Clinicopathological importance of immunohistochemical expression of OCT4, c-MYC and Ki-67 in colorectal cancer by Rabia Hursitoglu, Abdulkadir Yasir Bahar, Sezen Koçarslan, Gökmen Aktaş, Neslihan Kurtul, Emine Kılınç

“…CSCs become dormant in the cell cycle, which is one of the mechanisms of escape in drug resistance. We hypothesized that including Ki67 immunohistochemical staining in our study would increase the specificity in detecting CSCs. …”
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Update on New Antigens in the Pathogenesis of Membranous Nephropathy by Maurizio Salvadori, Aris Tsalouchos

“…The remaining 30% were called secondary because they developed due to well-known diseases such as autoimmune diseases, tumours, infections, or drug assumptions. The discoveries of the M-type phospholipase A2 receptor and of thrombospondin type 1 domain containing 7A as causative antigens in a part of the so-called primary membranous nephropathies opened new knowledge on the effective causes of a large part of these diseases. …”
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Anti-Inflammation Property of Syzygium cumini (L.) Skeels on Indomethacin-Induced Acute Gastric Ulceration by Lanchakon Chanudom, Jitbanjong Tangpong

“…Indomethacin, nonsteroidal anti-inflammatory drug (NSAIDs), induced gastric damage and perforation through the excess generation of reactive oxygen species (ROS). …”
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Molecular Docking Study of Caffeic Acid as Acetylcholinesterase Inhibitor by Stephanus Satria Wira Waskitha, Enade Perdana Istyastono, Florentinus Dika Octa Riswanto

“…Acetylcholinesterase (AChE) receptor is a receptor that has been widely used as a potential drug target for Alzheimer's disease. Caffeic acid is a phenolic compound that had been experimentally proven to be an inhibitor of AChE. …”
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Modern approaches of effective prevention of NSAIDs-gastropathy by A. Ye. Karateyev

“…Upper gastrointestinal lesions, related to intake of nonsteroid anti-inflammatory drugs (NSAIDs) represent a serious social and medical problem. …”
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Impact of Polypharmacy on the Rehabilitation Outcome of Japanese Stroke Patients in the Convalescent Rehabilitation Ward by Eiji Kose, Riku Maruyama, Susumu Okazoe, Hiroyuki Hayashi

“…We divided stroke patients into those taking six or more drugs (polypharmacy group) and those taking less than six drugs (nonpolypharmacy group) upon admission. …”
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Challenges relating to comparison of flavonoid glycosides dissolution profiles from Sutherlandia frutescens products by Mbamalu Oluchi N., Syce James, Samsodien Halima

“…Unlike the case of conventional drug formulations, dissolution tests have hitherto not been required for herbal medicinal products commercially available in South Africa. …”
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Beyond Tumors: The Pivotal Role of TRIM Proteins in Chronic Non-Tumor Lung Diseases by Huang X, Yu W, Wei A, Wang X, Chen S

“…We highlight their potential as biomarkers and therapeutic targets, offering promising avenues for drug development in these debilitating respiratory disorders. …”
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In Vivo Antiplasmodial, Anti-Inflammatory, and Analgesic Properties, and Safety Profile of Root Extracts of Haematostaphis barteri Hook F. (Anacardiaceae) by Johnson Nyarko Boampong

“…Malaria is an endemic disease globally and the conundrum of drug resistance has led to the search for newer antimalarial agents. …”
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“Pharmacological” analysis of atrial fibrillation maintenance mechanism: reentry, wavelets, or focal? by Alexander Burashnikov

“…Electrophysiological alterations induced by anti-AF drugs before AF cardioversion may help delineate the mechanism of AF maintenance. …”
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Results of non-interventional observational study of ursodeoxycholic acid in primary biliary cirrhosis by Yelena N. Shirokova, Anna F. Sheptulina

“…Efficacy and safety investigation of the drug was carried out at the day 30 (visit 2) and at the day 90 (visit 3) according to the laboratory tests results, quality of life assessment by SF-36 questionnaire, registration of frequency and severity of the adverse events (AE). …”
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Identification of New Potential APE1 Inhibitors by Pharmacophore Modeling and Molecular Docking by In Won Lee, Jonghwan Yoon, Gunhee Lee, Minho Lee

“…Apurinic/apyrimidinic endonuclease 1 (APE1) is an enzyme responsible for the initial step in the base excision repair pathway and is known to be a potential drug target for treating cancers, because its expression is associated with resistance to DNA-damaging anticancer agents. …”
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The Effect of Dantonic Pill on β-Catenin Expression in a Rat Model of Streptozotocin-Induced Early Stage of Diabetic Nephropathy by Zhou Shuhong, Lv Hongjun, Cui Bo, Xu Li, Shi Bingyin

“…After the treatments of DP and irbesartan, the albuminuria level, kidney weight/body weight, and thickness of the glomerular basement membrane were decreased, but the expression of β-catenin was not downregulated in the renal cortex. The effective drug target of DP to ameliorate albuminuria and renal hypertrophy should not inhibit the upregulated expression of β-catenin in rats with STZ-induced early-stage diabetic damage.…”
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Metformin Ameliorates D-Galactose-Induced Senescent Human Bone Marrow-Derived Mesenchymal Stem Cells by Enhancing Autophagy by Pingting Ye, Lei Feng, Dan Zhang, Ruihao Li, Yixuan Wen, Xiaohan Tong, Shuo Shi, Chunyan Dong

“…Metformin, an oral hypoglycemic drug for type 2 diabetes, has been shown to have antiaging effects. …”
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In silico analysis of ventricular action potential with a current–voltage‐time representation: Thresholds, membrane resistance, repolarization reserve by Massimiliano Zaniboni

“…Abstract The waveform of ventricular action potential (AP) is a key determinant of the cardiac cycle, a marker of beating pathophysiology, and a target for anti‐arrhythmic drug design. The information contained in the waveform, though, is limited to the actual dynamics of the AP under consideration. …”
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Antioxidant and cytotoxic potentials of Streptomyces gilvigriseus MUSC 26T isolated from mangrove soil in Malaysia by Hooi-Leng Ser, Wai-Fong Yin, Kok-Gan Chan, Tahir Mehmood Khan, Bey-Hing Goh, Learn-Han Lee

“…By the same token, the availability of its genome sequence allows further investigation into the biosynthetic gene clusters responsible for the production of these compounds which could essentially accelerate its development as chemopreventive drug(s).…”
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Cricoid chondroma presenting as upper airway obstruction: A report of a rare case by Samuel Sisay Hailu, MD, Eyoel Degafu, MD, Tequam Debebe, MD, Yonas Shumiye, MD, Bizunesh Dires, MD, Bethlehem Tesfasilassie Kibrom, MD

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Ovarian Epithelial Cancer Stem Cells by Irena Conic, Irena Dimov, Desanka Tasic-Dimov, Biljana Djordjevic, Vladisav Stefanovic

“…Finally, this review discusses the signaling pathways that are important regulators of candidate EOCSC maintenance and function, their potential role in the distinct pathogenesis of different EOC subtypes, as well as potential mechanisms and clinical relevance of EOCSC involvement in drug resistance.…”
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Forced degradation of tacrolimus and the development of a UHPLC method for impurities determination by Peterka Tanja Rozman, Lušin Tina Trdan, Bergles Jure, Ham Zoran, Grahek Rok, Urleb Uroš

“…The forced degradation study in solution revealed tacrolimus instability under stress alkaline, thermal, light and photolytic conditions and in the presence of a radical initiator or metal ions. The drug was stable at pH 3–5. Solid-state degradation studies conducted on amorphous tacrolimus demonstrated its sensitivity to light, elevated temperature, humidity and oxidation.…”
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PERSPEKTIF REMAJA TENTANG KESEHATAN REPRODUKSI SEBAGAI UPAYA PENCEGAHAN PENYIMPANGAN PERILAKU SEKSUAL DI KABUPATEN BEKASI by Maesaroh Maesaroh, Eka Kartikawati, Devi Anugrah

“…One of the negative impacts facilitated by the spread through the media was deviant behavior that occurred in various parts of the world which was later imitated by young people in Indonesia. Drug abuse, sexual behavior outside of marriage and sexual orientation deviation or known as LGBT (Lesbian, Gay, Bisexual, Transgender). …”
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