Research progress in the regulation of endothelial cells and smooth muscle cells using a micro–nanostructure by Songhao Liu, Juan Yan, Mengyu Gao, Hongxia Yang

“…As one of the most effective measures to treat them, vascular stents have been widely studied by researchers, and presently, the most commonly used is a drug-eluting stent, which reduces the process of rapid endothelialization because the drug is not selective. …”
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Fully automated CFD simulation system research based on design scheme tree by Zijun Liu

“…Abstract Compared with the remarkable achievements of computer-aided drug discovery systems for drug discovery, the role of computational fluid dynamics (CFD) in flow channel design requires further development. …”
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Isolation of MDCK cells with low expression of mdr1 gene and their use in membrane permeability screening by BOKULIĆ ANA, PADOVAN JASNA, STUPIN-POLANČEC DARIJA, MILIĆ ASTRID

“…The Madin-Darby canine kidney (MDCK) cell line is frequently used for permeability screening in drug discovery. It contains endogenous transporters, most prominently canine multidrug resistance P-glycoprotein (Mdr1), which can interfere with studies of P-glycoprotein substrate assessment and permeability measurements. …”
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Semiconducting Carbon Nanotube-Based Nanodevices for Monitoring the Effects of Chlorphenamine on the Activities of Intracellular Ca2+ Stores by Viet Anh Pham Ba, Ngoc Pham Van Bach, Thien Nguyen Luong, Khoa Viet Nguyen

“…This enabled the statistically meaningful analysis of drug effects on cells without errors from device variations. …”
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The Therapeutic Potential of Medicinal Foods by Nelvana Ramalingum, M. Fawzi Mahomoodally

“…Health professionals now recognize that a synergism of drug therapy and nutrition might confer optimum outcomes in the fight against diseases. …”
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The emergence of cell-based protein arrays to test for polyspecific off-target binding of antibody therapeutics by Diana M. Norden, Carmen T. Navia, Jonathan T. Sullivan, Benjamin J. Doranz

“…Case studies and off-target rates at different phases of biotherapeutic drug approval suggest that off-target binding is likely a major cause of adverse events and drug attrition.…”
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Efficacy of daclatasvir and asunaprevir for viral hepatitis С in two donor lung recipients by D. T. Abdurakhmanov, Ye. . Sidorova, I. N. Tikhonov, N. A. Mukhin, V. T. Ivashkin

“…To estimate efficacy and safety of direct antiviral drugs for hepatitis C treatment in donor lung recipients. …”
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Resveratrol-loaded metal-organic framework for mitochondria-targeted amplified CO gas therapy by Fengqin Wang, Yinfang Jiang, Yang Wang

“…In vitro experimental results demonstrate that the combination therapy, involving both RES drug and CO gas therapy, exhibits a synergistic effect against cancer cells. …”
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Ginsenoside Rk2 alleviates hepatic ischemia/reperfusion injury by enhancing AKT membrane translocation and activation by Hong Shen, Jiajun Fu, Jiayue Liu, Toujun Zou, Kun Wang, Xiao‐Jing Zhang, Jian‐Bo Wan

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Combined alverine citrate and simeticonein preparation in the treatment of irritable bowel syndrome by Ye. A. Poluektova, S. Yu. Kuchumova, V. T. Ivashkin

“…To assess the effect of combined drug meteospasmyl on intensity of clinical symptoms of irritable bowel syndrome (IBS).Material and methods. …”
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Dimethomorph induces heart and vascular developmental defects by disrupting thyroid hormone in zebrafish embryos by You Wei, Yunlong Meng, Kun Jia, Weijian Lu, Yushan Huang, Huiqiang Lu

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Role of Dolutegravir/Lamivudine in the Management of Pregnant People Living with HIV-1: A Narrative Review by William R. Short, Parul Patel, Gustavo Verdier, Ana Puga, Vani Vannappagari, Annemiek de Ruiter, Bryn Jones

“…Abstract Lowering viral load during pregnancy is regarded as the most important method of reducing human immunodeficiency virus 1 (HIV-1) vertical transmission risk, and minimizing fetal exposure to drugs is a guiding principle during pregnancy. Dolutegravir/lamivudine (DTG/3TC) has demonstrated high efficacy, a high barrier to resistance, and a good safety profile in non-pregnant individuals; however, DTG/3TC is not recommended by perinatal HIV treatment guidelines for initial therapy in pregnant people living with HIV-1 because of limited data on use of the 2-drug regimen during pregnancy. …”
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Polyp and tumor microenvironment reprogramming in colorectal cancer: insights from mucosal bacteriome and metabolite crosstalk by Hadi Feizi, Hossein Samadi Kafil, Andrey Plotnikov, Vladimir Kataev, Alexander Balkin, Ekaterina Filonchikova, Mohammad Ahangarzadeh Rezaee, Reza Ghotaslou, Mohammad Sadrkabir, Hiva Kadkhoda, Fadhil S. Kamounah, Sergei Nikitin

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Development of vitex-derived polymer nanofibers using electrochemical sensors for the treatment of polycystic ovarian syndrome in rats as an animal model by Zaid H. Mahmoud, Uday Abdul-Reda Hussein, Najwa Aljbory, Mohammed Jawad Alnajar, Laleh Maleknia, Abolfazl Mirani, Ehsan kianfar

“…Results: The results showed that the drug was well incorporated into the fibers and released slowly and sustainedly from the nanofibers for 30 days. …”
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Blood Genomics Identifies Three Subtypes of Systemic Lupus Erythematosus: “IFN-High,” “NE-High,” and “Mixed” by Mintian Cui, Taotao Li, Xinwei Yan, Chao Wang, Qi Shen, Hongbiao Ren, Liangshuang Li, Ruijie Zhang

“…Systemic lupus erythematosus (SLE) is a systemic and multifactorial autoimmune disease, and its diverse clinical manifestations affect molecular diagnosis and drug benefits. Our study was aimed at defining the SLE subtypes based on blood transcriptome data, analyzing functional patterns, and elucidating drug benefits. …”
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Development of Fulminant Type 1 Diabetes Mellitus in a Patient with DRESS Syndrome by Pedro Perez, Wilson Sze, Daniel Lozeau, Dipa Avichal, Joshua Miller

“…Drug reaction with eosinophilia and systemic symptoms (DRESS) syndrome, also known as drug-induced hypersensitivity syndrome, is a serious, sometimes lethal, immunological reaction to drug metabolites involving multiple organ systems. …”
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Epidemiological and molecular characterization of investigation of Mycoplasma gallisepticum of goose origin in Guangdong (China) by Nan Zhang, Yixin Jia, Weihuo Li, Yangshuo Li, Jingyi Liang, Zhaofeng Yao, Sheng Yuan, Hong Yang, Huanzhong Ding, Yuanyuan Zhou

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Bufalin targets the SRC-3/c-Myc pathway in chemoresistant cells to regulate metastasis induced by chemoresistance in colorectal cancer by Jinbao Chen, Chenqi Wu, Kun Yu, Jinpei Liu, Jiahua Yang, Wei Li, Xiaoxia Tang, Yihai Shi, Ke Xu, Yi Chen, Xiaoyu Qin

“…Bufalin has a therapeutic effect on both metastasis and drug resistance, but how bufalin affects chemoresistance-mediated metastasis remains unclear. …”
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Differences in influenza testing and treatment in micropolitan versus metropolitan areas in the U.S. using medicare claims data from 2010 to 2016 by Alexia Couture, F. Scott Dahlgren, Hector S. Izurieta, Richard A. Forshee, Yun Lu, Carrie Reed

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Insulin Treatment Attenuates Small Nerve Fiber Damage in Rat Model of Type 2 Diabetes by Laura J. Andreasen, Rikke K. Kirk, Christian Fledelius, Mark A. Yorek, Jens Lykkesfeldt, Thorbjorn Akerstrom

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