Anti-Diarrheal Activity of the Aqueous Leaf Extract of <i>Ageratum Conyzoides</i> in Wistar Rats by JOT Emudainohwo, EO Erhirhie, EG Moke

“…Although, it was not also comparable to that of intraperitoneal injection of standard drug, Atropine sulphate at a dose of 0.1 mg/kg body weight. …”
Get full text

Viability Reagent, PrestoBlue, in Comparison with Other Available Reagents, Utilized in Cytotoxicity and Antimicrobial Assays by Namrita Lall, Cynthia Joan Henley-Smith, Marco Nuno De Canha, Carel Basson Oosthuizen, Danielle Berrington

“…PrestoBlue was able to clearly indicate the minimum inhibitory concentration (MIC) of various positive drug controls on various microbial strains. PrestoBlue was also a good indicator of the 50% inhibitory concentration (IC50) of positive drug controls on various cell lines.…”
Get full text

An exploratory study of INPP4B, a biomarker of gemcitabine chemoresistance in pancreatic cancer by REN Jiaqiang, WU Shuai, SU Tong, LI Jie, HAN Liang, WU Zheng

“…Immunohistochemical analysis revealed that INPP4B expression was significantly higher in drug resistant pancreatic cancer tissues compared to non-drug resistant tissues, and lower in normal tissues than in both cancerous tissue types. …”
Get full text

Tumor-Associated Macrophages and Neutrophils in Tumor Microenvironment by Jaehong Kim, Jong-Sup Bae

Get full text

2025: A year of uncertainty and opportunity for public health by Luke Wolfenden, Terry Slevin

Get full text

Gastrointestinal Inflammation and Repair: Role of Microbiome, Infection, and Nutrition by Helieh S. Oz, Sung-Ling Yeh, Manuela G. Neuman

Get full text

Antibody to Hepatitis C Virus in Risk Groups in Canada by RK Chaudhary, Theresa Mo

“…The prevalence of antibodies against hepatitis C virus (HCV) was studied in hemophiliacs, hemodialysis patients, intravenous drug abusers, female prisoners, homosexuals, individuals with no markers of recent hepatitis A or B virus infections and normal individuals (federal public servants), by an enzyme immunoassay (Ortho Diagnostic Systems Inc). …”
Get full text

Development of Microneedle Patch Loaded with Bacopa monnieri Solid Lipid Nanoparticles for the Effective Management of Parkinson’s Disease by Delna Joy, Jobin Jose, Shabana Bibi, Akshay Bandiwadekar, Gopika Gopan, Clara Mariana Gonçalves Lima, Talha Bin Emran, Fahad A. Alhumaydhi, Harsha Ashtekar, Sandeep D. S, Carlos Adam Conte-Junior

“…The demand for drug delivery systems (DDS) to treat Parkinson’s disease (PD) is still high, and microneedle (MN) assisted transdermal DDS offers enormous potential. …”
Get full text

Green Synthesize and Characterization of Copper Nanoparticles Using Iranian Propolis Extracts by Yasamin Seyyed Hajizadeh, Naser Harzandi, Ebrahim Babapour, Mohsen Yazdanian, Reza Ranjbar

“…The green synthesis of CuNPs from Gilan and Khalkhal propolis can be an appropriate candidate for clinical applications such as drug delivery systems, drug formulation, and biomedical applications.…”
Get full text

Optimized digital workflow for pathologist-grade evaluation in bleomycin-induced pulmonary fibrosis mouse model by Toshiki Goto, Akira Sano, Shinichi Onishi, Natsuko Hada, Rui Kimata, Saori Matsuo, Sohei Oyama, Atsuhiko Kato, Hideaki Mizuno, Masaki Yamazaki

“…This deep learning-based fibrosis grade assessment has the potential to streamline drug development for pulmonary fibrosis by offering higher granularity and reproducibility in evaluating BLM model.…”
Get full text

Synthesis, Characterization, and Antibacterial Activities of 1H-Imidazo [5, 6-f] [1,10] Phenanthroline-2(3H)-Thione and Its Ni(II) and Cu(II) Complexes by Radiet Anbessie Tirkeso, Tilahun Wubalem Tsega, Gebru G/Tsadik Amdemichael

“…As multidrug resistant pathogens are emerging, the search for novel potent drug candidates is ever going. Heterocycles are known by their broad spectrum of biological activities, so a search for a new drug from heterocycles can elevate the chance of success. …”
Get full text

Allergic Interstitial Nephritis Manifesting as a Striated Nephrogram by Irfan Moinuddin, Erika Bracamonte, Bijin Thajudeen, Amy Sussman, Machaiah Madhrira, James Costello

“…Guidelines suggest that AIN should be suspected in a patient who presents with an elevated serum creatinine and a urinalysis that shows white cells, white cell casts, or eosinophiluria. Drug-induced AIN is suspected if AKI is temporally related to the initiation of a new drug. …”
Get full text

Synthetic Cannabinoid Abuse and a Rare Alpha-1-Antitrypsin Mutant Causing Acute Fulminant Hepatitis: A Case Report and Review of the Literature by Kurt J. Knowles, Eric X. Wei, Abhishek Seth, John Bienvenu, James Morris, Kenneth Manas, Paul Jordan, Moheb Boktor

“…This case illustrates the possible need to expand routine drug testing for SCs and consider A-1-AT phenotyping in certain clinical scenarios.…”
Get full text

Handling Imbalance Classification Virtual Screening Big Data Using Machine Learning Algorithms by Sahar K. Hussin, Salah M. Abdelmageid, Adel Alkhalil, Yasser M. Omar, Mahmoud I. Marie, Rabie A. Ramadan

“…Virtual screening is the most critical process in drug discovery, and it relies on machine learning to facilitate the screening process. …”
Get full text

Spatial epidemiological analysis based on township scale and analysis of influencing factors of pulmonary tuberculosis cure of Changshu city from 2015 to 2022. by Xiao-Yan Xu, Zheng-Yuan Zhou, Li-Qiang Gong, Li-Qiang Xu, Xiao-Kang Jiao, Bian Yin, Tian-Hong Jiang

“…Diagnosis delay, TB strain types, and drug sensitivity were independent predictors of the cure of new PTB patients.…”
Get full text

Direct oral anticoagulants (DOACs): From the laboratory point of view by Margetić Sandra, Goreta Sandra Šupraha, Ćelap Ivana, Razum Marija

“…Direct oral anticoagulants (DOACs) represent a new generation of drugs that have been increasingly used in the prevention and treatment of thromboembolic states. …”
Get full text

Preparation and investigation of mefenamic acid – polyethylene glycol – sucrose ester solid dispersions by Fülöp Ibolya, Gyéresi Árpád, Kiss Lóránd, Deli Mária A., Croitoru Mircea Dumitru, Szabó-Révész Piroska, Aigner Zoltán

“…Mefenamic acid (MA) is a widely used non-steroidal antiinflammatory (NSAID) drug. The adverse effects typical of NSAIDs are also present in the case of MA, partly due to its low water solubility. …”
Get full text

In Vitro Assessment of Antifungal Caspofungin on Leishmania donovani Culture Isolation by Narayan Raj Bhattarai, Keshav Rai, Suman Rijal, Basudha Khanal

“…In this study, we examine the effect of antifungal drug caspofungin on the promastigote stage of Leishmania donovani. …”
Get full text

T-2 toxin induces senescence in human neuroblastoma SH-SY5Y cells by regulating the HIF-1α/p53/p21 pathway by Yating Wang, Xu Wang, Qinghua Wu

Get full text

Nanomaterial-Based Carbon Paste Electrodes for Voltammetric Determination of Naproxen in Presence of Its Degradation Products by Hassan A. M. Hendawy, Waheed M. Salem, Mahmmoud S. Abd-Elmonem, Elmorsy Khaled

Get full text