Unlocking Dabrafenib’s Potential: A Quality by Design (QBD) Journey to Enhance Permeation and Oral Bioavailability through Nanosponge Formulation by Konda Sri Chaya Reddy, Darna Bhikshapathi, Jaini Pavan Kumar

“…An area under the curve (AUC0-t) of 7.95-fold greater and a Cmax 7.356 times higher than those of the free drug was demonstrated by the optimized β-CD NSPs, which showed a notable boost. …”
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Pangenome Analysis of Helicobacter pylori Isolates from Selected Areas of Africa Indicated Diverse Antibiotic Resistance and Virulence Genes by Biigba Yakubu, Edwin Moses Appiah, Andrews Frimpong Adu

“…The challenge facing Helicobacter pylori (H. pylori) infection management in some parts of Africa is the evolution of drug-resistant species, the lack of gold standard in diagnostic methods, and the ineffectiveness of current vaccines against the bacteria. …”
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Experimentally Induced Pulpal Lesion and Substance P Expression: Effect of Ketoprofen—A Preliminary Study by Gian Marco Abbate, Paola Sacerdote, Giada Amodeo, Alessandro Mangano, Luca Levrini

“…To evaluate substance P (SP) and the effect of ketoprofen administration, a nonsteroidal anti-inflammatory drug (NSAID), on SP in the pulp of upper third molars with experimentally induced pulpal lesion. …”
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Application of Nanomaterial-Mediated Ferroptosis Regulation in Kidney Disease by Zhu J, Zhang Z, Chu Y, Xie Z, Zeng D, Jin L, Li L

“…The imbalance of iron homeostasis and lipid metabolism affects the occurrence and progression of kidney diseases by triggering ferroptosis, which is considered an important target for the development of kidney disease drugs. However, in clinical practice, targeted ferroptosis therapy for kidney diseases faces obstacles such as poor drug solubility, low drug resistance, and imprecise targeting. …”
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Influence of Food on the Bioavailability of an Enteric-Coated Tablet Formulation of Omeprazole 20 mg Under Repeated Dose Conditions by ABR Thomson, P Sinclair, A Matisko, E Rosen, T Andersson, B Olofsson

“…On the last day of each treatment period, blood samples for the determination of plasma omeprazole concentrations were collected at baseline and at predetermined intervals over the 24 h period following drug administration. …”
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Construction of Two mCherry Plasmids (pXG-mCherry) for Transgenic Leishmania: Valuable Tools for Future Molecular Analysis by Andrés Vacas, Conor Sugden, Óscar Velasco-Rodriguez, Miriam Algarabel-Olona, José Peña-Guerrero, Esther Larrea, Celia Fernández-Rubio, Paul A. Nguewa

“…Thus, the pursuit for new antileishmanial drugs is a priority. The available methods for drug screening based on colorimetric assays using vital dyes are time-consuming. …”
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Chemical Constituents from Uapaca guineensis (Phyllanthaceae), and the Computational Validation of Their Antileishmanial and Anti-inflammatory Potencies by Gervais Mouthé Happi, Mireille Towa Yimtchui, Sikiru Akinyeye Ahmed, Shina Salau, Liliane Clotilde Dzouemo, Klev Gaïtan Sikam, Jean Duplex Wansi

“…Furthermore, the ADMET studies of compounds have been done to evaluate their drug-likeness. Results demonstrate that all the isolated compounds showed a better affinity for both receptors’ binding sites than the standard drugs miltefosine and aspirin. …”
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Individual Prognosis Regarding Effectiveness of a Therapeutic Intervention Using Pre-Therapeutic “Kinesiology Muscle Test” by Ingrid Waxenegger, P. Christian Endler, Beatrix Wulkersdorfer, Heinz Spranger

“…Each of 11 test persons with elevated total cholesterol values received a naturopathic drug supposed to lower cholesterol level on a daily basis for eight consecutive weeks. …”
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Colorimetric Sensor Based on β-Cyclodextrin-Functionalized Silver Nanoparticles for Zidovudine Sensitive Determination by Farhad Ghanizadeh Gerayeli, Farnaz Hosseini, Zohreh Bagheri, Amir Savardashtaki, Zahra Shabaninejad, Ali Mohammad Amani, Sohrab Najafipour

“…Zidovudine (ZDV) is an antiviral drug against HIV that was approved by the FDA on March, 1987. …”
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The Perspective of Therapeutic Antibody Marketing in Iran: Trend and Estimation by 2025 by Monireh Golpour, Pouya Vatanpour, Mina Amini, Majid Saeedi, Nasim Hafezi, Alireza Rafiei

“…Data on the status of MTAs in the country (from 2008 to 2018) were obtained from the Food and Drug Deputy of Mazandaran University of Medical Sciences. …”
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Antidiabetic Activity of Benzopyrone Analogues in Nicotinamide-Streptozotocin Induced Type 2 Diabetes in Rats by Yogendra Nayak, Venkatachalam Hillemane, Vijay Kumar Daroji, B. S. Jayashree, M. K. Unnikrishnan

“…Benzopyrones are proven antidiabetic drug candidate in diabetic drug discovery. In this view novel synthetic benzopyrone analogues were selected for testing in experimental diabetes. …”
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A Reduction in ADAM17 Expression Is Involved in the Protective Effect of the PPAR-α Activator Fenofibrate on Pressure Overload-Induced Cardiac Hypertrophy by Si-Yu Zeng, Hui-Qin Lu, Qiu-Jiang Yan, Jian Zou

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Crystal structure of (E)-2-((3-fluoropyridin-4-yl)methylene)-7-methoxy-3,4-dihydronaphthalen-1(2H)-one, C17H14FNO2 by Wang Chen, Wang Lei, Meng Qing-Guo, Huang Zhi-Xin, Ma Nuan-Nuan, Wang Chun-Hua

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hpvPDB: An Online Proteome Reserve for Human Papillomavirus by Satish Kumar, Lingaraja Jena, Sangeeta Daf, Kanchan Mohod, Peyush Goyal, Ashok K. Varma

“…Affluent information in this reserve could be of help for researchers involved in structural virology, cancer research, drug discovery, and vaccine design.…”
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Identification of Potential Herbal Inhibitor of Acetylcholinesterase Associated Alzheimer’s Disorders Using Molecular Docking and Molecular Dynamics Simulation by Chandrabhan Seniya, Ghulam Jilani Khan, Kuldeep Uchadia

“…Cholinesterase inhibitors (ChE-Is) are the standard for the therapy of AD associated disorders and are the only class of approved drugs by the Food and Drug Administration (FDA). …”
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Multistaged In Silico Discovery of the Best SARS-CoV-2 Main Protease Inhibitors amongst 3009 Clinical and FDA-Approved Compounds by Ibrahim H. Eissa, Abdulrahman M. Saleh, Sara T. Al-Rashood, Abdul-Aziz M. M. El-Attar, Ahmed M. Metwaly

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Biochemical Behaviours of Salmeterol/Fluticasone Propionate in Treating Asthma and Chronic Obstructive Pulmonary Diseases (COPD) by Hilla Mills, Ronald Acquah, Nova Tang, Luke Cheung, Susanne Klenk, Ronald Glassen, Magali Pirson, Alain Albert, Duong Trinh Hoang, Thang Nguyen Van

“…The ICS can work synergically with LABAS (long-acting β2-antagonists) and so many other medicines like bronchodilators. The drugs used for the treatment of asthma and COPD are metabolised once in the body system and at the same time exerting the therapeutic effect provided the concentration of the drug is within the therapeutic window. …”
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Evaluation and testing of polymethylmetacrylic (PMMA) bone cements with admixed Amphotericin B by Florian A. Frank, Barbara Krampitz, Julia Steiner, Rainer Strathausen, Mario Morgenstern, Martin Clauss, Klaus-Dieter Kühn

“…Compression strength was slightly decreased, bending and impact strength significantly decreased whereas bending modulus was increased. Drug elution was high within the first 24 h and decreased over time until day 5. …”
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MDM2 inhibition is associated with the emergence of TP53-altered clonal hematopoiesis by Vishesh Khanna, Gohar Eslami, Rochelle Reyes, Robert Diep, Sebastian Fernandez-Pol, Henning Stehr, Carlos Jose Suarez, Harlan Pinto, James M. Ford, Tian Yi Zhang, Christopher T. Chen

“…Herein, we report a 51-year-old female with MDM2-amplified, TP53-wild type adenoid cystic carcinoma who was treated with a MDM2 inhibitor and developed persistent pancytopenia despite drug discontinuation. Her pancytopenia was associated with 20 distinct pathogenic TP53 mutations in peripheral blood and bone marrow not present in drug-resistant tumor tissue. …”
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Reinstatement of Morphine-Induced Conditioned Place Preference in Mice by Priming Injections by B. Ribeiro Do Couto, M. A. Aguilar, C. Manzanedo, M. Rodríguez-Arias, J. Miñarro

“…To construct a model of relapse of drug abuse in mice, the induction, we evaluated the extinction and reinstatement of morphine-induced place preference. …”
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