Recent Advances in ADAM17 Research: A Promising Target for Cancer and Inflammation by Marcia L. Moss, Dmitry Minond

“…Researchers have now developed potential drugs for ADAM17 that are selective and do not have the side effects which were seen in earlier chemical entities that targeted this enzyme. …”
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Ipilimumab: A First-in-Class  T-Cell Potentiator for Metastatic Melanoma by Bartosz Chmielowski

“…In 2011, ipilimumab (3 mg/kg every 3 weeks for 4 doses) was approved by the Food and Drug Administration for unresectable or metastatic melanoma. …”
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Cardiopulmonary Failure Requiring ECMO Bypass Resulting from Leukemia Cell Lysis in a Patient with Childhood Acute Myelomonocytic Leukemia by Michael Huang, Erin Owen, Scott Myers, Ashok Raj

“…Cytokine release syndrome from rapid cell lysis was the likely cause as infectious workup failed to reveal a definitive etiology and drug hypersensitivity testing to the chemotherapy agents was negative.…”
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Case Report of Probable DRESS Syndrome Associated with Ribociclib by Florian Carneiro, Marine Bove, Frédérique Beau-Salinas, Tevy San, Pierre Combe

“…Drug reaction with eosinophilia and systemic symptoms (DRESS) is a rare but known and potentially severe side effect of drugs. …”
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Spectrophotometric Determination of Adefovir Dipivoxil in bulk and Pharmaceutical Formulation by Zaheer Ahmed, Y. N. Manohara, K. P. Channabasawaraj, Manish Majumdar

“…The second method is based on the reaction of drug with 1,2 naphthaquinone -4-sulphonic acid sodium salt, under alkaline conditions which absorbs maximally at 454 nm. …”
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Synthesis and Evaluation of Some New Isoquine Analogues for Antimalarial Activity by Chandra Nath Saha, Sanjib Bhattacharya, Dipak Chetia

“…Amodiaquine is a 4-aminoquinoline antimalarial that can cause adverse side effects including hepatic and haematological toxicity. The drug toxicity involves the formation of an electrophilic metabolite, amodiaquine quinoneimine (AQQI), which binds to cellular macromolecules leading to hepatotoxicity and agranulocytosis. …”
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Lithium Induced Amenorrhea: A First Case Report by Balakumar KE, Vandana Tayal, Vidhya Egambarame, Vandana Roy

“…Although antipsychotic medications are known to cause amenorrhea due to dopamine receptor blockade, which may result in hyperprolactinemia, the patient’s symptoms began before she started these medications. Only drug that she was on for long period is lithium. …”
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Incidental Discovery of Hepatocellular Carcinoma on 18F-PSMA PET CT Performed for Prostate Cancer Reassessment by Lauren Hekman, Eva Napierkowski, Natalie C. Hartman, Jeffrey L. Ellis, Robert H. Wagner, Davide Bova, Maria M. Picken, Robert C. Flanigan

“…Prostate-specific membrane antigen positron emission tomography (PSMA PET) has been approved by the Food and Drug Administration (FDA) to identify prostate cancer in the setting of biochemical recurrence but can also identify other malignancies. 18F-PSMA PET has not been studied as a potential tool for hepatocellular carcinoma (HCC). …”
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Electronic Tools for Infectious Diseases and Microbiology by Steven D Burdette

“…New electronic tools include e-mail listservs, electronic drug databases and search engines that allow focused clinical questions. …”
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The high-density lipoprotein binding protein HDLBP is an unusual RNA-binding protein with multiple roles in cancer and disease by Jonathan Feicht, Ralf-Peter Jansen

“…We also aim at addressing the possible use of HDLBP as a drug target or biomarker and discuss its future implications.…”
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Catatonia as a Result of a Traumatic Brain Injury by Jessica Berthelot, Jacob Cambre, Madeline Erwin, Jennifer Phan

“…We discuss factors that led to the delay in diagnosis, including lack of training in recognition of catatonia, suspicion of feigned symptoms for secondary gain, and the implication of stigma in an African American young male arrested for a drug-related crime.…”
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In Utero Stem Cell Transplantation: Potential Therapeutic Application for Muscle Diseases by Neeladri Chowdhury, Atsushi Asakura

“…We therefore propose in utero transplantation as a potential method to generate patient-derived humanized skeletal muscle as well as muscle stem cells in animals for therapeutic purposes as well as patient-specific drug screening.…”
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Rimonabant: From RIO to Ban by Amir H. Sam, Victoria Salem, Mohammad A. Ghatei

“…This paper provides a brief overview of the Rimonabant story and places the recent spate of FDA rejections of other centrally acting weight loss drugs entering Phase 3 trials in this context.…”
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The therapeutic agents that target ATP-sensitive potassium channels by Rubaiy Hussein N.

“…ATP-sensitive potassium (KATP) channels are a major drug target for the treatment of type-2 diabetes. …”
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Synthesis and Characterization of Novel Copolymeric Resveratrol Conjugates by Yan-Jing Ng, Heather A. E. Benson, David H. Brown, Yan Chen

“…Resveratrol (RSV), naturally found in plants, is known to have health benefits and has been proposed as a potential anticancer and cardioprotective drug. However, due to its molecular structure, it undergoes rapid metabolism in the body resulting in low bioavailability. …”
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South African Rheumatism and Arthritis Association 2024 updated guidelines for the management of rheumatoid arthritis by G Tarr, N Govind, M Seboka, E Gardiner, B Hodkinson

“…These guidelines recommend a treat-to-target strategy using a composite disease activity score at each visit, with frequent follow-up and escalation or switching of disease-modifying antirheumatic drug (DMARD) therapy until the goal of low disease activity is achieved. …”
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Nanoparticle-Based Therapies for Management of Subarachnoid Hemorrhage, Neurotrauma, and Stroke by Grace Hey, Ilyas Mehkri, Yusuf Mehkri, Hasan Maqbool, Mubariz Tahirkheli, Samuel Woodford, Brandon Lucke-Wold

“…Nanoparticle (NP) technology allows for deliberate, modular, and minimally invasive drug delivery. This literature review encompasses pertinent information on the impact and versatility of nanoparticle therapeutics when treating neurotrauma, stroke, and SAH. …”
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Mathematical Model for Transmission and Control of Malaria Disease in Ihandiro Sub-County Kasese District. by Birumbu, Brian

“…A mathematical model was developed to examine the dynamics of malaria in Uganda, factoring in drug resistance, treatment methods, and the use of mosquito nets as preventive measures. …”
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The hypolipidemic effect of MI-883, the combined CAR agonist/ PXR antagonist, in diet-induced hypercholesterolemia model by Jan Dusek, Ivana Mejdrová, Klára Dohnalová, Tomas Smutny, Karel Chalupsky, Maria Krutakova, Josef Skoda, Azam Rashidian, Ivona Pavkova, Kryštof Škach, Jana Hricová, Michaela Chocholouskova, Lucie Smutna, Rajamanikkam Kamaraj, Miloš Hroch, Martin Leníček, Stanislav Mičuda, Dirk Pijnenburg, Rinie van Beuningen, Michal Holčapek, Libor Vítek, Magnus Ingelman-Sundberg, Oliver Burk, Thales Kronenberger, Radim Nencka, Petr Pavek

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The gut–kidney axis is regulated by astragaloside IV to inhibit cyclosporine A-induced nephrotoxicity by Cong Han, Ran-ran Gao, Le Zhou, Wei Li

“…Six coexpression pathways related to transcription and metabolism, including the citrate cycle, ascorbate and aldarate metabolism, proximal tubule bicarbonate reclamation, glycolysis/gluconeogenesis, ferroptosis, and drug metabolism–cytochrome P450, were identified. …”
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