Exploring target selectivity in designing and identifying PI3Kα inhibitors for triple negative breast cancer with fragment-based and bioisosteric replacement approach by Debojyoti Halder, Shreya Mukherjee, R. S. Jeyaprakash

“…The significant development is hindered by the multi-drug resistance and poor patient compliance. PIK3CA gene mutation is one of the important causes of TNBC, which causes dysregulation of the cell cycle and cell proliferation. …”
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Tacrolimus toxicity management in a pregnant kidney transplant recipient with newly diagnosed human immunodeficiency virus: A case report by Ahmad Matarneh, Ravi chokshi, Sundus Sardar, Dinia Salmeron, James O’brien, Fareeha Khalil, Naman Trivedi, Nasrollah Ghahramani, Vaqar Shah

“…Notably, tacrolimus is highly susceptible to drug-drug interactions. Even minor adjustments in highly active antiretroviral therapy can result in significant fluctuations in tacrolimus levels, potentially leading to subtherapeutic concentrations (increasing the risk of rejection) or supratherapeutic levels with toxicity. …”
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Comparative Pharmacokinetic Studies of Four Ginsenosides in Rat Plasma by UPLC-MS/MS after Oral Administration of Panax quinquefolius-Acorus gramineus and Panax quinquefolius Extra... by Hailong Xie, Dongxue Wang, Wenjun Zhang, Xinjia Yan, Ying Zhao

“…Panax quinquefolius (PQ) and Acorus gramineus (AG) are drug target pairs in traditional Chinese medicine (TCM), which are used to treat age-related diseases. …”
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Tumor microbiome: roles in tumor initiation, progression, and therapy by Shengxin Zhang, Jing Huang, Zedong Jiang, Huan Tong, Xuelei Ma, Yang Liu

“…Additionally, tumor microbiome is closely associated with drug resistance and influences therapeutic efficacy by modulating immune responses, drug metabolism, and apoptotic pathways. …”
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The Prevalence of Swarming Genes in Escherichia coli Isolated from UTI and Catheter-Associated UTI by Hamza I. Kaittan, May T. Flayyih

“…An important health concern nowadays is drug-resistant bacteria. Objectives: To assess the prevalence of swarming genes in E. coli responsible for UTIs and catheter-associated UTIs, and determine their antibiotic resistance. …”
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Evaluation of the Acute Hepatoprotective Potential of Hydroethanolic Extract of Duranta erecta L. Parts by Shadrack Donkor, Christopher Larbie, Gustav Komlaga, Benjamin Obukowho Emikpe

“…The findings suggest that hydroethanolic Duranta erecta ripe fruits extract possesses hepatoprotective and antioxidative activities against CCl4- and acetaminophen-induced toxicity and could be developed as a potent agent for drug-induced liver diseases.…”
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Postpartum changes in maternal physiology and milk composition: a comprehensive database for developing lactation physiologically-based pharmacokinetic models by Neel Deferm, Neel Deferm, Jean Dinh, Jean Dinh, Amita Pansari, Masoud Jamei, Khaled Abduljalil

“…IntroductionPharmacotherapy during lactation often lacks reliable drug safety data, resulting in delayed treatment or early cessation of breastfeeding. …”
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Women's perception of risks of adverse fetal pregnancy outcomes: a large-scale multinational survey by Irene Petersen, Hedvig Nordeng, Angela Lupattelli, Rachel L McCrea

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Network Pharmacology Reveals Polyphyllin II as One Hit of Nano Chinese Medicine Monomers against Nasopharyngeal Carcinoma by Meng-Zhe Yang, Bei-Bei Zhang, Jian-Chun Huang, Xian-Yu Bai, Zhen-Qiang Liang, Xiang Yi, Ning Xu, Yuan-Jiao Huang, Ai-Jun Jiao

“…Taken together, this study revealed the potential drug targets and underlying mechanisms of polyphyllin II against NPC through modern network pharmacology, which provided a certain theoretical basis for the future nano TCM research.…”
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Synthesis, DFT Analysis, and Evaluation of Antibacterial and Antioxidant Activities of Sulfathiazole Derivatives Combined with In Silico Molecular Docking and ADMET Predictions by Yoseph Samuel, Ankita Garg, Endale Mulugeta

“…Compound 11b also showed high binding scores with both proteins. Drug likeness and ADMET of synthesized compounds were predicted. …”
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Analysis of Phenolic and Flavonoid Content, α-Amylase Inhibitory and Free Radical Scavenging Activities of Some Medicinal Plants by Lalit Kala Pandey, Khaga Raj Sharma

“…However, a detailed study can be performed in these plants to isolate the active chemical compounds and to evaluate in vivo pharmacological activities to know the active drug candidates for the future drug development process.…”
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The value of revascularization and adherence to therapy in the development of cardiovascular complications in long-term monitoring of patients with myocardial infarction of the rig... by V.Y. Tseluyko, T.A. Lozova, V.P. Zheleznyy, O.S. Sasyuk

“…The aim – to evaluate the role of deferred revascularization and adherence to drug therapy as factors affecting long-term prognosis of patients with myocardial infarction (MI) of the right ventricle (RV) on the background of the Q-myocardial infarction of the left ventricle (LV) posterior wall (PW). …”
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Engineering a tumor-selective prodrug T-cell engager bispecific antibody for safer immunotherapy by Amelia C. McCue, Stephen J. Demarest, Karen J. Froning, Michael J. Hickey, Stephen Antonysamy, Brian Kuhlman

“…T-cell engaging (TCE) bispecific antibodies are potent drugs that trigger the immune system to eliminate cancer cells, but administration can be accompanied by toxic side effects that limit dosing. …”
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Azithromycin-loaded liposomal hydrogel: a step forward for enhanced treatment of MRSA-related skin infections by Rukavina Zora, Jøraholmen May Wenche, Božić Dunja, Frankol Ivana, Gašparović Petra Golja, Škalko-Basnet Nataša, Klarić Maja Šegvić, Vanić Željka

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Patient Preference for Once-Weekly Dosing in Type 2 Diabetes Mellitus in Japan by Rohini Sen, Alan L. Shields, Koichiro Atsuda

“…Daily dosing was preferred over QW dosing in the overall population, however, preference for QW was higher in younger, full-time working, treatment naïve subjects, who are/or currently taking 0 or 1 drugs or more than 6 drugs.…”
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Neuron-Specific Fluorescence Reporter-Based Live Cell Tracing for Transdifferentiation of Mesenchymal Stem Cells into Neurons by Chemical Compound by Do Won Hwang, Hyun Woo Kwon, Jaeho Jang, Hee Jung Jung, Kwang Rok Kim, Dong Soo Lee

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Hepatitis C Prevalence on the Rise but Screening at Safety Net Institutions Lagging behind by Jarin Prasa, Syed S. Karim, Bobby Jacob, Paul Mustacchia

“…Despite effective antiviral medications, acute infections have increased in recent years, likely due to IV drug use and the opioid epidemic. Previous guidelines recommended one-time screening for individuals born between 1945 and 1965. …”
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Relation of Vitamin D levels with positive and negative symptoms of schizophrenia – A hospital based cross-sectional comparative study by Soumitra Ghosh, Bikashita Deka

“…Aims and Objectives: We aimed to estimate and compare serum Vitamin D levels in drug-free cases of schizophrenia and in healthy control groups. …”
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Tumor organoids in cancer medicine: from model systems to natural compound screening by Rong Cong, Can Lu, Xinying Li, Zhijie Xu, Yaqin Wang, Shusen Sun

“…Articles related to agriculture, ecology, synthetic work or published in languages other than English were excluded.Results and conclusions The review identifies key challenges related to the efficiency and variability of organoid generation and discusses ongoing efforts to enhance their predictive capabilities in drug screening and personalized medicine. Recent studies utilizing patient-derived organoid models for natural compound screening are highlighted, demonstrating the potential of these models in developing new classes of anticancer agents. …”
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Knowledge on hydroxychloroquine prescription and attitude toward its use in COVID-19 – A survey-based study among doctors by T P Afra, N A Uvais, Anuradha Bishnoi, Edavalath Sukesh, Salin Eliyas, N A Bishurul Hafi, T Muhammed Razmi

“…Results: Of 115 respondents, the majority considered HCQ a safe drug (86.1%) and were in favor of its usage in COVID-19 trials (81.7%) or health-care/contact prophylaxis (60.9%) but against its use as a mass prophylactic agent (80.9%). …”
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