Henrique Soares Carneiro, Transformaciones del significado de la palabra “droga”: de las especias coloniales al prohibicionismo contemporáneo by David Herrera Castrillón, Henrique Soares Carneiro

“…Abstract Henrique Carneiro's text analyzes the conceptual evolution that gives the term "drug"a multiplicity of meanings, ranging from poison to medicine, from original substances of the country to phytotherapeutic medicines, and also examines the conflicts between indigenous knowledge and its appropriation by colonial society.…”
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Mania as a Rare Adverse Event Secondary to Steroid Eye Drops by Moayyad Alsalem, Majed A. Alharbi, Rayan A. Alshareef, Raghad Khorshid, Salman Thabet, Abdulrahman Alghamdi

“…These behavioral or psychiatric adverse events usually appear within a few days after commencing GCs and are possibly to reverse with drug withdrawal. We present a rare case of a 75-year-old woman who developed mania during treatment with GC eye drops following cataract surgery. …”
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Research progress of double network hydrogel in the field of bone regeneration by ZHANG Tianyi, ZHENG Yi, LYU Wenhao, MA Ning

“…This article summarizes the advantages of DN hydrogels used in bone tissue regeneration, and introduces the effect of DN hydrogel systems on the behavior of loading cells, drug delivering in bone reparation, and the application of DN hydrogel system in microenvironment construction, bioactive composite materials, and antibacterial activity to meet the needs of bone regeneration.…”
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Moving “Forward” in Plasmodium Genetics through a Transposon-Based Approach by Bharath Balu

“…Even with certain limitations, the technique has already shown significant promise to increase our understanding of parasite biology needed for rationalized drug and vaccine design. Further improvements to the mutagenesis technique and the design of novel genetic screens should lead us to some exciting discoveries about the critical weaknesses of Plasmodium, and greatly aid in the development of new disease intervention strategies.…”
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Cannabidiol Rescues Acute Hepatic Toxicity and Seizure Induced by Cocaine by Luciano Rezende Vilela, Lindisley Ferreira Gomides, Bruna Araújo David, Maísa Mota Antunes, Ariane Barros Diniz, Fabrício de Araújo Moreira, Gustavo Batista Menezes

“…Cocaine is a commonly abused illicit drug that causes significant morbidity and mortality. …”
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In situ template synthesized silver nanoparticulate banana fibre materials with antimicrobial and antibiotic release properties: Efficacy evaluation in ex vivo wound infection mode... by Pompi Das, Debajit Mahanta, Sharmila Giogi, Tarh Kaha, Ngurang Nisha, Sanjeeb Kalita

“…Controlled release studies of amoxicillin-loaded composites demonstrated sustained drug release over 72 hours, achieving a cumulative release of 81.6 % in BFS-SNP-AMOX. …”
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Embracing Generative Artificial Intelligence in Clinical Research and Beyond by Henry P. Foote, MD, Chuan Hong, PhD, Mohd Anwar, PhD, Maria Borentain, MD, Kevin Bugin, PhD, Nancy Dreyer, PhD, MPH, Josh Fessel, MD, PhD, Nitender Goyal, MD, Morgan Hanger, MPP, Adrian F. Hernandez, MD, Christoph P. Hornik, MD, PhD, MPH, Jennifer G. Jackman, PhD, MBA, Alistair C. Lindsay, MD, MPH, DPhil, Michael E. Matheny, MD, Kerem Ozer, MD, Jan Seidel, PhD, Norman Stockbridge, MD, PhD, Peter J. Embi, MD, Christopher J. Lindsell, PhD

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Lymphatic-derived oxysterols promote anti-tumor immunity and response to immunotherapy in melanoma by Mengzhu Sun, Laure Garnier, Romane Chevalier, Martin Roumain, Chen Wang, Julien Angelillo, Julien Montorfani, Robert Pick, Dale Brighouse, Nadine Fournier, David Tarussio, Stéphanie Tissot, Jean-Marc Lobaccaro, Tatiana V. Petrova, Camilla Jandus, Daniel E. Speiser, Manfred Kopf, Caroline Pot, Christoph Scheiermann, Krisztian Homicsko, Giulio G. Muccioli, Abhishek D. Garg, Stéphanie Hugues

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Patterns of pharmacological treatment in patients with atrial fibrillation: an analysis from the prospective GLORIA-AF Registry Phase III by Bernadette Corica, Giulio Francesco Romiti, Giuseppe Boriani, Brian Olshansky, Tze-Fan Chao, Menno V. Huisman, Marco Proietti, Gregory Y. H. Lip, on behalf of the GLORIA-AF Investigators

“…Little is known about how prescribed drug patterns affect management and prognosis in patients with AF. …”
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Rifabutin and Furazolidone Could Be the Candidates of the Rescue Regimen for Antibiotic-Resistant H. pylori in Korea by Youn I Choi, Sang-Ho Jeong, Jun-Won Chung, Dong Kyun Park, Kyoung Oh Kim, Kwang An Kwon, Yoon Jae Kim, Seol So, Jeong Hoon Lee, Jin-Young Jeong, Sun-Mi Lee

“…However, microbiological culture data on drug-resistant H. pylori is lacking. This study evaluated the antimicrobial efficacy of candidate antibiotics against resistant H. pylori strains. …”
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PWWP domain-containing protein Crf4-3 specifically modulates fungal azole susceptibility by regulating sterol C-14 demethylase ERG11 by Pengju Yu, Shuting Ye, Mi Zhou, Long Zhang, Zhongchi Zhang, Xianyun Sun, Shaojie Li, Chengcheng Hu

“…ABSTRACT The widespread use of azole antifungals in agriculture and clinical settings has led to serious drug resistance. Overexpression of the azole drug target 14α-demethylase ERG11 (CYP51) is the most common fungal resistance mechanism. …”
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Options of improvement of efficacy of gastroesophageal reflux disease treatment by dioctaedric smectite by O. A. Storonova, A. S. Trukhmanov, N. Yu. Ivashkina, V. T. Ivashkin

“…Dioctaedric smectite appears an effective drug as monotherapy of NERD. The chief advantage in treatment of GERD is ability of the drug to stop all reflux types: acidic, weakly acidic, and weakly alkalinic.…”
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Development and Characterization of a Hydrogel Containing Chloramphenicol-Loaded Binary Ethosomes for Effective Transdermal Permeation and Treatment Acne in Rat Model by Liu RJ, Li M, Zhu Q, Liu HY, Zhang XX, Han XY, Yu MJ, Zhou JW, Han CY

“…CLSM and ATR-FTIR confirm that loading CAM into a binary ethosomes enables drugs to pass more easily through the stratum corneum. …”
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Development and Evaluation of Aloperine-Loaded Nanostructured Lipid Carriers for the Treatment of Pulmonary Arterial Hypertension by Liu H, Liu S, Ma P, Ma L, Liu Y, Zhao F, Zhou R

“…The drug release profile demonstrated good sustained-release characteristics in vitro, and the formulation remained stable for up to 15 days when stored at 4°C. …”
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High uric acid model in Caenorhabditis elegans by Zhenjing Li, Yibin Xue, Nifei Wang, Jingli Cheng, Xiaoying Dong, Qingbin Guo, Changlu Wang

“…A high uric acid model with low drug damage and high efficiency and stability was established in C. elegans after simply xanthine treatment. …”
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Thiopurines in the Management of Crohn’s Disease: Safety and Efficacy Profile in Patients with Normal TPMT Activity—A Retrospective Study by Amine Benmassaoud, Xuanqian Xie, Motaz AlYafi, Yves Theoret, Alain Bitton, Waqqas Afif, Talat Bessissow

“…Harvey-Bradshaw index, treatment failure, and drug-related adverse events were recorded. Results. …”
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AMPK: An energy sensor for non-small cell lung cancer progression and treatment by Zhi-Ting Zhong, Xu-Yan Wang, Ying Pan, Ke Zhou, Jing-Hui Chen, Yu-Qi Gao, Bo Dai, Zhi-Ling Zhou, Rui-Qi Wang

“…In summary, this paper highlights the critical importance of developing AMPK-targeted drugs to enhance therapeutic efficacy in NSCLC, as well as the potential for applying these drugs in clinical therapy to overcome drug resistance.…”
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Personalized Therapy in a Patient With EGFR-Mutated NSCLC Developing Sequential CCDC6-RET Fusion and BRAF V600E Mutation as Bypass Resistance Mechanisms by Arianna Marinello, MD, Claudia Parisi, MD, Damien Vasseur, PhD, David Combarel, PharmD, Juliette Bihoreau, NP, Pernelle Lavaud, MD, Rémy Ezzedine, MD, Lodovica Zullo, MD, Luc Friboulet, PhD, Gerard Zalcman, MD, PhD, Antoine Italiano, MD, PhD, Benjamin Besse, MD, PhD, Mihaela Aldea, MD, PhD

“…Nevertheless, treatment was discontinued for toxicity, highlighting the challenges of using multiple drug combinations to address complex resistance.…”
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Pirfenidone regulates seizures through the HMGB1/TLR4 axis to improve cognitive functions and modulate oxidative stress and neurotransmitters in PTZ-induced kindling in mice by Mansi Dahalia, Sparsh Gupta, Haya Majid, Divya Vohora, Nidhi

“…Pirfenidone, an antifibrotic drug, has shown anti-inflammatory and antioxidant properties in various disease models, including neurological conditions. …”
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Timeliness metrics for screening and preventing TB in household contacts of pulmonary TB patients in Kenya by D. Nair, P. Thekkur, I. Mbithi, M. Khogali, R. Zachariah, S. Dar Berger, S. Satyanarayana, A. M. V. Kumar, I. Kathure, J. Mwangi, A. F. Bochner, A. McClelland, J. M. Chakaya, A. D. Harries

“…In 65% of 1,105 HHCs eligible for further evaluation, anti-TB treatment, TPT or a decision for no drugs was made within 7 days of screening (“Second 7”). …”
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