Targeting ferroptosis: a promising approach for treating lung carcinoma by Ziyang Wu, Yan Zhang, Wendi Zhong, Kunjian Wu, Tian Zhong, Tao Jiang

“…Targeting ferroptosis improves tumor cell drug resistance and enhances the effectiveness of targeted drugs and immunotherapies. …”
Get full text

Crystal structure of (E)-7-methoxy-2-((6-methoxypyridin-3-yl)methylene)-3,4-dihydronaphthalen-1(2H)-one, C18H17NO3 by Wang Lei, Meng Qing-Guo, Jiang Nan, Wei Lin, Wang Chun-Hua

Get full text

Anti-Diarrheal Activity of the Aqueous Leaf Extract of <i>Ageratum Conyzoides</i> in Wistar Rats by JOT Emudainohwo, EO Erhirhie, EG Moke

“…Although, it was not also comparable to that of intraperitoneal injection of standard drug, Atropine sulphate at a dose of 0.1 mg/kg body weight. …”
Get full text

International Normalized Ratio (INR) Increases amongst Two Patients Living with HIV on Warfarin after Being Switched from a Nevirapine to a Dolutegravir-Based Antiretroviral Regime... by Natalie Sang, Sonak Pastakia, Samuel Nyanje

“…The increased use of dolutegravir-based regimens in the treatment of HIV is unmasking drug interactions, particularly in patients who were previously on nevirapine. …”
Get full text

Effects of Bile Acids and Nisin on the Production of Enterotoxin by Clostridium perfringens in a Nutrient-Rich Medium by Miseon Park, Fatemeh Rafii

Get full text

The Combination Therapy with Zoledronic Acid and Propranolol Improves the Trabecular Microarchitecture and Mechanical Property in an Rat Model of Postmenopausal Osteoporosis by Deepak Kumar Khajuria, Rema Razdan, D. Roy Mahapatra

“…With respect to improvement in the mechanical strength of the lumbar spine and the femoral mid-shaft, the combination treatment of ZOL and PRO was more effective than each drug administered as a monotherapy. Moreover, combination therapy using ZOL and PRO preserved the trabecular microarchitecture better than single-drug therapy using ZOL or PRO in OVX rats. …”
Get full text

Formulation and Evaluation of Guggul Lipid Nanovesicles for Transdermal Delivery of Aceclofenac by Praveen Kumar Gaur, Shikha Mishra, Vidhu Aeri

“…Context. Most new drugs have low water solubility and liposome is an important formulation to administer such drugs; however, it is quite unstable and has negligible systemic absorption. …”
Get full text

Recent research progress on metal ions and metal-based nanomaterials in tumor therapy by Yongcheng Xu, Aikebaier Reheman, Wenhua Feng, Wenhua Feng, Wenhua Feng

“…Metal-based nanomaterials can achieve targeted therapy for tumors through various mechanisms, reducing damage to normal tissues; they can also serve as drug carriers, improving the stability and bioavailability of drugs; at the same time, some metal-based nanomaterials also have photothermal, photodynamic, and other characteristics, which can be used for phototherapy of tumors. …”
Get full text

A physiologically-based pharmacokinetic model for the antibiotic ertapenem by Michele L. Joyner, Cammey C. Manning, Whitney Forbes, Michelle Maiden, Ariel N. Nikas

“…Furthermore, ertapenem is highly bound in human blood plasma; therefore, nonlinear binding is incorporated in the model since only the free portion of the drug can saturate tissues and, hence, is the only portion of the drug considered to be medicinally effective. …”
Get full text

An overview of methods for the treatment and diagnosis of dementia with Lewy bodies. Clinical case analysis by M. Š. Markevičiūtė, M. Karnickas, A. Bagdonaitė

“…The treatment of DLB is also complex and challenging due to the high risk of adverse drug reactions. A drug prescribed to control one symptom of the disease may worsen other symptoms. …”
Get full text

AVP-GPT2: A Transformer-Powered Platform for De Novo Generation, Screening, and Explanation of Antiviral Peptides by Huajian Zhao, Gengshen Song

“…Future research will explore its application to other viral targets and its integration into existing drug development pipelines.…”
Get full text

Neratinib as a Potential Therapeutic for Mutant RAS and Osimertinib-Resistant Tumours by Paul Dent, Laurence Booth, Andrew Poklepovic, John F. Hancock

“…Neratinib is U.S. Food and Drug Administration (FDA)-approved as a neo-adjuvant therapy for use in HER2+ breast cancer. …”
Get full text

The Role Of Early Maladaptive Schemas And Coping Strategies In Substance Dependence by Bikem HACIÖMEROĞLU, Mehmet AK, Beyazit GARİP, Alper ÇINAR, Emel CONGOLOĞLU

“…In terms of coping strategies, the substance dependents scored significantly lower than the control group in positive reinterpretation and growth, seeking social support for instrumental reasons, active coping, and seeking social support for emotional reasons, and significantly higher in behavioral disengagement and alcohol-drug disengagement subscales. Moreover, alcohol-drug disengagement type of coping style was significantly predicted by schemas of emotional deprivation, emotional inhibition, enmeshment/dependence, entitlement/ insufficient self-control, abandonment/instability, punitiveness, defectiveness/shame, vulnerability to harm or illness, and unrelenting standards/hypercriticalness. …”
Get full text

Extract of Sesbania grandiflora Ameliorates Hyperglycemia in High Fat Diet-Streptozotocin Induced Experimental Diabetes Mellitus by Ghanshyam Panigrahi, Chhayakanta Panda, Arjun Patra

“…Insulin tolerance test was carried out on 25th day of drug treatment period. Serum analyses for lipid profile and SGOT and SGPT and serums creatinine, urea, protein, SOD, and MDA were also carried out. …”
Get full text

In vivo investigation of antihyperalgesic and antinociceptive effects of peat formulations by Zagorchev Plamen Ivanov, Apostolova Elisaveta Georgieva, Pilicheva Bissera Asenova, Draganova-Filipova Milena Nenkova, Kokova Vesela Yulieva, Lukanov Julian Borisov

Get full text

Spectrscopic and Conductometric Analysis of Gabapentin by Sara M. Anis, Mervat M. Hosny, Hisham E. Abdellatef, Mohamed N. El-Balkiny

“…The molar combining ratio for methods (A-B) was found to be (2:1) (drug: reagent) while for method (C-D) it was found to be (1:1).…”
Get full text

Computational evaluation on spectroscopic (FT-IR, Raman), electronic and biological, and NLO properties of cirsilineol by DFT, ADMET, and molecular docking method by Tirth Raj Paneru, Poonam Tandon, Bhawani Datt Joshi

“…This study aims to investigate the spectroscopic, electronic, and biological properties of drugs and predict their suitability for drug-like candidates to inhibit prostate cancer. …”
Get full text

Computational evaluation on spectroscopic (FT-IR, Raman), electronic and biological, and NLO properties of cirsilineol by DFT, ADMET, and molecular docking method by Tirth Raj Paneru, Poonam Tandon, Bhawani Datt Joshi

“…This study aims to investigate the spectroscopic, electronic, and biological properties of drugs and predict their suitability for drug-like candidates to inhibit prostate cancer. …”
Get full text

Resolution of Crizotinib-Associated Fulminant Hepatitis following Cessation of Treatment by Gregory W. Charville, Sukhmani K. Padda, Richard K. Sibley, Ajithkumar Puthillath, Paul Y. Kwo

“…This case highlights the potential reversibility of fulminant crizotinib-associated hepatoxicity, possibly related to supratherapeutic dosing, when managed with abrupt stoppage of the drug and initiation of supportive care.…”
Get full text

Development and application of an LC-MS/MS method for the combined quantification of oxysterols and bile acids by Martin Roumain, Giulio G. Muccioli

Get full text