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4461
Kinomic profiling to predict sunitinib response of patients with metastasized clear cell Renal Cell Carcinoma
Published 2025-02-01“…With modest OS improvement and variable response and toxicity predictive and/or prognostic biomarkers are needed to personalize patient management: Prediction of individual TKI therapy response and resistance will increase successful treatment outcome while reducing unnecessary drug use and expense. The aim of this study was to investigate whether kinase activity analysis can predict sunitinib response and/or toxicity using tissue samples obtained from primary clear cell RCC (ccRCC) from a cohort of clinically annotated patients with mRCC receiving sunitinib as first-line treatment. …”
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4462
High expression of SULF1 is associated with adverse prognosis in breast cancer brain metastasis
Published 2025-01-01“…Moreover, the sensitivity of SULF1 to existing drugs was explored using drug databases such as RNAactDrug and CADSP. …”
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4463
Probiotics Can Boost the Antitumor Immunity of CD8+T Cells in BALB/c Mice and Patients with Colorectal Carcinoma
Published 2020-01-01“…Background. The drug resistance and the immune suppression in the tumor microenvironment are important factors affecting tumor progression. …”
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4464
Treatment of autonomous intestinal neuropathy in critical care by prucalopride and multistrain probiotic
Published 2018-08-01“…Therapeutic approaches including prescription of prokinetic drug prucalopride and multistrain probiotic containing bifido-and lactobacilli are presented (Bifidobacterium bifidum, B. longum, B. infantis, Lactobacillus rhamnosus). …”
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4465
Molecular and pharmacological heterogeneity of ETV6::RUNX1 acute lymphoblastic leukemia
Published 2025-01-01“…Re-introducing PAX5 in ETV6::RUNX1 ALL of the C2 subtype converts its gene expression and drug resistance profile to C1, with partial blockade of G1 to S transition mediated by CDK6 expression. …”
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4466
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4467
Enhancing chemotherapy response prediction via matched colorectal tumor-organoid gene expression analysis and network-based biomarker selection
Published 2025-02-01“…We applied Consensus Weighted Gene Co-expression Network Analysis (WGCNA) across three datasets: CRC tumors, matched organoids, and an independent organoid dataset with IC50 drug response values, to identify key gene modules and hub genes linked to chemotherapy response, particularly 5-fluorouracil (5-FU). …”
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4468
Coupled CRC 2D and ALI 3D Cultures Express Receptors of Emerging Viruses and Are More Suitable for the Study of Viral Infections Compared to Conventional Cell Lines
Published 2020-01-01“…This novel model can be used for studying virus biology and host response to viral infection and for antiviral drug discovery.…”
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4469
Formulation, characterization, and evaluation of curcumin-loaded ginger-derived nanovesicles for anti-colitis activity
Published 2024-12-01“…Finally, the drugs' in vivo distribution and anti-colitis activity were investigated in mice. …”
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4471
Characteristics and real-world medication persistence of people living with HIV treated with DTG/3TC or BIC/FTC/TAF: a hospital claims database study in Japan
Published 2024-09-01“…Comparable medication persistence was observed with both regimens, aligning with findings from other countries. The 2-drug single-tablet regimen DTG/3TC may be an important ART regimen for PLWH with multiple morbidities and polypharmacy in an aging society. …”
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4472
Effects of Bedaquiline on Antimicrobial Activity and Cytokine Secretion of Macrophages Infected with Multidrug-Resistant Mycobacterium tuberculosis Strains
Published 2022-01-01“…Bedaquiline (Bdq) exerts bactericidal effects against drug-susceptible and drug-resistant Mycobacterium tuberculosis strains, including multidrug-resistant M. tuberculosis strains (MDR-MTBs). …”
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4473
Side Effects of Chloroquine and Primaquine and Symptom Reduction in Malaria Endemic Area (Mâncio Lima, Acre, Brazil)
Published 2015-01-01“…Side effects of antimalarial drug can overlap with malaria symptoms. We evaluated 50 patients with vivax malaria in Mâncio Lima, Acre, treated with chloroquine and primaquine. …”
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4474
Dual functional hydrogel of osteoclastic-inhibition and osteogenic-stimulation for osteoporotic bone defect regeneration
Published 2025-04-01“…In this study, we designed a drug delivery system composed of mesoporous bioactive glass (MBG) and photo-crosslinked hyaluronic acid methacrylate (HAMA). …”
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4475
Clinical Biochemistry /
Published 2017Table of Contents: “…Biochemical investigations and quality control / David Cameron -- Automation / Tim James -- Kidney disease / Edmund Lamb -- Hyperuricaemia and gout / Joanne Marsden -- Fluid and electrolyte disorders / Tim James -- Acid-base disorders / David Tierney -- Clinical enzymology and biomarkers / Paul Collinson, Amy Lloyd -- Liver function tests / Roy Sherwood -- Abnormalities of lipid metabolism / Mike France -- Disorders of calcium, phosphate, and magnesium homeostasis / Nessar Ahmed -- Abnormal pituitary function ; Thyroid disease / Garry McDowell -- Diabetes mellitus and hypoglycaemia / Allen Yates, Ian Laing -- Adrenal disease / John Honour -- Reproductive endocrinology / Ian Laing, Julie Thornton -- Biochemical nutrition / Pat Twomey, William Simpson -- Gastrointestinal disorders and malabsorption / Garry McDowell, Gordon Brydon -- Specific protein markers / Gerald Maguire -- Cancer biochemistry and tumour markers / Joanne Adaway, Gilbert Wieringa -- Inherited metabolic disorders and newborn screening / Mary Anne Preece -- Therapeutic drug monitoring / Robin Whelpton, Nigel Brown, Robert Flanagan -- Chemical toxicology / Gwendolen Ayers.…”
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4476
Clinical Biochemistry ; fundamentals of biomedical science /
Published 2017Table of Contents: “…Biochemical investigations and quality control / David Cameron -- Automation / Tim James -- Kidney disease / Edmund Lamb -- Hyperuricaemia and gout / Joanne Marsden -- Fluid and electrolyte disorders / Tim James -- Acid-base disorders / David Tierney -- Clinical enzymology and biomarkers / Paul Collinson, Amy Lloyd -- Liver function tests / Roy Sherwood -- Abnormalities of lipid metabolism / Mike France -- Disorders of calcium, phosphate, and magnesium homeostasis / Nessar Ahmed -- Abnormal pituitary function ; Thyroid disease / Garry McDowell -- Diabetes mellitus and hypoglycaemia / Allen Yates, Ian Laing -- Adrenal disease / John Honour -- Reproductive endocrinology / Ian Laing, Julie Thornton -- Biochemical nutrition / Pat Twomey, William Simpson -- Gastrointestinal disorders and malabsorption / Garry McDowell, Gordon Brydon -- Specific protein markers / Gerald Maguire -- Cancer biochemistry and tumour markers / Joanne Adaway, Gilbert Wieringa -- Inherited metabolic disorders and newborn screening / Mary Anne Preece -- Therapeutic drug monitoring / Robin Whelpton, Nigel Brown, Robert Flanagan -- Chemical toxicology / Gwendolen Ayers.…”
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4477
A Serious Case of Poisoning Caused by Oral Ingestion of Water-Soluble Fertilizer
Published 2024-10-01“…Physicians implemented antimicrobial stewardship to reduce antimicrobial drug resistance and the risk of hospital infection, and the patient’s inflammatory response was well controlled. …”
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4478
Using In Silico Methods to Identify Protein Tyrosine Kinase A (PtkA) Homolog in Non-Tuberculous Mycobacteria (NTM)
Published 2024-11-01“…Unlike <i>Mycobacterium tuberculosis</i> (<i>Mtb</i>), the causative agent of tuberculosis, NTM species exhibit different pathogenic characteristics and drug resistance mechanisms, making them increasingly relevant in clinical settings. …”
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4479
Applications and challenges in designing VHH-based bispecific antibodies: leveraging machine learning solutions
Published 2024-12-01“…The development of bispecific antibodies that bind at least two different targets relies on bringing together multiple binding domains with different binding properties and biophysical characteristics to produce a drug-like therapeutic. These building blocks play an important role in the overall quality of the molecule and can influence many important aspects from potency and specificity to stability and half-life. …”
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4480
RP-HPLC Determination of Atomoxetine Hydrochloride in Bulk and Pharmaceutical Formulations
Published 2011-01-01“…The method is simple, rapid, selective and economical too and can be used for the routine analysis of drug in pharmaceutical formulations.…”
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