Exploring the anticancer potential of Hewittia malabarica through phytochemical analysis and molecular docking study by Shiji Thozhukkad Moosaripparambil, Kannan Vadakkadath Meethal

“…Abstract Natural resources provide valuable medicinal components that are highly sought after as alternatives to synthetic drugs for treating serious diseases like cancer. …”
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Investigation of the Proliferation, Apoptosis/Necrosis, and Cell Cycle Phases in Several Human Multiple Myeloma Cell Lines. Comparison of Viscum album QuFrF Extract with Vincristin... by Eva Kovacs

“…Viscum album QuFrF (VAQuFrF) extract is an experimental drug that is not used in the treatment in tumour patients. …”
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Structural comparison of human and Plasmodium proteasome β5 subunits: informing selective inhibitor design for anti-malaria agents by Muhammad Yasir, Jinyoung Park, Eun-Taek Han, Won Sun Park, Jin-Hee Han, Wanjoo Chun

“…Abstract Background The Plasmodium proteasome emerges as a promising target for anti-malarial drug development due to its potential activity against multiple life cycle stages. …”
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Metal Content in Dandelion (Taraxacum officinale) Leaves: Influence of Vehicular Traffic and Safety upon Consumption as Food by Agnese Giacomino, Mery Malandrino, Maria Laura Colombo, Sergio Miaglia, Pietro Maimone, Sebastiano Blancato, Eleonora Conca, Ornella Abollino

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Ensemble Methods with Voting Protocols Exhibit Superior Performance for Predicting Cancer Clinical Endpoints and Providing More Complete Coverage of Disease-Related Genes by Runyu Jing, Yu Liang, Yi Ran, Shengzhong Feng, Yanjie Wei, Li He

“…The ensemble methodologies provide a more complete coverage of relevant genes, which can facilitate the exploration of cancer mechanisms and the identification of potential drug targets.…”
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Hypertension Knowledge, Attitude, and Practice in Adult Hypertensive Patients at a Tertiary Care Hospital in Sri Lanka by Udaya Ralapanawa, Kameera Bopeththa, Noorika Wickramasurendra, Sampath Tennakoon

“…Almost 75% of the patients had optimum drug compliance. It was revealed that forgetfulness was the frequent cause for poor drug compliance.…”
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High Performance Liquid Chromatographic Assay for the Simultaneous Determination of Posaconazole and Vincristine in Rat Plasma by Hadeel A. Khalil, Ahmed F. El-Yazbi, Tarek S. Belal, Dalia A. Hamdy

“…The assay was validated as per ICH guidelines and is appropriate for pharmacokinetics drug-drug interaction studies.…”
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Mechanisms and therapeutic implications of gene expression regulation by circRNA-protein interactions in cancer by Nan Zhang, Xinjia Wang, Yu Li, Yiwei Lu, Chengcheng Sheng, Yumeng Sun, Ningye Ma, Yisheng Jiao

“…Additionally, we explore the role of CPIs in tumor drug resistance to gain a deeper understanding of their potential applications in the development of new anti-cancer therapeutic approaches.…”
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MicroRNA in Cervical Cancer: OncomiRs and Tumor Suppressor miRs in Diagnosis and Treatment by Kouji Banno, Miho Iida, Megumi Yanokura, Iori Kisu, Takashi Iwata, Eiichiro Tominaga, Kyoko Tanaka, Daisuke Aoki

“…Previous approaches to development of siRNA as a drug have provided information for establishment of therapy based on these approaches, and an anti-miR-21 inhibitor has been developed. miRNAs also have effects on drug resistance and may be useful in combination therapy with other drugs.…”
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Inhibition of the SARS-CoV-2 Main Protease by Isoquercitrin γ-Cyclodextrin Inclusion Complex Formulations: A Biochemical and In Silico Study by Martin Wurtele, Camila Coelho, Gloria Gallo, Claudia Campos, Leon Hardy, Yunierkis Perez Castillo, Masamitsu Moriwaki, Mahendra P. Kapoor, Damião Pergentino de Sousa

“…The main protease (Mpro) of SARS-CoV-2 is a well-established drug target for rational drug design of COVID-19 inhibitors. …”
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Pharmacogenomics Tools for Precision Public Health and Lessons for Low- and Middle-Income Countries: A Scoping Review by Borbón A, Briceño JC, Valderrama-Aguirre A

“…Angélica Borbón,1 Juan Carlos Briceño,2 Augusto Valderrama-Aguirre3 1Technological Innovation Management, University of the Andes, Bogotá, Colombia; 2Department of Biomedical Engineering, Director of Technological Innovation Management Programs, University of the Andes, Bogotá, Colombia; 3Department of Biological Sciences, Faculty of Sciences, Director of the Biomedical Research Institute Group, University of the Andes, Bogotá, ColombiaCorrespondence: Augusto Valderrama-Aguirre, Email a.valderramaa@uniandes.edu.coAbstract: Pharmacogenomics is the integration of genomics and pharmacology to optimize drug response and reduce side effects. In terms of personalized or individualized medicine, PGx is defined as the identification and analysis of specific genetic variants associated with particular drug treatments for each patient. …”
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Yield of TB screening in prisons in Tajikistan by S. Moe, M. Asozoda, A. Aung, Z. Dusmatova, F. Akintore, E. Nshimiyimana, A. Zavqibekov, N. Sitali, W.K. Mulanda, T. Cullip, A. Sinha

“…RESULTS: A total of 7,223 screenings were conducted, identifying 31 TB cases, including 17 drug-susceptible TB cases, eight drug-resistant TB cases, and six clinically diagnosed cases. …”
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Versatility of Chitosan-Based Biomaterials and Their Use as Scaffolds for Tissue Regeneration by José Carlos Viana Ribeiro, Rodrigo Silveira Vieira, Iracema Matos Melo, Vilana Maria Adriano Araújo, Vilma Lima

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Validated UPLC-MS/MS Method for Determination of Futibatinib and Its Pharmacokinetics in Beagle Dogs by Heng Li, Hao-Zhe Ding, Yi-Lin Wang, Feng Zhang, Ya-Hao Song, Xiang-Jun Qiu

“…This method would also be used to study drug-drug interaction (DDI).…”
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Novel Ethyl 1,5-Disubstituted-1H-Pyrazole-3-Carboxylates as a New Class of Antimicrobial Agents by Radwan Awwad A., Ghorab Mostafa M., Alsaid Mansour S., Alanazi Fares K.

“…Ethyl 5-(4-bromo-2-chlorophenyl)- 1-phenyl-1H-pyrazole-3-carboxylate (16) (MIC = 0.015 μmol mL-1) is more active than fluconazole (0.020 μmol mL-1) as a reference drug against C. parapsilosis.…”
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Application of Generative Artificial Intelligence Models for Accurate Prescription Label Identification and Information Retrieval for the Elderly in Northern East of Thailand by Parinya Thetbanthad, Benjaporn Sathanarugsawait, Prasong Praneetpolgrang

“…Both models operated in a zero-shot capacity, utilizing Retrieval-Augmented Generation (RAG) with DrugBank references to ensure contextual relevance and accuracy. …”
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Efficacy and safety of pharmacological treatments in inclusion body myositis: a systematic review by Pedro M Machado, Eduardo José Ferreira Santos, Nicholas Yapp, Pedro Sousa, Bayram Farisogullari, Hermaleigh Townsley

“…Trials of methotrexate (MTX), intravenous immunoglobulin, interferon beta-1a and MTX, MTX and anti-T-lymphocyte immunoglobulin, oxandrolone, MTX and azathioprine, bimagrumab, arimoclomol, and sirolimus provided low-quality to high-quality evidence of having no effect on the progression of IBM.Conclusions Drug interventions for IBM were not effective for most of the outcomes of interest. …”
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Targets and Candidate Agents for Type 2 Diabetes Treatment with Computational Bioinformatics Approach by Qiong Wang, Zhigang Zhao, Jing Shang, Wei Xia

“…We sought to explore the molecular mechanism of type 2 diabetes (T2D) and identify potential drug targets and candidate agents for T2D treatment. …”
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Plain Language Summary of Publication: What is the effect of the medicine vibegron in the treatment of overactive bladder in patients with and without bladder leakage? by David Staskin, Jeffrey Frankel, Steven G. Gregg, Janet Owens-Grillo

“…The medicine vibegron was approved in 2020 by the US Food and Drug Administration (also called the FDA) to treat overactive bladder. …”
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Phenotypic and Molecular Characterization of β-Lactamases among Enterobacterial Uropathogens in Southeastern Nigeria by M. C. Ugwu, M. Shariff, C.M. Nnajide, K Beri, U. M. Okezie, I. R. Iroha, C. O. Esimone

“…The aim of the study was to characterize enterobacterial uropathogens with respect to drug resistance. One hundred (100) enterobacterial uropathogens were studied. …”
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