Sustained-Release Fillers for Dentin Disinfection: An Ex Vivo Study by Bernhard Funk, Sharonit Sahar-Helft, David Kirmayer, Michael Friedman, Doron Steinberg

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Identification of cuproptosis and ferroptosis-related subtypes and development of a prognostic signature in colon cancer. by Yinghao He, Fuqiang Liu, Qingshu Li, Zheng Jiang

“…Further analysis of the relationship between the model and immune cells and functions revealed potential therapeutic targets. Drug sensitivity analysis revealed associations between the expression of model-related genes and drug sensitivity, suggesting their involvement in tumor resistance through certain mechanisms. …”
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Mothers at the Intersection of Trauma, Addiction, and Involvement with the Criminal Legal System: An Analysis of Multiple Case Studies by Monica Solinas-Saunders PhD, Maureen L. Petrunich-Rutherford PhD, Mark D. Thomas PhD, Natasha R. Brown PhD, Kevin L. McElmurry PhD, Melissa A. Jones PhD, Abigail M. Cognetti BSc, Lytina Andrews BSc, Amira Zahabi BSc

“…Further, the 6 cases were used to describe the difficulties experienced by participants across 3 major life transitions: (1) childhood (2) initiation to drug use and addiction disorders (3) motherhood . …”
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Virtual Screening, Toxicity Evaluation and Pharmacokinetics of Erythrina Alkaloids as Acetylcholinesterase Inhibitor Candidates from Natural Products by Permana A, Akili AWR, Hardianto A, Latip JB, Sulaeman AP, Herlina T

“…The applicability of Lipinski’s Rule of Five was applied to evaluate oral drug-likeness.Results: 8-Oxoerymelanthine ( 128) exhibited the highest binding affinity and remarkable stability in molecular dynamics simulations. …”
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Exploring the Mechanism of Antioxidant Action of Bitter Almond Based on Network Pharmacology and Molecular Docking Techniques by Xuehua Feng, Jingya Niu, Zurong Song, Ali Tao, Rumin Zong, Wenqing Pei, Panpan Gong

“…The active ingredients of bitter almond were obtained through the traditional Chinese medicine systematic pharmacology database and analysis platform (TCMSP), and the main active ingredients were screened by bioavailability (OB) and drug-like properties (DL); the GeneCards database was used to search antioxidant-related disease targets through the traditional Chinese medicine systematic pharmacology database and analysis; building a “drug-disease-target” visual network map with Cytoscape 3.9.0 software; a protein interaction (PPI) network was constructed using STRING website and core targets were screened; GO function and KEGG pathway enrichment analysis were obtained using Metoscape. …”
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Renewable Human Cell Model for Type 1 Diabetes Research: EndoC-βH5/HUVEC Coculture Spheroids by James M. Porter, Michael Yitayew, Maryam Tabrizian

“…In vitro drug screening for type 1 diabetes therapies has largely been conducted on human organ donor islets for proof of efficacy. …”
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Effectiveness of Vildagliptin in Clinical Practice: Pooled Analysis of Three Korean Observational Studies (the VICTORY Study) by Sunghwan Suh, Sun Ok Song, Jae Hyeon Kim, Hyungjin Cho, Woo Je Lee, Byung-Wan Lee

“…Data were pooled from the vildagliptin postmarketing survey (PMS), the vildagliptin/metformin fixed drug combination (DC) PMS, and a retrospective observational study of vildagliptin/metformin (fixed DC or free DC). …”
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Helicobacter pylori Infection in Persons with Intellectual Disability in Residential Care in Israel by Joav Merrick, Shoshana Aspler, Inessa Dubman

“…In case of positive serology, triple drug treatment (amoxycillin, metronidazole, and pantoprazole or omepra-zole) was initiated for 1 week. …”
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<i>Ajuga reptans</i> L. Herb Extracts: Phytochemical Composition and Pharmacological Activity Screening by Svitlana Maliuvanchuk, Andriy Grytsyk, Oksana Popadynets, Taras Kotyk, Ain Raal, Oleh Koshovyi

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Online Monitoring Oxidative Products and Metabolites of Nicotine by Free Radicals Generation with Fenton Reaction in Tandem Mass Spectrometry by Shih-Shin Liang, Yow-Ling Shiue, Chao-Jen Kuo, Su-Er Guo, Wei-Ting Liao, Eing-Mei Tsai

“…As a xenobiotic metabolism, hydrophobic compounds are usually converted into more hydrophilic products through enzyme systems such as cytochrome oxidase P450, sulfotransferases, and UDP-glucuronosyltransferases to deliver drug metabolites out of the cell during the drug metabolic process. …”
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Pentazocine Misuse among Sickle Cell Disease Patients and The Role of Lack of Enforcement of Opioid Dispensing Regulations by Community Pharmacies: A Descriptive Observational Stud... by Oluomachi Charity Nnachi, Chinedu Obasi Akpa, Favour Ogonna Nwani, Oghenevwogaga Obukohwo Edenya

“…Most of the local pharmacies/drug shop proprietors are aware of drug laws guiding controlled medicines in Nigeria. …”
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Molecular Modeling Studies of Substituted 2,4,5-Trisubstituted Triazolinones Aryl and Nonaryl Derivatives as Angiotensin II AT1 Receptor Antagonists by Mukesh C. Sharma, D. V. Kohli, Smita Sharma

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Valproic acid intoxication – The importance of toxicological analysis and correct management: A case report by André Valle de Bairros, Karol Andriely de Vargas Paier, Leonardo Corrêa Cardoso, Fernanda Ziegler Reginato, Gustavo Andrade Ugalde, Ivy Bauer Lovatel, Miguel Roehrs

“…Case description: A 15-year-old girl purposely ingested about 100 drug tablets according to family members. Gastric lavage with activated charcoal was performed at home using a nasogastric tube and patient just was taken to the hospital around 10 h after drug ingestion, arriving in shock state. …”
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Association of CYP2C9∗3 and CYP2C8∗3 Non-Functional Alleles with Ibuprofen-Induced Upper Gastrointestinal Toxicity in a Saudi Patient by Amina M. Bagher

“…Ibuprofen is a non-steroidal anti-inflammatory drug (NSAID) widely used to alleviate pain and inflammation. …”
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Oxytocin Versus Dinoprostone For Labor Induction in Multiparous Women with Unfavorable Cervix by Gul Nihal Buyuk, Umit Yasemin Sert, Zeynep Asli Oskovi Kaplan, Serkan Kahyaoglu

“… OBJECTIVE: Dinoprostone is a drug of choice in our daily practice for the induction of labor. …”
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A randomised controlled trial of fluoxetine versus naltrexone in compulsive sexual behaviour disorder: presentation of the study protocol by Jussi Jokinen, Josephine Savard, Katarina Görts Öberg, Cecilia Dhejne

“…The study is financed by grants and entirely independent of the manufacturers.Exclusion criteria include severe psychiatric or psychical illness, changes to concurrent medication and non-compatible factors contraindicating the use of either drug. The primary outcome measure is the Hypersexual Disorder: Current Assessment Scale (HD: CAS), and tolerability will be assessed by the Udvalg for Kliniske Undersogelser side effect rating scale (UKU), drug accountability, adherence to treatment and drop-out rate. …”
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Systematic analysis of the pharmacogenomics landscape towards clinical implementation of precision therapeutics in Greece by George P. Patrinos, Kariofyllis Karamperis, Margarita-Ioanna Koufaki, Maria Skokou, Zoe Kordou, Eirini Sparaki, Margarita Skaraki, Christina Mitropoulou

“…Abstract Pharmacogenomics (PGx) aims to delineate a patient’s genetic profile with differences in drug efficacy and/or toxicity, particularly focusing on genes encoding for drug-metabolizing enzymes and transporters. …”
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Barriers and facilitators to implementing six monthly multi-month dispensing of antiretroviral therapy in two urban HIV clinics during the COVID-19 Era in Malawi. by Rachel Chamanga, Agatha Bula, Denview Magalasi, Stella Mahuva, Mulinda Nyirenda, Kwasi Torpey, Thulani Maphosa, Mitch Matoga

“…Major barriers to the implementation of 6-MMD were low drug supply and lack of understanding of the policy. …”
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An in-depth study of indolone derivatives as potential lung cancer treatment by Mohammed Er-rajy, Mohamed El fadili, Radwan Alnajjar, Sara Zarougui, Somdutt Mujwar, Khalil Azzaoui, Hatem A. Abuelizz, Belkheir Hammouti, Menana Elhallaoui

“…The ADMET analysis revealed that these compounds exhibited favourable drug-like properties, meeting nearly all the key pharmacological criteria required for potential therapeutic agents. …”
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Ecotope-Based Entomological Surveillance and Molecular Xenomonitoring of Multidrug Resistant Malaria Parasites in Anopheles Vectors by Prapa Sorosjinda-Nunthawarasilp, Adisak Bhumiratana

“…MDR malaria is the heritable and hypermutable property of human malarial parasite populations that can decrease in vitro and in vivo susceptibility to proven antimalarial drugs as they exhibit dose-dependent drug resistance and delayed parasite clearance time in treated patients. …”
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