YOUTH RESTIVENESS IN NIGERIA: AN EVALUATION OF IKORODU LOCAL GOVERNMENT, LAGOS, NIGERIA by NIYI ADEGOKE, Odedokun Ezekiel Adeyemi, Odunayo Tolulope Ojo

“…The paper reveals that drug abuse, illiteracy, unemployment, poverty, and poor child up bringing among others are some of the causes by youth restiveness. …”
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Zinc Transporters, Mechanisms of Action and Therapeutic Utility: Implications for Type 2 Diabetes Mellitus by Stephen A. Myers, Alex Nield, Mark Myers

“…This previously unexplored concept would raise a whole new area of research into the pathophysiology of insulin resistance and introduce a new class of drug target with utility for diabetes pharmacotherapy.…”
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Antioxidant and Anti-Inflammatory Properties of Melatonin in Secondary Traumatic Brain Injury by Mariusz Sieminski, Michalina Reimus, Maria Kałas, Ewelina Stępniewska

“…Melatonin, a sleep–wake-cycle-regulating neurohormone, exerts strong antioxidant and anti-inflammatory effects and is well tolerated when used as a drug. Due to these properties, it is very reasonable to consider melatonin as a potential therapeutic molecule for TBI treatment. …”
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Study on Preparation Technology and Physical Fingerprint of Chuilian Jianpi Granules Based on QbD by Guangjiao Zhou, Xiao-Wei Li, Jin-Cai Li, Xue-Hua Feng

“…The optimum formula conditions of Chuilian Jianpi granules were as follows: the dosage ratio of drug to adjuvant was 1 : 0.8, lactose:mannitol = 1.5 : 1, and the amount of wetting agent (90% ethanol) was 25% of the granules, with high-speed stirring granulation. …”
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Clozapine-carboxylic acid plasticized co-amorphous dispersions: Preparation, characterization and solution stability evaluation by Ali Ahmed Mahmoud Abdelhaleem, Ali Adel Ahmed, Maghrabi Ibrahim Abdullah

“…Co-amorphous dispersions were prepared using modified solvent evaporation methodology at drug/plasticizer stoichiometric ratios of 1:1, 1:1.5 and 1:2. …”
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Shikonin Induces Glioma Necroptosis, Stemness Decline, and Impedes (Immuno)Proteasome Activity by Xianyun Qin, Lu Zhang, Jilan Liu, Yan Lu, Fuyao Zhou, Feng Jin

“…The discussion extends to the potential of Shikonin as a promising therapeutic agent in the management of gliomas, offering a novel avenue for drug development in this challenging clinical context.…”
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Immunosenescence of Polymorphonuclear Neutrophils by Inga Wessels, Judith Jansen, Lothar Rink, Peter Uciechowski

“…This could form the basis for drug development in order to prevent or treat age-related diseases, and thus to unburden the public health systems.…”
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Family support and adherence to treatment in people affected by tuberculosis by Cesar Raul Castro Galarza, Maritsa Julia Camarena Cristóbal, Ilse Faustina Fernandez Honorio

“…<p><strong>Background</strong>: Adherence to treatment in tuberculosis is relevant, both for its effect to be successful and to limit the emergence of drug resistance.<br /><strong>Objective</strong>: to determine the relationship between family support and adherence to treatment in patients with tuberculosis.…”
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Exosomes, their sources, and possible uses in cancer therapy in the era of personalized medicine by Tomas Zemanek, Lubos Danisovic, Andreas Nicodemou

“…Recent advancements in exosome-based therapy have highlighted its utility in drug delivery and immunotherapy. This review examines the composition and sources of exosomes within the immune microenvironment of solid tumors and delves into the mechanisms and pathways through which exosomes impact immunotherapy. …”
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Lumateperone tosylate, A Selective and Concurrent Modulator of Serotonin, Dopamine, and Glutamate, in the Treatment of Schizophrenia by Kunal Maini, Janice W. Hollier, Haley Gould, Victoria Bollich, John LaForge, Elyse M. Cornett, Amber N. Edinoff, Adam M. Kaye, Alan D. Kaye

“…Lumateperone tosylate is an FDA-approved drug that can be given only at the 42mg dose once daily with no titration requirements.…”
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Solid Lipid Nanoparticles Based on L-Cysteine for Progesterone Intravaginal Delivery by Roberta Cassano, Sonia Trombino

“…For this reason, a material capable of ensuring the permanence of the formulation in the administration site for the time needed to guarantee the transmucosal absorption of the steroid was synthetized in order to reduce the number of administrations and to ensure an effective concentration of drug at the site of action. To this end, an ester, 2,3-dihydroxypropanoate of octadecyl (stearyl glycerine), containing two hydroxyl groups was initially synthesized. …”
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Genipin Cross-Linked Chitosan-Polyvinylpyrrolidone Hydrogels: Influence of Composition and Postsynthesis Treatment on pH Responsive Behaviour by Chinyelumndu Jennifer Nwosu, Glenn Adam Hurst, Katarina Novakovic

“…Understanding the factors that influence the pH responsive behaviour of biocompatible cross-linked hydrogel networks is essential when aiming to synthesise a mechanically stable and yet stimuli responsive material suitable for various applications including drug delivery and tissue engineering. In this study the behaviour of intelligent chitosan-polyvinylpyrrolidone-genipin cross-linked hydrogels is examined as a function of their composition and postsynthesis treatment. …”
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A Rare Case of Rivaroxaban Causing Delayed Symptomatic Hepatocellular Injury and Hyperbilirubinemia by Keith Glenn, Patrick Chen, Mustafa Musleh, Rao Pallivi, Melissa Grilliot

“…As Rivaroxaban has increased in popularity, it has been accompanied with a growing body of evidence displaying its ability to cause drug induced liver injury (DILI). Observation. A 74-year-old Caucasian female developed Rivaroxaban DILI two weeks after finishing a 14-day course. …”
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Integration of Artificial Intelligence and Blockchain Technology in Healthcare and Agriculture by Sonali Vyas, Mohammad Shabaz, Prajjawal Pandit, L. Rama Parvathy, Isaac Ofori

“…Integrating these advanced approaches in agriculture is critical for managing food supply chains, drug supply chains, quality maintenance, and intelligent prediction. …”
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Consequences of Hyperoxia and the Toxicity of Oxygen in the Lung by William J. Mach, Amanda R. Thimmesch, J. Thomas Pierce, Janet D. Pierce

“…Oxygen (O2) is life essential but as a drug has a maximum positive biological benefit and accompanying toxicity effects. …”
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A Unique Case of Cardiac Arrest following K2 Abuse by Saif Ibrahim, Farah Al-Saffar, Thomas Wannenburg

“…We describe a case of out-of-hospital cardiac arrest temporally related to abuse of the synthetic cannabinoid street drug known as K2. To our knowledge, there are no previously documented cases of sudden cardiac death associated with synthetic cannabinoids although they have been linked to myocardial infarction in teenagers despite normal coronary angiography (Mir et al. (2011)).…”
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Epigenetic Modifications and Potential New Treatment Targets in Diabetic Retinopathy by Lorena Perrone, Carmela Matrone, Lalit P. Singh

“…Evidences have provided that after a period of poor glucose control insulin or diabetes drug treatment fails to prevent the development and progression of DR even when good glycemic control is reinstituted (glucose normalization), suggesting a metabolic memory phenomenon. …”
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Safety of Pegfilgrastim (Neulasta) in Patients with Sickle Cell Trait/Anemia by Pashtoon Murtaza Kasi, Mrinal M. Patnaik, Prema P. Peethambaram

“…Prescribing information available on manufacturer’s website for the drug warns us about possible severe sickle cell crises related to the medication but does not report the actual incidence or the use in patients with sickle cell trait. …”
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Safe Handling of Food and Water in a Hurricane or Related Disaster by Ronald H. Schmidt, Keith L. Schneider, Renée M. Goodrich, Amarat Simonne, Douglas L. Archer

“…Recommendations have also been included from additional up-to-date sources such as the: Centers for Disease Control and Prevention (CDC), Environmental Protection Agency (EPA), Food and Drug Administration (FDA), Florida Department of Agriculture and Consumer Services (DOACS), Florida Department of Health (DOH), Federal Emergency Management Agency (FEMA), and American Red Cross. …”
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Responsive nanomaterials in biomedicine, patent path and prospect analysis by Xinrui Liu, Hongmei Yuan

“…In recent years, responsive nanomaterials have demonstrated tremendous potential in biomedical applications due to their unique advantages in precise drug delivery and controlled release. For complex diseases such as cancer, chronic inflammation, and genetic disorders, traditional treatment methods are often limited by insufficient targeting and significant side effects. …”
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