). …”
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Synthesis and Antitumor Activity of a GSH Inert Bisphosphonate Platinum (II) Complex by Lu Ma, Hua Liu, Yichun Ju, Kai Chen, Yi Yang, Zhichao Zhou, Zhenqin Zhang, Zheng Cai

“…Traditional platinum chemotherapeutic agents for osteosarcoma inevitably have acquired drug resistance and serious side effects, which have limited their utility. …”
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Effectiveness of Polyclonal Antibody Immunoconjugate Treatment with Propamidine Isethionate for Amoebic Keratitis in Golden Hamsters by Manuel Enrique Ávila-Blanco, Sandra Lizbeth Aguilera-Martínez, Javier Ventura-Juarez, Jorge Pérez-Serrano, Elizabeth Casillas-Casillas, Luis Fernando Barba-Gallardo

“…Propamidine isethionate is frequently used for AK treatment, in vivo study we are found IL-1β and IL-10 expression and caspase 3 activity is significantly increased with respect to the group that was inoculated with the amoeba without receiving any treatment, suggesting that it may be an effect of the toxicity of this drug on the corneal tissue. Application of the immunoconjugate showed enhanced amoebicidal and anti-inflammatory activities, with comparison to propamidine isethionate only. …”
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Potential of Black Phosphorus in Immune-Based Therapeutic Strategies by Wenjuan Dong, Hu Wang, Hailin Liu, Chunqiao Zhou, Xuelin Zhang, Song Wang, Lin He

“…In conclusion, BP shows promise in natural antitumor biological activity, biological imaging, drug delivery, PTT/PDT/SDT/PAT/PIT, nanovaccines, nanoadjuvants, and combination immunotherapy regimens.…”
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Bilateral Basal Ganglion Hemorrhage after Severe Olanzapine Intoxication by Kerstin Schweyer, Bastian Fatke, Kornelia Kreiser, Christian Rabe, Christian Seifert, Benno Ikenberg

“…Olanzapine is a second-generation antipsychotic drug which is generally considered safe with well therapeutic antipsychotic effects. …”
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Application of adoptive cell therapy in malignant melanoma by Qianrong Hu, Jiangying Xuan, Lu Wang, Kangjie Shen, Zixu Gao, Yuhong Zhou, Chuanyuan Wei, Jianying Gu

“…Patients with advanced melanoma suffer a poor prognosis and generally cannot benefit well from surgical resection and chemo/target therapy due to metastasis and drug resistance. Thus, adoptive cell therapy (ACT), employing immune cells with specific tumor-recognizing receptors, has emerged as a promising therapeutic approach to display on-tumor toxicity. …”
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Extraintestinal manifestations of inflammatory bowel diseases: arthropathy and arthritis by Gulustan Hamid Sadygova

“…Meditate analysis of extraintestinal IBD manifestations, in particular IBD-associated arthropathy and arthritis, expands potential of time the diagnosis and adequate drug treatment to decrease disability risk and to improve quality of life of IBD patients.…”
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The Influence of Nanoparticle on Vaccine Responses against Bacterial Infection by Sareh Bagheri-Josheghani, Bita Bakhshi, Shahin Najar-peerayeh

“…Nanoparticles could function as a drug delivery tool, as an adjuvant to promote antigen processing, and as an immune modulator to induce immune responses. …”
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Estimation for Two Sensitive Variables Using Randomization Response Model Under Stratified Random Sampling by Gi-Sung Lee, Ki-Hak Hong, Sung-Hwan Kim, Chang-Kyoon Son

“…When direct survey are about sensitive characteristics such as addiction to drugs, alcoholism, proneness to tax invasion and sexual violence, nonresponse bias and response bias become serious problems because people oftentimes do not wish to give true information. …”
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Potential Azo-8-hydroxyquinoline derivatives as multi-target lead candidates for Alzheimer's disease: An in-depth in silico study of monoamine oxidase and cholinesterase inhibitors... by Fatima Zahra Guerguer, Bouchra Rossafi, Oussama Abchir, Yasir S Raouf, Dhabya Bakhit Albalushi, Abdelouahid Samadi, Samir Chtita

“…These findings identify molecules 14c and 17c as promising multi-target candidates for the treatment of AD, based on an in-depth computational study aimed at minimizing drug development costs and time. Future work will include the synthesis of these molecules followed by in-depth in vitro and in vivo testing to validate their potential therapeutic efficacy.…”
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The Role of MicroRNAs in Cardiac Stem Cells by Nima Purvis, Andrew Bahn, Rajesh Katare

“…Stem cells are considered as the next generation drug treatment in patients with cardiovascular disease who are resistant to conventional treatment. …”
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Convergence of nanotechnology and artificial intelligence in the fight against liver cancer: a comprehensive review by Manjusha Bhange, Darshan Telange

“…Nanotechnology enables precise, targeted drug delivery, enhancing the efficacy of therapeutics while minimizing off-target effects. …”
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Factors Affecting the Quality of Life of the Elderly in Iraq and Turkiye and Differences Between the Two Cultures by Tahsin Barış Değer, Hatem Al Yasarı

“…In Iraq, factors affecting low QOL were age 85 years and older, female gender, being single, low educational level, not having a regular salary, insufficient income, chronic disease, drug use and disability. Factors effective on high QOL were eating healthily, walking or exercising regularly, praying five times a day, and reading the Qur'an in Iraq. …”
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Immunological responses in patients with tuberculosis and in vivo effects of acetyl-L-carnitine oral administration by Emilio Jirillo, Maria Altamura, Carlo Marcuccio, Cosimo Tortorella, Claudio De Simone, Salvatore Antonaci

“…In view of the presence of nonspecific and specific immune deficits in TBC patients, a clinical trial was carried out in a group of 20 individuals with active pulmonary TBC by oral administration of acetyl-L-carnitine (ALC). This drug, which has been shown to possess immunomodulating activities, was able to upregulate the T-dependent antibacterial activity in TBC patients after 30 days' treatment, while the same activity decreased in patients receiving placebo only. …”
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PREVENTING VIOLENCE CRIMES (KIDNAPPING, ARMED ROBBERY, BRIGANDAGE OR COMMUNITY MASSACRE) WITH DRONES: AN EFFECTIVE ALTERNATIVE TO VEHICULAR PATROLS IN NIGERIA by GABRIEL SALIFU, DANIEL OLASUNKANMI OLADAPO

“…In the 21st century, the families off springs are endangered with multiple social vices that range from internet fraud (yahoo yahoo), kidnapping, lesbianism, drug abuse, homosexuality, bestiality, incest, ritual killing and others. …”
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Inhibition of Glycogen Synthase Kinase and the Neuroprotective Function of Conjugated ZnO-Osthol Nanoparticles in Alzheimer’s Disease by Nahed S. Alharthi, Fahad M. Aldakheel, Abdulkarim S. Binshaya

“…We conclude from our observations that osthol is a potential drug for the treatment of a neurodegenerative disease, Alzheimer’s. …”
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