Sedative Effect of Nasal Midazolam-Ketamine at Different Doses on 3-6-year-old Uncooperative Dental Patients by Masoud Fallahinejad Ghajari, Ghassem Ansari, Mostafa Mohaveri, Ahmad Eghbali Zarch, Sajjad Razavi

“…Meanwhile, group B received the opposite drug sequence to assess any sequence effect. Dental treatment was initiated with local anesthesia administration. …”
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Serum glutathione peroxidase-3 concentration at diagnosis as a biomarker for assessing disease activity and damage of antineutrophil cytoplasmic antibody-associated vasculitis at d... by Jihye Chung, Jang Woo Ha, Yong-Beom Park, Yong-Beom Park, Sang-Won Lee, Sang-Won Lee

“…BackgroundIn this study, we investigated whether serum glutathione peroxidase-1 (GPX-3) concentration at diagnosis could be used to assess vasculitis activity and damage at diagnosis in immunosuppressive drug-naïve patients with antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV).MethodsWe included 71 immunosuppressive drug-naïve patients newly diagnosed with AAV. …”
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Bioinformatics analysis combined with experimental validation reveals the biological role of the ILK gene in prostate cancer by Xiao-xiang Yu, Yi Liu, Rong-jiang Luo, Zi-xuan Song, Wen-kai Chen, Zeng-mi Mo, Feng-jing Wang

“…Moreover, we conducted Mfuzz expression pattern clustering analysis, gene set enrichment analysis (GSEA), immune function analysis, transcription factor (TF) analysis, and drug prediction. Results 544 significant genes were identified by WGCNA. …”
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In Vitro Evaluation of a Stable Monomeric Gold(II) Complex with Hematoporphyrin IX: Cytotoxicity against Tumor and Kidney Cells, Cellular Accumulation, and Induction of Apoptosis by Georgi Momekov, Dilyan Ferdinandov, Spiro Konstantinov, Sonja Arpadjan, Daniela Tsekova, Galina Gencheva, Panayot R. Bontchev, Margarita Karaivanova

“…The complex exhibits strong cytotoxicity, whereby the leukaemia- and lymphoma-derived cell lines are more sensitive, with IC50 values comparable to those of the reference anticancer drug cisplatin. In contrast, the solid tumor models are more sensitive to the platinum drug. …”
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Molecular Characterization and Epidemiology of Carbapenem-Resistant Enterobacteriaceae Isolated from Pediatric Patients in Guangzhou, Southern China by Fei Gao, Zhile Xiong, Bingshao Liang, Zhenting Huang, Qiulian Deng, Jielin Wang, Huamin Zhong, Yan Long, Sufei Zhu

“…Therefore, this study aimed to investigate the epidemiology of CRE, drug resistance, and resistance mechanisms in children in Guangzhou, Southern China. …”
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Economic Spectrofluorometric Bioanalysis of Empagliflozin in Rats’ Plasma by Bassam Ayoub, Noha El Zahar, Haidy Michel, Mariam Tadros

“…Enhanced liquid-liquid extraction, using diethyl ether (DEE), was successfully employed for the improved extraction of empagliflozin from rats’ plasma based on its high value of logP as 1.8 that boosted the drug migration from plasma to the organic layer. …”
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Risk Factors for Acute Hemorrhagic Rectal Ulcer Syndrome and Its Prognosis: A Density Case-Control Study by Toshihiko Komai, Fumio Omata, Yasutoshi Shiratori, Daiki Kobayashi, Hiroko Arioka

“…This study revealed that hospitalization, antithrombotic drug use, and lower serum albumin value were significant risk factors for AHRUS, and that AHRUS was an unfavorable prognostic condition. …”
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Association between chiropractic spinal manipulation for sciatica and opioid-related adverse events: A retrospective cohort study. by Robert J Trager, Zachary A Cupler, Roshini Srinivasan, Elleson G Harper, Jaime A Perez

“…<h4>Background</h4>Patients receiving chiropractic spinal manipulation (CSM) for spinal pain are less likely to be prescribed opioids, and some evidence suggests that these patients have a lower risk of any type of adverse drug event. We hypothesize that adults receiving CSM for sciatica will have a reduced risk of opioid-related adverse drug events (ORADEs) over a one-year follow-up compared to matched controls not receiving CSM.…”
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Comparing Prednisone and Methotrexate to Off-label Biologic Infliximab for Management of Ocular Uveitis: A Cost-minimization Analysis by William V. Padula, Miguel Cordero-Coma, Taygan Yilmaz, William V. Padula, Michéal J. Gallagher, Jonathan D. Campbell

“…Clinical trials of infliximab in the uveitis population are needed to reduce the uncertain estimates of inflixmab treatment success and the drug’s cost-effectiveness.…”
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Identification of Epinastine as CD96/PVR inhibitor for cancer immunotherapy by Xiangrui Zhang, Lihan Zhang, Beibei Li, Qingchao Wang, Peixin Chen, Ranran Shi, Xiuman Zhou, Xiaoshuang Niu, Wenjie Zhai, Yahong Wu, Wenhui Shen, Xiaowen Zhou, Wenshan Zhao

“…Conclusions Our results demonstrated that the development of small molecule inhibitor Epinastine targeting CD96/PVR pathway, which proposed a promising strategy and drug candidate for cancer immunotherapy. Graphical Abstract…”
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Structural and free energy landscape analysis for the discovery of antiviral compounds targeting the cap-binding domain of influenza polymerase PB2 by Amr S. Abouzied, Saad Alqarni, Kareem M. Younes, Sanad M. Alanazi, Dana M. Alrsheed, Rawabi K. Alhathal, Bader Huwaimel, Akram M. Elkashlan

“…The polymerase basic protein 2 (PB2) of the influenza virus plays a crucial role in the viral replication process, making the CAP-binding domain of PB2 an attractive target for antiviral drug development. This study aimed to identify and evaluate potential inhibitors of the influenza polymerase PB2 CAP-binding domain using computational drug discovery methods. …”
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The design of paper-based electroanalytical microfluidic device coupled with post-synthesized molecularly imprinted polymers (rGO/Au@Ag2S/PANI/polyacrylamide) for the detection of... by Mina Adampourezare, Karim Asadpour-Zeynali, Miguel de la Guardia, Jafar Ezzati Nazhad Dolatabadi

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The Role of miRNAs in the Regulation of Pancreatic Cancer Stem Cells by Sabrina Bimonte, Antonio Barbieri, Maddalena Leongito, Giuseppe Palma, Vitale del Vecchio, Michela Falco, Raffaele Palaia, Vittorio Albino, Mauro Piccirillo, Alfonso Amore, Antonella Petrillo, Vincenza Granata, Francesco Izzo

“…Several studies have shown that pancreatic cancer stem cells (PCSCs) play different roles in the regulation of drug resistance and recurrence in pancreatic cancer. …”
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Geographic Distribution of HCV Genotypes and Efficacy of Direct-Acting Antivirals in Chronic HCV-Infected Patients in North and Northeast China: A Real-World Multicenter Study by Wencong Li, Jing Liang, Jihong An, Lingdi Liu, Yihui Hou, Lu Li, Wen Zhao, Luyao Cui, Ningning Xue, Zaid Al-Dhamin, Tao Han, Yuemin Nan, Liaoyun Zhang

“…SVR12 was higher in noncirrhosis versus compensated cirrhosis patients (100% vs. 97.09%, p=0.022). No severe drug-related adverse event was observed. Conclusions. …”
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Intelligent in-cell electrophysiology: Reconstructing intracellular action potentials using a physics-informed deep learning model trained on nanoelectrode array recordings by Keivan Rahmani, Yang Yang, Ethan Paul Foster, Ching-Ting Tsai, Dhivya Pushpa Meganathan, Diego D. Alvarez, Aayush Gupta, Bianxiao Cui, Francesca Santoro, Brenda L. Bloodgood, Rose Yu, Csaba Forro, Zeinab Jahed

“…We developed a physics-informed deep learning model to reconstruct iAP waveforms from extracellular recordings recorded from NEAs and Microelectrode arrays (MEAs), demonstrating its potential for non-invasive, long-term, high-throughput drug cardiotoxicity assessments. This AI-based model paves the way for future electrophysiology research across various cell types and drug interactions.…”
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Effect of Fentanyl as an Adjuvant to Brachial Plexus Block for Upper Extremity Surgeries: A Systematic Review and Meta-Analysis of RCTs by Liangsong Song, Shulian Tan, Qingmin Chen, He Li

“…We explore the PubMed, Embase, ScienceDirect, CENTRAL, and Google Scholar databases for all randomized controlled trials (RCTs) comparing adjuvant fentanyl with placebo/no drug for patients undergoing upper extremity surgery under brachial plexus block. …”
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Antimildew Treatment and Control Effect of Citral on Bamboo by Jingjing Zhang, Chungui Du, Rui Peng, Ailian Hu, Qi Li, Chunlin Liu, Yingying Shan, Shiqin Chen, Wenxiu Yin

“…The concentration of citral therefore had a significant effect on the drug loading of the antimildew-treated bamboo strips. …”
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Characterization of Nutritional Composition, Antioxidative Capacity, and Sensory Attributes of Seomae Mugwort, a Native Korean Variety of Artemisia argyi H. Lév. & Vaniot by Jae Kyeom Kim, Eui-Cheol Shin, Ho-Jeong Lim, Soo Jung Choi, Cho Rong Kim, Soo Hwan Suh, Chang-Ju Kim, Gwi Gun Park, Cheung-Seog Park, Hye Kyung Kim, Jong Hun Choi, Sang-Wook Song, Dong-Hoon Shin

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Health-related quality of life outcomes reporting associated with FDA approvals in haematology and oncology by Bishal Gyawali, Pallawi Torka, Kristopher Attwood, Medhavi Gupta, Othman Salim Akhtar, Bhavyaa Bahl, Angel Mier-Hicks, Kayla Catalfamo

“…This study aimed to examine the HRQoL reporting in cancer drug trials leading to Food and Drug Administration (FDA) approvals.Methods and analysis This retrospective cohort study analysed HRQoL data for trials leading to FDA approvals between July 2015 and May 2020. …”
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An In-Depth Study of Personalized Anesthesia Management Models in Gastrointestinal Endoscopy Based on Multimodal Deep Learning by Hanqi Shi, Hongyu Wang, Xibing Ding, Zheng Dang

“…In the experimental evaluations, the model demonstrated superior performance in drug usage prediction tasks. Compared with LSTM networks integrated with convolutional neural networks (CNN) and support vector machines (SVM), the LSTM model combined with GMO and sparse matrix classifiers, along with personalized physiological data, achieved a recall rate of 83% and an F1-score of 0.711 in drug usage prediction. …”
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