Cleaner Production Quality Regulation Strategy of Pharmaceutical with Collusive Behavior and Patient Feedback by Junmei Rong, Lilong Zhu

“…This paper’s two innovations are as follows: first, it not only considers the collusion between pharmaceutical companies and medical service agencies, but also introduces patient feedback to study drug quality regulation strategies from a microperspective; second, this paper constructs a tripartite evolutionary game model involving cleaner production pharmaceutical companies, medical service agencies, and the governments to analyze the evolutionary stability using the Lyapunov first rule. …”
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Continuous Production of Docetaxel-Loaded Nanostructured Lipid Carriers Using a Coaxial Turbulent Jet Mixer with Heating System by Hyeon Su Lim, Won Il Choi, Jong-Min Lim

“…The optimized synthesis yields NLCs around 80 nm, ideal for targeted drug delivery by enhanced permeability and retention (EPR) effect. …”
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Unravelling the impact of SARS-CoV-2 on hemostatic and complement systems: a systems immunology perspective by Didar Murad, Rehan Zafar Paracha, Maryum Nisar

“…Furthermore, our analysis reveals that drug interventions have a restorative impact on these factors. …”
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Ligand-Based Pharmacophore Modeling and Virtual Screening of RAD9 Inhibitors by Nirmal K. Prasad, Vishnupriya Kanakaveti, Siddhartha Eadlapalli, Ramakrishna Vadde, Angamba Potshangbam Meetei, Vaibhav Vindal

“…Overexpression of RAD9 interacts with BCL-2 proteins and blocks the binding sites of BCL-2 family proteins to interact with chemotherapeutic drugs and leads to drug resistance. Focusing on this interaction, the present study was designed to identify the interaction sites of RAD9 to bind BCL-2 protein and also to inhibit RAD9-BCL-2 interactions by designing novel small molecule inhibitors using pharmacophore modeling and to restore BCL-2 for interacting with anticancer drugs. …”
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Experience of application of modern laxatives at treatment of functional constipation at adults by Ye. K. Baranskaya

“…Observation demonstrated high clinical efficacy of laxative effect of macrogoal: 38 patents rates the drug as «perfect» and «good» vs 2 as «satisfactory».…”
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Optimization of Carrier-Based Dry Powder Inhaler Performance: A Review by Tanu Mehta, Saeed Najafian, Komalkumar Patel, Justin Lacombe, Bodhisattwa Chaudhuri

“…Therefore, API is usually blended with a coarse carrier to improve flowability, and due to its large size, it is more fluidizable than the micronized drug. Carrier-based DPI formulations usually consist of micronized drugs, a coarse carrier, and additional components, such as micronized lactose and force control agents, including magnesium stearate or leucine. …”
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A bibliometric analysis of research on dementia comorbid with depression from 2005 to 2024 by Xia Li, Wei Su, Lili Cai

“…This research area is currently focused on cognitive impairments, the role of gut microbiota, and non-drug interventions. Future directions emphasize the importance of early detection and intervention, a deeper understanding of the gut-brain axis, and the integration of technology in treatment strategies. …”
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<i>In-vitro</i> Characterization of Optimized Multi-Unit Dosage Forms of Theophylline and its Solid State Characterisation by MU Uhumwangho, KV Murthy Ramana

“…The objective of this study is to compare the drug release profile of an optimized multi-unit dose (MU) tablet consisting of rapid and slow release components, a formulated sustained released tablet and two brands of sustained release tablet formulations in the market with a designed model. …”
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Pimobendan oral solution is bioequivalent to pimobendan chewable tablets in beagle dogs by Olaf Kuhlmann, Michael Markert

“…Results Pimobendan was verified as a high variability drug. Based on the RSABE method, both formulations were bioequivalent. …”
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In Vitro Evaluation of Native Taro Boloso-I Starch as a Disintegrant in Tablet Formulations by Tamrat Balcha Balla, Nisha MaryJoseph, Anteneh Belete

“…Introduction. In drug delivery, solid dosage forms, of which tablet is the commonest, are still the leading preferences. …”
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Benzylthiouracil-Induced Glomerulonephritis by Sihem Trimeche Ajmi, Rim Braham, Sarra Toumi, Molka Chadli Chaieb, Amel Maaroufi, Koussay Ach, Larbi Chaieb

“…Vasculitis is a rare complication of antithyroid drugs (ATDs). It was first described with Propylthiouracil (PTU). …”
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Five-Year Retrospective Review of Acute Generalized Exanthematous Pustulosis by Chitprapassorn Thienvibul, Vasanop Vachiramon, Kumutnart Chanprapaph

“…We found high association with systemic drugs. Carbapenems were one of the leading culprit drugs. …”
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Cisplatin-Associated Ototoxicity: A Review for the Health Professional by Jessica Paken, Cyril D. Govender, Mershen Pillay, Vikash Sewram

“…Cisplatin is an effective drug used in the treatment of many cancers, yet its ototoxic potential places cancer patients, exposed to this drug, at risk of hearing loss, thus negatively impacting further on a patient’s quality of life. …”
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Isolation of Acinetobacter in patients admitted to Intensive Care Units by Midiela López López, Juan Rafael Zerquera Rodriguez, Midiala Iglesias López, Yanet Rodríguez Zulueta

“…More than 80% of the isolations were resistant to most β-lactam antibiotics and it was found a high percentage of multi-drug and pan-drug resistant strains (41,6% and 48,1% respectively).…”
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Proteomics and Its Current Application in Biomedical Area: Concise Review by Semira Gobena, Bemrew Admassu, Mebrie Zemene Kinde, Abebe Tesfaye Gessese

“…Biomedical researchers tirelessly seek cutting-edge technologies to advance disease diagnosis, drug discovery, and therapeutic interventions, all aimed at enhancing human and animal well-being. …”
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Microwave Assisted Synthesis, Spectral and Antifungal Studies of 2-Phenyl-N,N′-bis(pyridin-4-ylcarbonyl)butanediamide Ligand and Its Metal Complexes by Rayees Ahmad Shiekh, Maqsood Ahmad Malik, Shaeel Ahmed Al-Thabaiti, Mohmmad Younus Wani, Arshid Nabi

“…In vitro antifungal activity of the ligand and its metal complexes revealed that the metal complexes are highly active compared to the standard drug. Metal complexes showed enhanced activity compared to the ligand, which is an important step towards the designing of antifungal drug candidates.…”
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Enhancement of Liver Targetability through Statistical Optimization and Surface Modification of Biodegradable Nanocapsules Loaded with Lamivudine by Srikar Grandhi, Moawia Al-Tabakha, Prameela Rani Avula

“…LMV was taken as a model drug to investigate the potential of ACNs developed in this work in achieving the liver targetability. …”
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Formation of composite hydrogel of carboxymethyl konjac glucomannan/gelatin for sustained release of EGCG by Lin Wang, Ning Zhou, Shengxuan Zheng, Jie Pang

“…Consequently, TA@n-HA/CKGM/G hydrogels using EGCG as a drug release model show the potential for drug delivery.…”
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Amygdalin isolated from Amygdalus mongolica protects against hepatic fibrosis in rats by Wang Jia, Zhou Hongbing, Wu Tong, Wu Peisai, Liu Quanli, Shi Songli

“…Liver tissue analysis revealed significantly lower activities of ALT, AST, ALP, SOD, and MDA in the drug-treated groups compared to the model group. …”
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<i>In-vitro</i> Characterization of Optimized Multi-Unit Dosage Forms of Theophylline and its Solid State Characterisation by MU Uhumwangho, KV Murthy Ramana

“…The objective of this study is to compare the drug release profile of an optimized multi-unit dose (MU) tablet consisting of rapid and slow release components, a formulated sustained released tablet and two brands of sustained release tablet formulations in the market with a designed model. …”
Get full text