Fusidic Acid and Lidocaine-Loaded Electrospun Nanofibers as a Dressing for Accelerated Healing of Infected Wounds by Alsulami KA, Bakr AA, Sirwi A, Elfaky MA, Shaik RA, Alshehri BY, Aodah AH, Al Fayez N, Alshehri AA, Almughem FA, Halwani AA, Tawfik EA

“…Furthermore, both drugs were fully released from the nanofibers within 48 hours. …”
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Enhanced effect of radiofrequency ablation on HCC by siRNA-PD-L1-endostatin Co-expression plasmid delivered by Pengfei Chen, Kun Li, Jinwei Chen, He Hei, Jiaxin Geng, Nannan Huang, Mengyu Lei, Huijie Jia, Jianzhuang Ren, Chenwang Jin

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Finding new ways to treat overdoses by Jill R Turner, Jocelyn Martin

“…Reversing opioid overdoses in rats using a drug that does not enter the brain prevents the sudden and severe withdrawal symptoms associated with therapeutics that target the central nervous system.…”
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Perineuronal Nets and CNS Plasticity and Repair by Daniela Carulli, Jessica C. F. Kwok, Tommaso Pizzorusso

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Mediators of Interorgan Crosstalk in Metabolic Inflammation by Massimo Collino, Assaf Rudich, Daniel Konrad

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A Review of 11 Years of Stenotrophomonas maltophilia Blood Isolates at a Tertiary Care Institute in Canada by Prenilla Naidu, Stephanie Smith

“…BACKGROUND: Stenotrophomonas maltophilia has emerged as a significant nosocomial pathogen with increasing resistance to trimethoprim/sulphamethoxazole (TMP/SMX), the current drug of choice for treatment.…”
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Causality of Blood Metabolites on Proliferative Diabetic Retinopathy: Insights From a Genetic Perspective by Zhaoxiang Wang, Bing Lu, Li Zhang, Yuwen Xia, Xiaoping Shao, Shao Zhong

“…Conclusion: These metabolites have the potential to be used as biomarkers and are promising for future research into the mechanisms and drug targets for PDR.…”
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Acute Management of Cocaine-Associated Methaemoglobinaemia by Immo Weichert

“…Methaemoglobinaemia is a potentially life-threatening complication of problem drug use. This is a case report of a 29-year-old man who presented himself cyanosed after a cocaine binge. …”
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Screening and Treatment of Immigrants and Refugees to Canada for Tuberculosis: Implications of the Experience of Canada and other Industrialized Countries by Roger E Thomas, Brian Gushulak

“…Objective: To assess the incidence of tuberculosis in immigrants and refugees in Canada and other industrialized countries; the effectiveness of the screening process; the incidence of drug resistance; recommendations for prophylaxis and therapy; and indications for and effectiveness of directly observed therapy.…”
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Soil-Transmitted Helminth Reinfection and Associated Risk Factors among School-Age Children in Chencha District, Southern Ethiopia: A Cross-Sectional Study by Zerihun Zerdo, Tsegaye Yohanes, Befikadu Tariku

“…Mass drug administration (MDA) to the most risky population including school-age children (SAC) is the central strategy to control soil-transmitted helminth (STH) infection. …”
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Cholestasis in Chronic Liver Disease and the Role of Ademetionine in its Treatment (Literature Review and Expert Panel Resolution) by K. L. Raikhelson, A. O. Bueverov, E. A. Kondrashina, M. V. Maevskaya, I. B. Khlynov, E. N. Shirokova, V. T. Ivashkin

“…Ademetionine is an effective drug that, due to its pleiotropic action and favourable safety profile, can be used in various chronic liver diseases accompanied by cholestasis, including as a part of the complex therapy.…”
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Clinic Attendance for Medication Refills and Medication Adherence amongst an Antiretroviral Treatment Cohort in Uganda: A Prospective Study by Setor Kunutsor, John Walley, Elly Katabira, Simon Muchuro, Hudson Balidawa, Elizabeth Namagala, Eric Ikoona

“…Regular clinic attendance for antiretroviral (ARV) drug refills is important for successful clinical outcomes in HIV management. …”
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Trypsin-instructed bioactive peptide nanodrugs with cascading transformations to improve chemotherapy against colon cancer by Can Wu, Xiao Wei Zhang, Manman Wang, Jinpan Sun, Jianfei Chen, Yanbin Guan, Xin Pang

“…Herein, a promising trypsin-responsive bioactive peptide-based nanodrug is constructed, which could significantly prolong the drug retention time in vivo by cascading transformations and improve chemotherapeutic efficacy. …”
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Role of Nanofibers in Encapsulation of the Whole Cell by Sudarshan Sahu, Avinash Sharma, Soham Mukherjee, Deepak Kumar, Fatih Sen, Rupak Nagraik, Avvaru Praveen Kumar

“…Electrospun nanofibers act as ideal native extracellular matrices for microorganisms and have also had a tremendous advantage in drug delivery systems where modern research is still underway. …”
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Whole-Body Physiologically Based Pharmacokinetic Modeling of GalNAc-Conjugated siRNAs by Emilie Langeskov Salim, Kim Kristensen, Erik Sjögren

“…<b>Background/Objectives</b>: N-acetyl-galactosamine small interfering RNAs (GalNAc-siRNA) are an emerging class of drugs due to their durable knockdown of disease-related proteins. …”
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Rheological Characterization and Printability of Sodium Alginate–Gelatin Hydrogel for 3D Cultures and Bioprinting by Mohan Kumar Dey, Ram V. Devireddy

“…The development of biocompatible hydrogels for 3D bioprinting is essential for creating functional tissue models and advancing preclinical drug testing. This study investigates the formulation, printability, mechanical properties, and biocompatibility of a novel Alg-Gel hydrogel blend (alginate and gelatin) for use in extrusion-based 3D bioprinting. …”
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Semantic Modeling for SNPs Associated with Ethnic Disparities in HapMap Samples by HyoYoung Kim, Won Gi Yoo, Junhyung Park, Heebal Kim, Byeong-Chul Kang

“…Entities for the network represented by "Gene," "Pathway," "Disease," "Chemical," "Drug," "ClinicalTrials," "SNP," and relationships between entity-entity were obtained through curation. …”
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Traditional Medicinal Herbs and Food Plants Have the Potential to Inhibit Key Carbohydrate Hydrolyzing Enzymes In Vitro and Reduce Postprandial Blood Glucose Peaks In Vivo by M. Fawzi Mahomoodally, A. Hussein Subratty, A. Gurib-Fakim, M. Iqbal Choudhary, S. Nahar Khan

“…Only FF and AM extracts/fractions were found to inhibit α-amylase activity significantly (P<0.05) and coparable to the drug acarbose. Amylase bioassay on isolated mouse plasma confirmed the inhibitory potential of AM and FF extracts with the ethyl acetate fraction of FF being more potent (P<0.05) than acarbose. …”
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The Role of Early Maladaptive Schemas and Coping Strategies in Substance Dependency by Bikem Haciomeroglu, Mehmet Ak, Beyazit Garip, Alper Cinar, Emel Congologlu

“…In terms of coping strategies, the substance dependents scored significantly lower than the control group in Positive Reinterpretation and Growth, Seeking Social Support for Instrumental Reasons, Active Coping, and Seeking Social Support for Emotional Reasons, and significantly higher in Behavioral Disengagement and Alcohol-drug Disengagement subscales. Moreover, Alcohol-drug disengagement type of coping style was significantly predicted by schemas of Emotional deprivation, Emotional inhibition, Enmeshment/dependence, Entitlement/ insufficient self-control, Abandonment/instability, Punitiveness, Defectiveness/shame, Vulnerability to harm or illness, and Unrelenting standards/hypercriticalness. …”
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Database Analysis of Eplerenone Use in Japanese Hypertensive Patients in Clinical Practice by Shoko Takahashi, Yoichi Ii, Yuji Yamamoto, Aya Ikeda, Yoko Fujimoto

“…Data of 160,992 hypertensive patients who used the same drugs for six months or more were collected from an insurance database from January 1, 2009, to December 31, 2013. …”
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