Activating PKC-ε induces HIV expression with improved tolerability. by Alivelu M Irrinki, Jasmine Kaur, Bally Randhawa, Ryan McFadden, Chelsea Snyder, Hoa Truong, Daniel Soohoo, Eric Hu, Helen Yu, Bernard P Murray, Bing Lu, Dmytro Kornyeyev, Ishak Darryl Irwan, Lan Nguyen, Yu-San Yang, Jean-Philippe Belzile, Uli Schmitz, Todd C Appleby, Brian Schultz, Jay Lalezari, Steven Deeks, Tomas Cihlar, Jeffrey P Murry

“…Using structure-based drug design, we developed a novel PKC agonist, C-233, with increased selectivity for PKC-ε. …”
Get full text

Optically driven microtools with an antibody‐immobilised surface for on‐site cell assembly by Shuntaro Mori, Takumi Ito, Hidekuni Takao, Fusao Shimokawa, Kyohei Terao

“…Abstract To enable the accurate reproduction of organs in vitro, and improve drug screening efficiency and regenerative medicine research, it is necessary to assemble cells with single‐cell resolution to form cell clusters. …”
Get full text

Chloroquine Inhibits Dengue Virus Type 2 Replication in Vero Cells but Not in C6/36 Cells by Kleber Juvenal Silva Farias, Paula Renata Lima Machado, Benedito Antônio Lopes da Fonseca

“…Since there is no dengue vaccine available for human use, we have set out to investigate the use of chloroquine as an antiviral drug against dengue. Chloroquine, an amine acidotropic drug known to affect intracellular exocytic pathways by increasing endosomal pH, was used in the in vitro treatment of Vero and C6/36 cells infected with dengue virus type 2 (DENV-2). …”
Get full text

Innovative Biomaterials Based on Collagen-Hydroxyapatite and Doxycycline for Bone Regeneration by Narcisa Mederle, Stefania Marin, Minodora Maria Marin, Elena Danila, Ovidiu Mederle, Madalina Georgiana Albu Kaya, Mihaela Violeta Ghica

“…The in vitro release of doxycycline was also determined and established by non-Fickian drug transport mechanism. Among the studied biomaterials, the most suitable one to easily deliver the drug and mimic bone structure, having compact structure and lower capacity to uptake water, was the one with 75% hydroxyapatite and being cross-linked.…”
Get full text

Synthetic augmentation of cancer cell line multi-omic datasets using unsupervised deep learning by Zhaoxiang Cai, Sofia Apolinário, Ana R. Baião, Clare Pacini, Miguel D. Sousa, Susana Vinga, Roger R. Reddel, Phillip J. Robinson, Mathew J. Garnett, Qing Zhong, Emanuel Gonçalves

“…The synthetically enhanced data increases statistical power, uncovering less studied mechanisms associated with drug resistance, and refines the identification of genetic associations and clustering of cancer cell lines. …”
Get full text

Suvorexant, a Novel Dual Orexin Receptor Antagonist, for the Management of Insomnia by Andrew H. Han, Caroline R. Burroughs, Evan P. Falgoust, Jamal Hasoon, Grace Hunt, Juyeon Kakazu, Tim Lee, Adam M. Kaye, Alan D. Kaye, Latha Ganti

“…While Suvorexant is safe, there are still adverse effects associated with the drug that needs to be considered. The most common adverse effects include dizziness, somnolence, headaches, and cognitive impairment…”
Get full text

Analytical Methods Used for the Detection and Quantification of Benzodiazepines by Zidane Qriouet, Zineb Qmichou, Nadia Bouchoutrouch, Hassan Mahi, Yahia Cherrah, Hassan Sefrioui

“…The prescription of psychotropic drugs, especially benzodiazepines (BZDs), occupies a preponderant place in the management of mental illnesses. …”
Get full text

A Study on Knowledge, Awareness, and Medication Adherence in Patients with Hypertension from a Tertiary Care Centre from Northern Sri Lanka by S. Pirasath, T. Kumanan, M. Guruparan

“…Most of the patients had poor drug compliance. The most common reasons for nonadherence were forgetfulness (70, 23.1%) and interruptions of daily routine (53, 17.5%). …”
Get full text

Impact of Temozolomide on Immune Response during Malignant Glioma Chemotherapy by Sadhak Sengupta, Jaclyn Marrinan, Caroline Frishman, Prakash Sampath

“…TMZ, a DNA alkylating agent, is the most successful antiglioma drug and has added several months to the life expectancy of malignant glioma patients. …”
Get full text

In silico binding role of flavonoids as SARS-CoV-2 main protease (Mpro) inhibitors: A dataset of molecular docking simulation-based high-throughput virtual screening (HTVS)Mendeley... by Mariyam Eema, Vasudeva Rao Avupati

“…Due to the lack of SARS-CoV-2-specific treatment options and rapidly mutating variants, the virus triggered waves of infection and death. Computer-assisted drug design techniques have allowed rapid virtual screening and molecular docking for the identification of numerous biological hit compounds. …”
Get full text

Imaging cells and nanoparticles using modulated optically computed phase microscopy by Xuan Liu, Rupak Bhakta, Emily Kryvorutsky, Yuanwei Zhang

“…Abstract Nanoparticles (NPs) have been successfully used as drug delivery systems. To develop and optimize NP-based drug delivery systems, it is essential to understand the dynamics of cell-NP interactions. …”
Get full text

Pharmaceutical Applications of Glucose Syrup from High Quality Cassava Flour in Oral Liquid Formulations by Ivan K. Simpson, Frederick W. A. Owusu, Mariam E. Boakye-Gyasi, Philomena Entsie, Marcel T. Bayor, Kwabena Ofori-Kwakye

“…All formulations passed the microbial load and drug content tests as specified by the British Pharmacopoeia. …”
Get full text

Enhancing hepatocellular carcinoma therapy with DOX-loaded SiO2 nanoparticles via mTOR-TFEB pathway autophagic flux inhibition by Huanyu Chen, Jun Liu, Zhichao Cao, Jiajia Li, Hong Zhang, Qianqian Yang, Jian Cheng, Yuxian Shen, Kewu He

“…Abstract Chemotherapeutic drugs often fail to provide long-term efficacy due to their lack of specificity and high toxicity. …”
Get full text

An Indirect Atomic Absorption Spectrometric Determination of Trifluoperazine Hydrochloride in Pharmaceutical Formulations Based on Chelate Formation with Palladium(II) by Ameen W. Qasim, Zuhair A. A. Khammas

“…The method is depended on the formation of metal complex between the drug (TFPH) and palladium(II) to form orange-yellowish product extractable in organic solvent prior to its aspiration into an air-acetylene flame and indirectly determined by AAS. …”
Get full text

Development and Validation of a Simple and Selective Analytical HPLC Method for the Quantification of Oxaliplatin by Breno Noronha Matos, Paula Martins de Oliveira, Thaiene Avila Reis, Taís Gratieri, Marcílio Cunha-Filho, Guilherme Martins Gelfuso

“…Such method will be essential during the future development of innovative, topical drug formulations for the treatment of mucosal and skin cancers. …”
Get full text

Decoding the Methylation Patterns of ABC Transporters in Colorectal Cancer by Nurul Nabilah Norhisan, Rashidah Baharudin, Nurul Qistina Rus Bakarurraini, Nur Alyaa Afifah Md Shahri, Francis Yew Fu Tieng, Imilia Ismail, Muhammad-Redha Abdullah-Zawawi, Learn-Han Lee, Nurul Syakima Ab Mutalib

“…The study provides insights into the epigenetic landscape of ABC genes in CRC, highlighting their potential roles in drug resistance, disease initiation, and progression. …”
Get full text

Therapy of Osteoporosis in Men with Teriparatide by Natalie E. Cusano, Aline G. Costa, Barbara C. Silva, John P. Bilezikian

“…Thereafter, it is necessary to treat with an antiresorptive drug to maintain, and perhaps increase, densitometric gains. …”
Get full text

Mutations of the Electron Transport Chain Affect Lifespan and ROS Levels in <i>C. elegans</i> by Fanni Ősz, Aamir Nazir, Krisztina Takács-Vellai, Zsolt Farkas

“…Finally, we examine the potential of <i>C. elegans</i> as a platform for testing ETC-targeting drug candidates, including OXPHOS inhibitors, which represent promising avenues in cancer therapeutics. …”
Get full text

Streptomyces-derived nano-doxorubicin: Clinical status and patents granted by Kaur Prabhjot, Bhandari Divya Dhawal, Chopra Hitesh

“…Streptomyces have been presented as a great source of antibiotics and anti-cancer drugs over the past century. Especially Streptomyces living in adverse conditions produce certain metabolites with cytolytic and anti-microbial activities, which have been utilised for manufacturing antimicrobial and anticancer drugs. …”
Get full text

Self-Medication among Medical and Nonmedical Students at the University of Gondar, Northwest Ethiopia: A Cross-Sectional Study by Zelalem T. Tesfaye, Asrat E. Ergena, Bilal T. Yimer

“…Despite having some benefits, self-medication increases risks such as unnecessary use of medication, extended duration of consumption, incorrect diagnosis, drug-drug interactions, and polypharmacy. Thus, the purpose of this study is to compare self-medication practice between medical and nonmedical students of the University of Gondar, Northwest Ethiopia. …”
Get full text