Whole-of-community interventions that address alcohol-related harms: protocol for a scoping review by Asha S George, Tanya Doherty, Mark Tomlinson, Nandi Siegfried, Ida Okeyo, Ulla Walmisley, Michelle De Jong, Carmen Späth, Nadine Harker

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Predictors, patterns, and correlates of moderate-severe psychological distress among New York City College Students during Waves 2–4 of COVID-19 by Craig J. Heck, Deborah A. Theodore, April Autry, Brit Sovic, Cynthia Yang, Sarah Ann Anderson-Burnett, Caroline Ray, Eloise Austin, Joshua Rotbert, Jason Zucker, Marina Catallozzi, Magdalena E. Sobieszczyk, Delivette Castor

“…Unique MS-PD correlates encompassed drug use and TGNC identity. Trajectories comprised Persistently (40%), Highly (24% MS-PD twice/thrice), Minimally (15% MS-PD once), and Never (21%) Distressed. …”
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ANGPTL3 overcomes sorafenib resistance via suppression of SNAI1 and CPT1A in liver cancer by Yang-Hsiang Lin, Cheng-Yi Chen, Hsiang-Cheng Chi, Meng-Han Wu, Ming-Wei Lai, Chau-Ting Yeh

“…Liver cancer, encompassing hepatocellular carcinoma (HCC) and hepatoblastoma, the latter of which primarily occurs in early childhood, is the most common malignant tumor arising from liver and is responsible for a significant number of cancer-related deaths worldwide. Targeted drugs have been used for anti-liver cancer treatment in the advanced stage, while their efficacy is greatly compromised by development of drug resistance. …”
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Mapping knowledge landscapes and emerging trends in artificial intelligence for antimicrobial resistance: bibliometric and visualization analysis by Zhongli Wang, Zhongli Wang, Gaopei Zhu, Shixue Li, Shixue Li

“…Keyword analysis identified six enduring research clusters from 2014 to 2024: sepsis, artificial neural networks, antimicrobial resistance, antimicrobial peptides, drug repurposing, and molecular docking, demonstrating the sustained integration of AI in antimicrobial therapy development. …”
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In-situ formation mechanism of endogenous fluorescent carbon dots during the roasting process of small yellow croaker (Larimichthys polyactis) by Yutong Qu, Shuyi Zhao, Jilong Ni, Long Jiao, Xiaoye Zhang, Soottawat Benjakul, Zhiyu Liu, Xiang Chen, Bin Zhang

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Improvement in XIa Selectivity of Snake Venom Peptide Analogue BF9-N17K Using P2′ Amino Acid Replacements by Li Ding, Zhiping Zhai, Tianxiang Qin, Yuexi Lin, Zhicheng Shuang, Fang Sun, Chenhu Qin, Hongyi Luo, Wen Zhu, Xiangdong Ye, Zongyun Chen, Xudong Luo

“…Coagulation factor XIa is a new serine-protease family drug target for next-generation anticoagulants. With the snake venom Kunitz-type peptide BF9 as the scaffold, we obtained a highly active XIa inhibitor BF9-N17K in our previous work, but it also inhibited the hemostatic target plasmin. …”
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Podophyllotoxin mediates hepatic toxicity via the C5a/C5aR/ROS/NLRP3 and cGMP/PKG/mTOR axis in rats based on toxicological evidence chain (TEC) concept by phosphoproteomic analysis by Chuanxin Liu, Xiaobin Huang, Jiao Kong, Xuejiao Li, Yuming Wang, Fangfang Zhang, Jiajia Duan

“…Background: Podophyllotoxin (PPT), a highly active compound extracted from the rhizome of Dysosma versipellis (DV), has been used as an effective anti-cancer drug clinically since the 1950s. It possesses various biological activities, including antiviral and antitumor effects. …”
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QALYs: The Math Doesn’t Work by Tia G. Sawhney, Angela Dobes, Sirimon O'Charoen

“…The quality-adjusted life-year (QALY) is a metric widely used when assessing the cost-effectiveness of drugs and other health interventions. The assessments are used in the development of recommendations for pricing, formulary placement decisions, and health policy decisions. …”
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Cannabinoid receptor 2 facilitates the Schwann cells‐dependent peripheral nerve regeneration by Heng Xu, Lu Wen, Yi Luo, Jiaying Zhou, Sheng Yao, Wei Ding, Jing Feng

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Remaining of contrast dye ice cap during PVI by cryoballoon ablation; a case report by Ahmad Yamini Sharif, Entezar Mehrabi Nasab

“…Abstract Pulmonary vein isolation (PVI) with cryoballoon (CB) ablation technology is widely used to treat drug-resistant atrial fibrillation (AF). During CB ablation, there is a possibility of forming an ice cap of contrast-color on top of the balloon. …”
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Viral Response to Specifically Targeted Antiviral Therapy for Hepatitis C and the Implications for Treatment Success by Curtis L Cooper

“…Optimism must be tempered with concerns related to the rapid development of drug resistance with resulting HCV rebound. Strategies including induction dosing with interferon and ribavirin, use of combination high-potency STAT-C molecules and an intensive emphasis on adherence to HCV antiviral therapy will be critical to the success of this promising advance in HCV therapy.…”
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Triple Active Antiretroviral Regimen Including Enfuvirtide Via the Biojector is Effective and Safe by Mona Loutfy, Colin Kovacs

“…For full HIV virological suppression, three fully active antiretroviral agents are required. New drug classes should be included to ensure that agents are fully active. …”
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Development of Biodegradable Delivery Systems Containing Novel 1,2,4-Trioxolane Based on Bacterial Polyhydroxyalkanoates by Sergei Y. Lipaikin, Ivan A. Yaremenko, Alexander O. Terent’ev, Tatiana G. Volova, Ekaterina I. Shishatskaya

“…Main systems’ characteristics were investigated: the particle yield, average diameter, zeta potential, surface morphology, loading capacity, and drug release profile of microparticles, as well as surface morphology and release profiles of OZ-containing films. …”
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DETERMINANTS OF PREFERANCE OF HOMEOPATHICF TO ALLOPATHIC TREATMENT by Aymen Naeem

“…It was introduced by a German doctor who believed that minimum dose of a drug can alleviate the symptoms similar to other conventional forms of treatment. …”
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The Canadian Multicentre MAC Treatment Study by Stephen D Shafran, The Canadian HIV Trials Network

“…While it is acknowledged thal MAC infection requires treatment with a combination of antimycobacterial drugs. the optimal regimen has not been defined. …”
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Progress in the structural modification and pharmacological activity of isosteviol by Tao Wang, Bowen Pan, Lijuan Liu, Zhangchao Dong, Wenhui Zhang, Xiongwei Liu, Ying Zhou, Yang Shi

“…Because of its unique diterpene skeleton, isosteviol is frequently used as an active framework in drug synthesis, thus helping medicinal chemists design highly selective, potentially active, and multifunctional isosteviol analogs for the treatment of various diseases. …”
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Allergic response to nasal administration of dexpanthenol in a child. A case report and a review of the literature by Mikołaj Turski, Małgorzata Łukasiewicz, Piotr Sajdak, Seweryn Ziajor, Artur Bednarski, Justyna Tomasik, Marcel Stodolak

“…The withdrawal of all drugs but cetirizine led to full recovery. Dexpanthenol, an alcohol analog of vitamin B5, is present in many drugs for its positive impact on tissue repair. …”
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COMPREHENSIVE TREATMENT OF PATIENTS WITH PROSTATITIS FROM THE VIEWPOINT OF MODERN REQUIREMENTS by H.V. Bachurin

“…The second causes of prostatitis were Staphylococcus epidermidis and hemolyticus in 31 patients. The opportunities of drug influence on microorganisms were clearly defined. …”
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