Surveillance and characteristics of vancomycin-resistant Enterococcus isolates in a Chinese tertiary hospital in Shenzhen, 2018 to 2024 by Hongwei Shen, Qiaomin Zhang, Shaobo Li, Tingting Huang, Wen Ma, Daming Wang, Peng Li

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Antimicrobial Susceptibility of <i>Salmonella typhi</i> and <i>paratyphi</i> among Pediatric Population at Tertiary Care Center of North Delhi: A Retrospective Study by Shekhar Biswas, Sulagna Tripathy, Arvind Kumar, Sanjay Chattree

“…With the inappropriate use of antibiotics and rising trends of multidrug-resistant (MDR) and extensively drug-resistant (XDR) typhoid, it is becoming a public health emergency. …”
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Efficacy and safety of the first domestic pegilated interferon alpha-2b «Pegaltevir» at chronic hepatitis C: pilot data of phase III clinical study by V. T. Ivashkin, Ye. N. Bessonova, P. O. Bogomolov, N. I. Geyvandova, K. V. Zhdanov, M. V. Mayevskaya, V. G. Morozov, V. D. Pasechnikov, I. Yu. Khomenko, A. V. Yagoda

“…Groups differed in relation to received drug and hepatitis C virus genotype. All patients received 1,5 mkg per 1 kg body weight per week of Pegaltevir or PegIntron and 800–1400 mg of ribavirin per day. …”
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Suicidality and Illness Course Worsening in a Male Patient with Bipolar Disorder during Tamoxifen Treatment for ER+/HER2+ Breast Cancer by Claudia Carmassi, Francesco Pardini, Valerio Dell’Oste, Annalisa Cordone, Virginia Pedrinelli, Marly Simoncini, Liliana Dell’Osso

“…Tamoxifen is a selective estrogenic receptor modulator (SERM) drug. In addition to its common use in breast cancer ER+, Tamoxifen has been object of growing interest in psychiatry as antimanic drug. …”
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Determinants of Virologic Failure among Adult HIV Patients on First-Line Antiretroviral Therapy at Waghimra Zone, Northern Ethiopia: A Case-Control Study by Abrham Emagnu, Zenahebezu Abay, Abera Balcha Bulti, Yaregal Animut

“…This study showed that poor adherence to treatment, longer duration on ART, experiencing drug toxicity, older age, and recent CD4 <200 cell/mm³ are factors that increase the risk of virologic failure.…”
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Simultaneous Quantification of Aspirin, Its Metabolite Salicylic Acid, and Salvianolic Acid B in Human Plasma Using UPLC-MS/MS by Weiyi Cao, Hezhi Yao, Zhenzhen Qian, Yi Wu, Shuge Wang, Rui Li, Rui Gao

“…To support clinical studies on drug-drug interactions (DDIs) between salvianolate injection and aspirin, a rapid and sensitive UPLC-MS/MS method for the simultaneous determination of aspirin (acetylsalicylic acid), its metabolite salicylic acid, and salvianolic acid B in human plasma was developed. …”
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Demographic and Clinical Determinants of Tuberculosis and TB Recurrence: A Double-Edged Retrospective Study from Pakistan by Mariam Ahmed Mujtaba, Matthew Richardson, Hira Shahzad, Muhammad Ishaq Javed, Ghazala Kaukab Raja, Pakeeza Arzoo Shaiq, Pranabashis Haldar, Sadia Saeed

“…Further exploring the TB cases increasing age, drug resistance and smear positivity stood out to be the major sociodemographic and clinical factors of TB recurrence despite high disease awareness.…”
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Knowledge and perceptions about clinical research and its ethical conduct among college students from non-science background: a representative nation-wide survey from India by Jeffrey Pradeep Raj, Suraj Kallarakal Tomy, Amrutha Jose, Aadrika Kashyap, Joseph Varghese Kureethara, Tomy K Kallarakal

“…Thus, we aim to investigate if the pandemic has influenced awareness and attitudes towards CR given the wide mass and social media coverage on drug/vaccine development process.Methods This was an online survey conducted among young adults enrolled as students in a university in south India between 15 September 2022 and 31 October 2022. …”
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VIBE: an R-package for VIsualization of Bulk RNA Expression data for therapeutic targeting and disease stratification by Indu Khatri, Saskia D. van Asten, Leandro F. Moreno, Brandon W. Higgs, Christiaan Klijn, Christiaan Klijn, Francis Blokzijl, Iris C. R. M. Kolder

“…BackgroundDevelopment of cancer treatments such as antibody-based therapy relies on several factors across the drug-target axis, including the specificity of target expression and characterization of downstream signaling pathways. …”
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Efficacy of PD-1/PD-L1 Inhibitors versus Chemotherapy in Lung Cancer with Brain Metastases: A Systematic Review and Meta-Analysis by Xiaojun Yang, Yihong Zeng, Qinquan Tan, Zhihua Huang, Jun Jia, Guanming Jiang

“…Further studies are needed to confirm the role of ICIs in different pathological types and drug treatment modalities.…”
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Discovery of orally bioavailable SARS-CoV-2 papain-like protease inhibitor as a potential treatment for COVID-19 by Yongzhi Lu, Qi Yang, Ting Ran, Guihua Zhang, Wenqi Li, Peiqi Zhou, Jielin Tang, Minxian Dai, Jinpeng Zhong, Hua Chen, Pan He, Anqi Zhou, Bao Xue, Jiayi Chen, Jiyun Zhang, Sidi Yang, Kunzhong Wu, Xinyu Wu, Miru Tang, Wei K. Zhang, Deyin Guo, Xinwen Chen, Hongming Chen, Jinsai Shang

“…Currently, all FDA-approved antiviral drugs against SARS-CoV-2 are RdRp or 3CLpro inhibitors. …”
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In vitro evaluation of the antibacterial effects of monomer components of Pithecellobium clypearia against aquatic pathogens and synergy with enrofloxacin by Wenhao Wu, Jiahao Zhang, Xiaoyin He, Wei Li, Chun Liu, Biao Jiang, Youlu Su

“…These compounds demonstrate greater efficacy against the multi-drug resistant Aeromonas schubertii strain WL23R compared to the sensitive A. schubertii strain WL23S, indicating their potential in combating antibiotic resistance. …”
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Data mining and safety analysis of voriconazole in patients with a hematological malignant tumor based on the FAERS database: differences between children and adults by Hao Li, Hao Li, Manxue Jiang, Manxue Jiang, Xiaona Pan, Lingti Kong, Lingti Kong, Lingti Kong

“…We assessed the adverse drug events (ADEs) of voriconazole in this population based on the US Food and Drug Administration Adverse Event Reporting System (FAERS) database to improve understanding of the safety of voriconazole.Research design and methodsADE reports for patients with a hematological malignant tumor using voriconazole between the first quarter of 2004 to the first quarter of 2024 were retrieved. …”
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Failure of Urological Implants in Spinal Cord Injury Patients due to Infection, Malfunction, and Implants Becoming Obsolete due to Medical Progress and Age-Related Changes in Human... by Subramanian Vaidyanathan, Bakul Soni, Gurpreet Singh, Peter Hughes, Fahed Selmi, Paul Mansour

“…In the first, paraplegic, patient, a sacral anterior root stimulator failed to produce erection, and a drug delivery system for intracavernosal administration of vasoactive drugs was therefore implanted; however, this implant never functioned (and, furthermore, such penile drug delivery systems to produce erection had effectively become obsolete following the advent of phosphodiesterase type 5 inhibitors). …”
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CD154 Induces Interleukin-6 Secretion by Kidney Tubular Epithelial Cells under Hypoxic Conditions: Inhibition by Chloroquine by Antoine Dewitte, Julien Villeneuve, Sébastien Lepreux, Marion Bouchecareilh, Xavier Gauthereau, Claire Rigothier, Christian Combe, Alexandre Ouattara, Jean Ripoche

“…The inhibition of CD154-induced IL-6 production by chloroquine suggests the potential usefulness of this drug as a therapeutic adjunct in conditions associated with acute kidney injury.…”
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Uncovering the Mechanism of Action of Antiprotozoal Agents: A Survey on Photoaffinity Labeling Strategy by Alessandro Giraudo, Cristiano Bolchi, Marco Pallavicini, Roberto Di Santo, Roberta Costi, Francesco Saccoliti

“…The lack of robustly validated targets and the complexity of parasite’s diseases have made phenotypic screening a preferential drug discovery strategy for the identification of new chemical entities. …”
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SAA3 deficiency exacerbates intestinal fibrosis in DSS-induced IBD mouse model by Xiaodong Zou, Tong Wu, Jianjiao Lin, Tao Su, Hui Xiao, Chuyan Ni, Lijuan Hu, Wenchu Lin, Weilin Chen, Richard D. Ye, Li Xiang

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Characterization of Pulmonary Vein Dimensions Using High-Definition 64-Slice Computed Tomography prior to Radiofrequency Catheter Ablation for Atrial Fibrillation by Catherine Gebhard, Nazmi Krasniqi, Barbara E. Stähli, Bernd Klaeser, Tobias A. Fuchs, Jelena R. Ghadri, Laurent Haegeli, Thomas F. Lüscher, Philipp A. Kaufmann, Firat Duru

“…This retrospective study included 50 patients (mean age 60.2 ± 11.4 years, 30 males) undergoing cardiac HDCT scanning before RFCA for drug refractory AFib and 50 age-, BMI-, and sex-matched controls with normal sinus rhythm undergoing HDCT. …”
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Exploring nanocomposite materials in clinical dermatology: Innovations for treating skin diseases by Sandipan Dasgupta, Subhasundar Maji, Sanjay Dey, Moitreyee Chattopadhyay, Ananya Chanda, Satarupa Acharjee, Kousik Santra, Kazi Asraf Ali

“…The future of nanocomposites in dermatology looks promising, with innovations in personalized medicine, smart drug delivery, and multifunctional materials driving progress. …”
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ZSH‐2208: A novel retinoid with potent anti‐tumour effects on ESCC stem cells via RARγ–TNFAIP3 axis by Ruoxue Chen, Xuan Huang, Jiayun Hou, Junjie Ni, Wenrui Zhao, Quanlin Li, Heng Jiao, Xin Cao

“…Additionally, clinical studies in ESCC still lack drug candidates that effectively target CSCs. Therefore, our team developed a series of novel retinoids that target retinoic acid receptors (RARs), with enhanced potency, broader efficacy and minimised toxic side effects against CSCs. …”
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