Clinical Trials in Chronic Liver Disease - What Do They Achieve? by Jenny Heathcote

“…The past 30 years have seen rapid growth in the number of clinical trials in liver disease; due mostly to effective drug discovery programs by the pharmaceutical industry. …”
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Coronary-Artery Bypass Grafting by J. Alexander, P. Smith

“…The advances of CABG over percutaneous coronary intervention and drug therapy in various clinical situations are analyzed. …”
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Tissue-Derived Stem Cell Research 2017 by Ming Li, Kequan Guo, Luca Vanella

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Effects of neuroleptics and antidepressants on the cardiovascular system: literature review by V. Rutkauskas

“…It is important to evaluate the patient’s cardiovascular risk and consider it before choosing and prescribing the most appropriate drug. This review provides literature data on the adverse effects of neuroleptics and antidepressants on the cardiovascular system. …”
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Valine potentiates cefoperazone-sulbactam to kill methicillin-resistant Staphylococcus aureus by Shao-hua Li, Yuan Tao, Zhi-cheng Yang, Huan-zhe Fu, Hui-yin Lin, Xuan-xian Peng, Hui Li

“…Therefore, the combination of valine and SCF is a new drug candidate effective against MRSA.…”
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Preparation of Tragopogon graminifolius-loaded electrospun nanofibers and evaluating its wound healing activity in a rat model of skin scar by Leila Almasi, Elham Arkan, Mohammad Hosein Farzaei, Amin Iranpanah, Cyrus Jalili, Fatemeh Abbaszadeh, Faranak Aghaz, Sajad Fakhri, Javier Echeverría

“…To evaluate the wound healing effects, rats were divided into four distinct groups, including negative control (untreated), phenytoin cream (as positive control), polymer (PVA/PEO/CS), and drug (nanofiber-containing 50% of TG extract; named PVA/PEO/CS/TG) groups. …”
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Suppressing recurrence in Sonic Hedgehog subgroup medulloblastoma using the OLIG2 inhibitor CT-179 by Yuchen Li, Chaemin Lim, Taylor Dismuke, Daniel S. Malawsky, Sho Oasa, Zara C. Bruce, Carolin Offenhäuser, Ulrich Baumgartner, Rochelle C. J. D’Souza, Stacey L. Edwards, Juliet D. French, Lucy S. H. Ock, Sneha Nair, Haran Sivakumaran, Lachlan Harris, Andrey P. Tikunov, Duhyeong Hwang, Coral Del Mar Alicea Pauneto, Mellissa Maybury, Timothy Hassall, Brandon Wainwright, Santosh Kesari, Gregory Stein, Michael Piper, Terrance G. Johns, Marina Sokolsky-Papkov, Lars Terenius, Vladana Vukojević, Leon F. McSwain, Timothy R. Gershon, Bryan W. Day

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Uridine-cytidine kinase 2 is correlated with immune, DNA damage repair and promotion of cancer stemness in pan-cancer by Jinlong Tian, Yanlei Li, Yu Tong, Yuan Zhang, Tingxiao Zhao, Yao Kang, Qing Bi

“…This study highlights its potential impact on drug sensitivity.…”
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Cigarette smoke compromises macrophage innate sensing in response to pneumococcal infection by Wei-Chih Liao, Chia-Huei Chou, Mao-Wang Ho, Jo-Tsen Chen, Shu-Ling Chou, Yu-Tsen Huang, Ngoc-Niem Bui, Hui-Yu Wu, Chi-Fan Lee, Wei-Chien Huang, Chih-Ho Lai

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Deciphering the role of flutamide, fluorouracil, and furomollugin based ionic liquids in potent anticancer agents: Quantum chemical, medicinal, molecular docking and MD simulation... by Danish Ali, Muhammad Arif Ali, Muhammad Sarfraz, Afifa Yousuf, Rasham Zulfiqar, Abdul Rauf, Hong-Liang Xu, Muhammad Arshad

“…Bioinformatics studies reveal that our studied ILs possess superior drug-likeness along with supportive medicinal chemistry parameters. …”
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Detection of low frequency artemisinin resistance mutations, C469Y, P553L and A675V, and fixed antifolate resistance mutations in asymptomatic primary school children in Kenya by Victor Osoti, Kevin Wamae, Leonard Ndwiga, Paul M. Gichuki, Collins Okoyo, Stella Kepha, Kibor Keitany, Regina Kandie, Stephen Aricha, Rosebella Kiplagat, Charles Mwandawiro, Philip Bejon, Robert W. Snow, Lynette Isabella Ochola-Oyier

“…Abstract Background To understand the emergence and spread of drug-resistant parasites in malaria-endemic areas, accurate assessment and monitoring of antimalarial drug resistance markers is critical. …”
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Vialess heterogeneous skin patch for multimodal monitoring and stimulation by Hyeokjun Lee, Soojeong Song, Junwoo Yea, Jeongdae Ha, Saehyuck Oh, Janghwan Jekal, Myung Seok Hong, Chihyeong Won, Han Hee Jung, Hohyun Keum, Sangyoon Han, Jeong Ho Cho, Taeyoon Lee, Kyung-In Jang

“…Our system includes electrical and optical modalities for hemodynamic and cardiovascular monitoring, and a force-electrically driven micropump for drug delivery. Each modality is demonstrated through on-demand drug delivery, flexible waveguide-based PPG monitoring, and ECG and body movement monitoring. …”
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Impact of discontinuation of cephazolin prophylaxis on the incidence of postoperative adverse events in cataract surgery by Kazutaka Uchida, Keita Takahama, Kenshiro Higashi, Yuki Kusano, Koki Matsumoto, Yoshihiro Nakagawa, Kazutaka Oda

“…The non-CEZ group had no adverse events and reduced drug costs by approximately 46,000 yen. Insurance claim amounts were also reduced. …”
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Exploring Caregivers’ Perceptions on the Impact of Nyaope and Alcohol Use on Tuberculosis Treatment Adherence in Limpopo Province, South Africa: A Qualitative Investigation by Hulisani Matakanye, Takalani Grace Tshitangano

“…Insufficient data exist on the effects of the nyaope drug use on TB treatment adherence among patients with the disease. …”
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Multidrug Resistance Protein-4 Influences Aspirin Toxicity in Human Cell Line by Isabella Massimi, Ambra Ciuffetta, Flavia Temperilli, Francesca Ferrandino, Alessandra Zicari, Fabio M. Pulcinelli, Maria Pia Felli

“…Overexpression of efflux transporters, in human cells, is a mechanism of resistance to drug and also to chemotherapy. We found that multidrug resistance protein-4 (MRP4) overexpression has a role in reducing aspirin action in patients after bypass surgery and, very recently, we found that aspirin enhances platelet MRP4 levels through peroxisome proliferator activated receptor-α (PPARα). …”
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A3 Adenosine Receptor Allosteric Modulator Induces an Anti-Inflammatory Effect: In Vivo Studies and Molecular Mechanism of Action by Shira Cohen, Faina Barer, Sara Bar-Yehuda, Adriaan P. IJzerman, Kenneth A. Jacobson, Pnina Fishman

“…The anti-inflammatory effect of LUF6000, mechanism of action, and the differential effects on inflammatory and normal cells position this allosteric modulator as an attractive and unique drug candidate.…”
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Formulation of Salam (Syzygium polyanthum (wight) walp) Leaves Ethanolic Extract Matrix Patch and Its Evaluation by Dian Eka Ermawati, Novi Andriani, Ulfa Afrinurfadhilah Darojati

“…Polymers were the patch's main component to control the drug release. Polyvinyl alcohol (PVA) and alpha-cellulose (AC) were polymers that can increase the rate of drug diffusion and form a strong film layer. …”
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The Inhibitory Effect of Alisol A 24-Acetate from Alisma canaliculatum on Osteoclastogenesis by Kwang-Jin Kim, Alain Simplice Leutou, Jeong-Tae Yeon, Sik-Won Choi, Seong Hwan Kim, Sung-Tae Yee, Kyung Hee Choi, Sang-Jip Nam, Young-Jin Son

“…Therefore, alisol A 24-acetate could be developed as a new structural scaffold for inhibitors of osteoclast differentiation in order to develop new drugs against osteoporosis.…”
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PEG-PLGA nanoparticles deposited in Pseudomonas aeruginosa and Burkholderia cenocepacia by Tinatini Tchatchiashvili, Helena Duering, Lisa Mueller-Boetticher, Christian Grune, Dagmar Fischer, Mathias W. Pletz, Oliwia Makarewicz

“…This work emphasizes the potential of PEG-PLGA-based formulations for advanced drug delivery strategies.…”
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Ghostly intrusion on a frightful Halloween night: a case report of dual valve endocarditis by Margarida Castro, Mariana Tinoco, Rafael Martins, Mário Jorge Amorim, Luísa Pinheiro, Marina Fernandes, Filipa Cardoso, Filipa Almeida, Paulo Pinho, João Português, António Lourenço

“…A 51-year-old male patient with intravenous drug usage presented with anorexia, fever, and dyspnea, rapidly progressing to septic shock with multiorgan dysfunction. …”
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