The known unknowns of the Hsp90 chaperone by Laura-Marie Silbermann, Benjamin Vermeer, Sonja Schmid, Katarzyna Tych

“…After decades of research, several ‘known unknowns’ about the molecular function of Hsp90 remain unanswered, hampering rational drug design for the treatment of cancers, neurodegenerative, and other diseases. …”
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VSL#3 Probiotic Upregulates Intestinal Mucosal Alkaline Sphingomyelinase and Reduces Inflammation by Isaac Soo, Karen L Madsen, Qassim Tejpar, Beate C Sydora, Richard Sherbaniuk, Benedetta Cinque, Luisa Di Marzio, Maria Grazia Cifone, Claudio Desimone, Richard N Fedorak

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Machine learning model to predict the adherence of tuberculosis patients experiencing increased levels of liver enzymes in Indonesia. by Dyah Aryani Perwitasari, Imaniar Noor Faridah, Haafizah Dania, Didik Setiawan, Triantoro Safaria

“…The antituberculosis adverse drug reaction and adherence may influence the success of treatment. …”
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Novel Method of Analysis for the Determination of Residual Formaldehyde by High-Performance Liquid Chromatography by Vittoria Delbono, Christopher P. Larch, Katrina Carol Newlands, Shona Rhydderch, Thomas Craven Baddeley, John Mervyn David Storey

“…Consequently, its residual level in drug substances and/or their intermediates needs to be accurately quantified. …”
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Applications of piggyBac Transposons for Genome Manipulation in Stem Cells by Yi Sun, Guang Liu, Yue Huang

“…Over the past few decades, forward genetic screens based on PB transposons have been successfully established to identify genes associated with drug resistance and stem cell-related characteristics. …”
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Leadership Networks as a Tool of Coercion in World Politics by A. I. Podberezkin, O. A. Podberezkina

“…Social media analysis is widely used in economics, sociology, in medical studies of spreading infectious diseases and in forensic science to stop terrorist networks and drug proliferation. Social media analysis is also used in political sphere. …”
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Prophylactic analgesic effect of paracetamol and ibuprofen in the extraction of teeth in children by Mery Cecilia Paccini Torres, Rafael Morales Vadillo

“…In the first two, the corresponding drug was administered orally 30 minutes before surgery (paracetamol 15 mg / kg or Ibuprofen 10 mg / kg). …”
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Risperidone-Induced Neutropenia in a Schizophrenic Patient: A Case Report and Literature Review by Ayodele Atolagbe, Stanley Nkemjika, Olusegun Popoola, Oluwatoyin Oladeji, Irina Kogan, Haroon Saeed, Tolulope Olupona

“…Risperidone, another SGA drug, is linked mainly with metabolic adverse effects, but rarely, blood dyscrasia adverse reactions have been reported. …”
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Antimicrobial Agents Based on Metal Complexes: Present Situation and Future Prospects by Bharti Sharma, Sudeep Shukla, Rohit Rattan, Musarrat Fatima, Mayurika Goel, Mamta Bhat, Shruti Dutta, Rakesh Kumar Ranjan, Mamta Sharma

“…A ray of hope, however, was witnessed in early 1940s with the development of new drug discovery and use of metal complexes as antibiotics. …”
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Blastomyscosis Acquired by Three Children in Toronto by Stacey Bernstein, Hermine I Brunner, Richard Summerbell, Upton Allen, Paul Babyn, Susan E Richardson

“…Pulmonary involvement was present in all three children, while one also had multifocal osteomyelitis. Drug therapy was successful in all three cases, either with amphotericin B followed by itraconazole, or itraconazole alone. …”
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Synthesis, Characterization, and Antimicrobial Activity Studies of Ni(II) Complex with Pyridine as a Ligand by Faridul Islam, Md. Amran Hossain, Nur Mostaq Shah, Hridika Talukder Barua, Md. Alamgir Kabir, Mohammad Jamshed Khan, Romel Mullick

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Therapeutic Activity of Lenalidomide in Mantle Cell Lymphoma and Indolent Non-Hodgkin’s Lymphomas by Marco Gunnellini, Lorenzo Falchi

“…Lenalidomide is an immunomodulatory drug with activity in multiple myeloma, myelodisplastic syndrome and chronic lymphoproliferative disorders. …”
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Preventing Foodborne Illness: E. coli “The Big Six” by Susanna Richardson, Renée M. Goodrich-Schneider, Keith R. Schneider

“…In addition to E. coli O157:H7, the U.S. Food and Drug Administration has identified six serogroups (or “strains”), known as the “big six,” which includes E. coli O26, O45, O103, O111, O121, and O145. …”
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Moscatilin inhibits vascular calcification by activating IL13RA2-dependent inhibition of STAT3 and attenuating the WNT3/β-catenin signalling pathway by Tingting Zhang, Mengmeng Zhu, Jialing Ma, Zhenghong Liu, Zhidan Zhang, Meijie Chen, Yaping Zhao, Huaxin Li, Shengnan Wang, Xiaoning Wei, Wenwen Zhang, Xiaoxiao Yang, Peter J. Little, Danielle Kamato, Hao Hu, Yajun Duan, Baotong Zhang, Jianbo Xiao, Suowen Xu, Yuanli Chen

“…However, effective therapeutic drugs and treatments to delay or prevent vascular calcification are lacking. …”
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Characteristics of adherent and non-adherent patients with hypertension in a Norwegian cross-sectional study by Eirik Olsen, Lene V. Halvorsen, Stine Rognstad, Arleen Aune, Karl Marius Brobak, Ola Undrum Bergland, Vibeke N. Kjær, Knut Liestøl, Marit D. Solbu, Rune Mo, Eva Gerdts, Morten Rostrup, Sverre E. Kjeldsen, Aud Høieggen, Mimi S. Opdal, Anne Cecilie K. Larstorp, Camilla L. Søraas

“…Conclusions: We found fewer non-adherent patients than expected in patients on ≥ 2 antihypertensive drugs compared to previous investigations of patients on ≥ 3 antihypertensive drugs. …”
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Exploring biomarkers and molecular mechanisms of Type 2 diabetes mellitus promotes colorectal cancer progression based on transcriptomics by Simin Luo, Yuhong Zhu, Zhanli Guo, Chuan Zheng, Xi Fu, Fengming You, Xueke Li

“…The relationship of key genes with immune cells and other cells was evaluated by immune infiltration algorithm and single-cell transcription analysis. Drug prediction was performed by cMAP and the obtained drugs were molecularly docked with the key genes. …”
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NF-κB/AP-1-Targeted Inhibition of Macrophage-Mediated Inflammatory Responses by Depigmenting Compound AP736 Derived from Natural 1,3-Diphenylpropane Skeleton by Van Thai Ha, Heung Soo Beak, Eunji Kim, Kwang-Soo Baek, Muhammad Jahangir Hossen, Woo Seok Yang, Yong Kim, Jun Ho Kim, Sungjae Yang, Jeong-Hwan Kim, Yung Hyup Joo, Chang Seok Lee, Joonho Choi, Hong-Ju Shin, Sungyoul Hong, Song Seok Shin, Jae Youl Cho

“…AP736 was identified as an antimelanogenic drug that can be used for the prevention of melasma, freckles, and dark spots in skin by acting as a suppressor of melanin synthesis and tyrosinase expression. …”
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Identification of EARS2 as a Potential Biomarker with Diagnostic, Prognostic, and Therapeutic Implications in Colorectal Cancer by Wang L, Deng X, Tang J, Gong Y, Bu S, Li Z, Liao B, Ding Y, Dai T, Liao Y, Li Y

“…Additionally, the relationships between EARS2 and immune cell infiltration, as well as responses to drug therapy, were examined. Following the knockdown of EARS2, we assessed cell proliferation, migration capabilities, and apoptosis. …”
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Left atrial strain predicts paroxysmal atrial fibrillation recurrence after catheter ablation: a 1-year study using three-dimensional speckle-tracking echocardiography by Rui Zhang, He Li, Yan Wang, Tianle Yu, Jiacheng Li, Yumeng Wu, Zhiwen Yu, Cuixing Liang, Dan Yu, Li Xue

“…Abstract Background Radiofrequency catheter ablation (RFCA) is a widely employed method for restoring sinus rhythm(SR) in patients with drug-refractory paroxysmal atrial fibrillation (PAF). …”
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Increased risk for alcohol- and other substance-exposed pregnancies among women who smoke tobacco: A secondary analysis of a primary care-based intervention by Thomas F. Northrup, Angela L. Stotts, Stephen M. Fischer, Kirk L. von Sternberg, Mary M. Velasquez

“…We compared women who did and did not smoke tobacco on alcohol and drug severity, and psychological distress (e.g. anxiety) at baseline. …”
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