Targeting the Heart of Mycobacterium: Advances in Anti-Tubercular Agents Disrupting Cell Wall Biosynthesis by Ahmad Diab, Henry Dickerson, Othman Al Musaimi

“…Currently, five approved drugs target cell wall biosynthesis in <i>Mycobacterium tuberculosis</i>. …”
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Formulation and Evaluation of Ketoconazole Nano-suspension by Eriska Agustin, Gita Deslia Sari

“…Ketoconazole is included in the Biopharmaceutical Classification System (BCS) II category, where the drug is poorly soluble in water but has high permeability. …”
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Disruption of the Serotonergic System after Neonatal Hypoxia-Ischemia in a Rodent Model by Kathryn M. Buller, Julie A. Wixey, Hanna E. Reinebrant

“…These changes can be prevented using two anti-inflammatory interventions; the postinsult administration of minocycline or ibuprofen. However, each drug has its own limitations and benefits for use in neonates to stem damage to the serotonergic network after hypoxia-ischemia. …”
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Natural Products for Cancer Therapy: A Review of Their Mechanism of Actions and Toxicity in the Past Decade by Yasir Osman Ali Abdalla, Bavani Subramaniam, Shaik Nyamathulla, Noorasyikin Shamsuddin, Norhafiza M. Arshad, Kein Seong Mun, Khalijah Awang, Noor Hasima Nagoor

“…The ethnopharmacological information gathered over many centuries and the presence of diverse metabolites have made the medicinal plants as the prime source of drugs. Despite the positive attributes of natural products, there are many questions pertaining to their mechanism of actions and molecular targets that impede their development as therapeutic agents. …”
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Nanotube Combined with Roller Skater Rehabilitation Therapy in the Treatment of Knee Arthritis by Peng Sun

“…Before and after the treatment, the therapeutic effect of the nanotube drug treatment group was improved by about 40%, and the therapeutic effect of the observation group of rehabilitation therapy with nanotube combined wheel athletes was increased by about 42%. …”
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Myoglobin Cast Nephropathy Diagnosed on Renal Biopsy in a Patient Treated for Malarial Infection by Ramya Varadarajan, Ashmi Patel, Haneen Salah, Neil Sutaria, Roberto Barrios, Luan Truong, Lillian Gaber, Ziad M. El-Zaatari

“…Previous literature has suggested mechanisms for the development of rhabdomyolysis in malarial infection, including inflammatory processes, direct effect of parasite accumulation, and drug-induced toxicity. Our case further implicates antimalarial therapy as a cause of rhabdomyolysis and increases awareness of myoglobin cast nephropathy as a potential complication of malaria.…”
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Microbial Tyrosinases: Promising Enzymes for Pharmaceutical, Food Bioprocessing, and Environmental Industry by Kamal Uddin Zaidi, Ayesha S. Ali, Sharique A. Ali, Ishrat Naaz

“…Melanin pigment synthesized by tyrosinase has found applications for protection against radiation cation exchangers, drug carriers, antioxidants, antiviral agents, or immunogen. …”
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Blockchain-Based Secure Traceable Scheme for Food Supply Chain by S. Thangamayan, Kalyani Pradhan, Ganesh Babu Loganathan, S. Sitender, S. Sivamani, Mulugeta Tesema

“…To implement the data update service and the food recall function, introduce the Food and Drug Administration node. Consumers have the option to not only enquire about food traceability throughout the manufacturing process but also to file complaints regarding the traceability system’s rights protection.…”
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Recent Advances in Metal–Organic Framework-Based Anticancer Hydrogels by Preeti Kush, Ranjit Singh, Parveen Kumar

“…Metal–organic frameworks (MOFs) are promising alternative approaches for efficient drug delivery and cancer theranostics owing to their unique properties and the direct transportation of drugs into cells followed by controlled release, but they suffer from certain limitations like rigidity, poor dispersibility, fragility, aggregation probability, and limited surface accessibility. …”
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Pharmacokinetic comparisons of S-oxiracetam and R-oxiracetam in beagle dogs by Wang Wusan, Ji Hui, Li Tingting, Jia Yuanwei, Xie Haitang

“…A pharmacokinetic comparison and conformational stability study of S-oxiracetam (S-ORT) and R-oxiracetam (R-ORT) in beagle dogs was used to investigate the possible mechanism of different effects of two oxiracetam enantiomers through a random crossover design. After drug administration to beagle dogs, blood samples were collected at different time points for pharmacokinetic analysis using the UPLC-ESI-MS/MS method. …”
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Core-in-cup/liquisol dual tackling effect on azelnidipine buccoadhesive tablet micromeritics, in vitro release, and mucoadhesive strength by Rashad Amira A., El-Helaly Sara Nageeb, Abd El Rehim Randa T., El-Gazayerly Omaima N.

“…These problems were addressed by implementing (1) a liquisol technique for promoting the dissolution rate in a controlled-release manner and (2) a core-in-cup bucco-adhesive drug delivery system as an alternative to the oral route. …”
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Complexation of Z-ligustilide with hydroxypropyl-β-cyclodextrin to improve stability and oral bioavailability by Lu Yapeng, Liu Siyuan, Zhao Yu, Zhu Li, Yu Shuqin

“…Further, oral bioavailability of LIG and the inclusion complex in rats were studied and the plasma drug concentration-time curves fitted well with the non-compartment model to estimate the absolute bioavailability, which was 7.5 and 35.9 %, respectively. …”
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Innovative bioinks for 3D bioprinting: Exploring technological potential and regulatory challenges by Vidhi Mathur, Prachi Agarwal, Meghana Kasturi, Varadharajan Srinivasan, Raviraja N Seetharam, Kirthanashri S Vasanthan

“…This review explores the innovative bioinks that are currently shaping the future of 3D bioprinting, focusing on their composition, functionality, and potential for tissue engineering, drug delivery, and regenerative medicine. The development of bioinks, incorporating natural and synthetic materials, offers unprecedented opportunities for personalized medicine. …”
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Peptic Ulcer at the End of the 20th Century: Biological and Psychological Risk Factors by Susan Levenstein

“…Many known ulcer risk factors, including smoking, nonsteroidal anti-inflammatory drug use, heavy drinking, loss of sleep and skipping breakfast, can increase under stress; the association of low socioeconomic status with ulcer is also accounted for in part by psychosocial factors. …”
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The Role of Cell Adhesion Molecule Genes Regulating Neuroplasticity in Addiction by Dawn E. Muskiewicz, George R. Uhl, F. Scott Hall

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Quantification of Rhodojaponin II and Rhodojaponin III in Rat Plasma by Ultra-Performance Liquid Chromatography-Tandem Mass Spectrometry by Cheng Sun, Wanhang Wang, Xi Bao, Dizhong Chen, Shenshen Mei, Jianshe Ma, Xiajuan Jiang

“…These results comply with relevant regulations for drug analysis in biological samples. Therefore, this method is deemed suitable for quantifying Rhodojaponin II and Rhodojaponin III levels in rats.…”
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Surgical Treatment of Atrial Fibrillation: A Review by Nadine Hiari

“…Because of the high recurrence rate of AF despite antiarrhythmic drug therapy for maintenance of sinus rhythm and the adverse effects of these drugs, there has been growing interest in nonpharmacological strategies. …”
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ANTI-INFLAMMATORY ACTIVITY OF BAWANG DAYAK (ELEUTHERINE BULBOSA (MILL. URB.))ETHANOL BULB EXTRACTS by Swandari Paramita, Muhammad Khairul Nuryanto

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“Magic Bullet”: Eccentric Macular Hole as a Complication from Dexamethasone Implant Insertion by Logan Christensen, Riley Sanders, Jeffrey Olson

“…Introduction. Intravitreal drug injections and implants are generally safe but do carry some risk, from both the procedure itself and adverse effects of the medications. …”
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A critical review on phytochemical profile and health promoting effects of mung bean (Vigna radiata) by Kumar Ganesan, Baojun Xu

“…The various curative potential of mung bean provides successive preclinical outcomes in the field of drug discovery and this review strongly recommends that mung bean is an excellent nutritive legume, which modulates or prevents chronic degenerative diseases. …”
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