Gene Therapy for HIV Infections: Intracellular Immunization by Alain Piché

“…The inability of traditional drug-based therapies to inhibit HIV replication effectively for extended periods of time has stimulated intense research to develop novel approaches for this disease. …”
Get full text

Investigating a Case of Recurrent Pleural Effusion by Patrícia Rodrigues, Maria Neves, João Pedro Ferreira, Miguel Araújo Abreu, Fernanda Almeida

“…We decided to suspend this drug, with resolution of the pleural effusion and respiratory complaints for more than a year now. …”
Get full text

Treatment of Inflammatory Bowel Disease in Children by D Grant Gall

“…Prednisone remains the drug of choice in severe ulcerative colitis and active Crohn's disease. …”
Get full text

Uncovering the Binding Mechanism of Mutated Omicron Variants via Computational Strategies by Sajjad Haider, Nadeem Ahmad, Muhammad Shafiq, Ali Raza Siddiqui, Mohammad Nur-e-Alam, Aftab Ahmed, Zaheer Ul-Haq

Get full text

Treatment of Severe Acetaminophen–Induced Hepatocellular Injury with Prostaglandin E: Two Case Reports by Marina Khatchatourian, Hillar Vellend

“…Drugs have long been recognized as culprits in hepatocellular injury. …”
Get full text

The Food Safety Modernization Act and the FDA Facility Registration Program by Susanna Richardson, Renée M. Goodrich-Schneider, Mark A. Ritenour, Michelle D. Danyluk, Keith R. Schneider

“…The Food Safety Modernization Act that President Obama signed into law January 4, 2011 represents the most sweeping update to food safety regulation since the Federal Food, Drug, and Cosmetic Act of 1938. As part of FSMA, registration is required of facilities that manufacture, process, pack or hold food for human or animal consumption. …”
Get full text

Squamous Cell Carcinoma of the Lung with Metastasis to the GI Tract Associated with EGFR Exon 19 Deletion by Glen J. Weiss, Agnes K. Liman, Jeffrey Allen, Philip Y. Cheung, Rajesh N. Kukunoor

“…Consideration of EGFR exon 19 mutation testing in SCC of the lung, particularly for those with GI tract metastasis, may identify this potentially drug-targetable entity.…”
Get full text

Clinical features of chronic pancreatitis at elderly patients with severe mesenteric atherosclerosis by O. S. Shifrin, I. A. Sokolina, T. L. Lemina

“…Gastroduodenal erosions with relative resistance to drug treatment were more frequently diagnosed in these patients.Conclusion. …”
Get full text

Leflunomide-Induced Hidradenitis Suppurativa by Achraf Machan, Hasna Azendour, Hamza Toufik, Lahsen Achemlal, Mohammed Boui, Naoufal Hjira

“…Hidradenitis suppurativa is an inflammatory disease of the pilosebaceous unit with a chronic intermittent course and a devastating effect on quality of life. Rare reports of drug-induced hidradenitis suppurativa exist. We report on 2 women on follow-up for rheumatoid arthritis, who presented hidradenitis suppurativa after different periods of treatment with leflunomide and who improved few weeks after discontinuation of the medication.…”
Get full text

Ulipristal Acetate in Myomectomy Optimization in an Infertile Patient with Giant Myomas by Elena de la Fuente, María Dolores Borrás, Miriam Rubio, Nuria Abril

“…The use of ulipristal acetate (UPA) has been recently introduced in the treatment of uterine leiomyomas. This drug has proven useful to control menometrorrhagia and to reduce myoma size. …”
Get full text

Stability Indicating Analytical Method Development and Validation of Efavirenz Quantification by High Performance Liquid Chromatographic Technique by R. Kumar, M. Sharma, G. R. Verma

“…A stability-indicating high performance liquid chromatography (HPLC) method is developed for the quantification of efavirenz drug substance. Selected mobile phase is a combination of 50 volume of acetonitrile and 50 volume of 0.86% w/v solution of ammonium dihydrogen phosphate, pH adjusted to 3.0 with orthophosphoric acid. …”
Get full text

Anti-Quorum Sensing in Pathogenic Microbes Using Plant-Based Bioactive Phytochemicals by Kumaran Subramanian, Harshni Selvaraj, Balakrishnan K, Pugazhvendan Sampath Renuga, Velmurugan S, Wilson Aruni

Get full text

NSAID-Induced Small Bowel Diaphragms and Strictures Diagnosed with Intraoperative Enteroscopy by Douglas A Shumaker, Kari Bladen, Ronald M Katon

“…Nonsteroidal anti-inflammatory drugs are known to cause mucosal damage in the stomach and duodenum, which may lead to hemorrhage and perforation. …”
Get full text

Molecular Basis of Triple Negative Breast Cancer and Implications for Therapy by Parvin F. Peddi, Matthew J. Ellis, Cynthia Ma

“…Understanding the molecular basis of triple negative breast cancer is crucial for effective new drug development. Recent genomewide gene expression and DNA sequencing studies indicate that this cancer type is composed of a molecularly heterogeneous group of diseases that carry multiple somatic mutations and genomic structural changes. …”
Get full text

Electrospun Fibers: Versatile Approaches for Controlled Release Applications by Sepideh Karimi Afshar, Mohammadmohsen Abdorashidi, Farid Abedin Dorkoosh, Hamid Akbari Javar

“…A lot of studies have been conducted, especially in tissue engineering and drug delivery using electrospun fibers. Loading many different drugs and bioactive agents on or within these fibers potentiates the efficacy of such systems; however, there are still no commercial products with this technology available in the market. …”
Get full text

The Individualized Management Approach for Acute Poisoning by Muneera Al-Jelaify, Suliman AlHomidah

“…Our opinions as experts from the King Saud University (KSU) Drug and Poison Information Center (DPIC) were considered in the review.…”
Get full text

A Case of Persistent Bacillus cereus Bacteremia Responding to a Combination of Vancomycin and Gentamicin by Hiroshi Sasano, Toshihiro Yoshizawa, Mai Suzuki, Yukiko Fukui, Ryutarou Arakawa, Naoto Tamura, Toshio Naito

“…This combination therapy may increase the risk of developing renal dysfunction, but the risk can be mitigated by appropriate therapeutic drug monitoring (TDM) and dose adjustments to achieve successful treatment.…”
Get full text

Role of interventions in diagnosis and management of lung disorders in rheumatic diseases by Venkata Nagarjuna Maturu, Chetan Rao Vaddepally, V Pratibh Prasad

“…The pulmonary manifestation can be a part of the active disease, or be because of infectious complications, drug-induced changes, or pulmonary manifestations of other organ failure. …”
Get full text

Oleanane and Stigmasterol-Type Triterpenoid Derivatives from the Stem Bark of Albizia gummifera and Their Antibacterial Activities by Tamrat Tesfaye Ayele, Getahun Tadesse Gurmessa, Zelalam Abdissa, Girmaye Kenasa, Negera Abdissa

“…Compounds 1, 2, and 4 showed marginal antibacterial activity with the growth inhibition zone ranging from 6.8 to 13.2 mm against the tested bacterial strains, with compounds 2 and 4 showing significant inhibition (13.0 and 13.2 mm) against S. flexneri and S. typhimurium, respectively. While, the standard drug, gentamycin showed inhibition zone 20.0 and 24.0 mm against S. flexneri and S. typhimurium, respectively.…”
Get full text

Synthesis and Evaluation of Antimicrobial Activities of Novel N-Substituted Indole Derivatives by Tanveer MahamadAlli Shaikh, Habtamu Debebe

“…Indole motifs are one of the most significant scaffolds in the discovery of new drugs. We have described a synthesis of new N-substituted indole derivatives (1-3), and their in vitro antimicrobial activities were investigated. …”
Get full text