Involvement of serotonin and eicosanoids in the rat paw oedema response to the essential oil of Pilocarpus spicatus by J. C. R. Silva, V. S. N. Rao

“…The oedemagenic activity of PSEO was also suppressed by pretreating the rats with the eicosanoid synthesis inhibitors, phenylbutazone, EP 10161 and dexamethasone. This last drug showed the greatest potency. These findings suggested a probable injury to dermal mast cells and liberation of arachidonate metabolites and eicosanoids at the late phase of oedema induced by PSEO.…”
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Rapid Onset Severe Immune Thrombocytopenia following mRNA COVID-19 Vaccine in a Young Patient by Jorge Avila, Huseyin Berk Degirmenci, Pamela Contreras Chavez, Elisabeth M. Battinelli, Jorge Fleisher

“…Commonly encountered differentials including heparin-induced thrombocytopenia and common viral etiologies were ruled out, and other causes such as drug reactions deemed unlikely as the etiology of this presentation after a broad workup. …”
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Successful Use of Cyclophosphamide as an Add-On Therapy for Multiple Myeloma Patients with Acquired Resistance to Bortezomib or Lenalidomide by Shigeki Ito, Tatsuo Oyake, Kazunori Murai, Yoji Ishida

“…In addition to switching drug classes, intensified treatment strategy, including increase in the dosage of current agents and addition of other agents, may be considered for these patients. …”
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The hydrochemistry of Angwan Mallam and environs (PART OF KEFFI SHEET 208 NE) by Adama Baba, Olalekan Agboola Olowoyeye

“…The findings will be a benefit to Environmental Impact Assessment of Agwa mallam as the water in the area meets the National Agency for Food, Drug Administration and Control, Draft for National Standard for Drinking water, and World Health Organization guideline. …”
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Native Aortic and Tricuspid Valve Endocarditis Complicated by Embolic ST Elevation Myocardial Infarction by Mumtaz Zaman, Richard Loynd, Anthony Donato

“…Following a failed attempt at thrombus extraction, a 3.0×38 mm bioabsorbable drug-eluting stent was placed. Echocardiography then revealed large mobile aortic valve vegetations with the largest measuring 1.4×1.7 cm, severe tricuspid regurgitation with a 1.1×0.5 cm mobile vegetation on the anterior leaflet along with a patent foramen ovale with right-to-left shunting. …”
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Clinical Experience with 5-Aminosalicylate Preparations in Inflammatory Bowel Disease - A Review by C.N. Williams

“…However, with 5-ASA the incidence of side effects is considerably lower; the number of patients discontinuing therapy is less; patient compliance is better, especially for the long term; dosage increase following inadequate action is more readily possible; and bacterial activation of the drug given is not necessary.…”
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The Protective Potential Role of ACE2 against COVID-19 by Fereshteh Golab, Gelareh Vahabzadeh, Leila SadeghRoudbari, Arefeh Shirazi, Robabeh Shabani, Sara Tanbakooei, Lida Kooshesh

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Targeting TRPM3 as a potential therapeutic approach for autosomal dominant polycystic kidney disease by Hüseyin Gül, Jamie A. Davies

“…We therefore examined the effect of pharmacological activators and inhibitors of TRPM3 on cyst formation in cultured mouse kidney rudiments exposed to a range of concentrations of forskolin, a cAMP-elevating drug commonly used experimentally to induce cysts in cultured kidneys. …”
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Recent Advances in Pharmacotherapy Development for Abdominal Aortic Aneurysm by Koichi Yoshimura, Hiroki Aoki

“…Furthermore, the development of biomarkers as well as appropriate drug delivery systems is essential to produce clinically practical pharmacotherapy for AAA.…”
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Phacoemulsification in Nanophthalmic Eye, a Way to Manage Glaucoma: Case Report by Dania Bamefleh, Konrad Schargel, Valmore A. Semidey, Faisal A. Altahan, Edward Schargel

“…We describe a case of closed-angle glaucoma in a nanophthalmic eye with increased intraocular pressure (IOP) on full medical treatment, along with concurrent drug side effects. As a first surgical procedure, we recommend phacoemulsification of the clear lens + IOL. …”
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Milnacipran for the Treatment of Fibromyalgia by Harshit Gupta, Brook Girma, Jack S. Jenkins, Sarah E. Kaufman, Christopher A. Lee, Alan D. Kaye

“…Milnacipran is one of three drugs currently approved by the FDA for the treatment of fibromyalgia. …”
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Benign Duodenal Stricture Treated with Surgical Correction and Dietary Therapy in a Golden Retriever by John C. Rowe, Alice A. Huang, Jin Heo, Nolie K. Parnell, Adam J. Rudinsky

“…Several inciting causes were identified as possible drivers of stricture formation, including nonsteroidal anti-inflammatory drug (NSAID) administration, mucosal ulceration, traumatic injury, or inflammatory intestinal disease. …”
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pH-responsive Vesicles with Tunable Membrane Permeability and Hydrodynamic Diameters from a Cross- linkable Amphiphilic Block Copolymer by Ruixue Chang, Yuelan Tian, Yong Wang, Jianglei Qin

“…This particular property has great potential and many applica‐ tions, since most drug-loading and controlled-release studies are conducted within this pH range.…”
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Levosimendan as Treatment Option in Severe Verapamil Intoxication: A Case Report and Review of the Literature by Mirjam Osthoff, Christine Bernsmeier, Stephan C. Marsch, Patrick R. Hunziker

“…Recommended therapy includes prevention of further absorption of the drug, inotropic therapy, calcium gluconate, and hyperinsulinemia/euglycemia therapy. …”
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Hypoxia-inducible factor in cancer: from pathway regulation to therapeutic opportunity by Brian M Ortmann

“…Consequently, understanding the cellular mechanisms underlying HIF activation and its downstream effects has become crucial to developing targeted cancer therapies for improving cancer patient outcomes and represents a key step towards precision medicine.Recent advancements in drug development have led to the emergence of HIF inhibitors, which aim to disrupt HIF-driven processes in cancer providing therapeutic benefit. …”
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Cotrimoxazole Prophylaxis Specifically Selects for Cotrimoxazole Resistance in Streptococcus mutans and Streptococcus sobrinus with Varied Polymorphisms in the Target Genes folA an... by Buwembo William, Charles Mugisha Rwenyonyi, Göte Swedberg, Fred Kironde

“…Considerable polymorphisms were found in the folP gene in S. mutans, but this could not be linked to sulfonamide drug resistance. No variation was seen in folP or folA genes of S. sobrinus. …”
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Psoriasis: Unraveling Disease Mechanisms and Advancing Pharmacological and Nanotechnological Treatments by Miao M, Yan J, Sun Y, Liu J, Guo S

“…We highlight the potential of nanotechnology to enhance drug delivery to affected skin areas, with microneedles emerging as a promising platform for psoriasis and other chronic inflammatory skin diseases.Keywords: biodegradable nanoparticles, clinical trials, skin inflammatory diseases, psoriasis, microneedles…”
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Improving the Activity and Selectivity of a Scorpion-Derived Peptide, A3a, against Acinetobacter baumannii through Rational Design by Dalton S. Möller, Mandelie van der Walt, Carel Oosthuizen, Miruna Serian, June C. Serem, Christian D. Lorenz, A. James Mason, Megan J. Bester, Anabella R. M. Gaspar

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Role of Macrophages in the Pathogenesis of Atopic Dermatitis by Sadaf Kasraie, Thomas Werfel

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Embryotoxic and Teratogenic Effects of Norfloxacin in Pregnant Female Albino Rats by Mohamed Aboubakr, Mohamed Elbadawy, Ahmed Soliman, Mohamed El-Hewaity

“…Conclusively, norfloxacin caused some fetal defects and abnormalities, so it is advisable to avoid using this drug during pregnancy.…”
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