Glioblastoma Stem Cells Microenvironment: The Paracrine Roles of the Niche in Drug and Radioresistance by Alessia Fidoamore, Loredana Cristiano, Andrea Antonosante, Michele d’Angelo, Erica Di Giacomo, Carlo Astarita, Antonio Giordano, Rodolfo Ippoliti, Elisabetta Benedetti, Annamaria Cimini

Get full text

A synthetic chronogenetic gene circuit for programmed circadian drug delivery by Lara Pferdehirt, Anna R. Damato, Kristin L. Lenz, Maria F. Gonzalez-Aponte, Daniel Palmer, Qing-Jun Meng, Erik D. Herzog, Farshid Guilak

“…Once implanted in vivo, the constructs expressed circadian rhythms and entrained to daily light cycles, producing daily increases in biologic drug at the peak of Per2 expression. This approach represents the development of a cell-based chronogenetic therapy for various applications in circadian medicine.…”
Get full text

Study on Nano Drug Particles in the Diagnosis and Treatment of Alzheimer’s Disease in the Elderly by ChangQing Li, Yu Xiang, Yunqian Wang, Ping Li

“…The reference group was given traditional treatment drugs, and the observation group was given nano drug particles. …”
Get full text

Effect of Dementia on the Use of Drugs for Secondary Prevention of Ischemic Heart Disease by Nicole R. Fowler, Amber E. Barnato, Howard B. Degenholtz, Angela M. Curcio, James T. Becker, Lewis H. Kuller, Oscar L. Lopez

Get full text

Organic Synthesis and Catalysis Enable Facile Access to Bioactive Compounds and Drugs by Svetlana B. Tsogoeva, Kirk S. Schanze

Get full text

Calotropis procera Latex-Induced Inflammatory Hyperalgesia—Effect of Antiinflammatory Drugs by Raman Sehgal, Vijay L. Kumar

“…Both antiinflammatory and antiserotonergic drugs significantly inhibited the hyperalgesia associated with DL-induced paw edema. …”
Get full text

The role of bismuth drugs in elevation of Helicobacter pylori infection eradication efficacy by A. A. Sheptulin

“…Absence of H. pylori resistance development to BTD, combined antibacterial and cytoprotective effects as well as good tolerance are important advantages of the drug. Conclusion. Addition of BTD to triple H. pylori eradication modes, that include different antibiotics (clarithromycin, levofloxacin and metronidazole) provide significant increase in efficacy of eradication at antibioticresistant Helicobacter pylori strains.…”
Get full text

A Novel Murine Model for the In Vivo Study of Transdermal Drug Penetration by Gábor Eros, Petra Hartmann, Szilvia Berkó, Eszter Csizmazia, Erzsébet Csányi, Anita Sztojkov-Ivanov, István Németh, Piroska Szabó-Révész, István Zupkó, Lajos Kemény

“…In conclusion, this model allows an exact in vivo study of drug penetration and absorption.…”
Get full text

Genotoxicity Revaluation of Three Commercial Nitroheterocyclic Drugs: Nifurtimox, Benznidazole, and Metronidazole by Annamaria Buschini, Lisa Ferrarini, Susanna Franzoni, Serena Galati, Mirca Lazzaretti, Francesca Mussi, Cristina Northfleet de Albuquerque, Tânia Maria Araújo Domingues Zucchi, Paola Poli

“…In this study, cytotoxic and genotoxic potential of three drugs, Nifurtimox (NFX), Benznidazole (BNZ), and Metronidazole (MTZ) was re-evaluated by different assays. …”
Get full text

Toxic Epidermal Necrolysis Associated with Antiepileptic Drugs and Cranial Radiation Therapy by Shereen Elazzazy, Taghrid Abu Hassan, Ashraf El Seid, Cicy Mary Jacob

“…Our case is a 42-year-old male patient, a case of gliosarcoma who developed purpuric dermatitis associated with phenytoin when combined with cranial radiation therapy; although phenytoin was discontinued and switched to levetiracetam, the patient had more severe symptoms of toxic epidermal necrolysis (TEN) on levetiracetam; the patient improved with aggressive symptom management, discontinuation of antiepileptic drugs (AEDs), and holding radiotherapy. Although TEN is a rare toxicity, physicians should pay a special attention to the monitoring of brain tumor patients on antiepileptic prophylaxis during cranial irradiation; furthermore, patients should be counselled to notify their physicians if they develop any new or unusual symptoms.…”
Get full text

Geographies of Cocaine: Trajectories of Colombian Women Imprisoned for Drug Trafficking in Ecuador by Ana María Cerón Cáceres

Get full text

Exploring genetic associations and drug targets for mitochondrial proteins and schizophrenia risk by Wenxi Sun, Ping Sun, Jin Li, Qun Yang, Qing Tian, Shiting Yuan, Xueying Zhang, Peng Chen, Chuanwei Li, Xiaobin Zhang

“…Moreover, we explored the GWAS catalog and the Drug-Gene Interaction Database (DGIdb) to identify and evaluate potential therapeutic targets. …”
Get full text

Orthostatic Hypotension Is a Predictor of Fatigue in Drug-Naïve Parkinson’s Disease by Jong Hyeon Ahn, Jin Whan Cho, Jinyoung Youn

“…OH and depression are the most relevant predictors for the development of fatigue in drug-naïve PD. The present study suggests that the management of autonomic symptoms and depression might be helpful for managing fatigue in PD.…”
Get full text

Priapism in Antipsychotic Drug Use: A Rare but Important Side Effect by Igne Sinkeviciute, Rune A. Kroken, Erik Johnsen

“…Priapism is a rare but important side effect of antipsychotic drugs which may evolve into a urological emergency. …”
Get full text

Protocol to identify small-molecule inhibitors against cancer drug resistance by Juan Wei, She-Yu Zhang, Xue-Yuan Zhou, Yong Wei, Hao-Ran Jia, Qin Wu, Weihong Tan

“…Summary: Drug resistance has emerged as a critical challenge in clinical cancer treatment. …”
Get full text

IS IT POSSIBLE TO USE BEVACIZUMAB BIOSIMILAR IN ALL INDICATIONS REGISTERED FOR ORIGINAL DRUG? by S. V. Orlov, N. L. Shimanovskii, S. N. Fogt

“…Currently, the European Medicines Agency (EMA) and the Food and Drug Administration (FDA) have identified specific conditions under which for biosimilars extrapolation of indications is possible. …”
Get full text

Biodegradable and Stimuli-Responsive Nanomaterials for Targeted Drug Delivery in Autoimmune Diseases by Nargish Parvin, Sang Woo Joo, Tapas K. Mandal

Subjects: Get full text

Initial Drug Regimen for Active Tuberculosis Cases in Montreal, 1995-1998 by Paul Rivest, Terry N Tannenbaum

“…OBJECTIVES: To evaluate the proportion of tuberculosis (TB) cases initially treated with the recommended four-drug regimen of isoniazid (INH), rifampin (RIF), pyrazinamide (PZA) and ethambutol (EMB) or streptomycin; and to identify factors associated with the choice of initial therapy.…”
Get full text

Polymer nanocomposites in diabetes management: advances in biosensors and drug delivery systems by Aniruddha Sen

Subjects: Get full text

Applications of cell penetrating peptide-based drug delivery system in immunotherapy by Jing-Jing Du, Ru-Yan Zhang, Shangchi Jiang, Shanshan Xiao, Yiting Liu, Yongheng Niu, Wen-Xiang Zhao, Dongyuan Wang, Dongyuan Wang, XianShi Ma

“…This review presented a new insight into CPPs for drug delivery, which could provide advice on the design of clinically effective systemic delivery systems using CPPs.…”
Get full text