Hydroxyapatite-ciprofloxacin delivery system: Synthesis, characterisation and antibacterial activity by Ciocilteu Maria-Viorica, Mocanu Andreea Gabriela, Mocanu Adriana, Ducu Catalin, Nicolaescu Oana Elena, Manda Valentin Costel, Turcu-Stiolica Adina, Nicolicescu Claudiu, Melinte Razvan, Balasoiu Maria, Croitoru Octavian, Neamtu Johny

“…The main objective of this study was to synthesize hydroxyapatite-ciprofloxacin composites using a chemical precipitation method and to evaluate the properties and in vitro release profile of the drug from the hydroxyapatite-ciprofloxacin composites. …”
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Cyclic di AMP phosphodiesterase nanovaccine elicits protective immunity against Burkholderia cenocepacia infection in mice by Wesam E. Gawad, Yosra I. Nagy, Tamer M. Samir, Ahmed Mohamed Ibrahim Mansour, Omneya M. Helmy

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Design, Synthesis, and In Vitro Kinetics Study of Atenolol Prodrugs for the Use in Aqueous Formulations by Rafik Karaman, Alaa Qtait, Khulod Khayyat Dajani, Saleh Abu Lafi

“…In addition, a linear correlation of the calculated and experimental rate values has drawn credible basis for designing atenolol prodrugs that are bitterless, are stable in neutral aqueous solutions, and have the potential to release the parent drug in a sustained release manner. For example, based on the calculated B3LYP/6-31 G (d,p) rates, the predicted t1/2 (a time needed for 50% of the prodrug to be converted into drug) values for atenolol prodrugs ProD 1-ProD 2 at pH 2 were 65.3 hours (6.3 hours as calculated by GGA: MPW1K) and 11.8 minutes, respectively. …”
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Post-TB sequelae in adolescent pulmonary TB survivors by C. Cesilia, F.R. Rinawan, P. Santoso, H.M. Nataprawira

“…OBJECTIVE: To compare the persistent clinical symptoms, chest X-ray (CXR), spirometry and echocardiography results in adolescent survivors of drug-susceptible (DS) and drug-resistant (DR) pulmonary TB (PTB). …”
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Coming of age in recovery: The prevalence and correlates of substance use recovery status among adolescents and emerging adults. by Douglas C Smith, Crystal A Reinhart, Shahana Begum, Janaka Kosgolla, John F Kelly, Brandon B Bergman, Marni Basic

“…Relative to propensity matched control samples, all three groups had significantly lower odds of prescription drug use. The PRO group had lower odds of past month cannabis use. …”
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Nuclear Magnetic Resonance Fingerprinting and Principal Component Analysis Strategies Lead to Anti-Tuberculosis Natural Product Discovery from Actinomycetes by Jianying Han, Xueting Liu, Lixin Zhang, Ronald J. Quinn, Miaomiao Liu

“…Background: The increasing prevalence of drug-resistant tuberculosis (TB) underscores the urgent need for novel antimicrobial agents. …”
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Temperature-Sensitive Gels for Intratumoral Delivery of β-Lapachone: Effect of Cyclodextrins and Ethanol by Marcilio S. S. Cunha-Filho, Carmen Alvarez-Lorenzo, Ramón Martínez-Pacheco, Mariana Landin

“…This paper shows that βLAP formulations involving temperature-reversible Pluronic gels may be suitable for intratumoral drug delivery purposes.…”
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A CDFT-Based Computational Peptidology (CDFT-CP) Study of the Chemical Reactivity and Bioactivity of the Marine-Derived Alternaramide Cyclopentadepsipeptide by Norma Flores-Holguín, Juan Frau, Daniel Glossman-Mitnik

“…The computational pharmacokinetics study revealed the potential ability of alternaramide as a therapeutic drug by interacting with GPCR ligands and protease inhibitors. …”
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The Role of the Patient Information Leaflet in Patients’Medication Therapy: A Case Study within the Kumasi Metropolis of Ghana by Frederick W. A. Owusu, Genevieve Naana Yeboah, Rahel Adutwiwah Aboagye, Cedric Dzidzor K. Amengor, Philomena Entsie

“…In conclusion, reading of the drug information leaflet was higher than that found in previous studies in Ghana. …”
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Retrograde Percutaneous Coronary Intervention in a Case of Takayasu Arteritis with Left Main Coronary Artery Chronic Total Occlusion by Prathap Kumar, Blessvin Jino, Stalin Roy, Manu Rajendran

“…However, PCI remains a good option for patients who develop graft failure after coronary artery bypass graft surgery (CABG). Drug-coated balloons help in repeat revascularization after stent failure in TA. …”
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The use of artificial intelligence in induced pluripotent stem cell-based technology over 10-year period: A systematic scoping review. by Quan Duy Vo, Yukihiro Saito, Toshihiro Ida, Kazufumi Nakamura, Shinsuke Yuasa

“…These enhancements are broadening the applications of iPSC technology in disease modelling, drug screening, and regenerative medicine. This review aims to explore the role of AI in the advancement of iPSC research.…”
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Ecofriendly colorimetric set-up coupled with mathematical filtration strategy for simultaneous determination of ipratropium and fenoterol in their novel anti-asthmatic metered dose... by Salma N. Ali, Hoda M. Marzouk, Ahmed S. Fayed, Samah S. Saad

“…The developed method is based on the properly optimized reaction of drugs under study with the charge transfer reagent 2,3-dichloro-5,6-dicyano-1,4-benzoquinone (DDQ), resulting in orange-colored complexes measured at 464.3 and 514.0 nm for IPR and FEN, respectively. …”
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Exploration of the Potential Mechanisms of Wumei Pill for the Treatment of Ulcerative Colitis by Network Pharmacology by Jinke Huang, Yijun Zheng, Jinxin Ma, Jing Ma, Mengxiong Lu, Xiangxue Ma, Fengyun Wang, Xudong Tang

“…Results. 129 active ingredients and 622 target genes were obtained. The drug-ingredient-target gene network revealed 52 active ingredients of WMP acting on 73 targets related to UC. …”
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What Governs Immediate or Delayed Cardioversion of Atrial Fibrillation by Direct Current Shock? by Amar T. AL-Hamdi, Azad J. Ali, Becker S. Alzand

“…The duration of the atrial fibrillation, the ventricular rate range before the intervention, the preceding drug therapy, patient weight, and left atrial size were measured to illuminate the factors that affect the reversion format. …”
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Two Rare Cases of Feline Toxic Epidermal Necrolysis: A Novel Therapeutic Approach With Medical-Grade Honey by Alexandra Peteoacă, Niels A. J. Cremers, Linsey J. F. Peters

“…Toxic epidermal necrolysis (TEN) is an acute and life-threatening dermatological condition that is drug-induced and characterized by extensive epidermal detachment. …”
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Clinical outcomes of neuroendoscopic resection of brain abscess guided by electromagnetic navigation among patients presenting at Jieyang People's Hospital in China by Mindong Huang, Jiandan Zou

“…After the operation, sensitive antibiotics were intravenously administered according to the bacterial culture and drug sensitivity test. Results: The headache symptoms of the 5 patients were significantly alleviated, and there was no residual limb dysfunction. …”
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A Golgi apparatus‑related subtype and risk signature predicts prognosis and evaluates immunotherapy response in gastric cancer by Ruyue Chen, Zengwu Yao, Lixin Jiang, Jinchen Hu

“…To assess the relationship between risk stratification and survival outcomes, drug sensitivity, and immune infiltration, we developed the Golgi Apparatus-Related Risk Signature (GARRS). …”
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Comparative Bioavailability of Four Marketed Sparfloxacin Formulations in Healthy Human Volunteers by K. Ravindra Rao, J. Vijaya Ratna, T. Manikya Rao

“…The serum concentrations of the drug were determined by microbiological assay. The pharmacokinetic parameters were calculated from the plasma concentration of sparfloxacin versus time data. …”
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Treatment approaches for idiopathic retroperitoneal fibrosis: a systematic review with meta-analysis by Annik Steimer, Mike O. Becker

“…Conclusions Considering the lack of clear evidence indicating that one drug is more effective than the other, the treatment choice should depend on factors such as the potential side effects of different drug therapies, patient comorbidities, and clinician expertise. …”
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Erratum to ‘Role of nanotechnology in neurosurgery: A review of recent advances and their applications’ [World Neurosurgery: X (22C) (2024)100298)] by Javed Iqbal, Evan Courville, Syed Faraz Kazim, Michael Kogan, Meic H. Schmidt, Christian A. Bowers

“…These nanoparticles exhibit significant potential in medicine, including in imaging techniques and diagnostic tools, tissue-engineered constructs, drug delivery systems, pharmaceutical therapeutics, and implants. …”
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