Large-scale evidence generation and evaluation across a network of databases for type 2 diabetes mellitus (LEGEND-T2DM): a protocol for a series of multinational, real-world compar... by Rohan Khera, Yuan Lu, Harlan M Krumholz, Martijn J Schuemie, Ruijun Chen, George Hripcsak, Marc A Suchard, Patrick B Ryan, Anna Ostropolets

“…Using an active comparator, new-user cohort design, LEGEND-T2DM will execute all pairwise class-versus-class and drug-versus-drug comparisons in each data source, producing extensive study diagnostics that assess reliability and generalisability through cohort balance and equipoise to examine the relative risk of cardiovascular and safety outcomes. …”
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A Multifunctional MIL-101-NH2(Fe) Nanoplatform for Synergistic Melanoma Therapy by Shang J, Chen Y, Wang F, Yang J, Li Y, Yang L, Liu X, Zhong Z, Yue C, Zhou M

“…MIL-101-NH2(Fe) was synthesized via a hydrothermal method. Drug release was evaluated under different pH conditions, and the photothermal effect was tested under near-infrared (NIR) laser irradiation. …”
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PretoxTM: a text mining system for extracting treatment-related findings from preclinical toxicology reports by Javier Corvi, Nicolás Díaz-Roussel, José M. Fernández, Francesco Ronzano, Emilio Centeno, Pablo Accuosto, Celine Ibrahim, Shoji Asakura, Frank Bringezu, Mirjam Fröhlicher, Annika Kreuchwig, Yoko Nogami, Jeong Rih, Raul Rodriguez-Esteban, Nicolas Sajot, Joerg Wichard, Heng-Yi Michael Wu, Philip Drew, Thomas Steger-Hartmann, Alfonso Valencia, Laura I. Furlong, Salvador Capella-Gutierrez

“…This provides a valuable resource for toxicology research, enhancing the efficiency of safety evaluations, saving time, and leading to more effective decision-making in the drug development process.…”
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Phosphorylation of SIRT7 by ATM causes DNA mismatch repair downregulation and adaptive mutability during chemotherapy by Lianhui Sun, Guangjian Fan, Zhuqing Zhang, Dong Chang, Xiaoyu Zhang, Tongqing Zhang, Jichuan Geng, Xiaoxia Zhang, Menghan Lin, Chen Hu, Jiaqi Zhou, Mengxue Wang, Liu Cao, Mary Zhang, Baokun He, Shengping Zhang, Chuangui Wang

“…Summary: Drug resistance significantly limits the efficacy of chemotherapy. …”
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Mycochemistry, antioxidant, anticancer activity, and molecular docking of compounds of F12 of ethyl acetate extract of Astraeus asiaticus with BcL2 and Caspase 3 by Swapan Kumar Ghosh, Koushik Pandey, Madhuparna Ghosh, Pradip Kumar Sur

“…Out of them Hexadecanoic acid, 9,12-Octadecadienoic acid and 3,4,5,6 Tetramethyloctane, exhibited suitable properties for drug -preparation and they showed anticancer activity and antioxidant activity as per NIST data base and library search. …”
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Oridonin: A natural terpenoid having the potential to modulate apoptosis and survival signaling in cancer by Abhishek Chauhan, Hemant Joshi, Divya Kandari, Diwakar Aggarwal, Ritu Chauhan, Hardeep Singh Tuli, Arpit Mehrotra, Abhilasha Sood, Ujjawal Sharma, Darin Mansor Mathkor, Shafiul Haque, Naveen Chandra Joshi, Laurent Dufossé

“…Its derivatives and novel delivery systems offer promising avenues for overcoming drug resistance and optimizing its therapeutic efficacy. …”
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Comparative functional analysis of a new CDR1-like ABC transporter gene in multidrug resistance and virulence between Magnaporthe oryzae and Trichophyton mentagrophytes by Jing Wang, Chenwen Xiao, Shuang Liang, Muhammad Noman, Yingying Cai, Zhen Zhang, Xueming Zhu, Rongyao Chai, Haiping Qiu, Zhongna Hao, Yanli Wang, Jiaoyu Wang, Guolian Bao, Guochang Sun, Fucheng Lin

“…TmCDR1 effectively rescued the drug sensitivity and virulence of ΔMocdr1 and mediated the drug resistance and animal skin infection in T. mentagrophytes. …”
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Tissue-Derived Stem Cell Research 2019 by Ming Li, Kequan Guo, Luca Vanella

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Ondansetron Treatment in a Child Presenting with Chronic Intractable Pruritus by Chantal Frigon, Joëlle Desparmet

“…The pruritus did not respond to conventional antipruritic drug treatment, but responded to ondansetron, a selective antagonist of 5-hydroxytryptamine type 3 receptors.…”
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Insulin Resistance, Type 1 and Type 2 Diabetes, and Related Complications 2015 by Joseph Fomusi Ndisang, Sharad Rastogi, Alfredo Vannacci

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Editorial: An integrative proposal in addiction and health behaviors psychosocial research: overview of new trends and future orientations by Álvaro García del Castillo-López, Álvaro García del Castillo-López, Álvaro García del Castillo-López

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Marine Natural Products Against Tuberculosis by Marcus Vinícius Nora De Souza

“…Due to the importance of nature as a source of new drug candidates, the aim of this review is to highlight the marine natural products, which exhibit antituberculosis activity, discovered between 2000 and 2005.…”
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Clozapine Serum Concentrations Are Disrupted by SARS-CoV-2 Vaccinations by Xenia A. K. Kersting, Nicoletta Momtahen, Klaus Lieb

“…It is well established that immune responses can trigger cytokine cascades affecting drug metabolism, which, in the case of clozapine treatment, can lead to severe intoxication.…”
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Minimizing Food Safety Hazards for Organic Growers by Amy Simonne, Danielle Treadwell

“…FCS-8872, a 9-page fact sheet by Amy Simonne and Danielle Treadwell, integrates the key requirements of the Food and Drug Administration Guide to Minimize Microbial Food Safety Hazards for Fresh Fruits and Vegetables (FDA GAPs) and the USDA National Organic Program (NOP) in order to emphasize the areas in which producers can most significantly reduce the food safety risk for their consumers. …”
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PLEYOTROPIC EFFECTS OF METFORMIN by L. Ju. Morgunov

“…Metformin, traditionally used for the therapy of diabetes mellitus, possesses a number of diverse pleyotropic effects. The drug, in addition to the glucose-lowering actions, has a beneficial effect on components of the metabolic syndrome, significantly reduces body weight.…”
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Management of Necrotising Fasciitis

“…Infection is usually of poly-microbial drug resistant organisms. Fasciotomy and surgical debridment was done in these cases under antibiotic cover but antibiotics failed to prove as effective mode of treatment …”
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Amphiphilic Poly(3-hydroxy alkanoate)s: Potential Candidates for Medical Applications by Baki Hazer

“…These hydrophobic natural polyesters, PHAs, need to have hydrophilic character particularly for drug delivery systems. In this manner, poly(ethylene glycol) (PEG) and hydrophilic functional groups such as amine, hydroxyl, carboxyl, and sulfonic acid have been introduced into the PHAs in order to obtain amphiphilic polymers. …”
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Corrigendum to “Antibacterial Properties of Aloe vera on Intracanal Medicaments against Enterococcus faecalis Biofilm at Different Stages of Development” by Negin Ghasemi, Mahsa Behnezhad, Mohammad Asgharzadeh, Elham Zeinalzadeh, Hossein Samadi Kafil

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