Frequency of congenital hypothyroidism in new born admitted with neonatal jaundice at tertiary care hospital peshawar by Abdul Ahad, Romana Bibi, Sijad Ur Rehman, Majid Ali Shah, Matea Ullah, Shahinda

“…Key words: Hypothyroidism, Jaundice, kernicterus, bilirubin, morbidity, anti-thyroid drugs. …”
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Insight into the Burden of Antimicrobial Resistance among Bacterial Pathogens Isolated from Patients Admitted in ICUs of a Tertiary Care Hospital in India by Garima Gautam, Shweta Satija, Ravinder Kaur, Anil Kumar, Divakar Sharma, Megh Singh Dhakad

“…The aim of the study was to determine the bacteriological profiles and their drug resistance pattern among different infections in ICU patients of a tertiary care hospital. …”
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Rational design, synthesis, in vitro, and in-silico studies of pyrazole‑phthalazine hybrids as new α‑glucosidase inhibitors by Mehrdad Roshan, Roghieh Mirzazadeh, Azadeh Tajmir-Riahi, Mohammad Sadegh Asgari

“…The synthesized compounds were tested against the yeast α-glucosidase enzyme and showed significantly higher activity than the standard drug Acarbose. The IC50 values ranged from 13.66 ± 0.009 to 494 ± 0.006 μM, compared to the standard drug Acarbose (IC50 = 720.18 ± 0.008). …”
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A Prospective Study of Azilsartan Medoxomil in the Treatment of Patients with Essential Hypertension and Type 2 Diabetes in Asia by Chaicharn Deerochanawong, Kuan-Cheng Chang, Yu Cho Woo, Wen-Ter Lai, Aurauma Chutinet

“…The incidence of TEAEs leading to study drug discontinuation (4.5%) and drug-related TEAEs (5.0% before 6 weeks; 3.9% after 6 weeks) was low. …”
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Thermal performance and MHD peristaltic flow of hybrid nanofluid (Au-Ta/Blood) in an asymmetric conduit with electro-osmosis and shape factor effects by K. Thirunavukarasan, G. Sucharitha

“…The latest developments in hybrid nanomaterials have a wide range of applications, including engineering, cooling systems, drug delivery and heat transfer phenomenon enhancement. …”
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Mycobacterium tuberculosis Lineage Distribution Using Whole-Genome Sequencing and Bedaquiline, Clofazimine, and Linezolid Phenotypic Profiles among Rifampicin-Resistant Isolates fr... by Andriansjah Rukmana, Cynthia Gozali, Linda Erlina

“…Indonesia is ranked second in the world for TB cases. New anti-TB drugs from groups A and B, such as bedaquiline, clofazimine, and linezolid, have been shown to be effective in curing drug resistance in TB patients, and Indonesia is already using these drugs to treat patients. …”
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The Antibacterial Effect of Tinospora Cordifolia (Guduchi) and Its Role in Combating Antimicrobial Resistance by Kavitha EZHILARASU, Anand KASIRANJAN, Shanmuga PRIYA, Anand KAMARAJ

“…Objective: Tinospora cordifolia, often known as 'Guduchi,' has a variety of medicinal characteristics, including those that are anti-diabetic, antiinflammatory, anti-periodic, anti-arthritic, anti-oxidant, anti-allergic, and anti-stress. Drug development projects face significant obstacles because of the rapid rise in antimicrobial drug resistance in the world healthcare system and the introduction of multidrug-resistant (MDR) strains. …”
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In Vivo Noninvasive Optical Imaging of Receptor-Mediated RGD Internalization Using Self-Quenched Cy5-Labeled RAFT-c(-RGDfK-) by Zhao-Hui Jin, Jesus Razkin, Veronique Josserand, Didier Boturyn, Alexeï Grichine, Isabelle Texier, Marie-Christine Favrot, Pascal Dumy, Jean-Luc Coll

“…These results demonstrate that the presence of a labile disulfide bridge between the targeting vector and a drug mimetic is an efficient way to deliver a dye, or a drug, intracellularly. …”
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Prescribers’ approval rate of pharmacist-initiated interventions to optimise patients’ clinical status of hypertension in the ambulatory care setting by Brajković Andrea, Bićanić Lucija Ana, Orehovački Helena, Prkačin Ingrid, Oliveira Djenane Ramalho De, Mucalo Iva

“…Sub-therapeutic dosage (32.6 %) and the need for additional drug therapy (30.9 %) were the two most commonly identified DTPs. …”
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Tackling Microbial Resistance and Emerging Pathogens with Next-Generation Antibiotics by Kar Jing Chong, Huang Feng, Vengadesh Letchumanan, Masita Arip, Omotayo Fatokun, Lazuardi Mochamad, Chin Tat Ng, Sasikala Chinnapan, Malarvili Selvaraja

“…Mechanisms include increased drug adhesion to bacterial cell walls, generating oxidative stress, and causing mistranslation by detaching ribosomes from tRNA. …”
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A Mysterious Gram-Positive Rods by Javzandulam Natsag, Zaw Min, Yasir Hamad, Bassel Alkhalil, Atiq Rahman, Richard Williams

“…We encountered a patient with a history of intravenous drug use presenting with fever, malaise and nausea who was found to have cavitary lung lesions. …”
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Intranasal Pharmacokinetics of Morphine ARER, a Novel Abuse-Deterrent Formulation: Results from a Randomized, Double-Blind, Four-Way Crossover Study in Nondependent, Opioid-Experie... by Lynn R. Webster, Carmela Pantaleon, Matthew Iverson, Michael D. Smith, Eric R. Kinzler, Stefan Aigner

“…The correlation between morphine PK and the pharmacodynamic parameter of drug liking, a measure of abuse potential, was also evaluated. …”
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Nanocrystal Agglomerates of Curcumin Prepared by Electrospray Drying as an Excipient-Free Dry Powder for Inhalation by Shahram Emami, Zahra Hemmati, Shadi Yaqoubi, Hamed Hamishehkar, Amin Alvani

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Determination of Cefoperazone Sodium in Presence of Related Impurities by Linear Support Vector Regression and Partial Least Squares Chemometric Models by Ibrahim A. Naguib, Eglal A. Abdelaleem, Hala E. Zaazaa, Essraa A. Hussein

“…The introduced results show the capability of the two proposed models to analyze cefoperazone in presence of its impurities 7-aminocephalosporanic acid and 5-mercapto-1-methyl-tetrazole with high trueness and selectivity (101.87 ± 0.708 and 101.43 ± 0.536 for PLSR and linear SVR, resp.). Analysis results of drug products were statistically compared to a reported HPLC method showing no significant difference in trueness and precision, indicating the capability of the suggested multivariate calibration models to be reliable and adequate for routine quality control analysis of drug product. …”
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Beyond boundaries: Charting the frontier of healthcare with big data and ai advancements in pharmacovigilance by Arohi Agarwal, Gagan Singh, Samyak Jain, Piyush Mittal

“…The contemporary trend of Big Data Analytics is pivotal, impacting not only the pharmaceutical industry but also transforming healthcare, contributing to personalized treatment, aiding in preventive healthcare, managing electronic health records, facilitating adverse drug reporting, and incorporating consumer reviews. …”
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Vertebral artery dissection in a patient with migraine treated with calcitonin gene-related peptide monoclonal antibody: a case report and FAERS database analysis by Daiki Tokuyasu, Shungo Imai, Shih-Pin Chen, Keiko Ihara, Narumi Watanabe, Yoshikane Izawa, Jin Nakahara, Satoko Hori, Tsubasa Takizawa

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Organoid models: applications and research advances in colorectal cancer by Yijie Wu, Yijie Wu, Yu Sha, Xingpo Guo, Ling Gao, Jian Huang, Song-Bai Liu, Song-Bai Liu

“…This article further analyzes the applications of adult stem cell-derived and pluripotent stem cell-derived organoids in colorectal cancer research and discusses advancements in organoids for basic research, drug research and development, personalized treatment evaluation and prediction, and regenerative medicine. …”
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Predictors of infliximab efficacy in patients with severe attack of ulcerative colitis by A. O. Golovenko, I. L. Khalif, O. V. Golovenko, V. V. Veselov

“…High cost of such treatment and risk of adverse events related to it requires definition of strict indications for application of this drug. It was necessary to detect factors due to which at early stage of biological therapy it is possible to decide whether infliximab will allow to achieve long-term clinical remission, and also to avoid operative treatment.Material and methods. …”
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Toxicological Evaluation and Protective Effects of Ethanolic Leaf Extract of Cassia spectabilis DC on Liver and Kidney Function of Plasmodium berghei-Infected Mice by Wiwied Ekasari, Anisah Mahardiani, Nindya T. Putri, Tutik S. Wahyuni, Heny Arwati

“…Currently, the presence of antimalarial drug resistance has become a major obstacle in the treatment of malaria. …”
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Identification of the Genomics and Transcriptomics Regulators of the DNA Damage Response in Breast Cancer by Mehdi Sadeghi, Mohammad Reza Karimi, Amir Hossein Karimi

“…Implementation of these drugs entails a series of unprecedented challenges, including the development of drug resistance to this treatment strategy. …”
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